MCL coexpression mm9:2574

Phase1 CAGE Peaks

	Short description
Mm9::chr10:68861472..68861488,+	p38@Ank3
Mm9::chr10:68861518..68861536,+	p30@Ank3
Mm9::chr19:30249933..30249956,-	p2@Gldc

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0019464	glycine decarboxylation via glycine cleavage system	0.000602640661809018
GO:0004375	glycine dehydrogenase (decarboxylating) activity	0.000602640661809018
GO:0005961	glycine dehydrogenase complex (decarboxylating)	0.000602640661809018
GO:0016642	oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor	0.000602640661809018
GO:0005960	glycine cleavage complex	0.000964225058894429
GO:0006546	glycine catabolic process	0.00241056264723607
GO:0006544	glycine metabolic process	0.00241056264723607
GO:0009071	serine family amino acid catabolic process	0.00241056264723607
GO:0009069	serine family amino acid metabolic process	0.0045532850003348
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	0.00482112529447214
GO:0009063	amino acid catabolic process	0.00924049014773828
GO:0030170	pyridoxal phosphate binding	0.00924049014773828
GO:0009310	amine catabolic process	0.00964225058894429
GO:0044270	nitrogen compound catabolic process	0.00964225058894429
GO:0042803	protein homodimerization activity	0.0158193173724867
GO:0019842	vitamin binding	0.0158193173724867
GO:0048037	cofactor binding	0.0230342652958113
GO:0042802	identical protein binding	0.0230342652958113
GO:0046983	protein dimerization activity	0.0251206002185654
GO:0006520	amino acid metabolic process	0.025793020325426
GO:0006519	amino acid and derivative metabolic process	0.0323704126914558
GO:0009308	amine metabolic process	0.0359392976497014
GO:0006807	nitrogen compound metabolic process	0.0369968962814927
GO:0044248	cellular catabolic process	0.0409795650030132
GO:0019752	carboxylic acid metabolic process	0.0415358486908369
GO:0006082	organic acid metabolic process	0.0415358486908369
GO:0009056	catabolic process	0.0469613315720805

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

---

Uber Anatomy

Ontology term	p-value	n
liver	1.52e-17	22
epithelial sac	1.52e-17	22
digestive gland	1.52e-17	22
epithelium of foregut-midgut junction	1.52e-17	22
anatomical boundary	1.52e-17	22
hepatobiliary system	1.52e-17	22
foregut-midgut junction	1.52e-17	22
hepatic diverticulum	1.52e-17	22
liver primordium	1.52e-17	22
septum transversum	1.52e-17	22
liver bud	1.52e-17	22
digestive tract diverticulum	1.90e-16	23
sac	1.90e-16	23
exocrine gland	1.56e-14	25
exocrine system	1.56e-14	25
abdomen element	7.45e-10	49
abdominal segment element	7.45e-10	49
abdominal segment of trunk	7.45e-10	49
abdomen	7.45e-10	49
eye	8.98e-09	9
camera-type eye	8.98e-09	9
simple eye	8.98e-09	9
immature eye	8.98e-09	9
ocular region	8.98e-09	9
visual system	8.98e-09	9
face	8.98e-09	9
optic cup	8.98e-09	9
optic vesicle	8.98e-09	9
eye primordium	8.98e-09	9
sense organ	2.74e-08	12
sensory system	2.74e-08	12
entire sense organ system	2.74e-08	12
subdivision of head	6.93e-08	11
mesenchyme	1.71e-07	61
entire embryonic mesenchyme	1.71e-07	61
head	2.05e-07	13

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}