UBERON:0000369: Difference between revisions
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{{UBERON | {{UBERON | ||
| | |alt_id=UBERON:BTO_0001311-FMA_77616 | ||
|anatomical_img_id=FMA:77616 | |||
| | |||
|comment=The term has been used in a few different ways: * It is a pair of nuclear masses which form the basal ganglia, along with the subthalamic nucleus and the substantia nigra. * It may also refer to both the basal ganglia and internal capsule collectively.[2] * According to the 1917 version of Gray's Anatomy, it is the combination of the lentiform nucleus (also known as the lenticular nucleus) and the caudate nucleus * According to BrainInfo it is a part of the basal ganglia comprising the globus pallidus and striatum | |comment=The term has been used in a few different ways: * It is a pair of nuclear masses which form the basal ganglia, along with the subthalamic nucleus and the substantia nigra. * It may also refer to both the basal ganglia and internal capsule collectively.[2] * According to the 1917 version of Gray's Anatomy, it is the combination of the lentiform nucleus (also known as the lenticular nucleus) and the caudate nucleus * According to BrainInfo it is a part of the basal ganglia comprising the globus pallidus and striatum | ||
|created_by= | |created_by= | ||
| | |def="The corpus striatum (striated body) is a compound structure consisting of the caudate nucleus and the lentiform nucleus, which consists of the putamen and the globus pallidus[WP]." [Wikipedia:Corpus_striatum] | ||
|derives_from= | |derives_from= | ||
|develops_from= | |develops_from=UBERON:0010082 | ||
|disjoint_from= | |||
|has_quality= | |has_quality= | ||
|id=UBERON:0000369 | |||
|is_a=UBERON:0002616 | |||
|is_obsolete= | |||
|located_in= | |located_in= | ||
|part_of= | |name=corpus striatum | ||
|namespace=FANTOM | |||
|obo_creation_date= | |||
|part_of=UBERON:0002420 | |||
|preceded_by= | |||
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl | |property_value=IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl | ||
| | |subset= | ||
| | |synonym="striate body" RELATED [BTO:0001311];;"striated body" RELATED [BTO:0001311] | ||
|union_of= | |||
|xref=BTO:0001311;;EFO:0000381;;EMAPA:17549;;EV:0100184;;FMA:77616;;GAID:667;;http://upload.wikimedia.org/wikipedia/commons/thumb/b/b3/Gray656.png/200px-Gray656.png;;MESH:A.08.186.211.730.885.105.487;;ncithesaurus:Corpus_Striatum;;SCTID:279318005;;VHOG:0001175 | |||
}} | }} |
Latest revision as of 17:08, 12 September 2014
Name: | corpus striatum | ||
---|---|---|---|
Namespace: | FANTOM | ||
Definition: | "The corpus striatum (striated body) is a compound structure consisting of the caudate nucleus and the lentiform nucleus, which consists of the putamen and the globus pallidus[WP]." [Wikipedia:Corpus_striatum] | ||
Xrefs: |
| ||
Synonyms: |
