Coexpression cluster:C5: Difference between revisions
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Latest revision as of 10:02, 17 September 2013
Full id: C5_Hepatocyte_liver_hepatocellular_Intestinal_kidney_small_pancreas
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| p.value | FDR | nGenes | nPathway | Name |
|---|---|---|---|---|
| 1.38373008989684e-06 | 1.53666867878017e-05 | 9 | 65 | Glycolysis / Gluconeogenesis (KEGG):00010 |
| 2.68840859891884e-09 | 4.15064059296494e-08 | 9 | 33 | Pentose and glucuronate interconversions (KEGG):00040 |
| 3.57317680244503e-10 | 6.28283587763252e-09 | 9 | 27 | Ascorbate and aldarate metabolism (KEGG):00053 |
| 1.26131093334504e-10 | 2.41942369941639e-09 | 11 | 44 | Fatty acid metabolism (KEGG):00071 |
| 9.30398640122054e-06 | 8.63613572000783e-05 | 4 | 9 | Synthesis and degradation of ketone bodies (KEGG):00072 |
| 1.02799524104262e-12 | 2.32400352707136e-11 | 9 | 16 | Primary bile acid biosynthesis (KEGG):00120 |
| 0.00560286357516248 | 0.0328390059544245 | 2 | 7 | Ubiquinone and other terpenoid-quinone biosynthesis (KEGG):00130 |
| 4.81855177775479e-20 | 2.34626405793752e-18 | 19 | 57 | Steroid hormone biosynthesis (KEGG):00140 |
| 2.68934589197162e-08 | 3.73994061018878e-07 | 5 | 7 | Caffeine metabolism (KEGG):00232 |
| 8.51119335326659e-07 | 1.01652554577693e-05 | 7 | 32 | Alanine, aspartate and glutamate metabolism (KEGG):00250 |
| 1.89898731881024e-15 | 5.72409034669942e-14 | 13 | 32 | Glycine, serine and threonine metabolism (KEGG):00260 |
| 1.99171074109835e-06 | 2.06680803133649e-05 | 7 | 36 | Cysteine and methionine metabolism (KEGG):00270 |
| 2.44864923355131e-09 | 3.87498741209495e-08 | 10 | 44 | Valine, leucine and isoleucine degradation (KEGG):00280 |
| 0.00136537303456685 | 0.00939436011826974 | 5 | 49 | Lysine degradation (KEGG):00310 |
| 3.67148171523499e-06 | 3.6313248839746e-05 | 8 | 55 | Arginine and proline metabolism (KEGG):00330 |
| 0.000132572441814994 | 0.00104897944586114 | 5 | 30 | Histidine metabolism (KEGG):00340 |
| 1.15742241382874e-09 | 1.92802207356209e-08 | 10 | 41 | Tyrosine metabolism (KEGG):00350 |
| 0.00269557052332202 | 0.0172353145582105 | 3 | 17 | Phenylalanine metabolism (KEGG):00360 |
| 2.71780834231728e-08 | 3.73994061018878e-07 | 9 | 42 | Tryptophan metabolism (KEGG):00380 |
| 7.82868489461075e-05 | 0.000643578901076442 | 5 | 27 | beta-Alanine metabolism (KEGG):00410 |
| 0.00560286357516248 | 0.0328390059544245 | 2 | 7 | Cyanoamino acid metabolism (KEGG):00460 |
| 2.44665981479108e-08 | 3.68746586372084e-07 | 10 | 55 | Starch and sucrose metabolism (KEGG):00500 |
| 8.98179572886623e-07 | 1.03372303570406e-05 | 8 | 46 | Other types of O-glycan biosynthesis (KEGG):00514 |
| 0.000466811871795254 | 0.00339645879133788 | 7 | 82 | Glycerophospholipid metabolism (KEGG):00564 |
| 2.43909284351746e-10 | 4.54101697043104e-09 | 12 | 59 | Arachidonic acid metabolism (KEGG):00590 |
| 3.66026922496034e-11 | 7.24047006062467e-10 | 10 | 30 | Linoleic acid metabolism (KEGG):00591 |
| 4.19737169355661e-06 | 4.08759428003282e-05 | 7 | 40 | Pyruvate metabolism (KEGG):00620 |
| 9.41379723034028e-06 | 8.63613572000783e-05 | 5 | 18 | Glyoxylate and dicarboxylate metabolism (KEGG):00630 |
| 1.36982826951654e-05 | 0.000123871613514853 | 6 | 32 | Propanoate metabolism (KEGG):00640 |
| 2.55051258197295e-08 | 3.73994061018878e-07 | 8 | 30 | Butanoate metabolism (KEGG):00650 |
| 0.00319461563139245 | 0.0198254087712885 | 3 | 18 | One carbon pool by folate (KEGG):00670 |
| 0.00269557052332202 | 0.0172353145582105 | 3 | 17 | Pantothenate and CoA biosynthesis (KEGG):00770 |
| 0.00119181239240936 | 0.00829029938895742 | 3 | 13 | Folate biosynthesis (KEGG):00790 |
| 7.13213925935899e-25 | 4.51464415117424e-23 | 23 | 64 | Retinol metabolism (KEGG):00830 |
| 5.21687263142201e-07 | 6.35053918401948e-06 | 8 | 43 | Porphyrin and chlorophyll metabolism (KEGG):00860 |
| 0.00184924264123798 | 0.0123217957042489 | 3 | 15 | Terpenoid backbone biosynthesis (KEGG):00900 |
| 1.1490674292272e-26 | 9.09199603376024e-25 | 25 | 71 | Metabolism of xenobiotics by cytochrome P450 (KEGG):00980 |
| 5.7994775815226e-31 | 5.24438472729115e-29 | 28 | 73 | Drug metabolism - cytochrome P450 (KEGG):00982 |
| 1.89504397344848e-16 | 6.31348860627834e-15 | 16 | 52 | Drug metabolism - other enzymes (KEGG):00983 |
| 5.08821214671478e-66 | 3.22083828887046e-63 | 125 | 1138 | Metabolic pathways (KEGG):01100 |
| 8.99792133075786e-05 | 0.000730215923380734 | 6 | 44 | ABC transporters (KEGG):02010 |
| 7.55436132996644e-13 | 1.77107804513658e-11 | 15 | 71 | PPAR signaling pathway (KEGG):03320 |
| 5.96783849789261e-10 | 1.02098426193676e-08 | 13 | 78 | Peroxisome (KEGG):04146 |
| 2.13106321854421e-49 | 6.74481508669241e-47 | 38 | 69 | Complement and coagulation cascades (KEGG):04610 |
| 5.29697994841978e-05 | 0.000447065107646629 | 5 | 25 | Maturity onset diabetes of the young (KEGG):04950 |
| 8.98179572886623e-07 | 1.03372303570406e-05 | 8 | 46 | Fat digestion and absorption (KEGG):04975 |
| 5.28045448663426e-18 | 1.96619275884676e-16 | 19 | 71 | Bile secretion (KEGG):04976 |
| 0.00064231175524978 | 0.00462026523946717 | 4 | 24 | Vitamin digestion and absorption (KEGG):04977 |
| 1.6279020535523e-06 | 1.71743666649768e-05 | 7 | 35 | Prion diseases (KEGG):05020 |
| 2.04217188567345e-09 | 3.31460206059306e-08 | 11 | 56 | Staphylococcus aureus infection (KEGG):05150 |
| 0.000119628914837543 | 0.000958545608761579 | 10 | 138 | Systemic lupus erythematosus (KEGG):05322 |
| 9.45957071067828e-07 | 1.06926933211774e-05 | 5 | 12 | Alanine and aspartate metabolism (Wikipathways):WP106 |
| 0.00144088557177118 | 0.00980731792399095 | 6 | 73 | AMPK signaling (Wikipathways):WP1403 |
| 1.30969201637984e-12 | 2.76345015456146e-11 | 14 | 61 | Selenium Pathway (Wikipathways):WP15 |
| 4.95665018531513e-15 | 1.42616343968385e-13 | 15 | 52 | Vitamin B12 Metabolism (Wikipathways):WP1533 |
| 3.64002708598001e-13 | 8.86206594394364e-12 | 7 | 7 | Nicotine metabolism (Wikipathways):WP1600 |
| 1.6279020535523e-06 | 1.71743666649768e-05 | 7 | 35 | Fluoropyrimidine Activity (Wikipathways):WP1601 |
| 7.07220082216455e-08 | 9.3264648342295e-07 | 5 | 8 | Codeine and morphine metabolism (Wikipathways):WP1604 |
| 0.000418111393066099 | 0.00311370013895106 | 5 | 38 | Nuclear Receptors (Wikipathways):WP170 |
| 1.14062244938212e-13 | 3.00839171024534e-12 | 15 | 63 | Folate Metabolism (Wikipathways):WP176 |
| 7.63360766803805e-19 | 3.45148118133435e-17 | 12 | 16 | Fatty Acid Omega Oxidation (Wikipathways):WP206 |
| 5.00442184398911e-05 | 0.000428080949627717 | 4 | 13 | Irinotecan Pathway (Wikipathways):WP229 |
| 0.00208036724534828 | 0.0137174215240152 | 8 | 135 | Adipogenesis (Wikipathways):WP236 |
| 0.000248461524219855 | 0.00191800176623376 | 3 | 8 | Glucocorticoid & Mineralcorticoid Metabolism (Wikipathways):WP237 |
| 0.00117366943972007 | 0.00829029938895742 | 4 | 28 | One Carbon Metabolism (Wikipathways):WP241 |
| 1.54229107883709e-17 | 5.42372362724378e-16 | 13 | 24 | Blood Clotting Cascade (Wikipathways):WP272 |
| 1.53664199531207e-18 | 6.48462922021695e-17 | 15 | 33 | Nuclear receptors in lipid metabolism and toxicity (Wikipathways):WP299 |
| 0.000454085363481117 | 0.00334227947771566 | 4 | 22 | Fatty Acid Biosynthesis (Wikipathways):WP357 |
| 0.00224774910695637 | 0.0146683008732308 | 3 | 16 | Mitochondrial LC-Fatty Acid Beta-Oxidation (Wikipathways):WP368 |
| 7.27627880348322e-21 | 3.8382370688374e-19 | 20 | 61 | cytochrome P450 (Wikipathways):WP43 |
| 1.78530856106882e-14 | 4.9134796485068e-13 | 12 | 29 | Statin Pathway (Wikipathways):WP430 |
| 2.73725423434075e-10 | 4.95051980096485e-09 | 11 | 47 | Tryptophan metabolism (Wikipathways):WP465 |
| 0.00573644725643992 | 0.0333134964525364 | 3 | 22 | Hedgehog Signaling Pathway (Wikipathways):WP47 |
| 0.000368040293129172 | 0.00277344649465198 | 3 | 9 | Steroid Biosynthesis (Wikipathways):WP496 |
| 0.00501612518012736 | 0.0302400689430535 | 3 | 21 | Urea cycle and metabolism of amino groups (Wikipathways):WP497 |
| 0.000147798792194765 | 0.00115502019085538 | 6 | 48 | Glycolysis and Gluconeogenesis (Wikipathways):WP534 |
