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{{Coexpression_clusters
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|coexpression_dpi_cluster_scores_median=0,0,0

Latest revision as of 11:40, 17 September 2013


Full id: C1211_small_lung_bile_clear_colon_rectal_tubular



Phase1 CAGE Peaks

Hg19::chr15:59903975..59903992,+p1@GCNT3
Hg19::chr15:59903999..59904006,+p13@GCNT3
Hg19::chr15:59904021..59904030,+p8@GCNT3
Hg19::chr15:59904033..59904043,+p14@GCNT3
Hg19::chr15:59904045..59904065,+p3@GCNT3
Hg19::chr15:59904077..59904099,+p2@GCNT3
Hg19::chr15:59904110..59904119,+p11@GCNT3


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
kidney cell5.85e-0917
kidney epithelial cell5.85e-0917
kidney tubule cell5.90e-0910
nephron tubule epithelial cell5.90e-0910
epithelial cell3.35e-08253
Uber Anatomy
Ontology termp-valuen
intestine1.78e-1617
gastrointestinal system4.13e-1525
subdivision of digestive tract2.24e-09118
small intestine2.31e-094
nephron tubule epithelium5.90e-0910
abdomen element7.29e-0954
abdominal segment element7.29e-0954
digestive system1.38e-08145
digestive tract1.38e-08145
primitive gut1.38e-08145
large intestine1.52e-0811
kidney2.22e-0826
kidney mesenchyme2.22e-0826
upper urinary tract2.22e-0826
kidney rudiment2.22e-0826
kidney field2.22e-0826
abdominal segment of trunk1.34e-0760
abdomen1.34e-0760
colon1.58e-079
trunk region element3.94e-07101
endoderm-derived structure3.96e-07160
endoderm3.96e-07160
presumptive endoderm3.96e-07160
Disease
Ontology termp-valuen
carcinoma2.67e-13106
adenocarcinoma3.93e-1325
cell type cancer1.30e-09143
clear cell adenocarcinoma9.33e-072


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.00215847
MA0004.10.502801
MA0006.10.341337
MA0007.10.483857
MA0009.10.973289
MA0014.10.0156227
MA0017.11.75854
MA0019.10.652951
MA0024.10.867125
MA0025.11.10816
MA0027.12.59001
MA0028.10.35747
MA0029.10.886702
MA0030.10.875089
MA0031.10.809638
MA0038.10.60704
MA0040.10.892629
MA0041.11.29551
MA0042.10.48922
MA0043.10.973609
MA0046.10.962263
MA0048.10.120314
MA0050.10.490116
MA0051.10.602745
MA0052.10.896548
MA0055.10.158296
MA0056.10
MA0057.10.115382
MA0058.10.406232
MA0059.10.404929
MA0060.10.224688
MA0061.10.198335
MA0063.10
MA0066.10.607474
MA0067.12.88073
MA0068.10.162298
MA0069.10.958358
MA0070.10.947018
MA0071.10.567661
MA0072.10.942461
MA0073.10.00958848
MA0074.10.60198
MA0076.10.422297
MA0077.10.934645
MA0078.10.703614
MA0081.10.405093
MA0083.10.980893
MA0084.11.48179
MA0087.10.939982
MA0088.10.0723293
MA0089.10
MA0090.10.436918
MA0091.10.505453
MA0092.10.467172
MA0093.10.344385
MA0095.10
MA0098.10
MA0100.10.621149
MA0101.13.41664
MA0103.10.332048
MA0105.10.695228
MA0106.10.648997
MA0107.12.1191
MA0108.20.806528
MA0109.10
MA0111.11.14351
MA0113.10.665691
MA0114.10.269076
MA0115.11.21667
MA0116.10.277571
MA0117.11.01134
MA0119.10.388712
MA0122.11.03753
MA0124.11.17486
MA0125.11.0901
MA0130.10
MA0131.10.722072
MA0132.10
MA0133.10
MA0135.11.00402
MA0136.10.614215
MA0139.10.186511
MA0140.10.564957
MA0141.10.403171
MA0142.10.777365
MA0143.10.66587
MA0144.14.6428
MA0145.10.0807715
MA0146.10.0127148
MA0147.10.281049
MA0148.10.528066
MA0149.10.555119
MA0062.20.193221
MA0035.20.564239
MA0039.20.00276064
MA0138.20.704862
MA0002.21.79899
MA0137.22.56211
MA0104.20.223944
MA0047.20.636643
MA0112.20.0758925
MA0065.20.591589
MA0150.10.430951
MA0151.10
MA0152.10.571637
MA0153.17.38131
MA0154.10.102476
MA0155.10.071478
MA0156.10.36627
MA0157.10.749547
MA0158.10
MA0159.10.281681
MA0160.11.34201
MA0161.10
MA0162.10.0249953
MA0163.10.0167306
MA0164.10.678332
MA0080.20.344472
MA0018.20.650405
MA0099.23.51215
MA0079.29.11084e-05
MA0102.21.51913
MA0258.10.245543
MA0259.10.289405
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EP300#203376.77394172622321.52695018318475e-065.86298346256001e-05
FOSL2#2355716.93020060456172.50368126508949e-092.11726289590835e-07
FOXA1#3169711.08141974938554.86782131208363e-083.14403457027027e-06
FOXA2#3170724.63046375266521.81353313360781e-101.89025535869128e-08
HEY1#2346274.040111043105715.68979821988558e-050.00095032278312271
MAFF#23764756.31535648994525.53198247536579e-138.02437107978789e-11
MAFK#7975727.10073313782999.28633553538878e-111.01237536219256e-08
NR3C1#2908714.9730233311735.91757635984462e-094.70339237021166e-07
POLR2A#543072.147453176558070.004747636447610280.0223411013315297
STAT1#6772720.70658749719926.11318612876182e-105.85201692118933e-08
STAT3#6774710.51946499715427.00768600129688e-084.25014935127436e-06
USF1#739176.361499277207962.37038582734158e-068.4032832797599e-05
USF2#7392712.99219738506961.59819543071901e-081.16804711398784e-06



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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