"striate body" RELATED [BTO:0001311] "striated body" RELATED [BTO:0001311] | ||
Comments: | The term has been used in a few different ways: * It is a pair of nuclear masses which form the basal ganglia, along with the subthalamic nucleus and the substantia nigra. * It may also refer to both the basal ganglia and internal capsule collectively.[2] * According to the 1917 version of Gray's Anatomy, it is the combination of the lentiform nucleus (also known as the lenticular nucleus) and the caudate nucleus * According to BrainInfo it is a part of the basal ganglia comprising the globus pallidus and striatum | ||
Alt_id: | UBERON:BTO_0001311-FMA_77616 |
Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data
Parents
is_a: | UBERON:0002616(regional part of brain) |
---|---|
develops_from: | UBERON:0010082(future corpus striatum) |
part_of: | UBERON:0002420(basal ganglion) |
Children
derives from: | FF:0011288 (mouse corpus striatum- adult sample),FF:0011392 (mouse corpus striatum- neonate N00 sample) |
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part of: | UBERON:0001873 (caudate nucleus),UBERON:0002435 (striatum) |
Ontology Tree: Loaded from BioPortal
Ontorolgy tree(Small window open)
FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology
Human (Homo sapiens)
- 10037-101F1 (nucleus accumbens, adult, pool1)
- 10152-102I8 (putamen, adult, donor10252)
- 10164-103B2 (caudate nucleus, adult, donor10252)
- 10176-103C5 (putamen, adult, donor10196)
- 10177-103C6 (caudate nucleus - adult, donor10196)
- 10354-105E3 (caudate nucleus, newborn, donor10223)
- 10365-105F5 (putamen, newborn, donor10223)
- 10372-105G3 (putamen, adult, donor10258)
- 11646-122D8 (Mouse Neurons - striatal, donor3)
- 11723-123D4 (Mouse Neurons - striatal, donor1)
... further results Mouse (Mus musculus)
- 10037-101F1 (nucleus accumbens, adult, pool1)
- 10152-102I8 (putamen, adult, donor10252)
- 10164-103B2 (caudate nucleus, adult, donor10252)
- 10176-103C5 (putamen, adult, donor10196)
- 10177-103C6 (caudate nucleus - adult, donor10196)
- 10354-105E3 (caudate nucleus, newborn, donor10223)
- 10365-105F5 (putamen, newborn, donor10223)
- 10372-105G3 (putamen, adult, donor10258)
- 11646-122D8 (Mouse Neurons - striatal, donor3)
- 11723-123D4 (Mouse Neurons - striatal, donor1)
Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0000369 (corpus striatum), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data
P-value | FFCP | Short description |
---|---|---|
2.57e-195 | FFCP PHASE1:Hg19::chr18:47967428..47967437,-#_47f376a0978832f9395eb029678d0732 | p@chr18:47967428..47967437, - |
2.57e-195 | FFCP PHASE2:Hg19::chr12:6031299..6031315,-#_47f376a0978832f9395eb029678d0732 | p@chr12:6031299..6031315, - |
2.57e-195 | FFCP PHASE1:Hg19::chr2:152828264..152828299,-#_47f376a0978832f9395eb029678d0732 | p@chr2:152828264..152828299, - |