| 2.61677147565039e-13 | 6.62566537634679e-12 | 10 | 20 | Complement Activation, Classical Pathway (Wikipathways):WP545 |
| 1.9361929144543e-34 | 2.04268352474929e-32 | 27 | 52 | Complement and Coagulation Cascades (Wikipathways):WP558 |
| 0.00560286357516248 | 0.0328390059544245 | 2 | 7 | Arachidonate Epoxygenase / Epoxide Hydrolase (Wikipathways):WP678 |
| 1.81572963037509e-15 | 5.72409034669942e-14 | 11 | 19 | Tamoxifen metabolism (Wikipathways):WP691 |
| 2.68934589197162e-08 | 3.73994061018878e-07 | 5 | 7 | Arylamine metabolism (Wikipathways):WP694 |
| 9.30398640122054e-06 | 8.63613572000783e-05 | 4 | 9 | Benzo(a)pyrene metabolism (Wikipathways):WP696 |
| 2.31717480668639e-07 | 2.93354330526497e-06 | 6 | 17 | Estrogen metabolism (Wikipathways):WP697 |
| 1.81502319584821e-07 | 2.34471363871819e-06 | 7 | 26 | Glucuronidation (Wikipathways):WP698 |
| 9.30398640122054e-06 | 8.63613572000783e-05 | 4 | 9 | Aflatoxin B1 metabolism (Wikipathways):WP699 |
| 3.51329617590013e-36 | 4.44783295868956e-34 | 42 | 175 | metapathway biotransformation (Wikipathways):WP702 |
| 0.00738766425881002 | 0.0425126497802431 | 2 | 8 | Methylation Pathways (Wikipathways):WP704 |
| 4.46461694586018e-05 | 0.000387137332428698 | 6 | 39 | Vitamin A and carotenoid metabolism (Wikipathways):WP716 |
| 0.00463520495274439 | 0.0282123532219923 | 12 | 296 | Metabolism of proteins (Reactome):REACT_17015 |
| 2.31525908343124e-06 | 2.32628412668567e-05 | 25 | 511 | Signaling in Immune system (Reactome):REACT_6900 |
| 0.00290043188870281 | 0.0183597338554888 | 5 | 58 | Metabolism of vitamins and cofactors (Reactome):REACT_11193 |
| 3.17716490172865e-08 | 4.27903272934943e-07 | 27 | 466 | Hemostasis (Reactome):REACT_604 |
| 5.57320186745515e-05 | 0.000464189050276199 | 10 | 126 | Metabolism of carbohydrates (Reactome):REACT_474 |
| 1.16772507979325e-36 | 1.84792493877282e-34 | 51 | 289 | Metabolism of lipids and lipoproteins (Reactome):REACT_22258 |
| 1.49127436166669e-06 | 1.62754598437071e-05 | 22 | 401 | Transmembrane transport of small molecules (Reactome):REACT_15518 |
| 2.80000811160267e-39 | 5.90801711548163e-37 | 40 | 130 | Biological oxidations (Reactome):REACT_13433 |
| 1.8695680249787e-23 | 1.07585141801047e-21 | 33 | 195 | Metabolism of amino acids and derivatives (Reactome):REACT_13 |
| 4.59334083263672e-07 | 5.70114656286087e-06 | 33 | 740 | TGF beta receptor down reg. targets (Netpath):NetPath_7 |
| 0.00354506634590815 | 0.0217866698733967 | 16 | 441 | AR up reg. targets (Netpath):NetPath_2 |
| 0.00174970166703408 | 0.0117825654811976 | 9 | 162 | AR down reg. targets (Netpath):NetPath_2 |
| 0.000308317573171555 | 0.00235138582912764 | 10 | 155 | IL-1 up reg. targets (Netpath):NetPath_13 |
| 0.00296954359330942 | 0.0186110999461867 | 16 | 433 | IL-2 up reg. targets (Netpath):NetPath_14 |
| 3.87221791942545e-18 | 1.53194621437269e-16 | 14 | 28 | {C5,29} (Static Module):NA |
| 1.67325185365669e-25 | 1.17685380373854e-23 | 21 | 46 | {F2,46} (Static Module):NA |
| 1.47619230371171e-05 | 0.000131609820880213 | 7 | 48 | {FCGR2B,50} (Static Module):NA |
| 0.00119181239240936 | 0.00829029938895742 | 3 | 13 | {IGF1,13} (Static Module):NA |
| 3.50002432970527e-11 | 7.14682387323689e-10 | 8 | 15 | {POR,15} (Static Module):NA |
| 2.03640620175381e-06 | 2.07910504146801e-05 | 8 | 51 | {RXRA,51} (Static Module):NA |
| 1.11068748855228e-12 | 2.42436269052962e-11 | 11 | 30 | {SDC1,30} (Static Module):NA |
| 1.60208697782611e-05 | 0.000140850146800545 | 9 | 87 | {SP1,88} (Static Module):NA |
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0009605 | response to external stimulus | 0 |
| GO:0009611 | response to wounding | 0 |
| GO:0006629 | lipid metabolic process | 2.89139240948697e-79 |
| GO:0005615 | extracellular space | 1.10468525943202e-72 |
| GO:0006082 | organic acid metabolic process | 2.99385298916314e-72 |
| GO:0019752 | carboxylic acid metabolic process | 9.93774306799495e-68 |
| GO:0044255 | cellular lipid metabolic process | 4.76446578041819e-66 |
| GO:0000267 | cell fraction | 8.31075338682487e-53 |
| GO:0005624 | membrane fraction | 7.95609508910185e-52 |
| GO:0006950 | response to stress | 2.89591997436832e-45 |
| GO:0005783 | endoplasmic reticulum | 5.4345875473548e-43 |
| GO:0044421 | extracellular region part | 1.84250505627199e-37 |
| GO:0005792 | microsome | 5.15523635033374e-37 |
| GO:0042598 | vesicular fraction | 3.03929935211145e-36 |
| GO:0042221 | response to chemical stimulus | 6.00062276576859e-35 |
| GO:0044432 | endoplasmic reticulum part | 8.83124996052041e-33 |
| GO:0002526 | acute inflammatory response | 2.47071018435742e-32 |
| GO:0016491 | oxidoreductase activity | 7.95765178559444e-32 |
| GO:0006952 | defense response | 1.74526495699789e-31 |
| GO:0005737 | cytoplasm | 1.84177340950484e-31 |
| GO:0044444 | cytoplasmic part | 8.13992551752306e-31 |
| GO:0006807 | nitrogen compound metabolic process | 2.97284824161002e-30 |
| GO:0005789 | endoplasmic reticulum membrane | 3.6271258270954e-30 |
| GO:0042175 | nuclear envelope-endoplasmic reticulum network | 2.33066795120569e-29 |
| GO:0006066 | alcohol metabolic process | 3.50811894115376e-27 |
| GO:0009308 | amine metabolic process | 3.92084235968594e-26 |
| GO:0007596 | blood coagulation | 4.52053070399091e-26 |
| GO:0032787 | monocarboxylic acid metabolic process | 7.03342292243682e-26 |
| GO:0050817 | coagulation | 7.62822470263557e-26 |
| GO:0007599 | hemostasis | 1.75315485219564e-25 |
| GO:0004857 | enzyme inhibitor activity | 5.79860328923202e-25 |
| GO:0050878 | regulation of body fluid levels | 1.17961365467816e-24 |
| GO:0042060 | wound healing | 4.65462264854435e-24 |
| GO:0065008 | regulation of biological quality | 1.33017387238081e-23 |
| GO:0005506 | iron ion binding | 7.89360388364522e-23 |
| GO:0006954 | inflammatory response | 1.71692139073823e-22 |
| GO:0006519 | amino acid and derivative metabolic process | 1.1458666007644e-21 |
| GO:0006520 | amino acid metabolic process | 2.71225943008758e-21 |
| GO:0006956 | complement activation | 1.67364571593223e-20 |
| GO:0002541 | activation of plasma proteins during acute inflammatory response | 1.67364571593223e-20 |
| GO:0008202 | steroid metabolic process | 9.4525933878553e-20 |
| GO:0002253 | activation of immune response | 2.98327470753472e-18 |
| GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | 4.76423642693228e-18 |
| GO:0006958 | complement activation, classical pathway | 6.53332487662893e-18 |
| GO:0002455 | humoral immune response mediated by circulating immunoglobulin | 2.26130849252929e-17 |
| GO:0004497 | monooxygenase activity | 4.12081667662592e-17 |
| GO:0006091 | generation of precursor metabolites and energy | 6.02203213986614e-17 |
| GO:0009056 | catabolic process | 6.02203213986614e-17 |
| GO:0050776 | regulation of immune response | 9.255523726504e-17 |
| GO:0050778 | positive regulation of immune response | 1.04031542161367e-16 |
| GO:0002684 | positive regulation of immune system process | 1.29358303292881e-16 |
| GO:0002682 | regulation of immune system process | 1.33388906321425e-16 |
| GO:0006959 | humoral immune response | 1.95860081167061e-16 |
| GO:0012505 | endomembrane system | 2.08327310764926e-16 |
| GO:0032501 | multicellular organismal process | 5.52434601314094e-16 |
| GO:0004866 | endopeptidase inhibitor activity | 2.76142165843602e-15 |
| GO:0006631 | fatty acid metabolic process | 3.81639916968301e-15 |
| GO:0031090 | organelle membrane | 4.99958553049701e-15 |
| GO:0051240 | positive regulation of multicellular organismal process | 5.9863031792717e-15 |
| GO:0030414 | protease inhibitor activity | 1.0155548245065e-14 |
| GO:0044248 | cellular catabolic process | 1.81990456423135e-14 |
| GO:0005319 | lipid transporter activity | 1.86345895858892e-14 |
| GO:0045087 | innate immune response | 2.77706968818621e-14 |
| GO:0006118 | electron transport | 7.64427919783992e-14 |
| GO:0006957 | complement activation, alternative pathway | 8.21137318778037e-14 |
| GO:0016064 | immunoglobulin mediated immune response | 1.06793076278122e-13 |
| GO:0006953 | acute-phase response | 1.39502061255821e-13 |
