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{{Coexpression_clusters
{
|full_id=C241_Reticulocytes_chronic_Tracheal_Hodgkin_Endothelial_Hair_thymus
|gostat_on_coexpression_clusters=

Latest revision as of 11:04, 17 September 2013


Full id: C241_Reticulocytes_chronic_Tracheal_Hodgkin_Endothelial_Hair_thymus



Phase1 CAGE Peaks


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


p.valueFDRnGenesnPathwayName
5.99867518672387e-433.79716139319621e-4020138Systemic lupus erythematosus (KEGG):05322
5.63622937924873e-218.91933299266112e-1912168Transcription (Reactome):REACT_1788
7.84918119551512e-060.0008280886161268464147Apoptosis (Reactome):REACT_578
3.04922576076662e-256.43386635521756e-231277Chromosome Maintenance (Reactome):REACT_22172
1.73801363727582e-072.20032526479119e-056295IL-2 down reg. targets (Netpath):NetPath_14
6.65759954444847e-050.00602037215947983214{HIST3H3,14} (Static Module):NA
3.75950083391575e-261.18988201393433e-231023{NAP1L1,23} (Static Module):NA



Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0000786nucleosome1.87240583009347e-47
GO:0006334nucleosome assembly1.24319715022904e-43
GO:0031497chromatin assembly8.59066900014577e-43
GO:0006333chromatin assembly or disassembly1.68503280504556e-40
GO:0065004protein-DNA complex assembly2.63900901022237e-40
GO:0000785chromatin3.40333775091688e-39
GO:0006325establishment and/or maintenance of chromatin architecture2.79277149428791e-36
GO:0006323DNA packaging3.20258264069125e-36
GO:0044427chromosomal part4.05997084508814e-36
GO:0005694chromosome6.27988319008739e-35
GO:0051276chromosome organization and biogenesis6.27988319008739e-35
GO:0065003macromolecular complex assembly6.17057389922228e-32
GO:0022607cellular component assembly2.47748302547154e-31
GO:0006259DNA metabolic process1.3234334413781e-27
GO:0006996organelle organization and biogenesis6.92115581620494e-26
GO:0043234protein complex2.21798198387936e-20
GO:0043232intracellular non-membrane-bound organelle2.54356941516884e-20
GO:0043228non-membrane-bound organelle2.54356941516884e-20
GO:0016043cellular component organization and biogenesis2.41082496854606e-19
GO:0003677DNA binding8.81390916446168e-19
GO:0032991macromolecular complex6.43074720407152e-18
GO:0044446intracellular organelle part1.9981622722602e-17
GO:0044422organelle part2.0058261240859e-17
GO:0006139nucleobase, nucleoside, nucleotide and nucleic acid metabolic process1.93426613118056e-14
GO:0005634nucleus3.73806364802859e-14
GO:0003676nucleic acid binding9.93882761845355e-14
GO:0043231intracellular membrane-bound organelle5.09762757670053e-12
GO:0043227membrane-bound organelle5.09762757670053e-12
GO:0043283biopolymer metabolic process6.80345903204537e-12
GO:0043229intracellular organelle2.82945618182235e-09
GO:0043226organelle2.82945618182235e-09
GO:0016584nucleosome positioning3.30511061749485e-09
GO:0043170macromolecule metabolic process7.1455221981178e-09
GO:0044237cellular metabolic process2.11542148816235e-07
GO:0044238primary metabolic process2.48135321557574e-07
GO:0044424intracellular part3.50192310313866e-07
GO:0005622intracellular8.50752770264734e-06
GO:0042742defense response to bacterium3.71707117147414e-05
GO:0009617response to bacterium5.02592023955664e-05
GO:0051707response to other organism0.000350500324494739
GO:0009607response to biotic stimulus0.000917422283520578
GO:0051704multi-organism process0.00134820086403117
GO:0006952defense response0.00645472099872346
GO:0044464cell part0.00693752947648842



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br><br>disease_data<br>


Cell Type
Ontology termp-valuen
animal cell2.48e-12679
eukaryotic cell2.48e-12679
native cell8.73e-11722
embryonic cell5.20e-09250
epithelial cell1.27e-08253
nucleate cell2.38e-0755
Disease
Ontology termp-valuen
hematologic cancer1.95e-1951
immune system cancer1.95e-1951
cancer3.93e-18235
disease of cellular proliferation6.75e-17239
leukemia1.99e-1539
myeloid leukemia2.29e-1131
organ system cancer5.56e-11137


