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Novel motif:32

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name:motif32_TRGNMCTNNT

Association to promoter expression in human samples
Summary:Significance of the correlation with CAGE expression, human
Analyst: Michiel de Hoon



link to source dataset

data



Association to promoter expression in mouse samples

Summary:Significance of the correlation with CAGE expression, mouse
Analyst: Michiel de Hoon



link to source dataset

data



GREAT analysis results for human

Summary:Genomic Enrichment of Annotations Tool (GREAT, Nat Biotechnol. 2010 May;28(5):495-501) is used to identify, both in human and in mouse, the gene ontology terms of biological processes enriched given the predicted TFBSs, and evaluated the overlap in the top-500 gene ontology terms between human and mouse. For each novel motif, the P value for the overlap was then evaluated by calculating its relative rank with respect to this background distribution.
Analyst: Michiel de Hoon



link to source dataset

data

GO IDGO Termp-value
GO:0043589 skin morphogenesis 7.859515e-56
GO:0070208 protein heterotrimerization 8.679309e-51
GO:0032964 collagen biosynthetic process 4.073815e-49
GO:0070206 protein trimerization 6.095474e-40
GO:0034505 tooth mineralization 3.363551e-38
GO:0030199 collagen fibril organization 1.559417e-37
GO:0032963 collagen metabolic process 2.017287e-31
GO:0030198 extracellular matrix organization 1.058597e-30
GO:0001957 intramembranous ossification 1.417197e-30
GO:0044259 multicellular organismal macromolecule metabolic process 1.566640e-30
GO:0071230 cellular response to amino acid stimulus 2.015949e-30
GO:0001101 response to acid 1.774055e-29
GO:0071229 cellular response to acid 4.370718e-29
GO:0060346 bone trabecula formation 6.368469e-29
GO:0071418 cellular response to amine stimulus 2.030101e-28
GO:0044236 multicellular organismal metabolic process 2.144386e-28
GO:0071417 cellular response to organic nitrogen 4.442446e-28
GO:0060351 cartilage development involved in endochondral bone morphogenesis 2.124309e-27
GO:0043588 skin development 1.038354e-25
GO:0048730 epidermis morphogenesis 1.240667e-25
GO:0043200 response to amino acid stimulus 1.380638e-25
GO:0030277 maintenance of gastrointestinal epithelium 4.550694e-25
GO:0010669 epithelial structure maintenance 6.644554e-23
GO:0006342 chromatin silencing 2.908229e-21
GO:0060343 trabecula formation 1.987936e-20
GO:0061383 trabecula morphogenesis 2.078114e-20
GO:0001958 endochondral ossification 2.103658e-20
GO:0030261 chromosome condensation 2.728314e-20
GO:0051291 protein heterooligomerization 1.998957e-19
GO:0014075 response to amine stimulus 1.063307e-18
GO:0071300 cellular response to retinoic acid 8.601127e-18
GO:0045814 negative regulation of gene expression, epigenetic 8.899962e-18
GO:0042476 odontogenesis 1.251721e-17
GO:0007411 axon guidance 3.010795e-17
GO:0071299 cellular response to vitamin A 5.512945e-17
GO:0060350 endochondral bone morphogenesis 1.779722e-16
GO:0022600 digestive system process 2.368919e-16
GO:0030168 platelet activation 4.445268e-16
GO:0006935 chemotaxis 6.391694e-16
GO:0065008 regulation of biological quality 2.472404e-15
GO:0032989 cellular component morphogenesis 2.627762e-15
GO:0033189 response to vitamin A 7.418028e-15
GO:0009605 response to external stimulus 9.294273e-15
GO:0007409 axonogenesis 9.684998e-15
GO:0050690 regulation of defense response to virus by virus 1.401854e-14
GO:0031175 neuron projection development 1.534522e-14
GO:0032526 response to retinoic acid 3.693154e-14
GO:0071295 cellular response to vitamin 3.825137e-14
GO:0009612 response to mechanical stimulus 4.387189e-14
GO:0048812 neuron projection morphogenesis 7.831128e-14
GO:0031960 response to corticosteroid stimulus 1.625332e-13
GO:0010243 response to organic nitrogen 1.893231e-13
GO:0048858 cell projection morphogenesis 3.618416e-13
GO:0032990 cell part morphogenesis 3.686754e-13
GO:0010812 negative regulation of cell-substrate adhesion 4.265224e-13
GO:0048667 cell morphogenesis involved in neuron differentiation 5.050657e-13
GO:0033273 response to vitamin 5.799812e-13
GO:0048739 cardiac muscle fiber development 1.150563e-12
GO:0010770 positive regulation of cell morphogenesis involved in differentiation 1.287713e-12
GO:0010718 positive regulation of epithelial to mesenchymal transition 1.596114e-12
GO:0090263 positive regulation of canonical Wnt receptor signaling pathway 1.730694e-12
GO:0040011 locomotion 4.339840e-12
GO:0042396 phosphagen biosynthetic process 5.777879e-12
GO:0031214 biomineral tissue development 7.449624e-12
GO:0031670 cellular response to nutrient 7.466187e-12
GO:0001775 cell activation 8.705226e-12
GO:0030030 cell projection organization 1.713943e-11
GO:0043206 fibril organization 2.507434e-11
GO:0007586 digestion 3.203423e-11
GO:0048666 neuron development 3.587483e-11
GO:0050896 response to stimulus 3.953051e-11
GO:0007599 hemostasis 4.828410e-11
GO:0034728 nucleosome organization 6.770528e-11
GO:0003008 system process 8.650338e-11
GO:0050878 regulation of body fluid levels 9.761184e-11
GO:0000902 cell morphogenesis 1.119307e-10
GO:0030048 actin filament-based movement 1.208377e-10
GO:0048468 cell development 1.480479e-10
GO:0007596 blood coagulation 2.486993e-10
GO:0046314 phosphocreatine biosynthetic process 2.536907e-10
GO:0000904 cell morphogenesis involved in differentiation 2.599447e-10
GO:0050900 leukocyte migration 3.964504e-10
GO:0008544 epidermis development 5.570894e-10
GO:0006333 chromatin assembly or disassembly 7.012027e-10
GO:0006323 DNA packaging 1.058680e-9
GO:0006941 striated muscle contraction 1.167718e-9
GO:0000302 response to reactive oxygen species 1.452392e-9
GO:0007584 response to nutrient 1.690497e-9
GO:0071732 cellular response to nitric oxide 1.804424e-9
GO:0001894 tissue homeostasis 1.940467e-9
GO:0015889 cobalamin transport 1.965794e-9
GO:0002697 regulation of immune effector process 2.759308e-9
GO:0071103 DNA conformation change 3.343138e-9
GO:0072358 cardiovascular system development 3.393357e-9
GO:0010035 response to inorganic substance 3.511718e-9
GO:0006928 cellular component movement 5.584531e-9
GO:0030177 positive regulation of Wnt receptor signaling pathway 5.688573e-9
GO:0034621 cellular macromolecular complex subunit organization 7.004667e-9
GO:0051591 response to cAMP 7.022189e-9
GO:0055008 cardiac muscle tissue morphogenesis 1.009341e-8
GO:0006334 nucleosome assembly 1.471641e-8
GO:0032496 response to lipopolysaccharide 1.634506e-8
GO:0006461 protein complex assembly 2.174907e-8
GO:0001880 Mullerian duct regression 2.358011e-8
GO:0070271 protein complex biogenesis 2.538126e-8
GO:0060349 bone morphogenesis 2.673293e-8
GO:0030239 myofibril assembly 2.679425e-8
GO:0030241 skeletal muscle myosin thick filament assembly 3.196235e-8
GO:0007015 actin filament organization 3.196516e-8
GO:0034622 cellular macromolecular complex assembly 3.235189e-8
GO:0071822 protein complex subunit organization 3.429653e-8
GO:0006600 creatine metabolic process 3.568735e-8
GO:0050688 regulation of defense response to virus 5.523907e-8
GO:0007179 transforming growth factor beta receptor signaling pathway 5.967953e-8
GO:0042359 vitamin D metabolic process 6.479221e-8
GO:0006338 chromatin remodeling 7.901038e-8
GO:0031497 chromatin assembly 8.465838e-8
GO:0071731 response to nitric oxide 8.930594e-8
GO:0001546 preantral ovarian follicle growth 9.180654e-8
