UBERON:0004208
From FANTOM5_SSTAR
| Name: | nephrogenic mesenchyme |
|---|---|
| Definition: | "Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchymal cells in the nephron" [GO:0072076] |
| Synonyms: |
"mesenchyme of nephron" EXACT [OBOL:automatic] "nephron mesenchyme" EXACT [OBOL:automatic] |
| Comments: | The detailed events associated with the differentiation of the nephrogenic mesenchyme are somewhat complex. It has been suggested that each terminal branch of the ureteric bud stimulates the associated cap mesenchyme tissue to form a renal vesicle (the most primitive stage of nephron development: a stage I nephron). This then elongates, becomes a comma-shaped and then an S-shaped body (stage II nephron), and makes contact with and fuses with the distal component of the ureteric bud. The latter then forms the collecting duct. One fold of the S-shaped body gives rise to Bowman遯ｶ蜀ｱ capsule (also termed the glomerular capsule). Soon afterwards, endothelial cells invade to make a capillary knot-like outgrowth, the glomerular tuft, which goes on to form the glomerulus. The inner epithelial layer of the Bowman遯ｶ蜀ｱ capsule (also called the visceral epithelium, or podocyte layer because it consists of podocytes) is closely apposed to the endothelial glomerulus. Together, the Bowman遯ｶ蜀ｱ capsule and the glomerulus comprise the definitive renal corpuscle. The rest of the nephron elongates to form components of the proximal tubule, the loop of Henle and the distal tubule. The distal pole of the developing nephron connects to the ureteric bud that induced it at an early stage of nephron/ collecting duct development, before differentiation of the proximal tubule, the loop of Henle and the distal tubule are complete. This connection allows the excretory products produced by the kidney to be removed and subsequently transferred, via the ureter, into the bladder where they are stored until it is appropriate to empty the bladder. [1] |
Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data
Parents
| is_a: | UBERON:0003104(mesenchyme) |
|---|
Children
| develops from: | UBERON:0001285 (nephron),UBERON:0004209 (renal vesicle) |
|---|
Ontology Tree: Loaded from BioPortal
Ontorolgy tree(Small window open)
FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology
Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0004208 (nephrogenic mesenchyme), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data
| P-value | FFCP | Short description |
|---|---|---|
| 1.05e-87 | FFCP PHASE2:Hg19::chr2:693380..693398,+#_d9e6b5011f13871310731e58ab649952 | p@chr2:693380..693398, + |
| 1.05e-87 | FFCP PHASE1:Hg19::chr2:693380..693398,+#_d9e6b5011f13871310731e58ab649952 | p@chr2:693380..693398, + |
