MCL coexpression mm9:2305

Phase1 CAGE Peaks

	Short description
Mm9::chr1:39535525..39535578,-	p1@Tbc1d8
Mm9::chr1:39535579..39535605,-	p2@Tbc1d8
Mm9::chr4:120261333..120261344,+	p1@Gm8439
Mm9::chrX:161418211..161418241,-	p2@Mospd2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0032313	regulation of Rab GTPase activity	0.0252887198426182
GO:0032482	Rab protein signal transduction	0.0252887198426182
GO:0032483	regulation of Rab protein signal transduction	0.0252887198426182
GO:0005097	Rab GTPase activator activity	0.0252887198426182
GO:0032318	regulation of Ras GTPase activity	0.0252887198426182
GO:0005099	Ras GTPase activator activity	0.0300028685053556
GO:0043087	regulation of GTPase activity	0.0350022168142687
GO:0046578	regulation of Ras protein signal transduction	0.0443617968118276
GO:0051336	regulation of hydrolase activity	0.0443617968118276
GO:0051056	regulation of small GTPase mediated signal transduction	0.0443617968118276
GO:0007265	Ras protein signal transduction	0.0443617968118276
GO:0005083	small GTPase regulator activity	0.0443617968118276
GO:0005096	GTPase activator activity	0.0443617968118276

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

---

Uber Anatomy

Ontology term	p-value	n
immaterial anatomical entity	7.65e-12	79
anatomical space	9.78e-10	57
anatomical cavity	8.54e-08	39
body cavity precursor	2.72e-07	38
body cavity	8.72e-07	37
body cavity or lining	8.72e-07	37

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}