MCL coexpression mm9:2086

Phase1 CAGE Peaks

	Short description
Mm9::chr13:75901337..75901359,+	p@chr13:75901337..75901359 +
Mm9::chr5:35385070..35385084,+	p@chr5:35385070..35385084 +
Mm9::chr5:35389132..35389142,+	p@chr5:35389132..35389142 +
Mm9::chr7:121638077..121638090,+	p@chr7:121638077..121638090 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0006368	RNA elongation from RNA polymerase II promoter	0.00849082427874535
GO:0008159	positive transcription elongation factor activity	0.00849082427874535
GO:0003711	transcription elongation regulator activity	0.00849082427874535
GO:0006354	RNA elongation	0.00849082427874535
GO:0031018	endocrine pancreas development	0.00950920211147191
GO:0050796	regulation of insulin secretion	0.01245116183932
GO:0031016	pancreas development	0.0126121740103004
GO:0046883	regulation of hormone secretion	0.0131238398324806
GO:0030073	insulin secretion	0.0131238398324806
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	0.0131238398324806
GO:0004112	cyclic-nucleotide phosphodiesterase activity	0.0131238398324806
GO:0042593	glucose homeostasis	0.0131238398324806
GO:0030072	peptide hormone secretion	0.0131238398324806
GO:0033500	carbohydrate homeostasis	0.0131238398324806
GO:0002790	peptide secretion	0.0131238398324806
GO:0003746	translation elongation factor activity	0.0131514028315503
GO:0015833	peptide transport	0.0151698640205953
GO:0046879	hormone secretion	0.0154569084645442
GO:0035270	endocrine system development	0.0171401863879458
GO:0051046	regulation of secretion	0.0176381730482426
GO:0008081	phosphoric diester hydrolase activity	0.0209903367375198
GO:0003001	generation of a signal involved in cell-cell signaling	0.0268015332072241
GO:0008135	translation factor activity, nucleic acid binding	0.0341544463540627

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
liver	7.73e-18	22
epithelial sac	7.73e-18	22
digestive gland	7.73e-18	22
epithelium of foregut-midgut junction	7.73e-18	22
anatomical boundary	7.73e-18	22
hepatobiliary system	7.73e-18	22
foregut-midgut junction	7.73e-18	22
hepatic diverticulum	7.73e-18	22
liver primordium	7.73e-18	22
septum transversum	7.73e-18	22
liver bud	7.73e-18	22
abdomen element	8.89e-18	49
abdominal segment element	8.89e-18	49
abdominal segment of trunk	8.89e-18	49
abdomen	8.89e-18	49
digestive tract diverticulum	8.90e-17	23
sac	8.90e-17	23
exocrine gland	1.10e-16	25
exocrine system	1.10e-16	25
trunk region element	1.83e-14	79
subdivision of trunk	2.86e-12	66
trunk	4.94e-12	90
immaterial anatomical entity	1.27e-11	79
trunk mesenchyme	7.64e-11	45
mesenchyme	1.76e-09	61
entire embryonic mesenchyme	1.76e-09	61
epithelial tube	2.88e-08	47
endocrine system	2.19e-07	72

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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