| 1.72e-83 | FFCP PHASE2:Hg19::chr15:66420804..66420837,-#_4da43d476d3f844cd6217d666a2883fe | p4@MEGF11 |
| 1.72e-83 | FFCP PHASE1:Hg19::chr15:66420804..66420837,-#_4da43d476d3f844cd6217d666a2883fe | p4@MEGF11 |
| 2.2e-74 | FFCP PHASE1:Hg19::chr7:27219833..27219845,-#_6dc97beafc1c66ea806d13b261150008 | p7@HOXA10 |
| 2.2e-74 | FFCP PHASE2:Hg19::chr7:27219833..27219845,-#_6dc97beafc1c66ea806d13b261150008 | p7@HOXA10 |
| 7.63e-66 | FFCP PHASE2:Hg19::chr1:1100457..1100470,+#_73f010210c7ed389a8e20dbd1b99499d | p@chr1:1100457..1100470, + |
| 7.63e-66 | FFCP PHASE1:Hg19::chr1:1100457..1100470,+#_73f010210c7ed389a8e20dbd1b99499d | p@chr1:1100457..1100470, + |
| 6.44e-62 | FFCP PHASE1:Hg19::chr10:102495147..102495159,+#_3343a9878a55dff1388b7e2059ba26ea | p4@PAX2 |
| 6.44e-62 | FFCP PHASE2:Hg19::chr10:102495147..102495159,+#_3343a9878a55dff1388b7e2059ba26ea | p4@PAX2 |
| 5.84e-60 | FFCP PHASE2:Hg19::chr18:3456189..3456200,+#_1a36de97e867e27867ea9a7a2fae5135 | p@chr18:3456189..3456200, + |
| 5.84e-60 | FFCP PHASE1:Hg19::chr18:3456189..3456200,+#_1a36de97e867e27867ea9a7a2fae5135 | p@chr18:3456189..3456200, + |
| 6.18e-60 | FFCP PHASE2:Hg19::chr10:102505954..102505973,+#_7ccea358c3c775d8c7dde23811f522d0 | p3@PAX2 |
| 6.18e-60 | FFCP PHASE1:Hg19::chr10:102505954..102505973,+#_7ccea358c3c775d8c7dde23811f522d0 | p3@PAX2 |
| 4.45e-59 | FFCP PHASE1:Hg19::chr20:6034607..6034616,-#_ec94d1d167d34384f85ca2afe0bf7820 | p6@LRRN4 |
| 4.45e-59 | FFCP PHASE2:Hg19::chr20:6034607..6034616,-#_ec94d1d167d34384f85ca2afe0bf7820 | p6@LRRN4 |
| 3.49e-58 | FFCP PHASE1:Hg19::chr5:74244100..74244117,+#_0d4c331dbdfb5a59054c50b7142b0776 | p@chr5:74244100..74244117, + |
| 3.49e-58 | FFCP PHASE2:Hg19::chr5:74244100..74244117,+#_0d4c331dbdfb5a59054c50b7142b0776 | p@chr5:74244100..74244117, + |
| 3.91e-56 | FFCP PHASE2:Hg19::chr20:6033532..6033548,-#_cc0e391df52ec627d78e0e5c0e3d1c8e | p2@AB527789 |
| 3.91e-56 | FFCP PHASE1:Hg19::chr20:6033532..6033548,-#_cc0e391df52ec627d78e0e5c0e3d1c8e | p2@AB527789 |
| 3.83e-55 | FFCP PHASE2:Hg19::chr16:86604624..86604648,+#_e8d55f8846658aaa324bd17e31ae1b50 | p@chr16:86604624..86604648, + |
| 3.83e-55 | FFCP PHASE1:Hg19::chr16:86604624..86604648,+#_e8d55f8846658aaa324bd17e31ae1b50 | p@chr16:86604624..86604648, + |
| 3.51e-54 | FFCP PHASE2:Hg19::chr16:86768403..86768437,+#_4ffb678b748199ae386f39ecbf4ebea5 | p@chr16:86768403..86768437, + |
| 3.51e-54 | FFCP PHASE1:Hg19::chr16:86768403..86768437,+#_4ffb678b748199ae386f39ecbf4ebea5 | p@chr16:86768403..86768437, + |
| 6.09e-53 | FFCP PHASE2:Hg19::chr16:3068288..3068312,-#_a2829cd1b266ce4c6d07e4d8e7aca237 | p2@CLDN6 |
| 6.09e-53 | FFCP PHASE1:Hg19::chr16:3068288..3068312,-#_a2829cd1b266ce4c6d07e4d8e7aca237 | p2@CLDN6 |
| 2.79e-52 | FFCP PHASE2:Hg19::chr1:81001398..81001426,+#_a9cc0be51fb7933b63bc4d32f76b6b34 | p1@ENST00000418041, p1@ENST00000443104 |