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.18612e-14
MA0004.10.0206186
MA0006.10.0598297
MA0007.10.391259
MA0009.10.222068
MA0014.16.18871e-05
MA0017.10.195688
MA0019.10.216967
MA0024.118.6263
MA0025.10.846718
MA0027.11.68322
MA0028.10.0713574
MA0029.10.16898
MA0030.10.16233
MA0031.10.1271
MA0038.13.17742
MA0040.10.513246
MA0041.10.768057
MA0042.10.208928
MA0043.10.632748
MA0046.11.15685
MA0048.10.428062
MA0050.11.36088
MA0051.10.38291
MA0052.13.81539
MA0055.10.0343553
MA0056.10
MA0057.10.000257395
MA0058.10.00757512
MA0059.10.0392191
MA0060.128.4988
MA0061.10.00525774
MA0063.10
MA0066.10.173138
MA0067.10.460571
MA0068.13.28654e-05
MA0069.11.14721
MA0070.11.75542
MA0071.10.0346008
MA0072.10.202487
MA0073.10
MA0074.10.0438478
MA0076.10.267221
MA0077.11.71284
MA0078.10.271002
MA0081.10.23631
MA0083.11.20309
MA0084.10.621693
MA0087.11.10213
MA0088.10.00280933
MA0089.10
MA0090.10.0533577
MA0091.10.0211033
MA0092.10.0691705
MA0093.10.00322942
MA0095.10
MA0098.10
MA0100.10.0495807
MA0101.10.0202861
MA0103.10.00265215
MA0105.10.000141506
MA0106.10.465934
MA0107.10.0242585
MA0108.223.5279
MA0109.10
MA0111.10.0602233
MA0113.10.230055
MA0114.10.123782
MA0115.11.81921
MA0116.10.0256136
MA0117.10.247205
MA0119.10.208521
MA0122.10.26509
MA0124.10.365763
MA0125.11.48206
MA0130.10
MA0131.12.70969
MA0132.10
MA0133.10
MA0135.10.679566
MA0136.10.179341
MA0139.10.000790166
MA0140.10.319998
MA0141.10.110437
MA0142.12.36825
MA0143.10.0645373
MA0144.10.0479109
MA0145.10.0221854
MA0146.15.6135e-11
MA0147.10.00103874
MA0148.10.491992
MA0149.10.0315445
MA0062.20.0148604
MA0035.20.0337499
MA0039.21.08603e-06
MA0138.20.0793656
MA0002.20.296218
MA0137.20.169735
MA0104.20.000264838
MA0047.20.443145
MA0112.22.32238e-06
MA0065.20.000651135
MA0150.10.283418
MA0151.10
MA0152.10.941217
MA0153.10.29008
MA0154.10.000124938
MA0155.10.000949233
MA0156.10.0781444
MA0157.10.666202
MA0158.10
MA0159.10.00105235
MA0160.10.119641
MA0161.10
MA0162.12.99755e-05
MA0163.13.13131e-11
MA0164.11.86196
MA0080.20.0194497
MA0018.22.87777
MA0099.20.0356983
MA0079.20
MA0102.20.6549
MA0258.10.00366784
MA0259.10.42884
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCL11A#5333573.483968170618410.003807134786115380.018805020333291
BCL3#6023621.81922282341374.34006651449099e-412.54647307138721e-38
BCLAF1#97743914.81496941745181.02890897892466e-385.68562036242924e-36
BRCA1#672248.49862342872587.04514769369977e-171.43149451358426e-14
CCNT2#905343.779488659942626.28480958565441e-141.00826302352713e-11
CEBPB#1051334.6148749412675.86154552284297e-161.12531976628713e-13
CHD2#1106356.351592968317371.1886081975187e-213.23273571720456e-19
E2F1#1869423.61597100043747.53542935178761e-181.63956813764864e-15
E2F4#1874378.223126871324993.73016297821215e-271.30729695060905e-24
E2F6#1876322.816648831830111.79885789256083e-091.56038969635515e-07
EBF1#1879142.187553260560810.003558468571277490.0180374150221146
EGR1#1958312.712869332265161.04457479505872e-087.88823911938809e-07
ELF1#1997463.436359756230641.17115945785052e-192.8984531426173e-17
ELK4#2005102.848365203240.002340426273766080.0132677511591953
EP300#2033495.823213062893638.8922482414325e-334.00300652623693e-30
ETS1#2113386.485840614801562.37109841958564e-247.30487161779071e-22
FOS#2353467.261507793142856.41389165691216e-343.00385843388453e-31
FOSL1#806174.877106280958090.0005612791076017450.0047899516848193
FOSL2#2355133.861273822093022.20978727127627e-050.000484035177904409