GO:0070252 actin-mediated cell contraction 9.537376e-8
GO:0030182 neuron differentiation 9.639221e-8
GO:0016032 viral reproduction 9.895055e-8
GO:0030049 muscle filament sliding 1.050176e-7
GO:0002237 response to molecule of bacterial origin 1.155143e-7
GO:0045214 sarcomere organization 1.158074e-7
GO:0048869 cellular developmental process 1.167596e-7
GO:0009611 response to wounding 1.188147e-7
GO:0071824 protein-DNA complex subunit organization 1.234563e-7
GO:0010717 regulation of epithelial to mesenchymal transition 1.334914e-7
GO:0048738 cardiac muscle tissue development 1.401302e-7
GO:0043933 macromolecular complex subunit organization 1.458167e-7
GO:0048644 muscle organ morphogenesis 1.557332e-7
GO:0031032 actomyosin structure organization 3.062055e-7
GO:0030154 cell differentiation 3.458298e-7
GO:0042221 response to chemical stimulus 3.656815e-7
GO:0007155 cell adhesion 3.734611e-7
GO:0008015 blood circulation 3.884433e-7
GO:0060415 muscle tissue morphogenesis 3.944731e-7
GO:0051259 protein oligomerization 3.946700e-7
GO:0060348 bone development 3.991388e-7
GO:2000491 positive regulation of hepatic stellate cell activation 4.149221e-7
GO:0009628 response to abiotic stimulus 4.412009e-7
GO:0060325 face morphogenesis 4.611516e-7
GO:0043900 regulation of multi-organism process 5.405775e-7
GO:0000910 cytokinesis 5.426929e-7
GO:0032502 developmental process 6.929957e-7
GO:0045010 actin nucleation 7.318109e-7
GO:0016192 vesicle-mediated transport 7.897352e-7
GO:0051014 actin filament severing 7.913082e-7
GO:0009235 cobalamin metabolic process 8.127002e-7
GO:0009653 anatomical structure morphogenesis 8.235287e-7
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 8.462884e-7
GO:0007162 negative regulation of cell adhesion 8.999915e-7
GO:0002831 regulation of response to biotic stimulus 9.024402e-7
GO:0003013 circulatory system process 1.012928e-6
GO:0009617 response to bacterium 1.122694e-6
GO:0051234 establishment of localization 1.126946e-6
GO:0060323 head morphogenesis 1.140303e-6
GO:0007281 germ cell development 1.148325e-6
GO:0002576 platelet degranulation 1.335130e-6
GO:0042060 wound healing 1.357178e-6
GO:0071842 cellular component organization at cellular level 1.398248e-6
GO:0007266 Rho protein signal transduction 1.418640e-6
GO:0051179 localization 1.471797e-6
GO:0060033 anatomical structure regression 1.562788e-6
GO:0032501 multicellular organismal process 1.566188e-6
GO:0072678 T cell migration 1.617836e-6
GO:0010810 regulation of cell-substrate adhesion 1.780566e-6
GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway 1.855544e-6
GO:0048747 muscle fiber development 1.917247e-6
GO:0031667 response to nutrient levels 2.019579e-6
GO:0065004 protein-DNA complex assembly 2.096483e-6
GO:0051716 cellular response to stimulus 2.320205e-6
GO:0070358 actin polymerization-dependent cell motility 2.425354e-6
GO:0060324 face development 2.440443e-6
GO:0014866 skeletal myofibril assembly 2.539614e-6
GO:0008064 regulation of actin polymerization or depolymerization 2.660962e-6
GO:0055002 striated muscle cell development 2.938176e-6
GO:0030029 actin filament-based process 3.018302e-6
GO:0006810 transport 3.024606e-6
GO:0071841 cellular component organization or biogenesis at cellular level 3.024943e-6
GO:0006936 muscle contraction 3.065011e-6
GO:0010171 body morphogenesis 3.269555e-6
GO:0048729 tissue morphogenesis 3.635137e-6
GO:0034109 homotypic cell-cell adhesion 3.650489e-6
GO:0002739 regulation of cytokine secretion involved in immune response 4.486499e-6
GO:0022008 neurogenesis 4.501803e-6
GO:0065003 macromolecular complex assembly 4.538079e-6
GO:0048856 anatomical structure development 4.588168e-6
GO:0071496 cellular response to external stimulus 5.162509e-6
GO:0001649 osteoblast differentiation 5.610586e-6
GO:0048871 multicellular organismal homeostasis 5.662337e-6
GO:0060426 lung vasculature development 5.815021e-6
GO:0060322 head development 6.415307e-6
GO:2000249 regulation of actin cytoskeleton reorganization 6.432211e-6
GO:0001944 vasculature development 7.757722e-6
GO:0051704 multi-organism process 7.962437e-6
GO:0006629 lipid metabolic process 8.070956e-6
GO:0055001 muscle cell development 8.334529e-6
GO:0051532 regulation of NFAT protein import into nucleus 9.734283e-6
GO:0043623 cellular protein complex assembly 9.751946e-6
GO:0007268 synaptic transmission 9.911084e-6
GO:0010506 regulation of autophagy 1.019272e-5
GO:0048699 generation of neurons 1.023999e-5
GO:0042542 response to hydrogen peroxide 1.025918e-5
GO:0002376 immune system process 1.034393e-5
GO:0017144 drug metabolic process 1.061978e-5
GO:0060828 regulation of canonical Wnt receptor signaling pathway 1.082018e-5
GO:0048545 response to steroid hormone stimulus 1.096767e-5
GO:0006026 aminoglycan catabolic process 1.135624e-5
GO:0048769 sarcomerogenesis 1.145993e-5
GO:0071460 cellular response to cell-matrix adhesion 1.217257e-5
GO:0030111 regulation of Wnt receptor signaling pathway 1.238444e-5
GO:0003214 cardiac left ventricle morphogenesis 1.271800e-5
GO:0034504 protein localization to nucleus 1.292314e-5
GO:0014002 astrocyte development 1.307290e-5
GO:0048613 embryonic ectodermal digestive tract morphogenesis 1.349869e-5
GO:0060461 right lung morphogenesis 1.349869e-5
GO:0090131 mesenchyme migration 1.349869e-5
GO:0060446 branching involved in open tracheal system development 1.349869e-5
GO:0002115 store-operated calcium entry 1.349869e-5
GO:0014822 detection of wounding 1.349869e-5
GO:0048371 lateral mesodermal cell differentiation 1.349869e-5
GO:2000279 negative regulation of DNA biosynthetic process 1.365294e-5
GO:0007605 sensory perception of sound 1.397329e-5
GO:0010927 cellular component assembly involved in morphogenesis 1.413680e-5
GO:0001568 blood vessel development 1.480797e-5
GO:0090288 negative regulation of cellular response to growth factor stimulus 1.487724e-5
GO:0003007 heart morphogenesis 1.624455e-5
GO:0016458 gene silencing 1.692820e-5
GO:0007154 cell communication 1.768529e-5
GO:0045198 establishment of epithelial cell apical/basal polarity 1.812510e-5
GO:0019254 carnitine metabolic process, CoA-linked 1.890374e-5
GO:0060048 cardiac muscle contraction 1.949212e-5
GO:0032274 gonadotropin secretion 1.949689e-5
GO:0002554 serotonin secretion by platelet 2.048245e-5
GO:0009991 response to extracellular stimulus 2.063495e-5
GO:0040029 regulation of gene expression, epigenetic 2.491937e-5
GO:0016477 cell migration 2.622504e-5
GO:0030335 positive regulation of cell migration 2.846668e-5
GO:0006887 exocytosis 3.053100e-5
GO:0016043 cellular component organization 3.119343e-5
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway 3.123811e-5
GO:0060907 positive regulation of macrophage cytokine production 3.167728e-5
GO:0032800 receptor biosynthetic process 3.208276e-5
GO:0034337 RNA folding 3.212602e-5
GO:0071276 cellular response to cadmium ion 3.281190e-5
GO:0008211 glucocorticoid metabolic process 3.293271e-5
GO:0045920 negative regulation of exocytosis 3.344861e-5
GO:0006979 response to oxidative stress 3.422348e-5
GO:2000147 positive regulation of cell motility 3.536992e-5
GO:0015031 protein transport 3.885713e-5
GO:0051293 establishment of spindle localization 3.934864e-5
GO:0009887 organ morphogenesis 4.034531e-5
GO:0070489 T cell aggregation 4.217246e-5
GO:0003012 muscle system process 4.287038e-5
GO:0040017 positive regulation of locomotion 4.425089e-5