| GO:0019724 | B cell mediated immunity | 1.40165072800523e-13 |
| GO:0002252 | immune effector process | 2.06537060668076e-13 |
| GO:0044270 | nitrogen compound catabolic process | 2.95753481287132e-13 |
| GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | 6.46470440435987e-13 |
| GO:0009063 | amino acid catabolic process | 9.55010020006509e-13 |
| GO:0004867 | serine-type endopeptidase inhibitor activity | 3.19193219040305e-12 |
| GO:0009310 | amine catabolic process | 3.31191807723765e-12 |
| GO:0019842 | vitamin binding | 7.26319479728249e-12 |
| GO:0048037 | cofactor binding | 1.29274184194658e-11 |
| GO:0002449 | lymphocyte mediated immunity | 1.64901680042327e-11 |
| GO:0050381 | unspecific monooxygenase activity | 1.81753338661827e-11 |
| GO:0005739 | mitochondrion | 2.04662684540391e-11 |
| GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | 2.2281662396568e-11 |
| GO:0002250 | adaptive immune response | 3.39616054864119e-11 |
| GO:0002460 | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 3.39616054864119e-11 |
| GO:0002443 | leukocyte mediated immunity | 4.88068229803667e-11 |
| GO:0051239 | regulation of multicellular organismal process | 8.44884415639297e-11 |
| GO:0020037 | heme binding | 2.27229655132565e-10 |
| GO:0046906 | tetrapyrrole binding | 2.27229655132565e-10 |
| GO:0019825 | oxygen binding | 2.50589354349228e-10 |
| GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen | 3.6225373965341e-10 |
| GO:0048518 | positive regulation of biological process | 3.83362537338242e-10 |
| GO:0008203 | cholesterol metabolic process | 7.56647535089964e-10 |
| GO:0006869 | lipid transport | 8.30563719774693e-10 |
| GO:0005579 | membrane attack complex | 8.87456341046129e-10 |
| GO:0030193 | regulation of blood coagulation | 2.62202886587067e-09 |
| GO:0004252 | serine-type endopeptidase activity | 3.13507029880344e-09 |
| GO:0042445 | hormone metabolic process | 3.46792985685546e-09 |
| GO:0019439 | aromatic compound catabolic process | 3.57328767622673e-09 |
| GO:0006694 | steroid biosynthetic process | 3.9306503325501e-09 |
| GO:0044262 | cellular carbohydrate metabolic process | 4.44201573346609e-09 |
| GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 5.6346991679113e-09 |
| GO:0044237 | cellular metabolic process | 6.5714856238089e-09 |
| GO:0016125 | sterol metabolic process | 7.62328553687844e-09 |
| GO:0006725 | aromatic compound metabolic process | 8.67941606759348e-09 |
| GO:0008206 | bile acid metabolic process | 8.67941606759348e-09 |
| GO:0044424 | intracellular part | 1.24603902490328e-08 |
| GO:0050818 | regulation of coagulation | 1.4965977773666e-08 |
| GO:0005777 | peroxisome | 1.58236132497063e-08 |
| GO:0042579 | microbody | 1.58236132497063e-08 |
| GO:0008610 | lipid biosynthetic process | 1.60354214194851e-08 |
| GO:0009991 | response to extracellular stimulus | 2.12438035105151e-08 |
| GO:0006706 | steroid catabolic process | 2.40126781536418e-08 |
| GO:0008236 | serine-type peptidase activity | 2.83829719300816e-08 |
| GO:0017171 | serine hydrolase activity | 2.96007730128119e-08 |
| GO:0008209 | androgen metabolic process | 4.56144394080795e-08 |
| GO:0044238 | primary metabolic process | 4.63572903642033e-08 |
| GO:0006558 | L-phenylalanine metabolic process | 8.63986212867513e-08 |
| GO:0030195 | negative regulation of blood coagulation | 8.63986212867513e-08 |
| GO:0006559 | L-phenylalanine catabolic process | 8.63986212867513e-08 |
| GO:0031667 | response to nutrient levels | 1.13763604405495e-07 |
| GO:0043231 | intracellular membrane-bound organelle | 1.41017105265428e-07 |
| GO:0043227 | membrane-bound organelle | 1.44000649839837e-07 |
| GO:0010033 | response to organic substance | 1.5460646756251e-07 |
| GO:0006508 | proteolysis | 1.64517478770032e-07 |
| GO:0016042 | lipid catabolic process | 1.71778086352701e-07 |
| GO:0005975 | carbohydrate metabolic process | 2.56749540315429e-07 |
| GO:0009636 | response to toxin | 3.44703885959541e-07 |
| GO:0050819 | negative regulation of coagulation | 4.20588546792209e-07 |
| GO:0016829 | lyase activity | 6.55199504716561e-07 |
| GO:0019835 | cytolysis | 6.55199504716561e-07 |
| GO:0051234 | establishment of localization | 8.33976110941765e-07 |
| GO:0030170 | pyridoxal phosphate binding | 8.90012428520422e-07 |
| GO:0009074 | aromatic amino acid family catabolic process | 9.78652993293396e-07 |
| GO:0008201 | heparin binding | 1.06981717165559e-06 |
| GO:0044446 | intracellular organelle part | 1.48894647927757e-06 |
| GO:0051179 | localization | 1.54689804279664e-06 |
| GO:0044422 | organelle part | 1.6816929992289e-06 |
| GO:0044425 | membrane part | 2.04335309310267e-06 |
| GO:0001871 | pattern binding | 2.10758056227082e-06 |
| GO:0006572 | tyrosine catabolic process | 2.50787006284807e-06 |
| GO:0009075 | histidine family amino acid metabolic process | 2.77550917198615e-06 |
| GO:0006547 | histidine metabolic process | 2.77550917198615e-06 |
| GO:0005496 | steroid binding | 2.95860954823807e-06 |
| GO:0044242 | cellular lipid catabolic process | 3.26633263926932e-06 |
| GO:0008015 | blood circulation | 3.54612127442122e-06 |
| GO:0003013 | circulatory system process | 3.54612127442122e-06 |
| GO:0005539 | glycosaminoglycan binding | 3.76213487684474e-06 |
| GO:0051384 | response to glucocorticoid stimulus | 4.557985934904e-06 |
| GO:0006810 | transport | 4.70836340846141e-06 |
| GO:0030247 | polysaccharide binding | 6.33669092534915e-06 |
| GO:0044429 | mitochondrial part | 6.48623731763337e-06 |
| GO:0006639 | acylglycerol metabolic process | 6.48623731763337e-06 |
| GO:0006638 | neutral lipid metabolic process | 6.48623731763337e-06 |
| GO:0009058 | biosynthetic process | 6.66399402325761e-06 |
| GO:0031960 | response to corticosteroid stimulus | 6.9940649219013e-06 |
| GO:0048545 | response to steroid hormone stimulus | 7.19844872750381e-06 |
| GO:0046486 | glycerolipid metabolic process | 8.33375982797054e-06 |
| GO:0048878 | chemical homeostasis | 9.33695286882618e-06 |
| GO:0016020 | membrane | 1.00777822649704e-05 |
| GO:0009725 | response to hormone stimulus | 1.03761640869684e-05 |
| GO:0006662 | glycerol ether metabolic process | 1.05079398519875e-05 |
| GO:0030168 | platelet activation | 1.05079398519875e-05 |
| GO:0005759 | mitochondrial matrix | 1.4709174971472e-05 |
| GO:0031980 | mitochondrial lumen | 1.4709174971472e-05 |
| GO:0006570 | tyrosine metabolic process | 1.48161923084879e-05 |
| GO:0008395 | steroid hydroxylase activity | 1.48161923084879e-05 |
| GO:0016840 | carbon-nitrogen lyase activity | 1.48161923084879e-05 |
| GO:0007584 | response to nutrient | 1.64502404030536e-05 |
| GO:0042446 | hormone biosynthetic process | 1.93139762409754e-05 |
| GO:0019216 | regulation of lipid metabolic process | 2.0478513286026e-05 |
| GO:0006090 | pyruvate metabolic process | 2.53873332525801e-05 |
| GO:0042627 | chylomicron | 2.75016563258536e-05 |
| GO:0008483 | transaminase activity | 3.02986392492287e-05 |
| GO:0030573 | bile acid catabolic process | 3.11866476173746e-05 |
| GO:0009072 | aromatic amino acid family metabolic process | 3.48003247946301e-05 |
| GO:0006805 | xenobiotic metabolic process | 3.73961406518664e-05 |
| GO:0030301 | cholesterol transport | 3.79535548432797e-05 |
| GO:0015918 | sterol transport | 3.79535548432797e-05 |
| GO:0006641 | triacylglycerol metabolic process | 3.79535548432797e-05 |
| GO:0005577 | fibrinogen complex | 4.65548364604654e-05 |
| GO:0042730 | fibrinolysis | 4.65548364604654e-05 |
| GO:0044464 | cell part | 5.48924754787123e-05 |
| GO:0015293 | symporter activity | 5.73798480488258e-05 |
| GO:0015020 | glucuronosyltransferase activity | 6.28659177767016e-05 |
| GO:0009410 | response to xenobiotic stimulus | 6.28659177767016e-05 |
| GO:0030005 | cellular di-, tri-valent inorganic cation homeostasis | 6.48627899625816e-05 |
| GO:0042592 | homeostatic process | 7.22097490848487e-05 |
| GO:0030212 | hyaluronan metabolic process | 7.27686355598628e-05 |
| GO:0046395 | carboxylic acid catabolic process | 7.27686355598628e-05 |
| GO:0016054 | organic acid catabolic process | 7.27686355598628e-05 |
