MCL coexpression mm9:1258

Phase1 CAGE Peaks

	Short description
Mm9::chr10:93052366..93052426,-	p1@Snrpf
Mm9::chr11:119161318..119161348,-	p1@Eif4a3
Mm9::chr11:59653247..59653265,-	p4@Cops3
Mm9::chr4:122817172..122817203,-	p1@Ppie
Mm9::chr6:91466000..91466052,+	p1@Lsm3
Mm9::chr7:16973106..16973122,-	p2@Sae1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005681	spliceosome	5.61954294543226e-06
GO:0008380	RNA splicing	6.66597430610392e-06
GO:0006397	mRNA processing	1.23376633643291e-05
GO:0016071	mRNA metabolic process	1.45117378951032e-05
GO:0006396	RNA processing	4.03625053793264e-05
GO:0044428	nuclear part	4.39995964132779e-05
GO:0030529	ribonucleoprotein complex	6.67731415176424e-05
GO:0030532	small nuclear ribonucleoprotein complex	6.67731415176424e-05
GO:0003723	RNA binding	0.000124435294817082
GO:0000375	RNA splicing, via transesterification reactions	0.000649988483381811
GO:0000398	nuclear mRNA splicing, via spliceosome	0.000649988483381811
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	0.000649988483381811
GO:0032991	macromolecular complex	0.000649988483381811
GO:0005634	nucleus	0.000769721621827877
GO:0044446	intracellular organelle part	0.00113519242690883
GO:0044422	organelle part	0.00113519242690883
GO:0030629	U6 snRNA 3'-end binding	0.00208829491364836
GO:0017070	U6 snRNA binding	0.00394401676804148
GO:0006374	nuclear mRNA splicing via U2-type spliceosome	0.00560388773734823
GO:0043231	intracellular membrane-bound organelle	0.00739199319082538
GO:0043227	membrane-bound organelle	0.00739199319082538
GO:0004839	ubiquitin activating enzyme activity	0.00739199319082538
GO:0017069	snRNA binding	0.00739199319082538
GO:0046540	U4/U6 x U5 tri-snRNP complex	0.00739199319082538
GO:0008641	small protein activating enzyme activity	0.0106270574167507
GO:0043283	biopolymer metabolic process	0.0106270574167507
GO:0016070	RNA metabolic process	0.0106270574167507
GO:0008180	signalosome	0.0113985425775183
GO:0043229	intracellular organelle	0.0117543994217399
GO:0043226	organelle	0.0117543994217399
GO:0008022	protein C-terminus binding	0.0148630715030053
GO:0005732	small nucleolar ribonucleoprotein complex	0.0166092194431962
GO:0010467	gene expression	0.0166720700225567
GO:0000184	mRNA catabolic process, nonsense-mediated decay	0.0166720700225567
GO:0003676	nucleic acid binding	0.0176196444999963
GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.0226282907447422
GO:0006402	mRNA catabolic process	0.0265999237757644
GO:0043170	macromolecule metabolic process	0.0265999237757644
GO:0044424	intracellular part	0.0265999237757644
GO:0006401	RNA catabolic process	0.0282804818424051
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	0.0289124408135589
GO:0016859	cis-trans isomerase activity	0.0289124408135589
GO:0044452	nucleolar part	0.0289124408135589
GO:0005622	intracellular	0.0289124408135589
GO:0016567	protein ubiquitination	0.0298271027999113
GO:0032446	protein modification by small protein conjugation	0.0345206046749659
GO:0016072	rRNA metabolic process	0.0389208784610221
GO:0006364	rRNA processing	0.0389208784610221
GO:0044238	primary metabolic process	0.0410485133826842
GO:0044237	cellular metabolic process	0.0410485133826842
GO:0046982	protein heterodimerization activity	0.0414298020721974

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br><br><br>

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TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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