GO:0071840 cellular component organization or biogenesis 4.447200e-5
GO:0006700 C21-steroid hormone biosynthetic process 4.601110e-5
GO:0001501 skeletal system development 4.747917e-5
GO:0043301 negative regulation of leukocyte degranulation 4.828865e-5
GO:0002029 desensitization of G-protein coupled receptor protein signaling pathway 5.110472e-5
GO:0044130 negative regulation of growth of symbiont in host 5.129588e-5
GO:0048870 cell motility 5.238042e-5
GO:0016095 polyprenol catabolic process 5.564308e-5
GO:0030801 positive regulation of cyclic nucleotide metabolic process 5.948554e-5
GO:0048731 system development 6.037957e-5
GO:0070060 'de novo' actin filament nucleation 6.041293e-5
GO:0016098 monoterpenoid metabolic process 6.068671e-5
GO:0007186 G-protein coupled receptor protein signaling pathway 6.096349e-5
GO:0030036 actin cytoskeleton organization 6.165977e-5
GO:0008104 protein localization 6.276372e-5
GO:0008217 regulation of blood pressure 6.353568e-5
GO:0045184 establishment of protein localization 6.378274e-5
GO:0002019 regulation of renal output by angiotensin 6.456021e-5
GO:0007522 visceral muscle development 6.843999e-5
GO:0090096 positive regulation of metanephric cap mesenchymal cell proliferation 7.024968e-5
GO:0050954 sensory perception of mechanical stimulus 7.469515e-5
GO:0051146 striated muscle cell differentiation 7.539982e-5
GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism 7.556721e-5
GO:0010720 positive regulation of cell development 7.673617e-5
GO:0031648 protein destabilization 7.952549e-5
GO:0002699 positive regulation of immune effector process 8.041395e-5
GO:0048706 embryonic skeletal system development 8.062843e-5
GO:0071495 cellular response to endogenous stimulus 8.123092e-5
GO:0070848 response to growth factor stimulus 8.357693e-5
GO:0043555 regulation of translation in response to stress 8.548991e-5
GO:0060249 anatomical structure homeostasis 9.397445e-5
GO:0007020 microtubule nucleation 9.440951e-5
GO:0000086 G2/M transition of mitotic cell cycle 9.564590e-5
GO:0007275 multicellular organismal development 9.612360e-5
GO:0007166 cell surface receptor linked signaling pathway 9.846438e-5
GO:0042559 pteridine-containing compound biosynthetic process 1.038526e-4
GO:0043060 meiotic metaphase I plate congression 1.042924e-4
GO:0002740 negative regulation of cytokine secretion involved in immune response 1.069046e-4
GO:0048609 multicellular organismal reproductive process 1.088240e-4
GO:0007283 spermatogenesis 1.101779e-4
GO:0000132 establishment of mitotic spindle orientation 1.137408e-4
GO:0055098 response to low-density lipoprotein particle stimulus 1.138247e-4
GO:0051641 cellular localization 1.138495e-4
GO:0034465 response to carbon monoxide 1.138919e-4
GO:0071363 cellular response to growth factor stimulus 1.157252e-4
GO:0002149 hypochlorous acid biosynthetic process 1.184591e-4
GO:0018283 iron incorporation into metallo-sulfur cluster 1.226027e-4
GO:0048841 regulation of axon extension involved in axon guidance 1.238415e-4
GO:0050715 positive regulation of cytokine secretion 1.257135e-4
GO:0031668 cellular response to extracellular stimulus 1.282577e-4
GO:0030832 regulation of actin filament length 1.288468e-4
GO:0051216 cartilage development 1.306732e-4
GO:0031669 cellular response to nutrient levels 1.316193e-4
GO:0030240 skeletal muscle thin filament assembly 1.319294e-4
GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway 1.328999e-4
GO:0044283 small molecule biosynthetic process 1.334672e-4
GO:0060047 heart contraction 1.339780e-4
GO:0032411 positive regulation of transporter activity 1.393732e-4
GO:0010950 positive regulation of endopeptidase activity 1.442364e-4
GO:0044029 hypomethylation of CpG island 1.442364e-4
GO:0042699 follicle-stimulating hormone signaling pathway 1.442364e-4
GO:0085018 maintenance of symbiont-containing vacuole via substance secreted by host 1.462378e-4
GO:0035378 carbon dioxide transmembrane transport 1.462378e-4
GO:0030950 establishment or maintenance of actin cytoskeleton polarity 1.462378e-4
GO:0035377 transepithelial water transport 1.462378e-4
GO:0010625 positive regulation of Schwann cell proliferation 1.650874e-4
GO:0006897 endocytosis 1.733889e-4
GO:0030819 positive regulation of cAMP biosynthetic process 1.761999e-4
GO:0019226 transmission of nerve impulse 1.805093e-4
GO:0048382 mesendoderm development 1.819015e-4
GO:0050707 regulation of cytokine secretion 1.911582e-4
GO:0051272 positive regulation of cellular component movement 1.915605e-4
GO:0048370 lateral mesoderm formation 1.932419e-4
GO:0071404 cellular response to low-density lipoprotein particle stimulus 2.026109e-4
GO:0007253 cytoplasmic sequestering of NF-kappaB 2.026109e-4
GO:0030816 positive regulation of cAMP metabolic process 2.033890e-4
GO:0048368 lateral mesoderm development 2.040600e-4
GO:0055003 cardiac myofibril assembly 2.056910e-4
GO:0006950 response to stress 2.091093e-4
GO:0050862 positive regulation of T cell receptor signaling pathway 2.134493e-4
GO:0030952 establishment or maintenance of cytoskeleton polarity 2.146933e-4
GO:0006270 DNA-dependent DNA replication initiation 2.218776e-4
GO:0016226 iron-sulfur cluster assembly 2.221425e-4
GO:0048352 paraxial mesoderm structural organization 2.278776e-4
GO:0021998 neural plate mediolateral regionalization 2.278776e-4
GO:0006692 prostanoid metabolic process 2.331298e-4
GO:0044057 regulation of system process 2.350943e-4
GO:0003026 regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback 2.351132e-4
GO:0040001 establishment of mitotic spindle localization 2.386479e-4
GO:0014896 muscle hypertrophy 2.433050e-4
GO:0022403 cell cycle phase 2.527225e-4
GO:0006259 DNA metabolic process 2.553313e-4
GO:0007010 cytoskeleton organization 2.567856e-4
GO:0018879 biphenyl metabolic process 2.685934e-4
GO:0031330 negative regulation of cellular catabolic process 2.701665e-4
GO:0008207 C21-steroid hormone metabolic process 2.730202e-4
GO:0007128 meiotic prophase I 2.756615e-4
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway 2.756730e-4
GO:0018149 peptide cross-linking 2.867089e-4
GO:0007507 heart development 3.003825e-4
GO:0046626 regulation of insulin receptor signaling pathway 3.004200e-4
GO:0044419 interspecies interaction between organisms 3.166546e-4
GO:0006702 androgen biosynthetic process 3.424302e-4
GO:0019255 glucose 1-phosphate metabolic process 3.450120e-4
GO:0009988 cell-cell recognition 3.478767e-4
GO:0043534 blood vessel endothelial cell migration 3.608314e-4
GO:0048843 negative regulation of axon extension involved in axon guidance 3.697490e-4
GO:0071593 lymphocyte aggregation 3.739933e-4
GO:0030913 paranodal junction assembly 3.739933e-4
GO:0051384 response to glucocorticoid stimulus 3.748413e-4
GO:0001919 regulation of receptor recycling 3.770920e-4
GO:0001503 ossification 3.791258e-4
GO:0000272 polysaccharide catabolic process 4.059874e-4
GO:0071402 cellular response to lipoprotein particle stimulus 4.113277e-4
GO:0030224 monocyte differentiation 4.166118e-4
GO:0048610 cellular process involved in reproduction 4.203100e-4
GO:0060291 long-term synaptic potentiation 4.232485e-4
GO:0045355 negative regulation of interferon-alpha biosynthetic process 4.242104e-4
GO:0034314 Arp2/3 complex-mediated actin nucleation 4.286896e-4
GO:0051580 regulation of neurotransmitter uptake 4.313413e-4
GO:0009607 response to biotic stimulus 4.397899e-4
GO:0050886 endocrine process 4.399370e-4
GO:0048708 astrocyte differentiation 4.582381e-4