FOXA1#3169203.888217455924725.62788235184651e-083.52591724621774e-06
FOXA2#3170125.185360790034792.55263336015647e-068.9822936489684e-05
GABPB1#2553161.983911252261660.00462492922581420.0218414191008279
GATA1#2623337.850704714831835.29863065004885e-231.5457644873197e-20
GATA2#2624204.471905871422455.35856617946625e-094.28517069844775e-07
GATA3#262583.822668962414880.001090731674018730.0076258485274362
GTF2B#29594525.21881310604548.3015813244955e-577.10662993400808e-54
GTF2F1#29625311.84564958716067.02103988624866e-545.6405414206148e-51
HEY1#23462543.827473619784362.23089890309063e-298.66144425798819e-27
HMGN3#9324233.300115748018667.92257646547208e-084.7389803177402e-06
IRF1#3659354.689486515346262.15404262613805e-174.51739071950265e-15
IRF3#36614537.09101490380762.49402641125534e-642.45729834306695e-61
JUN#3725183.951419744948322.56899895276952e-071.33285485160604e-05
JUNB#372694.833257788392819.16875838797133e-050.00133571761372763
JUND#3727496.01295672195931.92549118794376e-338.85887110914792e-31
KAT2A#264814151.3203508771934.68419733121762e-271.62529197699348e-24
MAFK#797583.803611668467360.001126105067359590.007721197947083
MEF2A#420592.959457512049060.003062619745409180.0161478666998581
MEF2C#420896.52284544620388.91861022492198e-060.000240312366687468
MXI1#4601264.543874778030565.75583371556123e-127.45823222604838e-10
MYC#4609302.748569406110211.63918086946744e-081.18967623923773e-06
NFKB1#4790555.295499795274752.22996736899318e-381.2067127567372e-35
NFYA#48003912.60697626830514.86097602747369e-362.47646573333329e-33
NFYB#4801349.99706966000423.05366060837617e-271.0810890178922e-24
NRF1#4899142.999016004700920.0001582844446524690.00199481949017246
PAX5#5079323.744317491187558.29467660754785e-131.17702137257567e-10
PBX3#5090269.996093506234164.06887158578937e-201.0415413714418e-17
POLR2A#5430572.147453176558071.19136376157406e-192.94148557671474e-17
POU2F2#5452579.106124057742521.93890343033548e-551.61997708288646e-52
POU5F1#5460211.76979654217210.01270532038883970.0458384329173011
PRDM1#63936.938471356708460.009400443239007160.0354699552526706
RDBP#79362978.16690729317063.52270968847638e-482.43647865665421e-45
REST#5978467.787742472664722.79928828858637e-351.38556810223541e-32
RFX5#5993428.877407977933232.36450442593599e-331.08309858658039e-30
RXRA#6256207.043725311976591.75258815348806e-122.40208076328267e-10
SETDB1#9869128.488426563791681.34028923477529e-089.86458543979537e-07
SIN3A#25942524.934421154287491.12879048385946e-325.0380234762307e-30
SMARCB1#659892.882007754919590.003650652333961990.01843935189373
SP1#6667565.598409775015622.16133187818758e-411.27529570636176e-38
SREBF1#672054.123320126358620.007282087574151320.0301297022485061
SRF#6722194.59905942072269.36780721169492e-097.14656258131633e-07
STAT2#677355.72489220933690.001820387176662330.0108957198890158
STAT3#6774274.982904472336221.98202226204488e-133.00000613080732e-11
TAF1#6872563.284396350907661.75559913207631e-286.45609217446894e-26
TAF7#68795310.63074874492932.11216857080828e-511.58699836954421e-48
TBP#6908563.641739622410485.60667282508411e-312.31444783865201e-28
TCF12#6938509.328477984374055.82767963345609e-443.68870929235467e-41
WRNIP1#568971121.19332645338844.34782803891637e-125.72613887208558e-10
YY1#7528484.135722736719047.91839839057802e-252.49845803478422e-22
ZBTB33#100094122.77638116191639.20018126289841e-496.49228196564762e-46
ZEB1#6935319.184936711295782.23736491997322e-236.73395259011765e-21



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data