2.57e-195 | FFCP PHASE2:Hg19::chr2:152828264..152828299,-#_47f376a0978832f9395eb029678d0732 | p@chr2:152828264..152828299, - |
2.57e-195 | FFCP PHASE2:Hg19::chr18:47967428..47967437,-#_47f376a0978832f9395eb029678d0732 | p@chr18:47967428..47967437, - |
2.57e-195 | FFCP PHASE1:Hg19::chr14:78638610..78638621,+#_47f376a0978832f9395eb029678d0732 | p@chr14:78638610..78638621, + |
2.57e-195 | FFCP PHASE1:Hg19::chr1:31352916..31352926,-#_47f376a0978832f9395eb029678d0732 | p@chr1:31352916..31352926, - |
2.57e-195 | FFCP PHASE2:Hg19::chr13:112726433..112726446,+#_47f376a0978832f9395eb029678d0732 | p@chr13:112726433..112726446, + |
2.57e-195 | FFCP PHASE1:Hg19::chr12:6031299..6031315,-#_47f376a0978832f9395eb029678d0732 | p@chr12:6031299..6031315, - |
2.57e-195 | FFCP PHASE2:Hg19::chr14:78638610..78638621,+#_47f376a0978832f9395eb029678d0732 | p@chr14:78638610..78638621, + |
2.57e-195 | FFCP PHASE2:Hg19::chr1:31352916..31352926,-#_47f376a0978832f9395eb029678d0732 | p@chr1:31352916..31352926, - |
2.57e-195 | FFCP PHASE1:Hg19::chr13:112726433..112726446,+#_47f376a0978832f9395eb029678d0732 | p@chr13:112726433..112726446, + |
6.72e-157 | FFCP PHASE2:Hg19::chr2:127783377..127783391,+#_dcff6c7eed4e767ba3bafbdfc5dcd559 | p2@BC051739 |
6.72e-157 | FFCP PHASE1:Hg19::chr2:3853961..3853984,+#_dcff6c7eed4e767ba3bafbdfc5dcd559 | p@chr2:3853961..3853984, + |
6.72e-157 | FFCP PHASE1:Hg19::chr10:97261874..97261887,-#_dcff6c7eed4e767ba3bafbdfc5dcd559 | p@chr10:97261874..97261887, - |
6.72e-157 | FFCP PHASE1:Hg19::chr15:35546024..35546035,-#_dcff6c7eed4e767ba3bafbdfc5dcd559 | p@chr15:35546024..35546035, - |
6.72e-157 | FFCP PHASE1:Hg19::chr3:57807798..57807809,+#_dcff6c7eed4e767ba3bafbdfc5dcd559 | p@chr3:57807798..57807809, + |
6.72e-157 | FFCP PHASE1:Hg19::chr17:19390211..19390223,+#_dcff6c7eed4e767ba3bafbdfc5dcd559 | p@chr17:19390211..19390223, + |
6.72e-157 | FFCP PHASE1:Hg19::chr2:127783377..127783391,+#_dcff6c7eed4e767ba3bafbdfc5dcd559 | p2@BC051739 |
6.72e-157 | FFCP PHASE2:Hg19::chr17:19390211..19390223,+#_dcff6c7eed4e767ba3bafbdfc5dcd559 | p@chr17:19390211..19390223, + |
6.72e-157 | FFCP PHASE2:Hg19::chr10:97261874..97261887,-#_dcff6c7eed4e767ba3bafbdfc5dcd559 | p@chr10:97261874..97261887, - |
6.72e-157 | FFCP PHASE2:Hg19::chr2:3853961..3853984,+#_dcff6c7eed4e767ba3bafbdfc5dcd559 | p@chr2:3853961..3853984, + |
6.72e-157 | FFCP PHASE2:Hg19::chr3:57807798..57807809,+#_dcff6c7eed4e767ba3bafbdfc5dcd559 | p@chr3:57807798..57807809, + |
6.72e-157 | FFCP PHASE1:Hg19::chr20:9496091..9496106,+#_dcff6c7eed4e767ba3bafbdfc5dcd559 | p@chr20:9496091..9496106, + |
6.72e-157 | FFCP PHASE2:Hg19::chr20:9496091..9496106,+#_dcff6c7eed4e767ba3bafbdfc5dcd559 | p@chr20:9496091..9496106, + |
6.72e-157 | FFCP PHASE2:Hg19::chr15:35546024..35546035,-#_dcff6c7eed4e767ba3bafbdfc5dcd559 | p@chr15:35546024..35546035, - |
1.5e-156 | FFCP PHASE1:Hg19::chr3:156008856..156008863,+#_a11a9965d44c69c72473f77b10d520de | p23@KCNAB1 |