| 2.79e-52 | FFCP PHASE1:Hg19::chr1:81001398..81001426,+#_a9cc0be51fb7933b63bc4d32f76b6b34 | p1@ENST00000418041, p1@ENST00000443104 |
| 1.61e-50 | FFCP PHASE2:Hg19::chr7:7606139..7606151,-#_6c206fd8575085b6f294ebfd22325bed | p@chr7:7606139..7606151, - |
| 1.61e-50 | FFCP PHASE1:Hg19::chr7:7606139..7606151,-#_6c206fd8575085b6f294ebfd22325bed | p@chr7:7606139..7606151, - |
| 1.96e-50 | FFCP PHASE2:Hg19::chr17:36104873..36104903,-#_4c6c388fdd0da81c3644fb5f05708fb4 | p3@HNF1B |
| 1.96e-50 | FFCP PHASE1:Hg19::chr17:36104873..36104903,-#_4c6c388fdd0da81c3644fb5f05708fb4 | p3@HNF1B |
| 1.73e-49 | FFCP PHASE1:Hg19::chr7:140227349..140227360,-#_70638d20b538b6aab1b6a8092bb22b98 | p@chr7:140227349..140227360, - |
| 1.73e-49 | FFCP PHASE2:Hg19::chr7:140227349..140227360,-#_70638d20b538b6aab1b6a8092bb22b98 | p@chr7:140227349..140227360, - |
| 2.61e-49 | FFCP PHASE1:Hg19::chr7:27219754..27219759,-#_8d7f56b32c4ceb978dc8e0cd25b389f1 | p16@HOXA10 |
| 2.61e-49 | FFCP PHASE2:Hg19::chr7:27219754..27219759,-#_8d7f56b32c4ceb978dc8e0cd25b389f1 | p16@HOXA10 |
| 3.13e-49 | FFCP PHASE1:Hg19::chr21:41029235..41029269,+#_cb6a7b55cca1880a4f7ad4933a65e6c4 | p2@B3GALT5 |
| 3.13e-49 | FFCP PHASE2:Hg19::chr21:41029235..41029269,+#_cb6a7b55cca1880a4f7ad4933a65e6c4 | p2@B3GALT5 |
| 4.07e-49 | FFCP PHASE2:Hg19::chr9:133986782..133986794,+#_7b425cd6db298644c516d9f8cce7a9dd | p4@AIF1L |
| 4.07e-49 | FFCP PHASE1:Hg19::chr9:133986782..133986794,+#_7b425cd6db298644c516d9f8cce7a9dd | p4@AIF1L |
| 1.12e-47 | FFCP PHASE1:Hg19::chr7:140227303..140227330,-#_ef82af357830d3fe18fd0cf46689181d | p@chr7:140227303..140227330, - |
| 1.12e-47 | FFCP PHASE2:Hg19::chr7:140227303..140227330,-#_ef82af357830d3fe18fd0cf46689181d | p@chr7:140227303..140227330, - |
| 1.23e-44 | FFCP PHASE2:Hg19::chr20:6034576..6034592,-#_19bd1805b38afe06a5fdead62c331549 | p3@LRRN4 |
| 1.23e-44 | FFCP PHASE1:Hg19::chr20:6034576..6034592,-#_19bd1805b38afe06a5fdead62c331549 | p3@LRRN4 |
| 3.62e-44 | FFCP PHASE1:Hg19::chr21:46826248..46826282,-#_f3c35e46584d337ee531019dd328eed7 | p@chr21:46826248..46826282, - |
| 3.62e-44 | FFCP PHASE2:Hg19::chr21:46826248..46826282,-#_f3c35e46584d337ee531019dd328eed7 | p@chr21:46826248..46826282, - |
| 3.06e-43 | FFCP PHASE2:Hg19::chr20:6034672..6034714,-#_05adfd5cadfc15a651c461e70aa3e8bd | p2@LRRN4 |
| 3.06e-43 | FFCP PHASE1:Hg19::chr20:6034672..6034714,-#_05adfd5cadfc15a651c461e70aa3e8bd | p2@LRRN4 |
| 1.81e-42 | FFCP PHASE2:Hg19::chr15:85403302..85403304,+#_954155af47effd887e015be19546209d | p@chr15:85403302..85403304, + |
| 1.81e-42 | FFCP PHASE1:Hg19::chr15:85403302..85403304,+#_954155af47effd887e015be19546209d | p@chr15:85403302..85403304, + |
| 1.82e-42 | FFCP PHASE2:Hg19::chr7:98453821..98453843,-#_f90e31b09ed039489065c2f0b3b8f880 | p@chr7:98453821..98453843, - |