| GO:0015125 | bile acid transmembrane transporter activity | 7.27686355598628e-05 |
| GO:0055066 | di-, tri-valent inorganic cation homeostasis | 7.44437640994105e-05 |
| GO:0004091 | carboxylesterase activity | 9.23481409537299e-05 |
| GO:0009069 | serine family amino acid metabolic process | 9.25792132857037e-05 |
| GO:0016841 | ammonia-lyase activity | 0.000110228514151099 |
| GO:0002376 | immune system process | 0.000112401933541027 |
| GO:0005102 | receptor binding | 0.000117651227356984 |
| GO:0006006 | glucose metabolic process | 0.000117651227356984 |
| GO:0006955 | immune response | 0.000127916211625167 |
| GO:0004022 | alcohol dehydrogenase activity | 0.000160439071319015 |
| GO:0016627 | oxidoreductase activity, acting on the CH-CH group of donors | 0.000163023060553068 |
| GO:0030003 | cellular cation homeostasis | 0.000173879867915859 |
| GO:0005625 | soluble fraction | 0.000174566712760573 |
| GO:0008652 | amino acid biosynthetic process | 0.000175527415681608 |
| GO:0016769 | transferase activity, transferring nitrogenous groups | 0.000176084175393016 |
| GO:0006094 | gluconeogenesis | 0.000189641377709247 |
| GO:0055080 | cation homeostasis | 0.000196878149832562 |
| GO:0005622 | intracellular | 0.000199441786401794 |
| GO:0006548 | histidine catabolic process | 0.00021739507184705 |
| GO:0009077 | histidine family amino acid catabolic process | 0.00021739507184705 |
| GO:0006702 | androgen biosynthetic process | 0.000248661260469893 |
| GO:0006699 | bile acid biosynthetic process | 0.000248661260469893 |
| GO:0015291 | secondary active transmembrane transporter activity | 0.000285806176916084 |
| GO:0043169 | cation binding | 0.000300790506288408 |
| GO:0009309 | amine biosynthetic process | 0.00031493347788047 |
| GO:0016877 | ligase activity, forming carbon-sulfur bonds | 0.000320957832929869 |
| GO:0022892 | substrate-specific transporter activity | 0.000327436394667042 |
| GO:0030246 | carbohydrate binding | 0.000356429003023295 |
| GO:0031402 | sodium ion binding | 0.000430050180718762 |
| GO:0046943 | carboxylic acid transmembrane transporter activity | 0.00046133224071795 |
| GO:0004175 | endopeptidase activity | 0.00047424393913338 |
| GO:0006637 | acyl-CoA metabolic process | 0.000505282754169386 |
| GO:0005342 | organic acid transmembrane transporter activity | 0.000527121959624898 |
| GO:0031224 | intrinsic to membrane | 0.000639332503240916 |
| GO:0008207 | C21-steroid hormone metabolic process | 0.000645299082880269 |
| GO:0019318 | hexose metabolic process | 0.000660366070946871 |
| GO:0043229 | intracellular organelle | 0.000714036556971835 |
| GO:0043226 | organelle | 0.000732829357164904 |
| GO:0043167 | ion binding | 0.000752499331596815 |
| GO:0005996 | monosaccharide metabolic process | 0.000781908079147423 |
| GO:0046146 | tetrahydrobiopterin metabolic process | 0.000783878605385646 |
| GO:0055082 | cellular chemical homeostasis | 0.000784829083136309 |
| GO:0006873 | cellular ion homeostasis | 0.000784829083136309 |
| GO:0016021 | integral to membrane | 0.000796602410223796 |
| GO:0008217 | regulation of blood pressure | 0.000833886879024288 |
| GO:0046872 | metal ion binding | 0.000833886879024288 |
| GO:0016051 | carbohydrate biosynthetic process | 0.000907660020321125 |
| GO:0006879 | cellular iron ion homeostasis | 0.000910417516515856 |
| GO:0055072 | iron ion homeostasis | 0.000910417516515856 |
| GO:0009064 | glutamine family amino acid metabolic process | 0.00110499553277753 |
| GO:0019319 | hexose biosynthetic process | 0.00115464189012677 |
| GO:0016597 | amino acid binding | 0.00115867613846538 |
| GO:0019627 | urea metabolic process | 0.00115867613846538 |
| GO:0043603 | amide metabolic process | 0.00115867613846538 |
| GO:0046890 | regulation of lipid biosynthetic process | 0.00115867613846538 |
| GO:0000050 | urea cycle | 0.00115867613846538 |
| GO:0042157 | lipoprotein metabolic process | 0.00115867613846538 |
| GO:0046364 | monosaccharide biosynthetic process | 0.00127364496620368 |
| GO:0046165 | alcohol biosynthetic process | 0.00127364496620368 |
| GO:0044271 | nitrogen compound biosynthetic process | 0.00139480765902331 |
| GO:0016746 | transferase activity, transferring acyl groups | 0.00154008343090746 |
| GO:0004421 | hydroxymethylglutaryl-CoA synthase activity | 0.00155616780073467 |
| GO:0003803 | coagulation factor IXa activity | 0.00155616780073467 |
| GO:0042304 | regulation of fatty acid biosynthetic process | 0.00155616780073467 |
| GO:0047150 | betaine-homocysteine S-methyltransferase activity | 0.00155616780073467 |
| GO:0018675 | (S)-limonene 6-monooxygenase activity | 0.00155616780073467 |
| GO:0003973 | (S)-2-hydroxy-acid oxidase activity | 0.00155616780073467 |
| GO:0050051 | leukotriene-B4 20-monooxygenase activity | 0.00155616780073467 |
| GO:0018676 | (S)-limonene 7-monooxygenase activity | 0.00155616780073467 |
| GO:0004184 | lysine carboxypeptidase activity | 0.00155616780073467 |
| GO:0033767 | 4-hydroxyacetophenone monooxygenase activity | 0.00155616780073467 |
| GO:0019113 | limonene monooxygenase activity | 0.00155616780073467 |
| GO:0016899 | oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor | 0.00155616780073467 |
| GO:0050746 | regulation of lipoprotein metabolic process | 0.00155616780073467 |
| GO:0003805 | coagulation factor XIa activity | 0.00155616780073467 |
| GO:0008028 | monocarboxylic acid transmembrane transporter activity | 0.00157463167411263 |
| GO:0006707 | cholesterol catabolic process | 0.00157463167411263 |
| GO:0019841 | retinol binding | 0.00157463167411263 |
| GO:0000038 | very-long-chain fatty acid metabolic process | 0.00157463167411263 |
| GO:0016127 | sterol catabolic process | 0.00157463167411263 |
| GO:0022804 | active transmembrane transporter activity | 0.00193849352902109 |
| GO:0050801 | ion homeostasis | 0.00204165084669448 |
| GO:0006544 | glycine metabolic process | 0.00211380021611858 |
| GO:0008289 | lipid binding | 0.00217683701170046 |
| GO:0004467 | long-chain-fatty-acid-CoA ligase activity | 0.00217974810146014 |
| GO:0015645 | fatty-acid ligase activity | 0.00217974810146014 |
| GO:0007586 | digestion | 0.00223227232749238 |
| GO:0008233 | peptidase activity | 0.002236454970084 |
| GO:0031226 | intrinsic to plasma membrane | 0.00226675085817577 |
| GO:0044272 | sulfur compound biosynthetic process | 0.00256112390836602 |
| GO:0014070 | response to organic cyclic substance | 0.00289545510092709 |
| GO:0009749 | response to glucose stimulus | 0.00289545510092709 |
| GO:0009746 | response to hexose stimulus | 0.00289545510092709 |
| GO:0042802 | identical protein binding | 0.00301361664028603 |
| GO:0006700 | C21-steroid hormone biosynthetic process | 0.00377047450712277 |
| GO:0004033 | aldo-keto reductase activity | 0.00377047450712277 |
| GO:0001775 | cell activation | 0.00385188185844666 |
| GO:0008415 | acyltransferase activity | 0.00385188185844666 |
| GO:0008194 | UDP-glycosyltransferase activity | 0.00385188185844666 |
| GO:0006022 | aminoglycan metabolic process | 0.00385188185844666 |
| GO:0005887 | integral to plasma membrane | 0.00385188185844666 |
| GO:0052185 | modification of structure of other organism during symbiotic interaction | 0.00385188185844666 |
| GO:0052331 | hemolysis by organism of red blood cells in other organism during symbiotic interaction | 0.00385188185844666 |
| GO:0051801 | cytolysis of cells in other organism during symbiotic interaction | 0.00385188185844666 |
| GO:0008898 | homocysteine S-methyltransferase activity | 0.00385188185844666 |
| GO:0044004 | disruption by symbiont of host cells | 0.00385188185844666 |
| GO:0051817 | modification of morphology or physiology of other organism during symbiotic interaction | 0.00385188185844666 |
| GO:0019836 | hemolysis by symbiont of host red blood cells | 0.00385188185844666 |
| GO:0031640 | killing of cells of another organism | 0.00385188185844666 |
| GO:0051818 | disruption of cells of other organism during symbiotic interaction | 0.00385188185844666 |
| GO:0051715 | cytolysis of cells of another organism | 0.00385188185844666 |