GO:0071222 cellular response to lipopolysaccharide 4.641518e-4
GO:0042407 cristae formation 4.707719e-4
GO:0043438 acetoacetic acid metabolic process 4.878718e-4
GO:0007165 signal transduction 5.100117e-4
GO:0051324 prophase 5.394550e-4
GO:0032049 cardiolipin biosynthetic process 5.452737e-4
GO:0045953 negative regulation of natural killer cell mediated cytotoxicity 5.570838e-4
GO:0006987 activation of signaling protein activity involved in unfolded protein response 5.570838e-4
GO:0008594 photoreceptor cell morphogenesis 5.599897e-4
GO:0010935 regulation of macrophage cytokine production 5.603981e-4
GO:0046903 secretion 5.682684e-4
GO:0051534 negative regulation of NFAT protein import into nucleus 5.735867e-4
GO:0070098 chemokine-mediated signaling pathway 5.936659e-4
GO:0044255 cellular lipid metabolic process 5.942901e-4
GO:0042446 hormone biosynthetic process 6.128818e-4
GO:0032374 regulation of cholesterol transport 6.222737e-4
GO:0006690 icosanoid metabolic process 6.256496e-4
GO:0035036 sperm-egg recognition 6.304297e-4
GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response 6.332942e-4
GO:0003408 optic cup formation involved in camera-type eye development 6.496630e-4
GO:0032069 regulation of nuclease activity 6.544276e-4
GO:0055093 response to hyperoxia 6.706469e-4
GO:0021589 cerebellum structural organization 6.987491e-4
GO:0060904 regulation of protein folding in endoplasmic reticulum 6.987491e-4
GO:0009822 alkaloid catabolic process 6.987491e-4
GO:0042994 cytoplasmic sequestering of transcription factor 7.032770e-4
GO:0051707 response to other organism 7.051663e-4
GO:0001516 prostaglandin biosynthetic process 7.419513e-4
GO:0007007 inner mitochondrial membrane organization 7.744097e-4
GO:0007229 integrin-mediated signaling pathway 7.745517e-4
GO:0040012 regulation of locomotion 7.765727e-4
GO:0033559 unsaturated fatty acid metabolic process 7.805622e-4
GO:0001956 positive regulation of neurotransmitter secretion 7.954398e-4
GO:0017156 calcium ion-dependent exocytosis 8.023358e-4
GO:0042692 muscle cell differentiation 8.375559e-4
GO:0003084 positive regulation of systemic arterial blood pressure 8.450301e-4
GO:0008202 steroid metabolic process 8.460776e-4
GO:0035684 helper T cell extravasation 8.595136e-4
GO:0003108 negative regulation of the force of heart contraction by chemical signal 8.595136e-4
GO:0071257 cellular response to electrical stimulus 8.634353e-4
GO:0000216 M/G1 transition of mitotic cell cycle 8.648573e-4
GO:0042758 long-chain fatty acid catabolic process 8.689428e-4
GO:0042413 carnitine catabolic process 8.689428e-4
GO:0046724 oxalic acid secretion 8.689428e-4
GO:0035994 response to muscle stretch 8.689428e-4
GO:0019265 glycine biosynthetic process, by transamination of glyoxylate 8.689428e-4
GO:0051270 regulation of cellular component movement 8.711983e-4
GO:0006693 prostaglandin metabolic process 9.050196e-4
GO:0060067 cervix development 9.296146e-4
GO:0042992 negative regulation of transcription factor import into nucleus 9.314322e-4
GO:0071157 negative regulation of cell cycle arrest 9.534189e-4
GO:0003015 heart process 9.677053e-4
GO:0045039 protein import into mitochondrial inner membrane 9.740183e-4
GO:0018206 peptidyl-methionine modification 9.973384e-4
GO:0002418 immune response to tumor cell 1.000160e-3
GO:0007223 Wnt receptor signaling pathway, calcium modulating pathway 1.018661e-3
GO:0023052 signaling 1.020911e-3
GO:0032940 secretion by cell 1.027749e-3
GO:0032236 positive regulation of calcium ion transport via store-operated calcium channel activity 1.042261e-3
GO:0003300 cardiac muscle hypertrophy 1.044069e-3
GO:0071219 cellular response to molecule of bacterial origin 1.050212e-3
GO:0009309 amine biosynthetic process 1.075067e-3
GO:0002904 positive regulation of B cell apoptosis 1.079315e-3
GO:0050877 neurological system process 1.089481e-3
GO:0002026 regulation of the force of heart contraction 1.091098e-3
GO:0051590 positive regulation of neurotransmitter transport 1.097248e-3
GO:0033013 tetrapyrrole metabolic process 1.098715e-3
GO:0030155 regulation of cell adhesion 1.107245e-3
GO:0032897 negative regulation of viral transcription 1.116253e-3
GO:0070230 positive regulation of lymphocyte apoptosis 1.124852e-3
GO:0009888 tissue development 1.163361e-3
GO:0006032 chitin catabolic process 1.171206e-3
GO:0030836 positive regulation of actin filament depolymerization 1.171206e-3
GO:0071385 cellular response to glucocorticoid stimulus 1.191234e-3
GO:0002158 osteoclast proliferation 1.194042e-3
GO:0043901 negative regulation of multi-organism process 1.199844e-3
GO:0045981 positive regulation of nucleotide metabolic process 1.204259e-3
GO:0055069 zinc ion homeostasis 1.219254e-3
GO:0048286 lung alveolus development 1.221411e-3
GO:0046456 icosanoid biosynthetic process 1.224954e-3
GO:0042445 hormone metabolic process 1.240078e-3
GO:0051414 response to cortisol stimulus 1.241703e-3
GO:0000305 response to oxygen radical 1.249268e-3
GO:0046628 positive regulation of insulin receptor signaling pathway 1.251093e-3
GO:0019695 choline metabolic process 1.285547e-3
GO:0042737 drug catabolic process 1.286409e-3
GO:0035089 establishment of apical/basal cell polarity 1.286409e-3
GO:0071346 cellular response to interferon-gamma 1.297806e-3
GO:0010897 negative regulation of triglyceride catabolic process 1.316061e-3
GO:0010987 negative regulation of high-density lipoprotein particle clearance 1.316061e-3
GO:0007000 nucleolus organization 1.327651e-3
GO:0006066 alcohol metabolic process 1.332173e-3
GO:0002720 positive regulation of cytokine production involved in immune response 1.338918e-3
GO:0006777 Mo-molybdopterin cofactor biosynthetic process 1.360952e-3
GO:0061350 planar cell polarity pathway involved in cardiac muscle tissue morphogenesis 1.378568e-3
GO:0061354 planar cell polarity pathway involved in pericardium morphogenesis 1.378568e-3
GO:0061349 planar cell polarity pathway involved in cardiac right atrium morphogenesis 1.378568e-3
GO:0060210 metestrus 1.378568e-3
GO:0061347 planar cell polarity pathway involved in outflow tract morphogenesis 1.378568e-3
GO:0061348 planar cell polarity pathway involved in ventricular septum morphogenesis 1.378568e-3
GO:0060463 lung lobe morphogenesis 1.381642e-3
GO:0055013 cardiac muscle cell development 1.387534e-3
GO:0015866 ADP transport 1.388306e-3
GO:0050714 positive regulation of protein secretion 1.405275e-3
GO:0007506 gonadal mesoderm development 1.420438e-3
GO:0048143 astrocyte activation 1.440186e-3
GO:0002718 regulation of cytokine production involved in immune response 1.449076e-3
GO:0070483 detection of hypoxia 1.449880e-3
GO:0030804 positive regulation of cyclic nucleotide biosynthetic process 1.497094e-3
GO:0032414 positive regulation of ion transmembrane transporter activity 1.524701e-3
GO:0014895 smooth muscle hypertrophy 1.535008e-3
GO:0003106 negative regulation of glomerular filtration by angiotensin 1.535008e-3
GO:0051045 negative regulation of membrane protein ectodomain proteolysis 1.546805e-3
GO:2000145 regulation of cell motility 1.563988e-3
GO:0006636 unsaturated fatty acid biosynthetic process 1.566626e-3
GO:0050433 regulation of catecholamine secretion 1.581148e-3
GO:0006766 vitamin metabolic process 1.582896e-3
GO:0000422 mitochondrion degradation 1.599655e-3
GO:0002682 regulation of immune system process 1.628978e-3
GO:0001738 morphogenesis of a polarized epithelium 1.629439e-3


