MCL coexpression mm9:1487

Phase1 CAGE Peaks

	Short description
Mm9::chrM:10603..10606,+	p@chrM:10603..10606 +
Mm9::chrM:7005..7022,+	p1@COX2
Mm9::chrM:7759..7794,+	p1@ATP8
Mm9::chrM:9452..9468,+	p1@ND3
Mm9::chrM:9870..9885,+	p1@ND4L
Mm9::chrX:60568425..60568442,+	p@chrX:60568425..60568442 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004666	prostaglandin-endoperoxide synthase activity	0.00864828482206447
GO:0046457	prostanoid biosynthetic process	0.00864828482206447
GO:0001516	prostaglandin biosynthetic process	0.00864828482206447
GO:0042640	anagen	0.00864828482206447
GO:0006693	prostaglandin metabolic process	0.00864828482206447
GO:0006692	prostanoid metabolic process	0.00864828482206447
GO:0048820	hair follicle maturation	0.00864828482206447
GO:0030216	keratinocyte differentiation	0.0110291891455478
GO:0046456	icosanoid biosynthetic process	0.0110291891455478
GO:0006690	icosanoid metabolic process	0.0110291891455478
GO:0004601	peroxidase activity	0.0110291891455478
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	0.0110291891455478
GO:0008217	regulation of blood pressure	0.0110291891455478
GO:0022404	molting cycle process	0.0110291891455478
GO:0001942	hair follicle development	0.0110291891455478
GO:0022405	hair cycle process	0.0110291891455478
GO:0042633	hair cycle	0.0110291891455478
GO:0042303	molting cycle	0.0110291891455478
GO:0006979	response to oxidative stress	0.0110291891455478
GO:0048589	developmental growth	0.0111762450008218
GO:0051213	dioxygenase activity	0.0121480923921976
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	0.0121480923921976
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	0.0121480923921976
GO:0006633	fatty acid biosynthetic process	0.0130747737990383
GO:0016053	organic acid biosynthetic process	0.0130747737990383
GO:0046394	carboxylic acid biosynthetic process	0.0130747737990383
GO:0021700	developmental maturation	0.0149016600010957
GO:0008015	blood circulation	0.0149016600010957
GO:0003013	circulatory system process	0.0149016600010957
GO:0008544	epidermis development	0.0149016600010957
GO:0007398	ectoderm development	0.0151720530253091
GO:0020037	heme binding	0.0156636767056972
GO:0046906	tetrapyrrole binding	0.0156636767056972
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	0.0171204733468471
GO:0005792	microsome	0.0201373783798591
GO:0042598	vesicular fraction	0.0201373783798591
GO:0006631	fatty acid metabolic process	0.0201373783798591
GO:0032787	monocarboxylic acid metabolic process	0.0261024143111298
GO:0008610	lipid biosynthetic process	0.0281794211559182
GO:0009888	tissue development	0.0327138004711554
GO:0005506	iron ion binding	0.0333924393317236
GO:0006118	electron transport	0.0348148901811313
GO:0006091	generation of precursor metabolites and energy	0.0442934516020941
GO:0042221	response to chemical stimulus	0.0443879234075191
GO:0005624	membrane fraction	0.0443879234075191
GO:0019752	carboxylic acid metabolic process	0.0443879234075191
GO:0006082	organic acid metabolic process	0.0443879234075191
GO:0000267	cell fraction	0.0480882650545563
GO:0044255	cellular lipid metabolic process	0.0480882650545563

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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