| 1.82e-42 | FFCP PHASE1:Hg19::chr7:98453821..98453843,-#_f90e31b09ed039489065c2f0b3b8f880 | p@chr7:98453821..98453843, - |
| 2.77e-42 | FFCP PHASE2:Hg19::chr20:6034598..6034603,-#_64f0fb9488c34d7aa35fa7ddfc615754 | p7@LRRN4 |
| 2.77e-42 | FFCP PHASE1:Hg19::chr20:6034598..6034603,-#_64f0fb9488c34d7aa35fa7ddfc615754 | p7@LRRN4 |
| 7.5e-42 | FFCP PHASE1:Hg19::chr10:102505493..102505546,+#_f0d6608134f331212076b0cf8c4feb5a | p2@PAX2 |
| 7.5e-42 | FFCP PHASE2:Hg19::chr10:102505493..102505546,+#_f0d6608134f331212076b0cf8c4feb5a | p2@PAX2 |
| 3.59e-41 | FFCP PHASE2:Hg19::chr9:71735910..71735923,+#_38c36254e84751066bd0fb268449085c | p16@TJP2 |
| 3.59e-41 | FFCP PHASE1:Hg19::chr9:71735910..71735923,+#_38c36254e84751066bd0fb268449085c | p16@TJP2 |
| 9.39e-41 | FFCP PHASE2:Hg19::chr1:94713418..94713436,+#_da5774721cd42bc6dacef1458cf4e5ac | p1@ENST00000413103 |
| 9.39e-41 | FFCP PHASE1:Hg19::chr1:94713418..94713436,+#_da5774721cd42bc6dacef1458cf4e5ac | p1@ENST00000413103 |
| 1.7e-40 | FFCP PHASE2:Hg19::chr20:6034828..6034857,-#_7e64db74d0108c568a50396c061125d7 | p5@LRRN4 |
| 1.7e-40 | FFCP PHASE1:Hg19::chr20:6034828..6034857,-#_7e64db74d0108c568a50396c061125d7 | p5@LRRN4 |
| 2.9e-40 | FFCP PHASE2:Hg19::chr1:20465872..20465881,+#_0db73e57a738d395ccb58a014c9680d5 | p2@PLA2G2F |
| 2.9e-40 | FFCP PHASE1:Hg19::chr1:20465872..20465881,+#_0db73e57a738d395ccb58a014c9680d5 | p2@PLA2G2F |
| 8.58e-40 | FFCP PHASE2:Hg19::chr9:133986807..133986821,+#_7292c1f098e7106d98dd317e9b5a04f6 | p3@AIF1L |
| 8.58e-40 | FFCP PHASE1:Hg19::chr9:133986807..133986821,+#_7292c1f098e7106d98dd317e9b5a04f6 | p3@AIF1L |
| 1.21e-39 | FFCP PHASE2:Hg19::chr2:31361432..31361442,-#_66c269e46af0036702da9dd8c893c98c | p6@GALNT14 |
| 1.21e-39 | FFCP PHASE1:Hg19::chr2:31361432..31361442,-#_66c269e46af0036702da9dd8c893c98c | p6@GALNT14 |
| 3.08e-39 | FFCP PHASE2:Hg19::chr20:6033120..6033128,-#_2f85ef56c017252e7af908b3e5d50499 | p4@AB527789 |
| 3.08e-39 | FFCP PHASE1:Hg19::chr20:6033120..6033128,-#_2f85ef56c017252e7af908b3e5d50499 | p4@AB527789 |
| 7.42e-37 | FFCP PHASE1:Hg19::chr6:24358114..24358125,-#_53982ee8be35e583abe5fc74e6bdaf67 | p4@DCDC2 |
| 7.42e-37 | FFCP PHASE2:Hg19::chr6:24358114..24358125,-#_53982ee8be35e583abe5fc74e6bdaf67 | p4@DCDC2 |
| 1.29e-36 | FFCP PHASE1:Hg19::chr2:693362..693373,+#_29e9f7b8da42d639f074d35c43b0df77 | p@chr2:693362..693373, + |
| 1.29e-36 | FFCP PHASE2:Hg19::chr2:693362..693373,+#_29e9f7b8da42d639f074d35c43b0df77 | p@chr2:693362..693373, + |
| 1.36e-36 | FFCP PHASE1:Hg19::chr2:177016336..177016350,+#_3ecd9c5cffedfeed2f6570856eb3696e | p1@HOXD4 |
| 1.36e-36 | FFCP PHASE2:Hg19::chr2:177016336..177016350,+#_3ecd9c5cffedfeed2f6570856eb3696e | p1@HOXD4 |