GREAT analysis results for mouse
Genomic Enrichment of Annotations Tool (GREAT, Nat Biotechnol. 2010 May;28(5):495-501) is used to identify, both in human and in mouse, the gene ontology terms of biological processes enriched given the predicted TFBSs, and evaluated the overlap in the top-500 gene ontology terms between human and mouse. For each novel motif, the P value for the overlap was then evaluated by calculating its relative rank with respect to this background distribution.
Analyst: Michiel de Hoon

link to source dataset

data

GO IDGO Termp-value
GO:0071230 cellular response to amino acid stimulus 1.491973e-31
GO:0071229 cellular response to acid 1.516784e-30
GO:0001957 intramembranous ossification 7.636047e-28
GO:0071417 cellular response to organic nitrogen 1.963237e-26
GO:0071418 cellular response to amine stimulus 2.244784e-26
GO:0060346 bone trabecula formation 5.676300e-25
GO:0032964 collagen biosynthetic process 3.347204e-22
GO:0043200 response to amino acid stimulus 1.965798e-20
GO:0010718 positive regulation of epithelial to mesenchymal transition 4.104005e-20
GO:0030199 collagen fibril organization 3.083025e-19
GO:0010770 positive regulation of cell morphogenesis involved in differentiation 1.441791e-18
GO:0010717 regulation of epithelial to mesenchymal transition 2.426359e-18
GO:0034505 tooth mineralization 4.131477e-18
GO:0070208 protein heterotrimerization 5.671475e-18
GO:0001101 response to acid 1.491439e-17
GO:0043589 skin morphogenesis 3.883809e-17
GO:0002740 negative regulation of cytokine secretion involved in immune response 6.513913e-17
GO:0060343 trabecula formation 8.159252e-17
GO:0010987 negative regulation of high-density lipoprotein particle clearance 9.381522e-17
GO:0010897 negative regulation of triglyceride catabolic process 9.381522e-17
GO:0002739 regulation of cytokine secretion involved in immune response 3.904312e-15
GO:0010916 negative regulation of very-low-density lipoprotein particle clearance 5.255166e-15
GO:0070508 cholesterol import 6.759232e-15
GO:0010982 regulation of high-density lipoprotein particle clearance 1.300614e-14
GO:0050713 negative regulation of interleukin-1 beta secretion 1.347387e-14
GO:0061383 trabecula morphogenesis 2.944652e-14
GO:0014075 response to amine stimulus 3.970514e-14
GO:0010989 negative regulation of low-density lipoprotein particle clearance 4.167679e-14
GO:0010985 negative regulation of lipoprotein particle clearance 8.307336e-14
GO:0070206 protein trimerization 8.913210e-14
GO:0034382 chylomicron remnant clearance 1.461879e-13
GO:0050711 negative regulation of interleukin-1 secretion 4.877942e-13
GO:0032963 collagen metabolic process 6.442147e-13
GO:0060351 cartilage development involved in endochondral bone morphogenesis 7.816697e-13
GO:0010984 regulation of lipoprotein particle clearance 9.380188e-13
GO:0051005 negative regulation of lipoprotein lipase activity 1.031430e-12
GO:0060621 negative regulation of cholesterol import 1.374374e-12
GO:0071260 cellular response to mechanical stimulus 3.086195e-12
GO:0044259 multicellular organismal macromolecule metabolic process 4.805448e-12
GO:0048730 epidermis morphogenesis 6.855920e-12
GO:0060620 regulation of cholesterol import 7.411625e-12
GO:0001935 endothelial cell proliferation 9.063496e-12
GO:0010903 negative regulation of very-low-density lipoprotein particle remodeling 9.213705e-12
GO:0044236 multicellular organismal metabolic process 1.182318e-11
GO:0001649 osteoblast differentiation 1.193292e-11
GO:0090263 positive regulation of canonical Wnt receptor signaling pathway 1.860703e-11
GO:0034377 plasma lipoprotein particle assembly 2.553390e-11
GO:0030198 extracellular matrix organization 2.654574e-11
GO:0032488 Cdc42 protein signal transduction 3.351256e-11
GO:0050710 negative regulation of cytokine secretion 4.718093e-11
GO:0006695 cholesterol biosynthetic process 9.001003e-11
GO:0001958 endochondral ossification 1.402013e-10
GO:0050995 negative regulation of lipid catabolic process 2.824805e-10
GO:0048261 negative regulation of receptor-mediated endocytosis 3.289960e-10
GO:0032375 negative regulation of cholesterol transport 3.335872e-10
GO:0010873 positive regulation of cholesterol esterification 6.053723e-10
GO:0043588 skin development 7.698601e-10
GO:0060192 negative regulation of lipase activity 7.699662e-10
GO:0016126 sterol biosynthetic process 7.982829e-10
GO:0032800 receptor biosynthetic process 1.000717e-9
GO:0010243 response to organic nitrogen 1.519847e-9
GO:0045717 negative regulation of fatty acid biosynthetic process 1.798832e-9
GO:0060325 face morphogenesis 4.955592e-9
GO:2000054 negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification 5.176150e-9
GO:0010872 regulation of cholesterol esterification 6.968982e-9
GO:0034380 high-density lipoprotein particle assembly 7.622115e-9
GO:0032691 negative regulation of interleukin-1 beta production 8.679010e-9
GO:0060323 head morphogenesis 1.051539e-8
GO:0045212 neurotransmitter receptor biosynthetic process 1.174927e-8
GO:0032930 positive regulation of superoxide anion generation 1.174927e-8
GO:0065005 protein-lipid complex assembly 1.224728e-8
GO:0060349 bone morphogenesis 1.298657e-8
GO:0031214 biomineral tissue development 1.344108e-8
GO:0050709 negative regulation of protein secretion 1.394184e-8
GO:0007584 response to nutrient 1.420825e-8
GO:0071295 cellular response to vitamin 1.444514e-8
GO:0048259 regulation of receptor-mediated endocytosis 1.595800e-8
GO:0060350 endochondral bone morphogenesis 1.612793e-8
GO:0010812 negative regulation of cell-substrate adhesion 1.691332e-8
GO:0034375 high-density lipoprotein particle remodeling 2.078320e-8
GO:0090209 negative regulation of triglyceride metabolic process 2.126084e-8
GO:0045806 negative regulation of endocytosis 2.266321e-8
GO:0032651 regulation of interleukin-1 beta production 2.319792e-8
GO:0032692 negative regulation of interleukin-1 production 2.750532e-8
GO:0008542 visual learning 3.462392e-8
GO:0006642 triglyceride mobilization 3.621376e-8
GO:0071356 cellular response to tumor necrosis factor 3.713626e-8
GO:0032928 regulation of superoxide anion generation 3.954228e-8
GO:0030177 positive regulation of Wnt receptor signaling pathway 3.955918e-8
GO:2000053 regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification 5.798007e-8
GO:0034612 response to tumor necrosis factor 5.858904e-8
GO:0032652 regulation of interleukin-1 production 7.045845e-8
GO:0045922 negative regulation of fatty acid metabolic process 7.048149e-8
GO:0007162 negative regulation of cell adhesion 8.401327e-8
GO:0006694 steroid biosynthetic process 1.063230e-7
GO:0019915 lipid storage 1.089836e-7
GO:0033273 response to vitamin 1.261375e-7
GO:0016191 synaptic vesicle uncoating 1.357801e-7
GO:0071300 cellular response to retinoic acid 1.745095e-7
GO:0071299 cellular response to vitamin A 2.473509e-7
GO:0001503 ossification 2.655921e-7
GO:0030261 chromosome condensation 2.720235e-7
GO:0071214 cellular response to abiotic stimulus 2.880311e-7
GO:0031670 cellular response to nutrient 3.257228e-7
GO:0010901 regulation of very-low-density lipoprotein particle remodeling 3.352788e-7
GO:0060828 regulation of canonical Wnt receptor signaling pathway 3.576426e-7
GO:0032682 negative regulation of chemokine production 5.223650e-7
GO:0060693 regulation of branching involved in salivary gland morphogenesis 5.249347e-7
GO:2000256 positive regulation of male germ cell proliferation 5.527741e-7
GO:0042231 interleukin-13 biosynthetic process 5.527741e-7
GO:0001579 medium-chain fatty acid transport 5.527741e-7
GO:0033189 response to vitamin A 5.529950e-7
GO:0034381 plasma lipoprotein particle clearance 5.641401e-7
GO:0090322 regulation of superoxide metabolic process 5.673364e-7
GO:0043534 blood vessel endothelial cell migration 6.134739e-7
