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MCL coexpression mm9:1955

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Phase1 CAGE Peaks

 Short description
Mm9::chr11:118280270..118280329,-p1@Cant1
Mm9::chr17:56416141..56416172,-p2@Ticam1
Mm9::chr17:56416173..56416196,-p1@Ticam1
Mm9::chr1:94807382..94807411,+p1@Rnpepl1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0002281macrophage activation during immune response0.00478981928606648
GO:0002275myeloid cell activation during immune response0.00478981928606648
GO:0004382guanosine-diphosphatase activity0.00478981928606648
GO:0045134uridine-diphosphatase activity0.00478981928606648
GO:0032481positive regulation of interferon type I production0.00478981928606648
GO:0002756MyD88-independent toll-like receptor signaling pathway0.00478981928606648
GO:0032479regulation of interferon type I production0.00478981928606648
GO:0045359positive regulation of interferon-beta biosynthetic process0.00558781633547003
GO:0032608interferon-beta production0.00558781633547003
GO:0045357regulation of interferon-beta biosynthetic process0.00558781633547003
GO:0043496regulation of protein homodimerization activity0.00558781633547003
GO:0045350interferon-beta biosynthetic process0.00558781633547003
GO:0045080positive regulation of chemokine biosynthetic process0.00797909631221298
GO:0009191ribonucleoside diphosphate catabolic process0.00797909631221298
GO:0002224toll-like receptor signaling pathway0.00797909631221298
GO:0009185ribonucleoside diphosphate metabolic process0.00797909631221298
GO:0002221pattern recognition receptor signaling pathway0.00797909631221298
GO:0043393regulation of protein binding0.00797909631221298
GO:0032755positive regulation of interleukin-6 production0.00797909631221298
GO:0009134nucleoside diphosphate catabolic process0.00797909631221298
GO:0045073regulation of chemokine biosynthetic process0.00797909631221298
GO:0009261ribonucleotide catabolic process0.00797909631221298
GO:0032606interferon type I production0.00797909631221298
GO:0050755chemokine metabolic process0.00797909631221298
GO:0045351interferon type I biosynthetic process0.00797909631221298
GO:0042033chemokine biosynthetic process0.00797909631221298
GO:0045429positive regulation of nitric oxide biosynthetic process0.00797909631221298
GO:0032602chemokine production0.00797909631221298
GO:0032675regulation of interleukin-6 production0.00797909631221298
GO:0032760positive regulation of tumor necrosis factor production0.00797909631221298
GO:0002218activation of innate immune response0.00797909631221298
GO:0002758innate immune response-activating signal transduction0.00797909631221298
GO:0042116macrophage activation0.00797909631221298
GO:0002366leukocyte activation during immune response0.00797909631221298
GO:0045428regulation of nitric oxide biosynthetic process0.00797909631221298
GO:0051607defense response to virus0.00797909631221298
GO:0002263cell activation during immune response0.00797909631221298
GO:0017110nucleoside-diphosphatase activity0.00797909631221298
GO:0032680regulation of tumor necrosis factor production0.00797909631221298
GO:0045088regulation of innate immune response0.00797909631221298
GO:0043330response to exogenous dsRNA0.00797909631221298
GO:0045089positive regulation of innate immune response0.00797909631221298
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascade0.00857241975304969
GO:0032496response to lipopolysaccharide0.00893560848184599
GO:0031663lipopolysaccharide-mediated signaling pathway0.00893560848184599
GO:0043331response to dsRNA0.00907473004625096
GO:0030890positive regulation of B cell proliferation0.00907473004625096
GO:0009132nucleoside diphosphate metabolic process0.00907473004625096
GO:0051092activation of NF-kappaB transcription factor0.0093813606238673
GO:0043122regulation of I-kappaB kinase/NF-kappaB cascade0.0093813606238673
GO:0032640tumor necrosis factor production0.00985383036871236
GO:0032635interleukin-6 production0.0103080576010432
GO:0046209nitric oxide metabolic process0.0103543449226258
GO:0002237response to molecule of bacterial origin0.0103543449226258
GO:0006809nitric oxide biosynthetic process0.0103543449226258
GO:0008624induction of apoptosis by extracellular signals0.011353845313042
GO:0051098regulation of binding0.011353845313042
GO:0001819positive regulation of cytokine production0.011353845313042
GO:0051091positive regulation of transcription factor activity0.011353845313042
GO:0030888regulation of B cell proliferation0.0117222027855616
GO:0009166nucleotide catabolic process0.0120784228007324
GO:0051090regulation of transcription factor activity0.0135018813592137
GO:0050871positive regulation of B cell activation0.0138183109552751
GO:0002274myeloid leukocyte activation0.0139074902637953
GO:0042100B cell proliferation0.0139074902637953
GO:0001817regulation of cytokine production0.0152161316117047
GO:0042108positive regulation of cytokine biosynthetic process0.015986540668856
GO:0007249I-kappaB kinase/NF-kappaB cascade0.0169605190275
GO:0002757immune response-activating signal transduction0.0169605190275
GO:0032946positive regulation of mononuclear cell proliferation0.0169605190275
GO:0050671positive regulation of lymphocyte proliferation0.0169605190275
GO:0004177aminopeptidase activity0.0169605190275
GO:0050864regulation of B cell activation0.0169605190275
GO:0002764immune response-regulating signal transduction0.0171825786600536
GO:0045727positive regulation of translation0.0178438091349992
GO:0031328positive regulation of cellular biosynthetic process0.018926585343238
GO:0009615response to virus0.0212804042114314
GO:0042035regulation of cytokine biosynthetic process0.021435129115765
GO:0050670regulation of lymphocyte proliferation0.0218761102146985
GO:0032944regulation of mononuclear cell proliferation0.0218761102146985
GO:0009891positive regulation of biosynthetic process0.0218761102146985
GO:0042089cytokine biosynthetic process0.0242682940231048
GO:0051251positive regulation of lymphocyte activation0.0242682940231048
GO:0042107cytokine metabolic process0.0242682940231048
GO:0009967positive regulation of signal transduction0.0255498198958522
GO:0009259ribonucleotide metabolic process0.0271877884826472
GO:0051247positive regulation of protein metabolic process0.0272577224380037
GO:0032943mononuclear cell proliferation0.0277664721503258
GO:0046651lymphocyte proliferation0.0277664721503258
GO:0044271nitrogen compound biosynthetic process0.0281969685644931
GO:0002253activation of immune response0.0282524973307041
GO:0051249regulation of lymphocyte activation0.0301130537999143
GO:0042113B cell activation0.0305037231379708
GO:0050865regulation of cell activation0.0305325895451643
GO:0045087innate immune response0.0312599260324409
GO:0008238exopeptidase activity0.0326632198979232
GO:0050778positive regulation of immune response0.0330106595549708
GO:0002684positive regulation of immune system process0.0333490289481452
GO:0001816cytokine production0.0333490289481452
GO:0050776regulation of immune response0.0369171102606543
GO:0009617response to bacterium0.0369171102606543
GO:0002682regulation of immune system process0.0369171102606543
GO:0051240positive regulation of multicellular organismal process0.0378444925897996
GO:0006917induction of apoptosis0.0409042361758859
GO:0012502induction of programmed cell death0.0409042361758859
GO:0006417regulation of translation0.0411420194124377
GO:0002252immune effector process0.0419927925617817
GO:0031326regulation of cellular biosynthetic process0.0428272703558116
GO:0009889regulation of biosynthetic process0.047277316629461
GO:0043065positive regulation of apoptosis0.0489525028519074
GO:0051707response to other organism0.0489525028519074
GO:0043068positive regulation of programmed cell death0.0489525028519074