| GO:0050994 | regulation of lipid catabolic process | 0.00385188185844666 |
| GO:0051883 | killing of cells in other organism during symbiotic interaction | 0.00385188185844666 |
| GO:0001907 | killing by symbiont of host cells | 0.00385188185844666 |
| GO:0001897 | cytolysis by symbiont of host cells | 0.00385188185844666 |
| GO:0052025 | modification by symbiont of host cell membrane | 0.00385188185844666 |
| GO:0017114 | wide-spectrum protease inhibitor activity | 0.00385188185844666 |
| GO:0052043 | modification by symbiont of host cellular component | 0.00385188185844666 |
| GO:0052188 | modification of cellular component in other organism during symbiotic interaction | 0.00385188185844666 |
| GO:0004873 | asialoglycoprotein receptor activity | 0.00385188185844666 |
| GO:0047961 | glycine N-acyltransferase activity | 0.00385188185844666 |
| GO:0046487 | glyoxylate metabolic process | 0.00385188185844666 |
| GO:0008453 | alanine-glyoxylate transaminase activity | 0.00385188185844666 |
| GO:0004505 | phenylalanine 4-monooxygenase activity | 0.00385188185844666 |
| GO:0052332 | modification by organism of cell membrane in other organism during symbiotic interaction | 0.00385188185844666 |
| GO:0052111 | modification by symbiont of host structure | 0.00385188185844666 |
| GO:0003865 | 3-oxo-5-alpha-steroid 4-dehydrogenase activity | 0.00385188185844666 |
| GO:0044003 | modification by symbiont of host morphology or physiology | 0.00385188185844666 |
| GO:0016747 | transferase activity, transferring groups other than amino-acyl groups | 0.00387405123170162 |
| GO:0009055 | electron carrier activity | 0.0041255849640261 |
| GO:0016787 | hydrolase activity | 0.00427947152530946 |
| GO:0016812 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides | 0.00431812202802879 |
| GO:0016645 | oxidoreductase activity, acting on the CH-NH group of donors | 0.00437514394771159 |
| GO:0065007 | biological regulation | 0.00468671932475504 |
| GO:0005829 | cytosol | 0.00535876692765962 |
| GO:0031668 | cellular response to extracellular stimulus | 0.00537665079324758 |
| GO:0031420 | alkali metal ion binding | 0.00544369463356022 |
| GO:0050660 | FAD binding | 0.00565711897195948 |
| GO:0015294 | solute:cation symporter activity | 0.00565711897195948 |
| GO:0016229 | steroid dehydrogenase activity | 0.0056706278630406 |
| GO:0046394 | carboxylic acid biosynthetic process | 0.0056706278630406 |
| GO:0016053 | organic acid biosynthetic process | 0.0056706278630406 |
| GO:0006790 | sulfur metabolic process | 0.00679542311924936 |
| GO:0003006 | reproductive developmental process | 0.00714859696680285 |
| GO:0050327 | testosterone 17-beta-dehydrogenase activity | 0.00714859696680285 |
| GO:0004060 | arylamine N-acetyltransferase activity | 0.00714859696680285 |
| GO:0015851 | nucleobase transport | 0.00714859696680285 |
| GO:0001561 | fatty acid alpha-oxidation | 0.00714859696680285 |
| GO:0004024 | alcohol dehydrogenase activity, zinc-dependent | 0.00714859696680285 |
| GO:0015370 | solute:sodium symporter activity | 0.00750830278361621 |
| GO:0015711 | organic anion transport | 0.00769302745255712 |
| GO:0043648 | dicarboxylic acid metabolic process | 0.00769302745255712 |
| GO:0033554 | cellular response to stress | 0.00769302745255712 |
| GO:0016741 | transferase activity, transferring one-carbon groups | 0.00825927553517739 |
| GO:0019840 | isoprenoid binding | 0.00914620570898684 |
| GO:0055088 | lipid homeostasis | 0.00914620570898684 |
| GO:0005501 | retinoid binding | 0.00914620570898684 |
| GO:0016740 | transferase activity | 0.00924771767267179 |
| GO:0019725 | cellular homeostasis | 0.010088901934086 |
| GO:0019866 | organelle inner membrane | 0.0104194350259674 |
| GO:0032502 | developmental process | 0.0105937804667987 |
| GO:0006732 | coenzyme metabolic process | 0.0106873700357516 |
| GO:0009743 | response to carbohydrate stimulus | 0.0106873700357516 |
| GO:0051704 | multi-organism process | 0.0108358239112089 |
| GO:0046483 | heterocycle metabolic process | 0.0110109844294669 |
| GO:0008035 | high-density lipoprotein binding | 0.0110109844294669 |
| GO:0006069 | ethanol oxidation | 0.0110109844294669 |
| GO:0015791 | polyol transport | 0.0110109844294669 |
| GO:0047760 | butyrate-CoA ligase activity | 0.0110109844294669 |
| GO:0042447 | hormone catabolic process | 0.0110109844294669 |
| GO:0006067 | ethanol metabolic process | 0.0110109844294669 |
| GO:0015205 | nucleobase transmembrane transporter activity | 0.0110109844294669 |
| GO:0015721 | bile acid and bile salt transport | 0.0110109844294669 |
| GO:0009791 | post-embryonic development | 0.0110109844294669 |
| GO:0031966 | mitochondrial membrane | 0.011046022211184 |
| GO:0048519 | negative regulation of biological process | 0.0110808961142457 |
| GO:0046930 | pore complex | 0.0115113997865549 |
| GO:0044249 | cellular biosynthetic process | 0.0116725431589124 |
| GO:0007610 | behavior | 0.0119671692634442 |
| GO:0016878 | acid-thiol ligase activity | 0.0119671692634442 |
| GO:0051017 | actin filament bundle formation | 0.0119671692634442 |
| GO:0046942 | carboxylic acid transport | 0.0119685975047429 |
| GO:0015849 | organic acid transport | 0.0125055152749967 |
| GO:0043233 | organelle lumen | 0.0125055152749967 |
| GO:0031974 | membrane-enclosed lumen | 0.0125055152749967 |
| GO:0051186 | cofactor metabolic process | 0.0130499770963131 |
| GO:0006814 | sodium ion transport | 0.0132969687383957 |
| GO:0009065 | glutamine family amino acid catabolic process | 0.0136174003410588 |
| GO:0000097 | sulfur amino acid biosynthetic process | 0.0136174003410588 |
| GO:0009071 | serine family amino acid catabolic process | 0.0136174003410588 |
| GO:0010035 | response to inorganic substance | 0.0137936656652863 |
| GO:0009889 | regulation of biosynthetic process | 0.0148622993721536 |
| GO:0030492 | hemoglobin binding | 0.0153737502456752 |
| GO:0033344 | cholesterol efflux | 0.0153737502456752 |
| GO:0006729 | tetrahydrobiopterin biosynthetic process | 0.0153737502456752 |
| GO:0004064 | arylesterase activity | 0.0153737502456752 |
| GO:0046689 | response to mercury ion | 0.0153737502456752 |
| GO:0045833 | negative regulation of lipid metabolic process | 0.0153737502456752 |
| GO:0001664 | G-protein-coupled receptor binding | 0.0154664408929112 |
| GO:0043176 | amine binding | 0.0160165740780478 |
| GO:0019438 | aromatic compound biosynthetic process | 0.0173663435415872 |
| GO:0043434 | response to peptide hormone stimulus | 0.0173663435415872 |
| GO:0051701 | interaction with host | 0.0173663435415872 |
| GO:0042558 | pteridine and derivative metabolic process | 0.0173663435415872 |
| GO:0030139 | endocytic vesicle | 0.0173663435415872 |
| GO:0005743 | mitochondrial inner membrane | 0.0181264478364733 |
| GO:0008168 | methyltransferase activity | 0.0195408687331036 |
| GO:0016810 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | 0.0196844575282337 |
| GO:0009719 | response to endogenous stimulus | 0.0204526339003621 |
| GO:0046460 | neutral lipid biosynthetic process | 0.0204526339003621 |
| GO:0046463 | acylglycerol biosynthetic process | 0.0204526339003621 |
| GO:0006527 | arginine catabolic process | 0.0204526339003621 |
| GO:0016847 | 1-aminocyclopropane-1-carboxylate synthase activity | 0.0204526339003621 |
| GO:0030104 | water homeostasis | 0.0204526339003621 |
| GO:0005740 | mitochondrial envelope | 0.0206964467512272 |
| GO:0006081 | aldehyde metabolic process | 0.0214748897627408 |
| GO:0006563 | L-serine metabolic process | 0.0214748897627408 |
| GO:0051716 | cellular response to stimulus | 0.0214748897627408 |
| GO:0048522 | positive regulation of cellular process | 0.0217942245347053 |
| GO:0030203 | glycosaminoglycan metabolic process | 0.0223916209493672 |
| GO:0016052 | carbohydrate catabolic process | 0.0227301546276792 |
| GO:0006695 | cholesterol biosynthetic process | 0.0236028857382074 |
| GO:0009894 | regulation of catabolic process | 0.0236028857382074 |
| GO:0006525 | arginine metabolic process | 0.0236028857382074 |
| GO:0015932 | nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity | 0.0236028857382074 |