GO:0060191 regulation of lipase activity 6.639730e-7
GO:0032526 response to retinoic acid 6.889372e-7
GO:0046069 cGMP catabolic process 7.864468e-7
GO:0045940 positive regulation of steroid metabolic process 8.118339e-7
GO:0033700 phospholipid efflux 8.526158e-7
GO:0003012 muscle system process 9.113759e-7
GO:0002642 positive regulation of immunoglobulin biosynthetic process 9.523023e-7
GO:0010896 regulation of triglyceride catabolic process 9.934622e-7
GO:0010951 negative regulation of endopeptidase activity 1.149321e-6
GO:0007338 single fertilization 1.275391e-6
GO:0010171 body morphogenesis 1.727713e-6
GO:0030300 regulation of intestinal cholesterol absorption 2.195312e-6
GO:0070328 triglyceride homeostasis 2.420301e-6
GO:0051291 protein heterooligomerization 2.446966e-6
GO:0001887 selenium compound metabolic process 2.663495e-6
GO:0007632 visual behavior 2.665050e-6
GO:0002874 regulation of chronic inflammatory response to antigenic stimulus 2.993083e-6
GO:0010720 positive regulation of cell development 3.215771e-6
GO:0071495 cellular response to endogenous stimulus 3.623699e-6
GO:0050673 epithelial cell proliferation 3.721991e-6
GO:0061028 establishment of endothelial barrier 3.857990e-6
GO:0006629 lipid metabolic process 4.028152e-6
GO:0032374 regulation of cholesterol transport 4.311301e-6
GO:0060324 face development 4.393849e-6
GO:0060348 bone development 4.514614e-6
GO:0071827 plasma lipoprotein particle organization 4.729760e-6
GO:0034104 negative regulation of tissue remodeling 4.925410e-6
GO:0046068 cGMP metabolic process 5.021213e-6
GO:0006641 triglyceride metabolic process 5.163821e-6
GO:0030111 regulation of Wnt receptor signaling pathway 5.306755e-6
GO:0050706 regulation of interleukin-1 beta secretion 5.435508e-6
GO:0048705 skeletal system morphogenesis 5.707002e-6
GO:0006639 acylglycerol metabolic process 6.032847e-6
GO:0051224 negative regulation of protein transport 6.149833e-6
GO:0090207 regulation of triglyceride metabolic process 6.199658e-6
GO:0043691 reverse cholesterol transport 7.186501e-6
GO:0061302 smooth muscle cell-matrix adhesion 7.941690e-6
GO:2000270 negative regulation of fibroblast apoptosis 8.554767e-6
GO:2000271 positive regulation of fibroblast apoptosis 8.554767e-6
GO:2000080 negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation 8.554767e-6
GO:0044345 stromal-epithelial cell signaling involved in prostate gland development 8.554767e-6
GO:0008211 glucocorticoid metabolic process 8.708391e-6
GO:0032369 negative regulation of lipid transport 8.715456e-6
GO:0050707 regulation of cytokine secretion 9.458011e-6
GO:0006638 neutral lipid metabolic process 9.952321e-6
GO:0050994 regulation of lipid catabolic process 1.127669e-5
GO:0045085 negative regulation of interleukin-2 biosynthetic process 1.197107e-5
GO:0046486 glycerolipid metabolic process 1.210196e-5
GO:0050704 regulation of interleukin-1 secretion 1.290193e-5
GO:2000079 regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation 1.387649e-5
GO:0071380 cellular response to prostaglandin E stimulus 1.387649e-5
GO:0042095 interferon-gamma biosynthetic process 1.387649e-5
GO:0006936 muscle contraction 1.426178e-5
GO:0010817 regulation of hormone levels 1.496890e-5
GO:0010747 positive regulation of plasma membrane long-chain fatty acid transport 1.516858e-5
GO:0006710 androgen catabolic process 1.516858e-5
GO:0022603 regulation of anatomical structure morphogenesis 1.858260e-5
GO:0044255 cellular lipid metabolic process 1.895543e-5
GO:0008203 cholesterol metabolic process 1.907974e-5
GO:0044058 regulation of digestive system process 1.945462e-5
GO:0033344 cholesterol efflux 2.050004e-5
GO:0051382 kinetochore assembly 2.166703e-5
GO:0046464 acylglycerol catabolic process 2.292200e-5
GO:0006939 smooth muscle contraction 2.504479e-5
GO:0006927 transformed cell apoptosis 2.620417e-5
GO:0051142 positive regulation of NK T cell proliferation 2.690377e-5
GO:0016042 lipid catabolic process 2.717408e-5
GO:0016125 sterol metabolic process 2.840318e-5
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 2.911779e-5
GO:0007266 Rho protein signal transduction 3.020124e-5
GO:0051004 regulation of lipoprotein lipase activity 3.112598e-5
GO:0019433 triglyceride catabolic process 3.620551e-5
GO:0051533 positive regulation of NFAT protein import into nucleus 3.845084e-5
GO:0043117 positive regulation of vascular permeability 3.845084e-5
GO:0042304 regulation of fatty acid biosynthetic process 3.852842e-5
GO:0071363 cellular response to growth factor stimulus 3.929431e-5
GO:0001944 vasculature development 3.952446e-5
GO:0061181 regulation of chondrocyte development 3.986879e-5
GO:0097006 regulation of plasma lipoprotein particle levels 4.006845e-5
GO:0033689 negative regulation of osteoblast proliferation 4.264778e-5
GO:0008610 lipid biosynthetic process 4.464800e-5
GO:0002718 regulation of cytokine production involved in immune response 4.561323e-5
GO:0045994 positive regulation of translational initiation by iron 4.806071e-5
GO:0061048 negative regulation of branching involved in lung morphogenesis 4.806071e-5
GO:0034116 positive regulation of heterotypic cell-cell adhesion 4.806071e-5
GO:0002037 negative regulation of L-glutamate transport 4.806071e-5
GO:0042158 lipoprotein biosynthetic process 4.918100e-5
GO:0070305 response to cGMP 4.984313e-5
GO:0043542 endothelial cell migration 6.035844e-5
GO:0008202 steroid metabolic process 6.078680e-5
GO:0045076 regulation of interleukin-2 biosynthetic process 6.230287e-5
GO:0008544 epidermis development 6.975954e-5
GO:0051346 negative regulation of hydrolase activity 6.994461e-5
GO:0033143 regulation of steroid hormone receptor signaling pathway 7.072181e-5
GO:0048565 digestive tract development 7.473891e-5
GO:0060322 head development 7.564621e-5
GO:0017156 calcium ion-dependent exocytosis 7.666975e-5
GO:0002318 myeloid progenitor cell differentiation 7.926154e-5
GO:0032757 positive regulation of interleukin-8 production 8.514814e-5
GO:0046641 positive regulation of alpha-beta T cell proliferation 8.606640e-5
GO:0042445 hormone metabolic process 8.793862e-5
GO:0030100 regulation of endocytosis 9.135302e-5
GO:0034103 regulation of tissue remodeling 9.410745e-5
GO:2000275 regulation of oxidative phosphorylation uncoupler activity 9.501119e-5
GO:0060627 regulation of vesicle-mediated transport 9.567340e-5
GO:0051383 kinetochore organization 9.629758e-5
GO:0009992 cellular water homeostasis 9.629758e-5
GO:0002876 positive regulation of chronic inflammatory response to antigenic stimulus 9.629758e-5
GO:0051261 protein depolymerization 9.715799e-5
GO:0030325 adrenal gland development 1.082908e-4
GO:0007202 activation of phospholipase C activity 1.089634e-4
GO:0033146 regulation of estrogen receptor signaling pathway 1.132576e-4
GO:0014819 regulation of skeletal muscle contraction 1.132576e-4
GO:0071321 cellular response to cGMP 1.235697e-4
GO:0006581 acetylcholine catabolic process 1.235697e-4
GO:0014034 neural crest cell fate commitment 1.278908e-4
GO:0031647 regulation of protein stability 1.305748e-4
GO:2000277 positive regulation of oxidative phosphorylation uncoupler activity 1.321148e-4
GO:0034695 response to prostaglandin E stimulus 1.417019e-4
GO:0008625 induction of apoptosis via death domain receptors 1.426192e-4
GO:0018904 organic ether metabolic process 1.430966e-4
GO:0015914 phospholipid transport 1.521904e-4
GO:0010939 regulation of necrotic cell death 1.533324e-4
GO:0007166 cell surface receptor linked signaling pathway 1.563524e-4
GO:0034369 plasma lipoprotein particle remodeling 1.569251e-4
GO:0002115 store-operated calcium entry 1.588545e-4
GO:0002921 negative regulation of humoral immune response 1.610938e-4
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production 1.615036e-4