1.5e-156 | FFCP PHASE2:Hg19::chr3:156008856..156008863,+#_a11a9965d44c69c72473f77b10d520de | p23@KCNAB1 |
3.35e-156 | FFCP PHASE1:Hg19::chr14:74893023..74893028,-#_defc547151d1f56fa5192373d93aefed | p6@SYNDIG1L |
3.35e-156 | FFCP PHASE2:Hg19::chr14:74893023..74893028,-#_defc547151d1f56fa5192373d93aefed | p6@SYNDIG1L |
6.94e-147 | FFCP PHASE1:Hg19::chr18:11752139..11752148,+#_0c08d89b2ad2f5a61d5edc1aeda6f212 | p27@GNAL |
6.94e-147 | FFCP PHASE1:Hg19::chr18:47967443..47967452,-#_0c08d89b2ad2f5a61d5edc1aeda6f212 | p@chr18:47967443..47967452, - |
6.94e-147 | FFCP PHASE1:Hg19::chrX:102663083..102663098,+#_0c08d89b2ad2f5a61d5edc1aeda6f212 | p@chrX:102663083..102663098, + |
6.94e-147 | FFCP PHASE2:Hg19::chr18:47967443..47967452,-#_0c08d89b2ad2f5a61d5edc1aeda6f212 | p@chr18:47967443..47967452, - |
6.94e-147 | FFCP PHASE2:Hg19::chr8:115354253..115354290,+#_0c08d89b2ad2f5a61d5edc1aeda6f212 | p@chr8:115354253..115354290, + |
6.94e-147 | FFCP PHASE1:Hg19::chr5:35195732..35195740,-#_0c08d89b2ad2f5a61d5edc1aeda6f212 | p22@PRLR |
6.94e-147 | FFCP PHASE2:Hg19::chr18:11752139..11752148,+#_0c08d89b2ad2f5a61d5edc1aeda6f212 | p27@GNAL |
6.94e-147 | FFCP PHASE1:Hg19::chr4:71945904..71945922,+#_0c08d89b2ad2f5a61d5edc1aeda6f212 | p@chr4:71945904..71945922, + |
6.94e-147 | FFCP PHASE1:Hg19::chr11:47617035..47617045,-#_0c08d89b2ad2f5a61d5edc1aeda6f212 | p@chr11:47617035..47617045, - |
6.94e-147 | FFCP PHASE1:Hg19::chr12:51984146..51984157,+#_0c08d89b2ad2f5a61d5edc1aeda6f212 | p11@SCN8A |
6.94e-147 | FFCP PHASE2:Hg19::chr4:71945904..71945922,+#_0c08d89b2ad2f5a61d5edc1aeda6f212 | p@chr4:71945904..71945922, + |
6.94e-147 | FFCP PHASE2:Hg19::chr12:51984146..51984157,+#_0c08d89b2ad2f5a61d5edc1aeda6f212 | p11@SCN8A |
6.94e-147 | FFCP PHASE1:Hg19::chr3:63542313..63542321,+#_0c08d89b2ad2f5a61d5edc1aeda6f212 | p@chr3:63542313..63542321, + |
6.94e-147 | FFCP PHASE1:Hg19::chr13:42614200..42614212,+#_0c08d89b2ad2f5a61d5edc1aeda6f212 | p2@DGKH |
6.94e-147 | FFCP PHASE2:Hg19::chr18:54898506..54898515,+#_0c08d89b2ad2f5a61d5edc1aeda6f212 | p@chr18:54898506..54898515, + |
6.94e-147 | FFCP PHASE2:Hg19::chr17:7271778..7271784,+#_0c08d89b2ad2f5a61d5edc1aeda6f212 | p@chr17:7271778..7271784, + |
6.94e-147 | FFCP PHASE2:Hg19::chr3:63542313..63542321,+#_0c08d89b2ad2f5a61d5edc1aeda6f212 | p@chr3:63542313..63542321, + |
6.94e-147 | FFCP PHASE2:Hg19::chr13:42614200..42614212,+#_0c08d89b2ad2f5a61d5edc1aeda6f212 | p2@DGKH |
6.94e-147 | FFCP PHASE2:Hg19::chr5:119669209..119669216,-#_0c08d89b2ad2f5a61d5edc1aeda6f212 | p5@ENST00000514240 |
6.94e-147 | FFCP PHASE2:Hg19::chr15:37777334..37777345,-#_0c08d89b2ad2f5a61d5edc1aeda6f212 | p@chr15:37777334..37777345, - |
6.94e-147 | FFCP PHASE1:Hg19::chr15:37777334..37777345,-#_0c08d89b2ad2f5a61d5edc1aeda6f212 | p@chr15:37777334..37777345, - |