Relative expression of the co-expression cluster over median <br>Analyst:




Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
intestine1.66e-1131
gastrointestinal system9.94e-1147
endoderm-derived structure4.15e-09118
endoderm4.15e-09118
presumptive endoderm4.15e-09118
digestive system1.51e-08116
digestive tract1.51e-08116
primitive gut1.51e-08116
subdivision of digestive tract7.64e-08114
adult organism1.05e-0751


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs




JASPAR motifs


Motifs-log10(p-value)
MA0003.12.89651
MA0004.11.64673
MA0006.10.497533
MA0007.10.672186
MA0009.11.15569
MA0014.10.581929
MA0017.10.528196
MA0019.10.964875
MA0024.11.11019
MA0025.11.39562
MA0027.12.81824
MA0028.12.19266
MA0029.12.46391
MA0030.11.09438
MA0031.11.05719
MA0038.10.846479
MA0040.11.16866
MA0041.10.604221
MA0042.10.589368
MA0043.11.25564
MA0046.11.1929
MA0048.10.266382
MA0050.10.731539
MA0051.10.856094
MA0052.11.17701
MA0055.10.125758
MA0056.10
MA0057.10.701847
MA0058.11.4226
MA0059.13.61572
MA0060.10.403071
MA0061.10.438628
MA0063.10
MA0066.10.834648
MA0067.11.50873
MA0068.12.83575
MA0069.11.17737
MA0070.11.16732
MA0071.10.73062
MA0072.11.15853
MA0073.16.10005
MA0074.10.795862
MA0076.10.550092
MA0077.11.13603
MA0078.10.891476
MA0081.10.621611
MA0083.11.25482
MA0084.11.84013
MA0087.11.21037
MA0088.10.582815
MA0089.10
MA0090.10.650768
MA0091.10.703314
MA0092.10.651119
MA0093.12.22418
MA0095.10
MA0098.10
MA0100.10.783305
MA0101.10.605676
MA0103.10.540576
MA0105.10.313353
MA0106.10.899777
MA0107.10.533522
MA0108.20.989014
MA0109.10
MA0111.10.666525
MA0113.10.869608
MA0114.10.43587
MA0115.11.25852
MA0116.10.497293
MA0117.11.22527
MA0119.10.606338
MA0122.11.24573
MA0124.11.45461
MA0125.11.37907
MA0130.10
MA0131.10.960068
MA0132.10
MA0133.10
MA0135.11.29308
MA0136.10.817395
MA0139.10.365453
MA0140.11.84211
MA0141.10.563066
MA0142.11.04199
MA0143.10.887119
MA0144.10.439506
MA0145.11.14526
MA0146.11.07887
MA0147.12.98268
MA0148.10.706718
MA0149.10.611881
MA0062.22.34802
MA0035.20.788288
MA0039.20.0220513
MA0138.20.951653
MA0002.20.965577
MA0137.21.37638
MA0104.22.66758
MA0047.20.845655
MA0112.20.608441
MA0065.20.609584
MA0150.10.67206
MA0151.10
MA0152.10.84577
MA0153.11.31015
MA0154.10.728853
MA0155.11.21457
MA0156.10.549102
MA0157.11.0083
MA0158.10
MA0159.10.465802
MA0160.10.71003
MA0161.10
MA0162.11.16288
MA0163.12.23835
MA0164.10.817786
MA0080.20.534538
MA0018.20.828253
MA0099.20.944966
MA0079.26.24625
MA0102.21.8929
MA0258.10.419871
MA0259.11.12353
MA0442.10
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