GO:0003008 system process 1.648622e-4
GO:0050821 protein stabilization 1.691278e-4
GO:0006662 glycerol ether metabolic process 1.700224e-4
GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus 1.780163e-4
GO:0032642 regulation of chemokine production 1.781092e-4
GO:0071504 cellular response to heparin 1.845312e-4
GO:0031667 response to nutrient levels 1.848842e-4
GO:0006650 glycerophospholipid metabolic process 1.886834e-4
GO:0071845 cellular component disassembly at cellular level 1.895887e-4
GO:0009214 cyclic nucleotide catabolic process 1.941298e-4
GO:0042439 ethanolamine-containing compound metabolic process 2.031916e-4
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation 2.097625e-4
GO:0022604 regulation of cell morphogenesis 2.181007e-4
GO:0030449 regulation of complement activation 2.209837e-4
GO:0055123 digestive system development 2.226411e-4
GO:0001885 endothelial cell development 2.247290e-4
GO:0032368 regulation of lipid transport 2.271532e-4
GO:0046503 glycerolipid catabolic process 2.285392e-4
GO:0051901 positive regulation of mitochondrial depolarization 2.347344e-4
GO:0060555 induction of necroptosis by extracellular signals 2.381400e-4
GO:0008306 associative learning 2.386180e-4
GO:0022411 cellular component disassembly 2.417154e-4
GO:0034623 cellular macromolecular complex disassembly 2.425381e-4
GO:0006198 cAMP catabolic process 2.425381e-4
GO:0045214 sarcomere organization 2.427467e-4
GO:0045213 neurotransmitter receptor metabolic process 2.435194e-4
GO:0035414 negative regulation of catenin import into nucleus 2.456726e-4
GO:0071503 response to heparin 2.459874e-4
GO:0045834 positive regulation of lipid metabolic process 2.522705e-4
GO:0001963 synaptic transmission, dopaminergic 2.721690e-4
GO:0003084 positive regulation of systemic arterial blood pressure 2.721690e-4
GO:0014874 response to stimulus involved in regulation of muscle adaptation 2.738110e-4
GO:0010769 regulation of cell morphogenesis involved in differentiation 2.824109e-4
GO:0010543 regulation of platelet activation 2.942934e-4
GO:0007440 foregut morphogenesis 3.120420e-4
GO:0010863 positive regulation of phospholipase C activity 3.134357e-4
GO:0060688 regulation of morphogenesis of a branching structure 3.235937e-4
GO:0002861 regulation of inflammatory response to antigenic stimulus 3.273559e-4
GO:0001568 blood vessel development 3.307383e-4
GO:0046470 phosphatidylcholine metabolic process 3.384336e-4
GO:0072358 cardiovascular system development 3.400621e-4
GO:0043462 regulation of ATPase activity 3.438729e-4
GO:0045916 negative regulation of complement activation 3.484199e-4
GO:0035412 regulation of catenin import into nucleus 3.623720e-4
GO:0048706 embryonic skeletal system development 3.632102e-4
GO:0002678 positive regulation of chronic inflammatory response 3.685551e-4
GO:0043438 acetoacetic acid metabolic process 3.691525e-4
GO:0042632 cholesterol homeostasis 3.756535e-4
GO:0032984 macromolecular complex disassembly 3.779154e-4
GO:0008291 acetylcholine metabolic process 3.923673e-4
GO:0015760 glucose-6-phosphate transport 3.923673e-4
GO:0072240 metanephric DCT cell differentiation 3.972187e-4
GO:2000117 negative regulation of cysteine-type endopeptidase activity 3.972187e-4
GO:0072227 metanephric macula densa development 3.972187e-4
GO:0002036 regulation of L-glutamate transport 3.972187e-4
GO:0032423 regulation of mismatch repair 4.038076e-4
GO:0014029 neural crest formation 4.038076e-4
GO:0010876 lipid localization 4.094606e-4
GO:0008624 induction of apoptosis by extracellular signals 4.170969e-4
GO:0090244 Wnt receptor signaling pathway involved in somitogenesis 4.176197e-4
GO:0071316 cellular response to nicotine 4.176197e-4
GO:0007186 G-protein coupled receptor protein signaling pathway 4.347998e-4
GO:0046640 regulation of alpha-beta T cell proliferation 4.570050e-4
GO:0044341 sodium-dependent phosphate transport 4.723149e-4
GO:0000185 activation of MAPKKK activity 4.977351e-4
GO:0001818 negative regulation of cytokine production 5.039710e-4
GO:0072520 seminiferous tubule development 5.055784e-4
GO:0060557 positive regulation of vitamin D biosynthetic process 5.055784e-4
GO:0002019 regulation of renal output by angiotensin 5.055784e-4
GO:0032103 positive regulation of response to external stimulus 5.221463e-4
GO:0002920 regulation of humoral immune response 5.451067e-4
GO:0043137 DNA replication, removal of RNA primer 5.492555e-4
GO:0032971 regulation of muscle filament sliding 5.492555e-4
GO:0051048 negative regulation of secretion 5.690079e-4
GO:0009950 dorsal/ventral axis specification 5.818367e-4
GO:0060312 regulation of blood vessel remodeling 5.857623e-4
GO:0001869 negative regulation of complement activation, lectin pathway 5.898902e-4
GO:0072530 purine-containing compound transmembrane transport 6.154679e-4
GO:0042058 regulation of epidermal growth factor receptor signaling pathway 6.331164e-4
GO:0031448 positive regulation of fast-twitch skeletal muscle fiber contraction 6.416753e-4
GO:0010518 positive regulation of phospholipase activity 6.891665e-4
GO:0009991 response to extracellular stimulus 6.895086e-4
GO:0010155 regulation of proton transport 6.942462e-4
GO:0034379 very-low-density lipoprotein particle assembly 6.958654e-4
GO:0002697 regulation of immune effector process 6.963351e-4
GO:0050727 regulation of inflammatory response 7.005999e-4
GO:0070602 regulation of centromeric sister chromatid cohesion 7.078614e-4
GO:0051259 protein oligomerization 7.195382e-4
GO:0007612 learning 7.200376e-4
GO:0044242 cellular lipid catabolic process 7.434434e-4
GO:0034097 response to cytokine stimulus 7.479658e-4
GO:0043624 cellular protein complex disassembly 7.584313e-4
GO:0001555 oocyte growth 7.749875e-4
GO:0006887 exocytosis 7.884808e-4
GO:0001990 regulation of systemic arterial blood pressure by hormone 8.036381e-4
GO:0010940 positive regulation of necrotic cell death 8.166790e-4
GO:0001955 blood vessel maturation 8.166790e-4
GO:0046488 phosphatidylinositol metabolic process 8.221992e-4
GO:0019953 sexual reproduction 8.469362e-4
GO:0072017 distal tubule development 8.585591e-4
GO:0051241 negative regulation of multicellular organismal process 9.030443e-4
GO:0034508 centromere complex assembly 9.540064e-4
GO:0006810 transport 9.571364e-4
GO:0071345 cellular response to cytokine stimulus 9.620014e-4
GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis 9.754347e-4
GO:0042447 hormone catabolic process 9.760630e-4
GO:0071803 positive regulation of podosome assembly 9.769715e-4
GO:0060684 epithelial-mesenchymal cell signaling 9.836231e-4
GO:0009187 cyclic nucleotide metabolic process 1.010139e-3
GO:0009125 nucleoside monophosphate catabolic process 1.026117e-3
GO:0043114 regulation of vascular permeability 1.029332e-3
GO:0050850 positive regulation of calcium-mediated signaling 1.069140e-3
GO:0046851 negative regulation of bone remodeling 1.093014e-3
GO:0006273 lagging strand elongation 1.096588e-3
GO:0006656 phosphatidylcholine biosynthetic process 1.105474e-3
GO:0007200 activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger 1.126509e-3
GO:0032729 positive regulation of interferon-gamma production 1.138397e-3
GO:0033159 negative regulation of protein import into nucleus, translocation 1.193956e-3
GO:0072218 metanephric ascending thin limb development 1.193956e-3
GO:0072233 metanephric thick ascending limb development 1.193956e-3
GO:0060559 positive regulation of calcidiol 1-monooxygenase activity 1.193956e-3
GO:0045668 negative regulation of osteoblast differentiation 1.219380e-3
GO:0010517 regulation of phospholipase activity 1.256899e-3
GO:0014827 intestine smooth muscle contraction 1.261762e-3
GO:0051272 positive regulation of cellular component movement 1.273238e-3
GO:0015793 glycerol transport 1.276506e-3