6.94e-147 | FFCP PHASE2:Hg19::chrX:102663083..102663098,+#_0c08d89b2ad2f5a61d5edc1aeda6f212 | p@chrX:102663083..102663098, + |
6.94e-147 | FFCP PHASE1:Hg19::chr18:54898506..54898515,+#_0c08d89b2ad2f5a61d5edc1aeda6f212 | p@chr18:54898506..54898515, + |
6.94e-147 | FFCP PHASE1:Hg19::chr5:119669209..119669216,-#_0c08d89b2ad2f5a61d5edc1aeda6f212 | p5@ENST00000514240 |
6.94e-147 | FFCP PHASE1:Hg19::chr8:115354253..115354290,+#_0c08d89b2ad2f5a61d5edc1aeda6f212 | p@chr8:115354253..115354290, + |
6.94e-147 | FFCP PHASE2:Hg19::chr11:47617035..47617045,-#_0c08d89b2ad2f5a61d5edc1aeda6f212 | p@chr11:47617035..47617045, - |
6.94e-147 | FFCP PHASE2:Hg19::chr5:35195732..35195740,-#_0c08d89b2ad2f5a61d5edc1aeda6f212 | p22@PRLR |
6.94e-147 | FFCP PHASE1:Hg19::chr17:7271778..7271784,+#_0c08d89b2ad2f5a61d5edc1aeda6f212 | p@chr17:7271778..7271784, + |
2.79e-131 | FFCP PHASE2:Hg19::chr11:26497871..26497889,+#_db98ee5ffc7804cf4a5eec7b3d866e8e | p@chr11:26497871..26497889, + |
2.79e-131 | FFCP PHASE2:Hg19::chr2:234227370..234227385,+#_db98ee5ffc7804cf4a5eec7b3d866e8e | p@chr2:234227370..234227385, + |
2.79e-131 | FFCP PHASE1:Hg19::chr10:97261901..97261919,-#_db98ee5ffc7804cf4a5eec7b3d866e8e | p@chr10:97261901..97261919, - |
2.79e-131 | FFCP PHASE1:Hg19::chr10:97261796..97261806,-#_db98ee5ffc7804cf4a5eec7b3d866e8e | p@chr10:97261796..97261806, - |
2.79e-131 | FFCP PHASE1:Hg19::chr11:26497871..26497889,+#_db98ee5ffc7804cf4a5eec7b3d866e8e | p@chr11:26497871..26497889, + |
2.79e-131 | FFCP PHASE1:Hg19::chr5:121648127..121648167,-#_db98ee5ffc7804cf4a5eec7b3d866e8e | p@chr5:121648127..121648167, - |
2.79e-131 | FFCP PHASE2:Hg19::chr10:97261796..97261806,-#_db98ee5ffc7804cf4a5eec7b3d866e8e | p@chr10:97261796..97261806, - |
2.79e-131 | FFCP PHASE1:Hg19::chr2:234227370..234227385,+#_db98ee5ffc7804cf4a5eec7b3d866e8e | p@chr2:234227370..234227385, + |
2.79e-131 | FFCP PHASE2:Hg19::chr10:97261901..97261919,-#_db98ee5ffc7804cf4a5eec7b3d866e8e | p@chr10:97261901..97261919, - |
2.79e-131 | FFCP PHASE1:Hg19::chr3:63428975..63428978,+#_db98ee5ffc7804cf4a5eec7b3d866e8e | p10@SYNPR |
2.79e-131 | FFCP PHASE2:Hg19::chr5:121648127..121648167,-#_db98ee5ffc7804cf4a5eec7b3d866e8e | p@chr5:121648127..121648167, - |
2.79e-131 | FFCP PHASE2:Hg19::chr3:63428975..63428978,+#_db98ee5ffc7804cf4a5eec7b3d866e8e | p10@SYNPR |
3.91e-131 | FFCP PHASE1:Hg19::chr7:111424575..111424587,-#_c25e680d933a387a15f5d6bf28912821 | p9@DOCK4 |
3.91e-131 | FFCP PHASE1:Hg19::chr1:242372439..242372456,+#_c25e680d933a387a15f5d6bf28912821 | p1@ENST00000421878 |
3.91e-131 | FFCP PHASE2:Hg19::chr7:111424575..111424587,-#_c25e680d933a387a15f5d6bf28912821 | p9@DOCK4 |
3.91e-131 | FFCP PHASE2:Hg19::chr1:242372439..242372456,+#_c25e680d933a387a15f5d6bf28912821 | p1@ENST00000421878 |
5.46e-131 | FFCP PHASE1:Hg19::chr3:85007662..85007678,+#_d12eba93ebfb70e08334697abf61b12e | p8@CADM2 |
5.46e-131 | FFCP PHASE2:Hg19::chr3:85007662..85007678,+#_d12eba93ebfb70e08334697abf61b12e | p8@CADM2 |
