MCL coexpression mm9:1236
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0009054 | electron acceptor activity | 0.0159947409747897 |
| GO:0016649 | oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor | 0.0159947409747897 |
| GO:0004174 | electron-transferring-flavoprotein dehydrogenase activity | 0.0159947409747897 |
| GO:0005739 | mitochondrion | 0.0159947409747897 |
| GO:0017133 | mitochondrial electron transfer flavoprotein complex | 0.0159947409747897 |
| GO:0045251 | electron transfer flavoprotein complex | 0.0159947409747897 |
| GO:0044444 | cytoplasmic part | 0.0164043131918743 |
| GO:0046039 | GTP metabolic process | 0.0179852122329424 |
| GO:0006228 | UTP biosynthetic process | 0.0179852122329424 |
| GO:0006183 | GTP biosynthetic process | 0.0179852122329424 |
| GO:0046036 | CTP metabolic process | 0.0179852122329424 |
| GO:0009209 | pyrimidine ribonucleoside triphosphate biosynthetic process | 0.0179852122329424 |
| GO:0046051 | UTP metabolic process | 0.0179852122329424 |
| GO:0009208 | pyrimidine ribonucleoside triphosphate metabolic process | 0.0179852122329424 |
| GO:0006241 | CTP biosynthetic process | 0.0179852122329424 |
| GO:0004550 | nucleoside diphosphate kinase activity | 0.0179852122329424 |
| GO:0009220 | pyrimidine ribonucleotide biosynthetic process | 0.019536278097304 |
| GO:0009218 | pyrimidine ribonucleotide metabolic process | 0.019536278097304 |
| GO:0009147 | pyrimidine nucleoside triphosphate metabolic process | 0.0201889437298985 |
| GO:0006221 | pyrimidine nucleotide biosynthetic process | 0.0275909713205747 |
| GO:0006220 | pyrimidine nucleotide metabolic process | 0.0275909713205747 |
| GO:0051539 | 4 iron, 4 sulfur cluster binding | 0.0275909713205747 |
| GO:0016645 | oxidoreductase activity, acting on the CH-NH group of donors | 0.0277780995794519 |
| GO:0016776 | phosphotransferase activity, phosphate group as acceptor | 0.0372444493694653 |
| GO:0005737 | cytoplasm | 0.0419193300402541 |
| GO:0019205 | nucleobase, nucleoside, nucleotide kinase activity | 0.0441731426607082 |
| GO:0051536 | iron-sulfur cluster binding | 0.0456348127013525 |
| GO:0051540 | metal cluster binding | 0.0456348127013525 |
| GO:0009145 | purine nucleoside triphosphate biosynthetic process | 0.0456348127013525 |
| GO:0009206 | purine ribonucleoside triphosphate biosynthetic process | 0.0456348127013525 |
| GO:0009201 | ribonucleoside triphosphate biosynthetic process | 0.0456348127013525 |
| GO:0009142 | nucleoside triphosphate biosynthetic process | 0.0456348127013525 |
| GO:0009205 | purine ribonucleoside triphosphate metabolic process | 0.0456348127013525 |
| GO:0009199 | ribonucleoside triphosphate metabolic process | 0.0456348127013525 |
| GO:0009144 | purine nucleoside triphosphate metabolic process | 0.0456348127013525 |
| GO:0031980 | mitochondrial lumen | 0.0456348127013525 |
| GO:0005759 | mitochondrial matrix | 0.0456348127013525 |
| GO:0009141 | nucleoside triphosphate metabolic process | 0.0465467683456577 |
| GO:0009152 | purine ribonucleotide biosynthetic process | 0.0465467683456577 |
| GO:0009260 | ribonucleotide biosynthetic process | 0.0466031801971308 |
| GO:0043231 | intracellular membrane-bound organelle | 0.0466031801971308 |
| GO:0043227 | membrane-bound organelle | 0.0466031801971308 |
| GO:0009150 | purine ribonucleotide metabolic process | 0.0470169299095507 |
| GO:0006164 | purine nucleotide biosynthetic process | 0.0470169299095507 |
| GO:0009259 | ribonucleotide metabolic process | 0.0494880727989972 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| epithelial tube | 8.60e-13 | 47 |