GO:0034762 regulation of transmembrane transport 1.286382e-3
GO:0043241 protein complex disassembly 1.310429e-3
GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway 1.358460e-3
GO:0060248 detection of cell density by contact stimulus involved in contact inhibition 1.358460e-3
GO:0072285 mesenchymal to epithelial transition involved in metanephric renal vesicle formation 1.358460e-3
GO:0032620 interleukin-17 production 1.358460e-3
GO:0002365 gamma-delta T cell lineage commitment 1.358460e-3
GO:0007371 ventral midline determination 1.358460e-3
GO:0046903 secretion 1.424323e-3
GO:0033147 negative regulation of estrogen receptor signaling pathway 1.446922e-3
GO:0071773 cellular response to BMP stimulus 1.481738e-3
GO:0071481 cellular response to X-ray 1.481738e-3
GO:0032411 positive regulation of transporter activity 1.518946e-3
GO:0071392 cellular response to estradiol stimulus 1.519146e-3
GO:0071374 cellular response to parathyroid hormone stimulus 1.519146e-3
GO:0009566 fertilization 1.540595e-3
GO:0042157 lipoprotein metabolic process 1.597817e-3
GO:0022616 DNA strand elongation 1.605091e-3
GO:0071107 response to parathyroid hormone stimulus 1.625478e-3
GO:0031347 regulation of defense response 1.627569e-3
GO:0009895 negative regulation of catabolic process 1.673085e-3
GO:0045060 negative thymic T cell selection 1.682280e-3
GO:0030335 positive regulation of cell migration 1.699751e-3
GO:2000147 positive regulation of cell motility 1.706051e-3
GO:0051583 dopamine uptake 1.739786e-3
GO:0015747 urate transport 1.739786e-3
GO:0042993 positive regulation of transcription factor import into nucleus 1.755262e-3
GO:0006323 DNA packaging 1.760284e-3
GO:0040017 positive regulation of locomotion 1.790728e-3
GO:0002863 positive regulation of inflammatory response to antigenic stimulus 1.857432e-3
GO:0008065 establishment of blood-nerve barrier 1.899985e-3
GO:0014873 response to muscle activity involved in regulation of muscle adaptation 1.899985e-3
GO:0061049 cell growth involved in cardiac muscle cell development 1.899985e-3
GO:0003331 positive regulation of extracellular matrix constituent secretion 1.899985e-3
GO:0001834 trophectodermal cell proliferation 1.899985e-3
GO:0002017 regulation of blood volume by renal aldosterone 1.899985e-3
GO:0015908 fatty acid transport 1.916421e-3
GO:0050927 positive regulation of positive chemotaxis 1.935992e-3
GO:0007588 excretion 2.057824e-3
GO:0007614 short-term memory 2.061913e-3
GO:0070172 positive regulation of tooth mineralization 2.076641e-3
GO:0006583 melanin biosynthetic process from tyrosine 2.076641e-3
GO:0032101 regulation of response to external stimulus 2.142453e-3
GO:0032722 positive regulation of chemokine production 2.182600e-3
GO:0010900 negative regulation of phosphatidylcholine catabolic process 2.246870e-3
GO:0051055 negative regulation of lipid biosynthetic process 2.352094e-3
GO:0046463 acylglycerol biosynthetic process 2.357531e-3
GO:0046504 glycerol ether biosynthetic process 2.397471e-3
GO:0045833 negative regulation of lipid metabolic process 2.409909e-3
GO:0042476 odontogenesis 2.458428e-3
GO:0051897 positive regulation of protein kinase B signaling cascade 2.475063e-3
GO:0051900 regulation of mitochondrial depolarization 2.504912e-3
GO:0003300 cardiac muscle hypertrophy 2.504912e-3
GO:0006631 fatty acid metabolic process 2.506806e-3
GO:0006309 DNA fragmentation involved in apoptotic nuclear change 2.568481e-3
GO:0043383 negative T cell selection 2.572833e-3
GO:0016082 synaptic vesicle priming 2.595678e-3
GO:0032474 otolith morphogenesis 2.609940e-3
GO:0003106 negative regulation of glomerular filtration by angiotensin 2.609940e-3
GO:0014895 smooth muscle hypertrophy 2.609940e-3
GO:0071347 cellular response to interleukin-1 2.619680e-3
GO:0051896 regulation of protein kinase B signaling cascade 2.638510e-3
GO:0003254 regulation of membrane depolarization 2.708944e-3
GO:0030239 myofibril assembly 2.718128e-3
GO:0045299 otolith mineralization 2.731218e-3
GO:0008039 synaptic target recognition 2.731218e-3
GO:0050901 leukocyte tethering or rolling 2.753808e-3
GO:0050926 regulation of positive chemotaxis 2.773228e-3
GO:0071312 cellular response to alkaloid 2.802711e-3
GO:0060071 Wnt receptor signaling pathway, planar cell polarity pathway 2.802711e-3
GO:0045948 positive regulation of translational initiation 2.859988e-3
GO:0045017 glycerolipid biosynthetic process 2.862890e-3
GO:0009612 response to mechanical stimulus 2.869256e-3
GO:0003230 cardiac atrium development 2.872821e-3
GO:0043206 fibril organization 2.884942e-3
GO:0016554 cytidine to uridine editing 2.899463e-3
GO:0010572 positive regulation of platelet activation 2.899463e-3
GO:0006461 protein complex assembly 2.906035e-3
GO:0051567 histone H3-K9 methylation 2.935997e-3
GO:0014896 muscle hypertrophy 2.961729e-3
GO:0006106 fumarate metabolic process 2.980818e-3
GO:0090200 positive regulation of release of cytochrome c from mitochondria 3.039047e-3
GO:0002016 regulation of blood volume by renin-angiotensin 3.039047e-3
GO:0071822 protein complex subunit organization 3.052849e-3
GO:0032770 positive regulation of monooxygenase activity 3.114117e-3
GO:0006869 lipid transport 3.122644e-3
GO:0050848 regulation of calcium-mediated signaling 3.158541e-3
GO:0042542 response to hydrogen peroxide 3.180985e-3
GO:0014910 regulation of smooth muscle cell migration 3.244308e-3
GO:0019605 butyrate metabolic process 3.261749e-3
GO:0070271 protein complex biogenesis 3.287336e-3
GO:0019432 triglyceride biosynthetic process 3.291449e-3
GO:0034763 negative regulation of transmembrane transport 3.364592e-3
GO:0097012 response to granulocyte macrophage colony-stimulating factor stimulus 3.394341e-3
GO:0019217 regulation of fatty acid metabolic process 3.400743e-3
GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin 3.553254e-3
GO:0071310 cellular response to organic substance 3.555815e-3
GO:0045061 thymic T cell selection 3.588500e-3
GO:0006897 endocytosis 3.594825e-3
GO:0010544 negative regulation of platelet activation 3.641944e-3
GO:0048266 behavioral response to pain 3.671669e-3
GO:0055088 lipid homeostasis 3.720381e-3
GO:0048255 mRNA stabilization 3.751787e-3
GO:0010999 regulation of eIF2 alpha phosphorylation by heme 3.781025e-3
GO:0009589 detection of UV 3.781025e-3
GO:0048016 inositol phosphate-mediated signaling 3.808930e-3
GO:0042761 very long-chain fatty acid biosynthetic process 3.847658e-3
GO:0030262 apoptotic nuclear change 3.867974e-3
GO:0030155 regulation of cell adhesion 3.875062e-3
GO:0035815 positive regulation of renal sodium excretion 3.900123e-3
GO:0002691 regulation of cellular extravasation 3.900123e-3
GO:0048840 otolith development 3.950995e-3
GO:0030730 sequestering of triglyceride 3.950995e-3
GO:0051532 regulation of NFAT protein import into nucleus 3.957689e-3
GO:0007265 Ras protein signal transduction 3.962102e-3
GO:0051234 establishment of localization 3.963148e-3
GO:0001501 skeletal system development 3.971738e-3
GO:0042088 T-helper 1 type immune response 3.983433e-3
GO:0050708 regulation of protein secretion 4.054590e-3
GO:0060683 regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling 4.096705e-3
GO:0030970 retrograde protein transport, ER to cytosol 4.096705e-3
GO:0034389 lipid particle organization 4.096705e-3
GO:0070848 response to growth factor stimulus 4.158525e-3
GO:0034694 response to prostaglandin stimulus 4.202729e-3
GO:0003270 Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation 4.292508e-3
GO:0014807 regulation of somitogenesis 4.292508e-3
GO:0014821 phasic smooth muscle contraction 4.332166e-3
GO:0033622 integrin activation 4.388057e-3
GO:0051336 regulation of hydrolase activity 4.478687e-3
GO:0045933 positive regulation of muscle contraction 4.509557e-3
GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal 4.522376e-3