| GO:0009893 | positive regulation of metabolic process | 0.0240843690574914 |
| GO:0007548 | sex differentiation | 0.0241595281090729 |
| GO:0006874 | cellular calcium ion homeostasis | 0.0242748392575163 |
| GO:0055074 | calcium ion homeostasis | 0.0242748392575163 |
| GO:0003707 | steroid hormone receptor activity | 0.0248527113777574 |
| GO:0016725 | oxidoreductase activity, acting on CH or CH2 groups | 0.0248527113777574 |
| GO:0019217 | regulation of fatty acid metabolic process | 0.0248527113777574 |
| GO:0001990 | regulation of systemic arterial blood pressure by hormone | 0.0248527113777574 |
| GO:0004029 | aldehyde dehydrogenase (NAD) activity | 0.0248527113777574 |
| GO:0030299 | cholesterol absorption | 0.0248527113777574 |
| GO:0008508 | bile acid:sodium symporter activity | 0.0248527113777574 |
| GO:0044241 | lipid digestion | 0.0248527113777574 |
| GO:0046504 | glycerol ether biosynthetic process | 0.0248527113777574 |
| GO:0009267 | cellular response to starvation | 0.0248527113777574 |
| GO:0018987 | osmoregulation | 0.0248527113777574 |
| GO:0045017 | glycerolipid biosynthetic process | 0.0248527113777574 |
| GO:0050886 | endocrine process | 0.0248527113777574 |
| GO:0043410 | positive regulation of MAPKKK cascade | 0.0248527113777574 |
| GO:0016290 | palmitoyl-CoA hydrolase activity | 0.0248527113777574 |
| GO:0042562 | hormone binding | 0.0251867402540229 |
| GO:0016289 | CoA hydrolase activity | 0.0251867402540229 |
| GO:0031326 | regulation of cellular biosynthetic process | 0.0265010652148149 |
| GO:0042803 | protein homodimerization activity | 0.0266000773717546 |
| GO:0050662 | coenzyme binding | 0.0272281140899592 |
| GO:0032934 | sterol binding | 0.0276924240494068 |
| GO:0008757 | S-adenosylmethionine-dependent methyltransferase activity | 0.0293698526216566 |
| GO:0006875 | cellular metal ion homeostasis | 0.03033007216533 |
| GO:0055065 | metal ion homeostasis | 0.03033007216533 |
| GO:0006518 | peptide metabolic process | 0.0303836074048902 |
| GO:0003014 | renal system process | 0.0304053418877035 |
| GO:0008172 | S-methyltransferase activity | 0.0304053418877035 |
| GO:0009895 | negative regulation of catabolic process | 0.0304053418877035 |
| GO:0030539 | male genitalia development | 0.0304053418877035 |
| GO:0019203 | carbohydrate phosphatase activity | 0.0304053418877035 |
| GO:0001568 | blood vessel development | 0.0314412046736382 |
| GO:0016831 | carboxy-lyase activity | 0.0323579114325519 |
| GO:0019395 | fatty acid oxidation | 0.0327621488490262 |
| GO:0000096 | sulfur amino acid metabolic process | 0.0327621488490262 |
| GO:0016410 | N-acyltransferase activity | 0.0327621488490262 |
| GO:0001944 | vasculature development | 0.0331084644372902 |
| GO:0001501 | skeletal development | 0.0335441347335389 |
| GO:0009306 | protein secretion | 0.0340115766977762 |
| GO:0006575 | amino acid derivative metabolic process | 0.0340366156360086 |
| GO:0015758 | glucose transport | 0.0356180483039547 |
| GO:0004745 | retinol dehydrogenase activity | 0.0361745959887185 |
| GO:0050892 | intestinal absorption | 0.0361745959887185 |
| GO:0031669 | cellular response to nutrient levels | 0.0361745959887185 |
| GO:0045834 | positive regulation of lipid metabolic process | 0.0361745959887185 |
| GO:0001658 | ureteric bud branching | 0.0361745959887185 |
| GO:0016714 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen | 0.0361745959887185 |
| GO:0019966 | interleukin-1 binding | 0.0361745959887185 |
| GO:0008514 | organic anion transmembrane transporter activity | 0.0361745959887185 |
| GO:0022414 | reproductive process | 0.0365787365144266 |
| GO:0045137 | development of primary sexual characteristics | 0.0395570765063278 |
| GO:0046914 | transition metal ion binding | 0.0409295142688045 |
| GO:0015749 | monosaccharide transport | 0.0410470439772311 |
| GO:0000051 | urea cycle intermediate metabolic process | 0.0410470439772311 |
| GO:0044403 | symbiosis, encompassing mutualism through parasitism | 0.0410470439772311 |
| GO:0044419 | interspecies interaction between organisms | 0.0410470439772311 |
| GO:0008645 | hexose transport | 0.0410470439772311 |
| GO:0031967 | organelle envelope | 0.0423458302786006 |
| GO:0051591 | response to cAMP | 0.0423458302786006 |
| GO:0050701 | interleukin-1 secretion | 0.0423458302786006 |
| GO:0009070 | serine family amino acid biosynthetic process | 0.0423458302786006 |
| GO:0004499 | flavin-containing monooxygenase activity | 0.0423458302786006 |
| GO:0016782 | transferase activity, transferring sulfur-containing groups | 0.043106001257402 |
| GO:0031975 | envelope | 0.043672611916759 |
| GO:0003995 | acyl-CoA dehydrogenase activity | 0.0438348871255134 |
| GO:0016126 | sterol biosynthetic process | 0.0438348871255134 |
| GO:0031325 | positive regulation of cellular metabolic process | 0.0441051265572853 |
| GO:0046983 | protein dimerization activity | 0.0448679643072332 |
| GO:0042493 | response to drug | 0.045025535447317 |
| GO:0005788 | endoplasmic reticulum lumen | 0.0454925728308762 |
| GO:0007626 | locomotory behavior | 0.0454925728308762 |
| GO:0004047 | aminomethyltransferase activity | 0.0454925728308762 |
| GO:0042403 | thyroid hormone metabolic process | 0.0454925728308762 |
| GO:0048806 | genitalia development | 0.0454925728308762 |
| GO:0016918 | retinal binding | 0.0454925728308762 |
| GO:0019958 | C-X-C chemokine binding | 0.0454925728308762 |
| GO:0016408 | C-acyltransferase activity | 0.0454925728308762 |
| GO:0003044 | regulation of systemic arterial blood pressure mediated by a chemical signal | 0.0454925728308762 |
| GO:0008219 | cell death | 0.0454925728308762 |
| GO:0016265 | death | 0.0454925728308762 |
| GO:0016835 | carbon-oxygen lyase activity | 0.0454925728308762 |
| GO:0010038 | response to metal ion | 0.0454925728308762 |
| GO:0043025 | cell soma | 0.0454925728308762 |
| GO:0008374 | O-acyltransferase activity | 0.0454925728308762 |
| GO:0044275 | cellular carbohydrate catabolic process | 0.0454925728308762 |
| GO:0008283 | cell proliferation | 0.0454925728308762 |
| GO:0031589 | cell-substrate adhesion | 0.0454925728308762 |
| GO:0001822 | kidney development | 0.0454925728308762 |
| GO:0016247 | channel regulator activity | 0.0454925728308762 |
| GO:0006935 | chemotaxis | 0.0454925728308762 |
| GO:0042330 | taxis | 0.0454925728308762 |
| GO:0051248 | negative regulation of protein metabolic process | 0.0454925728308762 |
| GO:0021782 | glial cell development | 0.0454925728308762 |
| GO:0016634 | oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor | 0.0454925728308762 |
| GO:0042594 | response to starvation | 0.0454925728308762 |
| GO:0009086 | methionine biosynthetic process | 0.0454925728308762 |
| GO:0005794 | Golgi apparatus | 0.0454925728308762 |
| GO:0048589 | developmental growth | 0.0454925728308762 |
| GO:0019722 | calcium-mediated signaling | 0.0454925728308762 |
| GO:0017187 | peptidyl-glutamic acid carboxylation | 0.0454925728308762 |
| GO:0018126 | protein amino acid hydroxylation | 0.0454925728308762 |
| GO:0003874 | 6-pyruvoyltetrahydropterin synthase activity | 0.0454925728308762 |
| GO:0006571 | tyrosine biosynthetic process | 0.0454925728308762 |
| GO:0048143 | astrocyte activation | 0.0454925728308762 |
| GO:0046417 | chorismate metabolic process | 0.0454925728308762 |
| GO:0050667 | homocysteine metabolic process | 0.0454925728308762 |
| GO:0004454 | ketohexokinase activity | 0.0454925728308762 |
| GO:0015886 | heme transport | 0.0454925728308762 |
| GO:0047787 | delta4-3-oxosteroid 5beta-reductase activity | 0.0454925728308762 |
| GO:0047017 | prostaglandin-F synthase activity | 0.0454925728308762 |
| GO:0004833 | tryptophan 2,3-dioxygenase activity | 0.0454925728308762 |
| GO:0004736 | pyruvate carboxylase activity | 0.0454925728308762 |
| GO:0009095 | aromatic amino acid family biosynthetic process, prephenate pathway | 0.0454925728308762 |
| GO:0043265 | ectoplasm | 0.0454925728308762 |
| GO:0004276 | furin activity | 0.0454925728308762 |
| GO:0008397 | sterol 12-alpha-hydroxylase activity | 0.0454925728308762 |