5.46e-131 | FFCP PHASE2:Hg19::chr14:101123580..101123593,+#_d12eba93ebfb70e08334697abf61b12e | p1@LINC00523 |
5.46e-131 | FFCP PHASE1:Hg19::chr14:101123580..101123593,+#_d12eba93ebfb70e08334697abf61b12e | p1@LINC00523 |
5.46e-131 | FFCP PHASE2:Hg19::chr2:212989626..212989648,-#_d12eba93ebfb70e08334697abf61b12e | p@chr2:212989626..212989648, - |
5.46e-131 | FFCP PHASE2:Hg19::chr19:1236637..1236645,-#_d12eba93ebfb70e08334697abf61b12e | p@chr19:1236637..1236645, - |
5.46e-131 | FFCP PHASE1:Hg19::chr19:1236637..1236645,-#_d12eba93ebfb70e08334697abf61b12e | p@chr19:1236637..1236645, - |
5.46e-131 | FFCP PHASE1:Hg19::chr2:212989626..212989648,-#_d12eba93ebfb70e08334697abf61b12e | p@chr2:212989626..212989648, - |
1.07e-130 | FFCP PHASE2:Hg19::chr22:24828830..24828842,+#_4e00f84e6e28e8799a4629e58719b11f | p14@ADORA2A |
1.07e-130 | FFCP PHASE1:Hg19::chr11:26495467..26495474,+#_4e00f84e6e28e8799a4629e58719b11f | p8@ANO3 |
1.07e-130 | FFCP PHASE2:Hg19::chr11:26495467..26495474,+#_4e00f84e6e28e8799a4629e58719b11f | p8@ANO3 |
1.07e-130 | FFCP PHASE1:Hg19::chr22:24828830..24828842,+#_4e00f84e6e28e8799a4629e58719b11f | p14@ADORA2A |
4.07e-130 | FFCP PHASE1:Hg19::chr16:84027018..84027029,+#_1ff2c933ae3bf60d221685ef77ed3ce7 | p@chr16:84027018..84027029, + |
4.07e-130 | FFCP PHASE2:Hg19::chr16:84027018..84027029,+#_1ff2c933ae3bf60d221685ef77ed3ce7 | p@chr16:84027018..84027029, + |
5.62e-113 | FFCP PHASE1:Hg19::chr3:154147920..154147931,-#_2d167f25acd589c475955d91795e2c6e | p3@GPR149 |
5.62e-113 | FFCP PHASE2:Hg19::chr3:154147920..154147931,-#_2d167f25acd589c475955d91795e2c6e | p3@GPR149 |
5.62e-113 | FFCP PHASE1:Hg19::chr13:98995904..98995913,+#_2d167f25acd589c475955d91795e2c6e | p@chr13:98995904..98995913, + |
5.62e-113 | FFCP PHASE2:Hg19::chr13:98995904..98995913,+#_2d167f25acd589c475955d91795e2c6e | p@chr13:98995904..98995913, + |
7.5e-113 | FFCP PHASE2:Hg19::chrX:37765754..37765765,+#_c63482ec1bef320e45dfabf1fac497c4 | p11@ENST00000449263 |
7.5e-113 | FFCP PHASE1:Hg19::chr11:80886203..80886231,+#_c63482ec1bef320e45dfabf1fac497c4 | p@chr11:80886203..80886231, + |
7.5e-113 | FFCP PHASE2:Hg19::chr11:80886203..80886231,+#_c63482ec1bef320e45dfabf1fac497c4 | p@chr11:80886203..80886231, + |
7.5e-113 | FFCP PHASE2:Hg19::chr6:12890045..12890049,+#_c63482ec1bef320e45dfabf1fac497c4 | p@chr6:12890045..12890049, + |
7.5e-113 | FFCP PHASE1:Hg19::chrX:37765754..37765765,+#_c63482ec1bef320e45dfabf1fac497c4 | p11@ENST00000449263 |
7.5e-113 | FFCP PHASE1:Hg19::chr6:12890045..12890049,+#_c63482ec1bef320e45dfabf1fac497c4 | p@chr6:12890045..12890049, + |
1.0e-112 | FFCP PHASE1:Hg19::chr2:242171468..242171498,-#_872352729f6ab857663ef16c7c9d50ba | p@chr2:242171468..242171498, - |
1.0e-112 | FFCP PHASE1:Hg19::chr2:7112752..7112770,+#_872352729f6ab857663ef16c7c9d50ba | p@chr2:7112752..7112770, + |