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CL:0000792

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Name:CD4-positive, CD25-positive, alpha-beta regulatory T cell
Namespace:FANTOM
Definition:"A CD4-positive, CD25-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [GOC:add, GOC:tfm, ISBN:0781735149, PMID:19464985]
Xrefs:
links:
FMA:84070
Synonyms: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte" EXACT []
"CD4-positive, CD25-positive, alpha-beta regulatory T-cell" EXACT []
"CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte" EXACT []
"suppressor T cell" BROAD []
"suppressor T lymphocyte" BROAD []
"suppressor T-cell" BROAD []
"suppressor T-lymphocyte" BROAD []


Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data


Parents

is_a:CL:0000624(CD4-positive, alpha-beta T cell),CL:0000815(regulatory T cell)



Children


is a:CL:0002677 (naive regulatory T cell),CL:0002678 (memory regulatory T cell)
derives from:FF:0011454 (CD4-positiveCD25-positive regulatory T cells (C57BL_6J) sample),FF:0011455 (CD4-positiveCD25-positive regulatory T cells (Balb_cAJcl) sample)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)


FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.


Human (Homo sapiens)

  • 11780-124A7 (CD4+CD25+CD45RA+ naive regulatory T cells, donor1)
  • 11782-124A9 (CD4+CD25+CD45RA- memory regulatory T cells, donor1)
  • 11814-124E5 (CD4+CD25+ regulatory T cells, pool1 (C57BL_6J))
  • 11818-124E9 (CD4+CD25+ regulatory T cells, pool2 (Balb_cAJcl))
  • 11945-126B1 (CD4+CD25+ regulatory T cells, PMA and ionomycin stimulation, 02hr, pool1 (C57BL 6J))

Mouse (Mus musculus)

  • 11780-124A7 (CD4+CD25+CD45RA+ naive regulatory T cells, donor1)
  • 11782-124A9 (CD4+CD25+CD45RA- memory regulatory T cells, donor1)
  • 11814-124E5 (CD4+CD25+ regulatory T cells, pool1 (C57BL_6J))
  • 11818-124E9 (CD4+CD25+ regulatory T cells, pool2 (Balb_cAJcl))
  • 11945-126B1 (CD4+CD25+ regulatory T cells, PMA and ionomycin stimulation, 02hr, pool1 (C57BL 6J))


Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000792 (CD4-positive, CD25-positive, alpha-beta regulatory T cell), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data