| GO:0003818 | complement factor I activity | 0.0454925728308762 |
| GO:0045922 | negative regulation of fatty acid metabolic process | 0.0454925728308762 |
| GO:0005350 | pyrimidine transmembrane transporter activity | 0.0454925728308762 |
| GO:0003802 | coagulation factor VIIa activity | 0.0454925728308762 |
| GO:0019531 | oxalate transmembrane transporter activity | 0.0454925728308762 |
| GO:0033778 | 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity | 0.0454925728308762 |
| GO:0008387 | steroid 7-alpha-hydroxylase activity | 0.0454925728308762 |
| GO:0047743 | chlordecone reductase activity | 0.0454925728308762 |
| GO:0006113 | fermentation | 0.0454925728308762 |
| GO:0015855 | pyrimidine transport | 0.0454925728308762 |
| GO:0047936 | glucose 1-dehydrogenase activity | 0.0454925728308762 |
| GO:0004621 | glycosylphosphatidylinositol phospholipase D activity | 0.0454925728308762 |
| GO:0045717 | negative regulation of fatty acid biosynthetic process | 0.0454925728308762 |
| GO:0046622 | positive regulation of organ growth | 0.0454925728308762 |
| GO:0004608 | phosphatidylethanolamine N-methyltransferase activity | 0.0454925728308762 |
| GO:0019265 | glycine biosynthetic process, by transamination of glyoxylate | 0.0454925728308762 |
| GO:0016034 | maleylacetoacetate isomerase activity | 0.0454925728308762 |
| GO:0046605 | regulation of centrosome cycle | 0.0454925728308762 |
| GO:0032145 | succinate-semialdehyde dehydrogenase binding | 0.0454925728308762 |
| GO:0008123 | cholesterol 7-alpha-monooxygenase activity | 0.0454925728308762 |
| GO:0006642 | triacylglycerol mobilization | 0.0454925728308762 |
| GO:0046904 | calcium oxalate binding | 0.0454925728308762 |
| GO:0008812 | choline dehydrogenase activity | 0.0454925728308762 |
| GO:0008488 | gamma-glutamyl carboxylase activity | 0.0454925728308762 |
| GO:0051659 | maintenance of mitochondrion localization | 0.0454925728308762 |
| GO:0004585 | ornithine carbamoyltransferase activity | 0.0454925728308762 |
| GO:0032804 | negative regulation of low-density lipoprotein receptor catabolic process | 0.0454925728308762 |
| GO:0003806 | coagulation factor XIIa activity | 0.0454925728308762 |
| GO:0047747 | cholate-CoA ligase activity | 0.0454925728308762 |
| GO:0008464 | gamma-glutamyl hydrolase activity | 0.0454925728308762 |
| GO:0001891 | phagocytic cup | 0.0454925728308762 |
| GO:0015682 | ferric iron transport | 0.0454925728308762 |
| GO:0006711 | estrogen catabolic process | 0.0454925728308762 |
| GO:0031701 | angiotensin receptor binding | 0.0454925728308762 |
| GO:0043126 | regulation of 1-phosphatidylinositol 4-kinase activity | 0.0454925728308762 |
| GO:0015288 | porin activity | 0.0454925728308762 |
| GO:0042360 | vitamin E metabolic process | 0.0454925728308762 |
| GO:0060019 | radial glial cell differentiation | 0.0454925728308762 |
| GO:0046606 | negative regulation of centrosome cycle | 0.0454925728308762 |
| GO:0004782 | sulfinoalanine decarboxylase activity | 0.0454925728308762 |
| GO:0046874 | quinolinate metabolic process | 0.0454925728308762 |
| GO:0046639 | negative regulation of alpha-beta T cell differentiation | 0.0454925728308762 |
| GO:0030569 | chymotrypsin inhibitor activity | 0.0454925728308762 |
| GO:0007228 | activation of hh target transcription factor | 0.0454925728308762 |
| GO:0030409 | glutamate formimidoyltransferase activity | 0.0454925728308762 |
| GO:0008112 | nicotinamide N-methyltransferase activity | 0.0454925728308762 |
| GO:0033782 | 24-hydroxycholesterol 7alpha-hydroxylase activity | 0.0454925728308762 |
| GO:0010037 | response to carbon dioxide | 0.0454925728308762 |
| GO:0032810 | sterol response element binding | 0.0454925728308762 |
| GO:0045581 | negative regulation of T cell differentiation | 0.0454925728308762 |
| GO:0033780 | taurochenodeoxycholate 6alpha-hydroxylase activity | 0.0454925728308762 |
| GO:0046173 | polyol biosynthetic process | 0.0454925728308762 |
| GO:0047305 | (R)-3-amino-2-methylpropionate-pyruvate transaminase activity | 0.0454925728308762 |
| GO:0050748 | negative regulation of lipoprotein metabolic process | 0.0454925728308762 |
| GO:0003807 | plasma kallikrein activity | 0.0454925728308762 |
| GO:0031335 | regulation of sulfur amino acid metabolic process | 0.0454925728308762 |
| GO:0007227 | signal transduction downstream of smoothened | 0.0454925728308762 |
| GO:0017174 | glycine N-methyltransferase activity | 0.0454925728308762 |
| GO:0042756 | drinking behavior | 0.0454925728308762 |
| GO:0008987 | quinolinate synthetase A activity | 0.0454925728308762 |
| GO:0000334 | 3-hydroxyanthranilate 3,4-dioxygenase activity | 0.0454925728308762 |
| GO:0047963 | glycine N-choloyltransferase activity | 0.0454925728308762 |
| GO:0009073 | aromatic amino acid family biosynthetic process | 0.0454925728308762 |
| GO:0042631 | cellular response to water deprivation | 0.0454925728308762 |
| GO:0003804 | coagulation factor Xa activity | 0.0454925728308762 |
| GO:0046600 | negative regulation of centriole replication | 0.0454925728308762 |
| GO:0031702 | type 1 angiotensin receptor binding | 0.0454925728308762 |
| GO:0008115 | sarcosine oxidase activity | 0.0454925728308762 |
| GO:0009853 | photorespiration | 0.0454925728308762 |
| GO:0006565 | L-serine catabolic process | 0.0454925728308762 |
| GO:0008887 | glycerate kinase activity | 0.0454925728308762 |
| GO:0002019 | angiotensin mediated regulation of renal output | 0.0454925728308762 |
| GO:0030567 | prothrombin activator activity | 0.0454925728308762 |
| GO:0003808 | protein C (activated) activity | 0.0454925728308762 |
| GO:0004760 | serine-pyruvate transaminase activity | 0.0454925728308762 |
| GO:0047536 | 2-aminoadipate transaminase activity | 0.0454925728308762 |
| GO:0009348 | ornithine carbamoyltransferase complex | 0.0454925728308762 |
| GO:0003941 | L-serine ammonia-lyase activity | 0.0454925728308762 |
| GO:0046599 | regulation of centriole replication | 0.0454925728308762 |
| GO:0046415 | urate metabolic process | 0.0454925728308762 |
| GO:0050591 | quinine 3-monooxygenase activity | 0.0454925728308762 |
| GO:0008389 | coumarin 7-hydroxylase activity | 0.0454925728308762 |
| GO:0003812 | alternative-complement-pathway C3/C5 convertase activity | 0.0454925728308762 |
| GO:0004346 | glucose-6-phosphatase activity | 0.0454925728308762 |
| GO:0004397 | histidine ammonia-lyase activity | 0.0454925728308762 |
| GO:0046724 | oxalic acid secretion | 0.0454925728308762 |
| GO:0042583 | chromaffin granule | 0.0454925728308762 |
| GO:0009414 | response to water deprivation | 0.0454925728308762 |
| GO:0042866 | pyruvate biosynthetic process | 0.0454925728308762 |
| GO:0009415 | response to water | 0.0454925728308762 |
| GO:0009854 | oxidative photosynthetic carbon pathway | 0.0454925728308762 |
| GO:0001760 | aminocarboxymuconate-semialdehyde decarboxylase activity | 0.0454925728308762 |
| GO:0050666 | regulation of homocysteine metabolic process | 0.0454925728308762 |
| GO:0004092 | carnitine O-acetyltransferase activity | 0.0454925728308762 |
| GO:0050038 | L-xylulose reductase activity | 0.0454925728308762 |
| GO:0018200 | peptidyl-glutamic acid modification | 0.0454925728308762 |
| GO:0047298 | (S)-3-amino-2-methylpropionate transaminase activity | 0.0454925728308762 |
| GO:0016942 | insulin-like growth factor binding protein complex | 0.0454925728308762 |
| GO:0050031 | L-pipecolate oxidase activity | 0.0454925728308762 |
| GO:0043691 | reverse cholesterol transport | 0.0454925728308762 |
| GO:0015091 | ferric iron transmembrane transporter activity | 0.0454925728308762 |
| GO:0015760 | glucose-6-phosphate transport | 0.0454925728308762 |
| GO:0004903 | growth hormone receptor activity | 0.0454925728308762 |
| GO:0050480 | imidazolonepropionase activity | 0.0454925728308762 |
| GO:0042567 | insulin-like growth factor ternary complex | 0.0454925728308762 |
| GO:0046813 | virion attachment, binding of host cell surface receptor | 0.0454925728308762 |
| GO:0004494 | methylmalonyl-CoA mutase activity | 0.0454925728308762 |
