MCL coexpression mm9:3123

Phase1 CAGE Peaks

	Short description
Mm9::chr17:87153028..87153049,+	p2@Epas1
Mm9::chr17:87153240..87153254,+	p1@Epas1
Mm9::chr2:60800858..60800878,-	p6@Rbms1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0043618	regulation of transcription from RNA polymerase II promoter in response to stress	0.0130597933285795
GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	0.0130597933285795
GO:0043620	regulation of transcription in response to stress	0.0130597933285795
GO:0048875	chemical homeostasis within a tissue	0.0130597933285795
GO:0043129	surfactant homeostasis	0.0130597933285795
GO:0042415	norepinephrine metabolic process	0.0136035786831511
GO:0002027	regulation of heart rate	0.0224422150894195
GO:0001892	embryonic placenta development	0.0224422150894195
GO:0001974	blood vessel remodeling	0.0244757078470398
GO:0033554	cellular response to stress	0.0244757078470398
GO:0051716	cellular response to stimulus	0.0244757078470398
GO:0003697	single-stranded DNA binding	0.0244757078470398
GO:0001666	response to hypoxia	0.0244757078470398
GO:0003690	double-stranded DNA binding	0.0244757078470398
GO:0001894	tissue homeostasis	0.0248996451830171
GO:0048871	multicellular organismal homeostasis	0.0248996451830171
GO:0001890	placenta development	0.0248996451830171
GO:0018958	phenol metabolic process	0.0248996451830171
GO:0006584	catecholamine metabolic process	0.0248996451830171
GO:0008016	regulation of heart contraction	0.027430425466154
GO:0042133	neurotransmitter metabolic process	0.027430425466154
GO:0030218	erythrocyte differentiation	0.027430425466154
GO:0003015	heart process	0.0293515286077098
GO:0060047	heart contraction	0.0293515286077098
GO:0006979	response to oxidative stress	0.0293515286077098
GO:0043566	structure-specific DNA binding	0.0301016548785821
GO:0046982	protein heterodimerization activity	0.0362215470398131
GO:0030324	lung development	0.0363956629082699
GO:0030323	respiratory tube development	0.0363956629082699
GO:0007005	mitochondrion organization and biogenesis	0.0363956629082699
GO:0006576	biogenic amine metabolic process	0.0376785679627757
GO:0048469	cell maturation	0.0376785679627757
GO:0042445	hormone metabolic process	0.0386746014954127
GO:0006575	amino acid derivative metabolic process	0.0386746014954127
GO:0001505	regulation of neurotransmitter levels	0.0386746014954127
GO:0021700	developmental maturation	0.0386746014954127
GO:0030099	myeloid cell differentiation	0.0386746014954127
GO:0003677	DNA binding	0.0386746014954127
GO:0008015	blood circulation	0.0386746014954127
GO:0003013	circulatory system process	0.0386746014954127
GO:0007601	visual perception	0.0427717939759727
GO:0050953	sensory perception of light stimulus	0.0427717939759727
GO:0006725	aromatic compound metabolic process	0.0427717939759727
GO:0001701	in utero embryonic development	0.0437547144648331
GO:0048771	tissue remodeling	0.0437547144648331
GO:0006260	DNA replication	0.046721929108951
GO:0001525	angiogenesis	0.046721929108951

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
tube	4.01e-13	114
anatomical conduit	2.70e-12	122
trunk region element	9.96e-11	79
subdivision of trunk	1.00e-10	66
trunk	1.34e-09	90
multi-cellular organism	3.80e-08	333
epithelial tube	6.39e-08	47
tissue	1.04e-07	349
abdomen element	1.27e-07	49
abdominal segment element	1.27e-07	49
abdominal segment of trunk	1.27e-07	49
abdomen	1.27e-07	49
organ	3.67e-07	266

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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