P-valueFFCPShort description
4.61e-131FFCP PHASE1:Hg19::chr1:113160702..113160706,-#_7eb629238f20182fa932493119f8e655p21@ST7L
4.61e-131FFCP PHASE2:Hg19::chr1:113160702..113160706,-#_7eb629238f20182fa932493119f8e655p21@ST7L
5.68e-99FFCP PHASE1:Hg19::chr11:111410267..111410269,+#_4b57093f8beed8fd80c81e4dee882aeap@chr11:111410267..111410269, +
5.68e-99FFCP PHASE2:Hg19::chr11:111410267..111410269,+#_4b57093f8beed8fd80c81e4dee882aeap@chr11:111410267..111410269, +
1.55e-98FFCP PHASE1:Hg19::chr3:73015629..73015632,+#_eb9aa43f6eeb17bec4109741d89cab77p@chr3:73015629..73015632, +
1.55e-98FFCP PHASE2:Hg19::chr3:73015629..73015632,+#_eb9aa43f6eeb17bec4109741d89cab77p@chr3:73015629..73015632, +
3.07e-86FFCP PHASE1:Mm9::chr7:108729732..108729745,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr7:108729732..108729745, +
3.07e-86FFCP PHASE2:Mm9::chr9:14708334..14708341,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp11@Folr4
3.07e-86FFCP PHASE1:Mm9::chr1:60967911..60967916,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr1:60967911..60967916, +
3.07e-86FFCP PHASE1:Mm9::chr10:13765981..13765988,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr10:13765981..13765988, +
3.07e-86FFCP PHASE1:Mm9::chr5:150229693..150229735,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr5:150229693..150229735, +
3.07e-86FFCP PHASE1:Mm9::chr12:17040514..17040521,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr12:17040514..17040521, +
3.07e-86FFCP PHASE1:Mm9::chr10:89010973..89010996,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr10:89010973..89010996, -
3.07e-86FFCP PHASE1:Mm9::chr4:102823636..102823677,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr4:102823636..102823677, +
3.07e-86FFCP PHASE1:Mm9::chr9:32530971..32530976,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr9:32530971..32530976, +
3.07e-86FFCP PHASE2:Mm9::chr2:78812885..78812894,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr2:78812885..78812894, +
3.07e-86FFCP PHASE2:Mm9::chr2:32306609..32306610,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr2:32306609..32306610, +
3.07e-86FFCP PHASE2:Mm9::chr9:14706346..14706355,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr9:14706346..14706355, -
3.07e-86FFCP PHASE2:Mm9::chr8:74526522..74526532,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr8:74526522..74526532, -
3.07e-86FFCP PHASE1:Mm9::chr17:26709187..26709203,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr17:26709187..26709203, -
3.07e-86FFCP PHASE2:Mm9::chr15:59354543..59354548,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr15:59354543..59354548, +
3.07e-86FFCP PHASE2:Mm9::chr8:84303823..84303825,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr8:84303823..84303825, +
3.07e-86FFCP PHASE2:Mm9::chr9:123843234..123843237,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr9:123843234..123843237, +
3.07e-86FFCP PHASE1:Mm9::chr4:151490543..151490552,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp6@Tnfrsf25
3.07e-86FFCP PHASE1:Mm9::chr6:106741792..106741797,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr6:106741792..106741797, +
3.07e-86FFCP PHASE1:Mm9::chr8:84303823..84303825,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr8:84303823..84303825, +
3.07e-86FFCP PHASE2:Mm9::chr17:35164593..35164602,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp6@Ng23
3.07e-86FFCP PHASE2:Mm9::chr5:124484631..124484634,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr5:124484631..124484634, -
3.07e-86FFCP PHASE1:Mm9::chr7:80757542..80757576,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr7:80757542..80757576, -
3.07e-86FFCP PHASE1:Mm9::chr1:69727854..69727859,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr1:69727854..69727859, +
3.07e-86FFCP PHASE1:Mm9::chrX:7154622..7154647,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chrX:7154622..7154647, +
3.07e-86FFCP PHASE2:Mm9::chr7:105641398..105641405,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr7:105641398..105641405, -
3.07e-86FFCP PHASE2:Mm9::chr10:18908457..18908466,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr10:18908457..18908466, -
3.07e-86FFCP PHASE1:Mm9::chr17:87518592..87518603,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr17:87518592..87518603, +
3.07e-86FFCP PHASE2:Mm9::chr6:48670473..48670480,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr6:48670473..48670480, +
3.07e-86FFCP PHASE2:Mm9::chrX:148215171..148215179,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chrX:148215171..148215179, +
3.07e-86FFCP PHASE2:Mm9::chr4:155400229..155400241,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp3@Tnfrsf18
3.07e-86FFCP PHASE2:Mm9::chrX:7161574..7161577,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chrX:7161574..7161577, +
3.07e-86FFCP PHASE2:Mm9::chr9:32530971..32530976,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr9:32530971..32530976, +
3.07e-86FFCP PHASE2:Mm9::chr10:22022863..22022865,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr10:22022863..22022865, +
3.07e-86FFCP PHASE2:Mm9::chr1:60944205..60944230,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr1:60944205..60944230, +
3.07e-86FFCP PHASE1:Mm9::chr15:59357447..59357449,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr15:59357447..59357449, +
3.07e-86FFCP PHASE1:Mm9::chr10:22023694..22023695,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr10:22023694..22023695, -
3.07e-86FFCP PHASE2:Mm9::chr16:89826368..89826391,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr16:89826368..89826391, +
3.07e-86FFCP PHASE1:Mm9::chr4:155396655..155396659,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr4:155396655..155396659, +
3.07e-86FFCP PHASE2:Mm9::chr10:58784974..58784979,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr10:58784974..58784979, -
3.07e-86FFCP PHASE2:Mm9::chr10:89010973..89010996,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr10:89010973..89010996, -
3.07e-86FFCP PHASE1:Mm9::chr9:14708334..14708341,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp11@Folr4
3.07e-86FFCP PHASE1:Mm9::chrX:7161176..7161185,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chrX:7161176..7161185, -
3.07e-86FFCP PHASE2:Mm9::chr7:106142059..106142061,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr7:106142059..106142061, -
