CL:0000815
From FANTOM5_SSTAR
| Name: | regulatory T cell | |
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| Namespace: | FANTOM | |
| Definition: | "A T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [GO_REF:0000031, GOC:add] | |
| Xrefs: |
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| Synonyms: |
"regulatory T lymphocyte" EXACT [] "regulatory T-cell" EXACT [] "regulatory T-lymphocyte" EXACT [] "suppressor T cell" BROAD [] "suppressor T lymphocyte" BROAD [] "suppressor T-cell" BROAD [] "suppressor T-lymphocyte" BROAD [] | |
| Comments: | This cell type may express FoxP3 and CD25 and secretes IL-10 and TGF-beta. |
Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data
Parents
| is_a: | CL:0002419(mature T cell) |
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Children
| is a: | CL:0000792 (CD4-positive, CD25-positive, alpha-beta regulatory T cell),FF:11943-126A8 (CD4+CD25+ regulatory T cells, antiCD3 CD28 stimulation, 06hr, pool1 (BalbcA)),FF:11944-126A9 (CD4+CD25+ regulatory T cells, antiCD3 CD28 stimulation, 06hr, pool1 (C57BL 6J)),FF:11946-126B2 (CD4+CD25+ regulatory T cells, PMA and ionomycin stimulation, 02hr, pool1 (BalbcA)) |
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Ontology Tree: Loaded from BioPortal
Ontorolgy tree(Small window open)
FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.
Human (Homo sapiens)
- 11780-124A7 (CD4+CD25+CD45RA+ naive regulatory T cells, donor1)
- 11782-124A9 (CD4+CD25+CD45RA- memory regulatory T cells, donor1)
- 11814-124E5 (CD4+CD25+ regulatory T cells, pool1 (C57BL_6J))
- 11818-124E9 (CD4+CD25+ regulatory T cells, pool2 (Balb_cAJcl))
- 11943-126A8 (CD4+CD25+ regulatory T cells, antiCD3 CD28 stimulation, 06hr, pool1 (BalbcA))
- 11944-126A9 (CD4+CD25+ regulatory T cells, antiCD3 CD28 stimulation, 06hr, pool1 (C57BL 6J))
- 11945-126B1 (CD4+CD25+ regulatory T cells, PMA and ionomycin stimulation, 02hr, pool1 (C57BL 6J))
- 11946-126B2 (CD4+CD25+ regulatory T cells, PMA and ionomycin stimulation, 02hr, pool1 (BalbcA))
Mouse (Mus musculus)
- 11780-124A7 (CD4+CD25+CD45RA+ naive regulatory T cells, donor1)
- 11782-124A9 (CD4+CD25+CD45RA- memory regulatory T cells, donor1)
- 11814-124E5 (CD4+CD25+ regulatory T cells, pool1 (C57BL_6J))
- 11818-124E9 (CD4+CD25+ regulatory T cells, pool2 (Balb_cAJcl))
- 11943-126A8 (CD4+CD25+ regulatory T cells, antiCD3 CD28 stimulation, 06hr, pool1 (BalbcA))
- 11944-126A9 (CD4+CD25+ regulatory T cells, antiCD3 CD28 stimulation, 06hr, pool1 (C57BL 6J))
- 11945-126B1 (CD4+CD25+ regulatory T cells, PMA and ionomycin stimulation, 02hr, pool1 (C57BL 6J))
- 11946-126B2 (CD4+CD25+ regulatory T cells, PMA and ionomycin stimulation, 02hr, pool1 (BalbcA))
Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000815 (regulatory T cell), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data