| exocrine gland | 5.53e-10 | 25 |
| exocrine system | 5.53e-10 | 25 |
| digestive tract diverticulum | 4.03e-09 | 23 |
| sac | 4.03e-09 | 23 |
| liver | 7.07e-09 | 22 |
| epithelial sac | 7.07e-09 | 22 |
| digestive gland | 7.07e-09 | 22 |
| epithelium of foregut-midgut junction | 7.07e-09 | 22 |
| anatomical boundary | 7.07e-09 | 22 |
| hepatobiliary system | 7.07e-09 | 22 |
| foregut-midgut junction | 7.07e-09 | 22 |
| hepatic diverticulum | 7.07e-09 | 22 |
| liver primordium | 7.07e-09 | 22 |
| septum transversum | 7.07e-09 | 22 |
| liver bud | 7.07e-09 | 22 |
| intestine | 3.69e-07 | 31 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 0.730824 |
| MA0004.1 | 1.3269 |
| MA0006.1 | 0.945134 |
| MA0007.1 | 0.52077 |
| MA0009.1 | 0.987341 |
| MA0014.1 | 0.883128 |
| MA0017.1 | 0.387481 |
| MA0019.1 | 0.800946 |
| MA0024.1 | 0.942716 |
| MA0025.1 | 1.22395 |
| MA0027.1 | 2.64231 |
| MA0028.1 | 0.370592 |
| MA0029.1 | 0.920529 |
| MA0030.1 | 0.927235 |
| MA0031.1 | 0.890871 |
| MA0038.1 | 0.686534 |
| MA0040.1 | 1.00009 |
| MA0041.1 | 1.15799 |
| MA0042.1 | 1.12834 |
| MA0043.1 | 1.08567 |
| MA0046.1 | 1.02391 |
| MA0048.1 | 0.486223 |
| MA0050.1 | 0.57678 |
| MA0051.1 | 0.695779 |
| MA0052.1 | 1.00829 |
| MA0055.1 | 0.0585191 |
| MA0056.1 | 0 |
| MA0057.1 | 0.149949 |
| MA0058.1 | 2.90242 |
| MA0059.1 | 1.99202 |
| MA0060.1 | 1.38604 |
| MA0061.1 | 0.307097 |
| MA0063.1 | 0 |
| MA0066.1 | 0.675169 |
| MA0067.1 | 1.33603 |
| MA0068.1 | 0.153907 |
| MA0069.1 | 1.00864 |
| MA0070.1 | 0.998765 |
| MA0071.1 | 2.40974 |
| MA0072.1 | 0.990133 |
| MA0073.1 | 1.22055 |
| MA0074.1 | 1.54084 |
| MA0076.1 | 1.04996 |
| MA0077.1 | 0.968053 |
| MA0078.1 | 0.729877 |
| MA0081.1 | 0.473489 |
| MA0083.1 | 1.08487 |
| MA0084.1 | 1.66561 |
| MA0087.1 | 1.04109 |
| MA0088.1 | 0.358337 |
| MA0089.1 | 0 |
| MA0090.1 | 0.500693 |
| MA0091.1 | 0.55008 |
| MA0092.1 | 1.25163 |
| MA0093.1 | 1.75322 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.626021 |
| MA0101.1 | 0.458688 |
| MA0103.1 | 0.398766 |
| MA0105.1 | 1.09694 |
| MA0106.1 | 0.737893 |
| MA0107.1 | 0.392331 |
| MA0108.2 | 0.824407 |
| MA0109.1 | 0 |
| MA0111.1 | 1.2824 |
| MA0113.1 | 0.708789 |
| MA0114.1 | 0.822296 |
| MA0115.1 | 2.46592 |
| MA0116.1 | 0.944657 |
| MA0117.1 | 1.05576 |
| MA0119.1 | 1.16221 |
| MA0122.1 | 1.07591 |
| MA0124.1 | 1.28237 |
| MA0125.1 | 1.20757 |
| MA0130.1 | 0 |
| MA0131.1 | 0.796279 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 1.1226 |
| MA0136.1 | 0.658622 |
| MA0139.1 | 0.682297 |
| MA0140.1 | 0.625902 |
| MA0141.1 | 2.82312 |
| MA0142.1 | 0.876028 |
| MA0143.1 | 0.725672 |
| MA0144.1 | 2.2889 |
| MA0145.1 | 0.761789 |
| MA0146.1 | 0.635245 |
| MA0147.1 | 0.858298 |
| MA0148.1 | 0.553294 |
| MA0149.1 | 0.464445 |
| MA0062.2 | 0.204999 |
| MA0035.2 | 0.630778 |
| MA0039.2 | 2.17024 |
| MA0138.2 | 0.788113 |
| MA0002.2 | 0.246463 |
| MA0137.2 | 0.416331 |
| MA0104.2 | 0.723439 |
| MA0047.2 | 0.685741 |
| MA0112.2 | 0.37938 |
| MA0065.2 | 0.380324 |
| MA0150.1 | 0.520653 |
| MA0151.1 | 0 |
| MA0152.1 | 0.685852 |
| MA0153.1 | 1.13945 |
| MA0154.1 | 0.159217 |
| MA0155.1 | 0.132921 |
| MA0156.1 | 1.04798 |
| MA0157.1 | 0.843181 |
| MA0158.1 | 0 |
| MA0159.1 | 1.58527 |
| MA0160.1 | 2.34632 |
| MA0161.1 | 0 |
| MA0162.1 | 0.397553 |
| MA0163.1 | 1.03138 |
| MA0164.1 | 0.658997 |
| MA0080.2 | 1.01893 |
| MA0018.2 | 0.669032 |
| MA0099.2 | 0.781628 |
| MA0079.2 | 0.0267793 |
| MA0102.2 | 1.7182 |
| MA0258.1 | 0.290587 |
| MA0259.1 | 0.833237 |
| MA0442.1 | 0 |