| 6.21e-36 | FFCP PHASE1:Hg19::chr2:176982078..176982095,+#_21e5b7dca00acec5f668f050f557961b | p@chr2:176982078..176982095, + |
| 6.21e-36 | FFCP PHASE2:Hg19::chr2:176982078..176982095,+#_21e5b7dca00acec5f668f050f557961b | p@chr2:176982078..176982095, + |
| 2.64e-35 | FFCP PHASE1:Hg19::chr20:6033140..6033181,-#_887908662d234baad1731f1a0b414967 | p1@AB527789 |
| 2.64e-35 | FFCP PHASE2:Hg19::chr20:6033140..6033181,-#_887908662d234baad1731f1a0b414967 | p1@AB527789 |
| 3.85e-35 | FFCP PHASE1:Hg19::chr2:108994466..108994485,+#_28c49459b8535ab5a1b9b2508fc5af81 | p3@SULT1C4 |
| 3.85e-35 | FFCP PHASE2:Hg19::chr2:108994466..108994485,+#_28c49459b8535ab5a1b9b2508fc5af81 | p3@SULT1C4 |
| 8.14e-35 | FFCP PHASE2:Hg19::chr18:43405633..43405645,+#_80f51aaf68a29d4c7f52f80429207d00 | p4@SIGLEC15 |
| 8.14e-35 | FFCP PHASE1:Hg19::chr18:43405633..43405645,+#_80f51aaf68a29d4c7f52f80429207d00 | p4@SIGLEC15 |
| 1.65e-34 | FFCP PHASE2:Hg19::chr10:91043420..91043437,+#_923d5fb94736621af1adbe7cf12ccbb7 | p1@ENST00000444849 |
| 1.65e-34 | FFCP PHASE1:Hg19::chr10:91043420..91043437,+#_923d5fb94736621af1adbe7cf12ccbb7 | p1@ENST00000444849 |
| 1.14e-33 | FFCP PHASE1:Hg19::chr17:171147..171161,+#_7d09be66a658d9a3d2a78c916befd87c | p@chr17:171147..171161, + |
| 1.14e-33 | FFCP PHASE2:Hg19::chr17:171147..171161,+#_7d09be66a658d9a3d2a78c916befd87c | p@chr17:171147..171161, + |
| 1.52e-33 | FFCP PHASE2:Hg19::chr14:57960456..57960478,-#_36ef14889442b1969fd90bfe7c17db2a | p2@C14orf105 |
| 1.52e-33 | FFCP PHASE1:Hg19::chr14:57960456..57960478,-#_36ef14889442b1969fd90bfe7c17db2a | p2@C14orf105 |
| 1.8e-33 | FFCP PHASE2:Hg19::chr2:31361543..31361564,-#_f966a962ed51eba4bb4a8ef49057170a | p5@GALNT14 |
| 1.8e-33 | FFCP PHASE1:Hg19::chr2:31361543..31361564,-#_f966a962ed51eba4bb4a8ef49057170a | p5@GALNT14 |
| 2.35e-33 | FFCP PHASE2:Hg19::chr3:190105935..190105966,+#_1b7e7fc17aa55023f5fa6806c9e1aa1e | p1@CLDN16 |
| 2.35e-33 | FFCP PHASE1:Hg19::chr3:190105935..190105966,+#_1b7e7fc17aa55023f5fa6806c9e1aa1e | p1@CLDN16 |
| 4.12e-33 | FFCP PHASE2:Hg19::chr17:36065029..36065045,-#_d8fd521c9f9c47fbc7b6e915725c475e | p@chr17:36065029..36065045, - |
| 4.12e-33 | FFCP PHASE1:Hg19::chr17:36065029..36065045,-#_d8fd521c9f9c47fbc7b6e915725c475e | p@chr17:36065029..36065045, - |
| 8.12e-33 | FFCP PHASE2:Hg19::chr17:35293950..35293973,-#_11073641f9129332db4ff65d5684971e | p1@ENST00000528383, p1@ENST00000529264, p1@ENST00000532387 |
| 8.12e-33 | FFCP PHASE1:Hg19::chr17:35293950..35293973,-#_11073641f9129332db4ff65d5684971e | p1@ENST00000528383, p1@ENST00000529264, p1@ENST00000532387 |
| 1.25e-32 | FFCP PHASE2:Hg19::chr22:30653574..30653606,-#_1eb70767d03fe355a5e1309b70987709 | p@chr22:30653574..30653606, - |
| 1.25e-32 | FFCP PHASE1:Hg19::chr22:30653574..30653606,-#_1eb70767d03fe355a5e1309b70987709 | p@chr22:30653574..30653606, - |
