MCL coexpression mm9:1069

Phase1 CAGE Peaks

	Short description
Mm9::chr11:33047808..33047828,-	p1@Fgf18
Mm9::chr2:110203061..110203070,-	p7@Fibin
Mm9::chr2:110203142..110203158,-	p2@Fibin
Mm9::chr2:110203249..110203259,-	p5@Fibin
Mm9::chr2:110203272..110203287,-	p4@Fibin
Mm9::chr2:110203292..110203308,-	p3@Fibin
Mm9::chr2:110203314..110203338,-	p1@Fibin

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0001957	intramembranous ossification	0.00753218282791926
GO:0002063	chondrocyte development	0.00753218282791926
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	0.00753218282791926
GO:0030947	regulation of vascular endothelial growth factor receptor signaling pathway	0.00753218282791926
GO:0001958	endochondral ossification	0.00964040159283091
GO:0048010	vascular endothelial growth factor receptor signaling pathway	0.0129087757991752
GO:0002062	chondrocyte differentiation	0.0129087757991752
GO:0005104	fibroblast growth factor receptor binding	0.014305658165835
GO:0051216	cartilage development	0.0320994530025149
GO:0030324	lung development	0.0325858050159078
GO:0009967	positive regulation of signal transduction	0.0325858050159078
GO:0030323	respiratory tube development	0.0325858050159078
GO:0001503	ossification	0.0403599296141723
GO:0031214	biomineral formation	0.0403599296141723
GO:0046849	bone remodeling	0.0412656971515578
GO:0048771	tissue remodeling	0.0454248818374421
GO:0001525	angiogenesis	0.0474795406709817
GO:0008083	growth factor activity	0.0474795406709817
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	0.0474795406709817
GO:0048514	blood vessel morphogenesis	0.0474795406709817
GO:0008284	positive regulation of cell proliferation	0.0474795406709817
GO:0001501	skeletal development	0.0474795406709817
GO:0048646	anatomical structure formation	0.0474795406709817
GO:0035295	tube development	0.0474795406709817
GO:0001568	blood vessel development	0.0474795406709817
GO:0001944	vasculature development	0.0474795406709817
GO:0005125	cytokine activity	0.047486145639546

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
multi-cellular organism	1.30e-08	333
lung	1.45e-07	14
respiratory tube	1.45e-07	14
respiration organ	1.45e-07	14
pair of lungs	1.45e-07	14
lung primordium	1.45e-07	14
lung bud	1.45e-07	14

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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