3.07e-86FFCP PHASE1:Mm9::chr6:48670473..48670480,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr6:48670473..48670480, +
3.07e-86FFCP PHASE2:Mm9::chr17:12884884..12884887,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr17:12884884..12884887, -
3.07e-86FFCP PHASE2:Mm9::chr1:69727854..69727859,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr1:69727854..69727859, +
3.07e-86FFCP PHASE1:Mm9::chr10:18781172..18781174,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr10:18781172..18781174, +
3.07e-86FFCP PHASE2:Mm9::chr3:142250588..142250598,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr3:142250588..142250598, +
3.07e-86FFCP PHASE2:Mm9::chr1:60970179..60970192,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr1:60970179..60970192, -
3.07e-86FFCP PHASE1:Mm9::chr8:74526430..74526446,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr8:74526430..74526446, -
3.07e-86FFCP PHASE1:Mm9::chr17:12884884..12884887,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr17:12884884..12884887, -
3.07e-86FFCP PHASE2:Mm9::chrX:7157611..7157617,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp4@Foxp3
3.07e-86FFCP PHASE2:Mm9::chr17:29566022..29566044,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr17:29566022..29566044, +
3.07e-86FFCP PHASE1:Mm9::chr1:60967956..60967966,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr1:60967956..60967966, +
3.07e-86FFCP PHASE1:Mm9::chr3:101090598..101090601,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr3:101090598..101090601, +
3.07e-86FFCP PHASE1:Mm9::chr11:118084068..118084106,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr11:118084068..118084106, -
3.07e-86FFCP PHASE1:Mm9::chr1:162743278..162743283,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr1:162743278..162743283, -
3.07e-86FFCP PHASE1:Mm9::chr10:92842861..92842879,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr10:92842861..92842879, -
3.07e-86FFCP PHASE1:Mm9::chr4:102843557..102843585,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr4:102843557..102843585, +
3.07e-86FFCP PHASE1:Mm9::chr17:26688385..26688421,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr17:26688385..26688421, +
3.07e-86FFCP PHASE1:Mm9::chr2:32306609..32306610,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr2:32306609..32306610, +
3.07e-86FFCP PHASE1:Mm9::chr15:59354543..59354548,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr15:59354543..59354548, +
3.07e-86FFCP PHASE1:Mm9::chr12:114668438..114668451,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr12:114668438..114668451, +
3.07e-86FFCP PHASE2:Mm9::chr15:59356135..59356143,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr15:59356135..59356143, -
3.07e-86FFCP PHASE2:Mm9::chr4:151490501..151490511,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp5@Tnfrsf25
3.07e-86FFCP PHASE2:Mm9::chr1:162743278..162743283,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr1:162743278..162743283, -
3.07e-86FFCP PHASE2:Mm9::chr17:35164610..35164618,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp5@Ng23
3.07e-86FFCP PHASE1:Mm9::chr15:5504747..5504756,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr15:5504747..5504756, +
3.07e-86FFCP PHASE2:Mm9::chr12:109240261..109240265,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr12:109240261..109240265, +
3.07e-86FFCP PHASE1:Mm9::chr1:69728149..69728150,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr1:69728149..69728150, +
3.07e-86FFCP PHASE1:Mm9::chr7:105641398..105641405,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr7:105641398..105641405, -
3.07e-86FFCP PHASE1:Mm9::chr13:113079356..113079360,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr13:113079356..113079360, -
3.07e-86FFCP PHASE2:Mm9::chr13:105413537..105413540,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr13:105413537..105413540, +
3.07e-86FFCP PHASE2:Mm9::chr17:12807573..12807582,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr17:12807573..12807582, +
3.07e-86FFCP PHASE1:Mm9::chr12:109240261..109240265,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr12:109240261..109240265, +
3.07e-86FFCP PHASE2:Mm9::chrX:7170204..7170205,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chrX:7170204..7170205, +
3.07e-86FFCP PHASE2:Mm9::chr2:139885951..139885958,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr2:139885951..139885958, -
3.07e-86FFCP PHASE1:Mm9::chr17:12807573..12807582,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr17:12807573..12807582, +
3.07e-86FFCP PHASE2:Mm9::chr15:12160236..12160239,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr15:12160236..12160239, +
3.07e-86FFCP PHASE2:Mm9::chr8:93597971..93597979,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr8:93597971..93597979, +
3.07e-86FFCP PHASE2:Mm9::chr13:113079356..113079360,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr13:113079356..113079360, -
3.07e-86FFCP PHASE1:Mm9::chr12:15821719..15821726,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr12:15821719..15821726, +
3.07e-86FFCP PHASE2:Mm9::chrX:7148320..7148329,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chrX:7148320..7148329, +
3.07e-86FFCP PHASE2:Mm9::chr9:14662914..14662922,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr9:14662914..14662922, +
3.07e-86FFCP PHASE1:Mm9::chr4:155400229..155400241,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp3@Tnfrsf18
3.07e-86FFCP PHASE2:Mm9::chr8:74526430..74526446,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr8:74526430..74526446, -
3.07e-86FFCP PHASE1:Mm9::chr16:89837454..89837462,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr16:89837454..89837462, -
3.07e-86FFCP PHASE1:Mm9::chrX:7161574..7161577,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chrX:7161574..7161577, +
3.07e-86FFCP PHASE2:Mm9::chr16:36770181..36770184,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr16:36770181..36770184, -
3.07e-86FFCP PHASE1:Mm9::chr7:106142059..106142061,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr7:106142059..106142061, -
3.07e-86FFCP PHASE1:Mm9::chr16:36770181..36770184,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr16:36770181..36770184, -
3.07e-86FFCP PHASE2:Mm9::chr1:69728149..69728150,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr1:69728149..69728150, +
3.07e-86FFCP PHASE1:Mm9::chr9:14706346..14706355,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr9:14706346..14706355, -