| GO:0001998 | angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure | 0.0454925728308762 |
| GO:0043540 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex | 0.0454925728308762 |
| GO:0002018 | renin-angiotensin regulation of aldosterone production | 0.0454925728308762 |
| GO:0030412 | formimidoyltetrahydrofolate cyclodeaminase activity | 0.0454925728308762 |
| GO:0030568 | plasmin inhibitor activity | 0.0454925728308762 |
| GO:0000053 | argininosuccinate metabolic process | 0.0454925728308762 |
| GO:0006114 | glycerol biosynthetic process | 0.0454925728308762 |
| GO:0015432 | bile acid-exporting ATPase activity | 0.0454925728308762 |
| GO:0019532 | oxalate transport | 0.0454925728308762 |
| GO:0031643 | positive regulation of myelination | 0.0454925728308762 |
| GO:0030407 | formimidoyltransferase activity | 0.0454925728308762 |
| GO:0004508 | steroid 17-alpha-monooxygenase activity | 0.0454925728308762 |
| GO:0018214 | protein amino acid carboxylation | 0.0454925728308762 |
| GO:0003842 | 1-pyrroline-5-carboxylate dehydrogenase activity | 0.0454925728308762 |
| GO:0043128 | positive regulation of 1-phosphatidylinositol 4-kinase activity | 0.0454925728308762 |
| GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process | 0.0454925728308762 |
| GO:0033791 | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity | 0.0454925728308762 |
| GO:0031703 | type 2 angiotensin receptor binding | 0.0454925728308762 |
| GO:0050996 | positive regulation of lipid catabolic process | 0.0454925728308762 |
| GO:0001887 | selenium metabolic process | 0.0454925728308762 |
| GO:0060155 | platelet dense granule organization and biogenesis | 0.0454925728308762 |
| GO:0017129 | triglyceride binding | 0.0454925728308762 |
| GO:0046327 | glycerol biosynthetic process from pyruvate | 0.0454925728308762 |
| GO:0019343 | cysteine biosynthetic process via cystathionine | 0.0454925728308762 |
| GO:0008554 | sodium-exporting ATPase activity, phosphorylative mechanism | 0.0454925728308762 |
| GO:0003813 | classical-complement-pathway C3/C5 convertase activity | 0.0454925728308762 |
| GO:0060020 | Bergmann glial cell differentiation | 0.0454925728308762 |
| GO:0016784 | 3-mercaptopyruvate sulfurtransferase activity | 0.0454925728308762 |
| GO:0051657 | maintenance of organelle localization | 0.0454925728308762 |
| GO:0045723 | positive regulation of fatty acid biosynthetic process | 0.0454925728308762 |
| GO:0003837 | beta-ureidopropionase activity | 0.0454925728308762 |
| GO:0003867 | 4-aminobutyrate transaminase activity | 0.0454925728308762 |
| GO:0047704 | bile-salt sulfotransferase activity | 0.0454925728308762 |
| GO:0009917 | sterol 5-alpha reductase activity | 0.0454925728308762 |
| GO:0001999 | renal response to blood flow during renin-angiotensin regulation of systemic arterial blood pressure | 0.0454925728308762 |
| GO:0004122 | cystathionine beta-synthase activity | 0.0454925728308762 |
| GO:0046636 | negative regulation of alpha-beta T cell activation | 0.0454925728308762 |
| GO:0032144 | 4-aminobutyrate transaminase complex | 0.0454925728308762 |
| GO:0005343 | organic acid:sodium symporter activity | 0.0463448754895659 |
| GO:0009891 | positive regulation of biosynthetic process | 0.0465221574505867 |
| GO:0015718 | monocarboxylic acid transport | 0.0482450908687858 |
| GO:0050821 | protein stabilization | 0.0482450908687858 |
| GO:0048659 | smooth muscle cell proliferation | 0.0482450908687858 |
| GO:0006939 | smooth muscle contraction | 0.0492397442742219 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| metabolising cell | 9.50e-54 | 12 |
| endopolyploid cell | 9.50e-54 | 12 |
| parenchymal cell | 9.50e-54 | 12 |
| polyploid cell | 9.50e-54 | 12 |
| hepatocyte | 9.50e-54 | 12 |
| endodermal cell | 4.21e-11 | 58 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 0 |
| MA0004.1 | 0.238226 |
| MA0006.1 | 8.58251e-15 |
| MA0007.1 | 0.718717 |
| MA0009.1 | 0.00131593 |
| MA0014.1 | 0 |
| MA0017.1 | 57.6834 |
| MA0019.1 | 0.382276 |
| MA0024.1 | 5.937e-05 |
| MA0025.1 | 1.7711 |
| MA0027.1 | 0.224555 |
| MA0028.1 | 0 |
| MA0029.1 | 2.73212 |
| MA0030.1 | 2.9574 |
| MA0031.1 | 3.70384 |
| MA0038.1 | 0.444161 |
| MA0040.1 | 1.02152 |
| MA0041.1 | 3.03189 |
| MA0042.1 | 1.51481 |
| MA0043.1 | 0.429595 |
| MA0046.1 | 57.134 |
| MA0048.1 | 1.60259e-08 |
| MA0050.1 | 0.00219024 |
| MA0051.1 | 0.0939876 |
| MA0052.1 | 0.205172 |
| MA0055.1 | 3.75441e-09 |
| MA0056.1 | 0 |
| MA0057.1 | 0 |
| MA0058.1 | 0.20933 |
| MA0059.1 | 4.97234 |
| MA0060.1 | 6.36456e-15 |
| MA0061.1 | 4.5939e-09 |
| MA0063.1 | 0 |
| MA0066.1 | 1.65148 |
| MA0067.1 | 0.000974201 |
| MA0068.1 | 1.32782e-09 |
| MA0069.1 | 0.187713 |
| MA0070.1 | 4.23834 |
| MA0071.1 | 7.05804 |
| MA0072.1 | 5.04755 |
| MA0073.1 | 0 |
| MA0074.1 | 1.2388 |
| MA0076.1 | 0 |
| MA0077.1 | 0.307256 |
| MA0078.1 | 2.07046 |
| MA0081.1 | 9.5448e-05 |
| MA0083.1 | 0.0188365 |
| MA0084.1 | 0.394439 |
| MA0087.1 | 0.538123 |
| MA0088.1 | 4.3855e-10 |
| MA0089.1 | 0 |
| MA0090.1 | 0.985453 |
| MA0091.1 | 0.427858 |
| MA0092.1 | 2.33502 |
| MA0093.1 | 0.417348 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 8.23117e-05 |
| MA0101.1 | 1.32668e-08 |
| MA0103.1 | 3.03666 |
| MA0105.1 | 0 |
| MA0106.1 | 0.00464027 |
| MA0107.1 | 3.6185e-08 |
| MA0108.2 | 0.124452 |
| MA0109.1 | 0 |
| MA0111.1 | 0.287377 |
| MA0113.1 | 2.42888 |
| MA0114.1 | 68.9116 |
| MA0115.1 | 13.4521 |
| MA0116.1 | 0.246359 |
| MA0117.1 | 0.000580944 |
| MA0119.1 | 0.614269 |
| MA0122.1 | 0.674169 |
| MA0124.1 | 0.822854 |
| MA0125.1 | 1.51502 |
| MA0130.1 | 0 |
| MA0131.1 | 8.49151e-06 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 1.66249 |
| MA0136.1 | 0.000355263 |
| MA0139.1 | 4.38769e-15 |
| MA0140.1 | 1.36575 |
| MA0141.1 | 17.4489 |
| MA0142.1 | 4.23275 |
| MA0143.1 | 3.88965 |
| MA0144.1 | 7.15295 |
| MA0145.1 | 6.93776e-12 |
| MA0146.1 | 0 |
| MA0147.1 | 9.78564e-05 |
| MA0148.1 | 7.47138 |
| MA0149.1 | 1.35006e-14 |
| MA0062.2 | 0 |
| MA0035.2 | 4.72882 |
| MA0039.2 | 0 |
| MA0138.2 | 1.63857 |
| MA0002.2 | 1.63641 |
| MA0137.2 | 6.30014 |
| MA0104.2 | 7.0173e-11 |
| MA0047.2 | 9.89381 |
| MA0112.2 | 0.878527 |
| MA0065.2 | 19.6932 |
| MA0150.1 | 0.0222142 |
| MA0151.1 | 0 |
| MA0152.1 | 13.2637 |
| MA0153.1 | 32.4606 |
| MA0154.1 | 0.220558 |
| MA0155.1 | 9.96424e-09 |
| MA0156.1 | 0.0019667 |
| MA0157.1 | 1.92017 |
| MA0158.1 | 0 |
| MA0159.1 | 7.34625 |
| MA0160.1 | 7.94286 |
| MA0161.1 | 0 |
| MA0162.1 | 0 |
| MA0163.1 | 0 |
| MA0164.1 | 1.32807 |
| MA0080.2 | 9.82224e-06 |
| MA0018.2 | 0.000120037 |
| MA0099.2 | 8.24968e-06 |
| MA0079.2 | 0 |
| MA0102.2 | 0.692205 |
| MA0258.1 | 8.55023 |
| MA0259.1 | 1.0717e-09 |
| MA0442.1 | 0 |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)
| TF | #promoters | Enrichment | p-value | q-value |
|---|---|---|---|---|
| BHLHE40#8553 | 73 | 1.32778370041725 | 0.0102513946456425 | 0.0381555739628033 |
| EP300#2033 | 529 | 1.45253959188167 | 2.48143737604472e-19 | 5.97140179992477e-17 |
| ESRRA#2101 | 39 | 7.64887403782282 | 2.29322817811041e-22 | 6.5082189590672e-20 |
| FOSL2#2355 | 239 | 1.64017752107428 | 8.92314948515049e-14 | 1.40561811324228e-11 |
| FOXA1#3169 | 556 | 2.49747441453519 | 1.94036851629233e-91 | 2.73851550639263e-88 |
| FOXA2#3170 | 446 | 4.45285238495691 | 1.14899512740396e-156 | 3.33333061419284e-153 |
| HDAC2#3066 | 402 | 2.18608809692897 | 1.75827901840646e-49 | 1.28414617065281e-46 |
| HEY1#23462 | 713 | 1.16765268493489 | 1.2555036887204e-06 | 5.02774347186617e-05 |
| HNF4A#3172 | 519 | 4.86650129646249 | 1.51185157824557e-201 | 6.57901112418288e-198 |
| HNF4G#3174 | 460 | 5.36140022787415 | 7.66124817319994e-194 | 3.07743499215703e-190 |
| MAFF#23764 | 67 | 1.52944016409661 | 0.000550506596730863 | 0.00470109226949915 |
| MAFK#7975 | 115 | 1.26330940853281 | 0.00722596342077644 | 0.0299069665412725 |
| RXRA#6256 | 356 | 2.8968640865551 | 5.32660407469614e-72 | 5.98177637588377e-69 |
| SP1#6667 | 554 | 1.27965272942443 | 2.41718941811729e-10 | 2.47256459979189e-08 |
| TCF7L2#6934 | 308 | 1.34463493370341 | 7.82650460857267e-08 | 4.69226357528543e-06 |
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
