Coexpression cluster:C4772

Full id: C4772_mesothelioma_extraskeletal_serous_Mesothelial_amniotic_Preadipocyte_Olfactory

Phase1 CAGE Peaks

Hg19::chr8:74206559..74206574,-	p7@RPL7
Hg19::chr8:74206784..74206821,+	p2@RDH10
Hg19::chr8:74206829..74206846,+	p1@RDH10

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004745	retinol dehydrogenase activity	0.0323753175403421

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
fat cell	1.39e-07	15

Uber Anatomy

Ontology term	p-value	n
subdivision of digestive tract	2.34e-09	129
endodermal part of digestive tract	2.34e-09	129
digestive system	3.17e-09	155
digestive tract	3.17e-09	155
primitive gut	3.17e-09	155
endoderm-derived structure	6.78e-09	169
endoderm	6.78e-09	169
presumptive endoderm	6.78e-09	169
trunk	2.36e-08	216
mixed endoderm/mesoderm-derived structure	2.38e-08	130
epithelial tube	4.19e-08	118
subdivision of trunk	1.20e-07	113
mesenchyme	1.36e-07	238
entire embryonic mesenchyme	1.36e-07	238

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
CCNT2#905	3	6.33620157696263	0.00393075003576489	0.0191350612000209
E2F1#1869	3	4.90738921487932	0.00846098534723939	0.0328021399710581
EGR1#1958	3	4.98817909481014	0.00805648813738344	0.0322750887832831
MAX#4149	3	6.45255550900712	0.00372191383426551	0.0187512281204465
MYC#4609	3	5.2222818716094	0.00702084375574015	0.0296286528610694
NR3C1#2908	3	14.973023331173	0.000297833119467548	0.00310495040567691
SIN3A#25942	3	5.40888472681514	0.00631896197799152	0.027849350973518
SIX5#147912	3	17.086715355459	0.000200406054632501	0.00240438919468854
YY1#7528	3	4.91117074985386	0.00844145534180826	0.0331447480898948
ZBTB7A#51341	3	7.3519093078759	0.00251625586028227	0.0141060250022555

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.