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Coexpression cluster:C4541

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Full id: C4541_parotid_salivary_Smooth_submaxillary_Mast_Hepatocyte_liver



Phase1 CAGE Peaks

Hg19::chr6:108279263..108279284,-p4@SEC63
Hg19::chr6:108279288..108279308,-p3@SEC63
Hg19::chr6:108279309..108279366,-p2@SEC63


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
fibroblast5.20e-0875
Uber Anatomy
Ontology termp-valuen
digestive system2.37e-09155
digestive tract2.37e-09155
primitive gut2.37e-09155
endoderm-derived structure2.94e-08169
endoderm2.94e-08169
presumptive endoderm2.94e-08169
gut epithelium5.72e-0854
surface structure8.87e-0895
gland1.05e-0759
organ5.70e-07511
subdivision of digestive tract7.64e-07129
endodermal part of digestive tract7.64e-07129
Disease
Ontology termp-valuen
cancer7.25e-09235
disease of cellular proliferation3.58e-08239
cell type cancer5.32e-08143


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BRCA1#672320.18423064322380.0001215704860271640.00164507644340385
CCNT2#90536.336201576962630.003930750035764890.0190941210690814
CHD2#1106310.34402283411690.0009033701102746880.00662503131430224
E2F1#186934.907389214879320.008460985347239390.0327316682846366
E2F4#1874312.66806031528440.0004917987006298980.00438662264028405
E2F6#187635.017155731697390.00791769806886330.0323988742943233
EGR1#195834.988179094810140.008056488137383440.0322157732054594
ETS1#211339.728760922202340.001085840092584840.00764693549760403
HDAC2#3066313.41562023662630.0004140761399857210.0039314270894517
IRF1#365937.63716375356390.002244692747297240.0128632903064459
JUND#372736.994663941871030.002921845042734990.0157531657848433
MAX#414936.452555509007120.003721913834265510.0187286417218432
MYC#460935.22228187160940.007020843755740150.0295796482716425
NFKB1#479035.488063424193840.006049381815655430.0270667203943637
PBX3#5090321.91451268674419.49854535978121e-050.00137322616117136
POU2F2#545239.106124057742520.001324165192682130.00885254695676155
REST#597839.650028716128020.001112636247114590.00770676595121373
SIN3A#2594235.408884726815140.006318961977991520.0278024211155351
TCF12#6938310.63446490218640.0008313523990202070.00631642755720001
YY1#752834.911170749853860.008441455341808260.0330962217299764
ZBTB33#10009331.66472502998123.14815888737575e-050.00063473082246841



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.