MCL coexpression mm9:2280

Phase1 CAGE Peaks

	Short description
Mm9::chr1:123224249..123224267,-	p9@Insig2
Mm9::chr2:110154372..110154384,-	p7@Bbox1
Mm9::chr2:110154391..110154403,-	p9@Bbox1
Mm9::chr2:110154423..110154449,-	p6@Bbox1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008336	gamma-butyrobetaine dioxygenase activity	0.00423663040837316
GO:0006991	response to sterol depletion	0.00423663040837316
GO:0045329	carnitine biosynthetic process	0.00423663040837316
GO:0009437	carnitine metabolic process	0.00635459742497994
GO:0042401	biogenic amine biosynthetic process	0.0254016766960898
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	0.0254016766960898
GO:0042398	amino acid derivative biosynthetic process	0.0254016766960898
GO:0006767	water-soluble vitamin metabolic process	0.0283527507694216
GO:0009309	amine biosynthetic process	0.0283527507694216
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	0.0283527507694216
GO:0051213	dioxygenase activity	0.0283527507694216
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	0.0283527507694216
GO:0006766	vitamin metabolic process	0.0283527507694216
GO:0008203	cholesterol metabolic process	0.0283527507694216
GO:0016125	sterol metabolic process	0.0283527507694216
GO:0006576	biogenic amine metabolic process	0.0283527507694216
GO:0044271	nitrogen compound biosynthetic process	0.0283527507694216
GO:0006575	amino acid derivative metabolic process	0.03064404692869
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	0.0416679741868591
GO:0008202	steroid metabolic process	0.044316444686879

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
exocrine gland	6.31e-12	25
exocrine system	6.31e-12	25
liver	2.02e-10	22
epithelial sac	2.02e-10	22
digestive gland	2.02e-10	22
epithelium of foregut-midgut junction	2.02e-10	22
anatomical boundary	2.02e-10	22
hepatobiliary system	2.02e-10	22
foregut-midgut junction	2.02e-10	22
hepatic diverticulum	2.02e-10	22
liver primordium	2.02e-10	22
septum transversum	2.02e-10	22
liver bud	2.02e-10	22
digestive tract diverticulum	8.71e-10	23
sac	8.71e-10	23
zone of skin	1.29e-08	5
skin epidermis	1.29e-08	5
skin of body	1.29e-08	5
integument	1.29e-08	5
surface	1.29e-08	5
outer epithelium	1.29e-08	5
integumental system	1.29e-08	5
enveloping layer of ectoderm	1.29e-08	5

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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