MCL coexpression mm9:57: Difference between revisions
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|coexpression_dpi_cluster_scores_median=0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.15255853577271,0.217642423519386,0.453198561547017,0.499789536222348,0.619594273244156,0.70019762069467,0.661546176698368,0.667860648773639,0.752560127453088,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0719044921483595,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0242538736058389,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | |coexpression_dpi_cluster_scores_median=0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.15255853577271,0.217642423519386,0.453198561547017,0.499789536222348,0.619594273244156,0.70019762069467,0.661546176698368,0.667860648773639,0.752560127453088,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0719044921483595,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0242538736058389,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0 | ||
|gostat_on_MCL_coexpression=GO:0005212;structural constituent of eye lens;4.11466020467449e-27;12965,12961,12960,12969,12964,12075,12959,17339,12962,12968,12958,12954,107993,12957!GO:0007423;sensory organ development;1.62980638952321e-15;12965,12961,12960,12969,12964,12959,17339,12962,12968,225998,12958,17116,12954,18508,12957!GO:0001654;eye development;3.95907961543224e-09;12968,12965,225998,17116,12969,12964,12954,17339,18508!GO:0007601;visual perception;1.45215011567418e-07;14686,225998,30044,12961,19661,17339,107993,20132!GO:0050953;sensory perception of light stimulus;1.45215011567418e-07;14686,225998,30044,12961,19661,17339,107993,20132!GO:0048856;anatomical structure development;1.49085116853024e-06;12965,12969,12964,232560,12959,12962,225998,12958,16873,21834,12957,12960,12961,17339,12968,12954,17116,319504,18508!GO:0043010;camera-type eye development;7.23467980032763e-06;12968,17116,12964,12954,17339,18508!GO:0048513;organ development;1.2006488370482e-05;12965,12969,12964,12959,12962,225998,12958,16873,21834,12957,12960,12961,17339,12968,12954,17116,18508!GO:0048731;system development;4.09711254815237e-05;12965,12969,12964,12959,12962,225998,12958,16873,21834,12957,12960,12961,17339,12968,12954,17116,319504,18508!GO:0007275;multicellular organismal development;0.000165782708021624;12965,12969,12964,12959,12962,225998,12958,16873,21834,12957,12960,12961,17339,12968,12954,17116,319504,18508!GO:0002088;lens development in camera-type eye;0.000199265764057703;12968,12964,17339!GO:0032502;developmental process;0.000277685306689043;12965,22178,12969,12964,232560,12959,12962,225998,12958,16873,21834,12957,12960,12961,17339,12968,12954,17116,18508,13190,319504!GO:0042803;protein homodimerization activity;0.00052656893383641;12961,12958,22178,21985,12957!GO:0006583;melanin biosynthetic process from tyrosine;0.00494743505034512;22178,13190!GO:0032501;multicellular organismal process;0.00510220334480083;12965,12969,12964,12959,12962,225998,12958,16873,107993,21834,12957,14686,30044,12960,12961,17339,12968,19661,12954,17116,238871,18508,319504,20132!GO:0042802;identical protein binding;0.00543504223972365;12961,12958,22178,21985,12957!GO:0046983;protein dimerization activity;0.00982244140145151;12961,12958,22178,21985,12957!GO:0042438;melanin biosynthetic process;0.0108520841059974;22178,13190!GO:0006582;melanin metabolic process;0.0108520841059974;22178,13190!GO:0018298;protein-chromophore linkage;0.0125761207296899;30044,20132!GO:0006570;tyrosine metabolic process;0.0169203505274675;22178,13190!GO:0042462;eye photoreceptor cell development;0.018806719076944;225998,18508!GO:0001754;eye photoreceptor cell differentiation;0.0236302765880239;225998,18508!GO:0042461;photoreceptor cell development;0.0256155598903208;225998,18508!GO:0046530;photoreceptor cell differentiation;0.037679085308237;225998,18508!GO:0007602;phototransduction;0.0393223031830384;14686,30044!GO:0009584;detection of visible light;0.0393223031830384;14686,30044!GO:0050962;detection of light stimulus during sensory perception;0.0393223031830384;14686,30044!GO:0050908;detection of light stimulus during visual perception;0.0393223031830384;14686,30044!GO:0009072;aromatic amino acid family metabolic process;0.0393223031830384;22178,13190!GO:0005921;gap junction;0.0393223031830384;17339,14611!GO:0009583;detection of light stimulus;0.0393223031830384;14686,30044!GO:0046148;pigment biosynthetic process;0.0393223031830384;22178,13190!GO:0004167;dopachrome isomerase activity;0.0393223031830384;13190!GO:0021902;commitment of a neuronal cell to a specific type of neuron in the forebrain;0.0393223031830384;18508!GO:0043437;butanoic acid metabolic process;0.0393223031830384;22178!GO:0021877;forebrain neuron fate commitment;0.0393223031830384;18508!GO:0000072;M phase specific microtubule process;0.0393223031830384;12954!GO:0043438;acetoacetic acid metabolic process;0.0393223031830384;22178!GO:0006198;cAMP catabolic process;0.0393223031830384;238871!GO:0048066;pigmentation during development;0.0437382348457268;22178,13190!GO:0042440;pigment metabolic process;0.0487134585644161;22178,13190! | |gostat_on_MCL_coexpression=GO:0005212;structural constituent of eye lens;4.11466020467449e-27;12965,12961,12960,12969,12964,12075,12959,17339,12962,12968,12958,12954,107993,12957!GO:0007423;sensory organ development;1.62980638952321e-15;12965,12961,12960,12969,12964,12959,17339,12962,12968,225998,12958,17116,12954,18508,12957!GO:0001654;eye development;3.95907961543224e-09;12968,12965,225998,17116,12969,12964,12954,17339,18508!GO:0007601;visual perception;1.45215011567418e-07;14686,225998,30044,12961,19661,17339,107993,20132!GO:0050953;sensory perception of light stimulus;1.45215011567418e-07;14686,225998,30044,12961,19661,17339,107993,20132!GO:0048856;anatomical structure development;1.49085116853024e-06;12965,12969,12964,232560,12959,12962,225998,12958,16873,21834,12957,12960,12961,17339,12968,12954,17116,319504,18508!GO:0043010;camera-type eye development;7.23467980032763e-06;12968,17116,12964,12954,17339,18508!GO:0048513;organ development;1.2006488370482e-05;12965,12969,12964,12959,12962,225998,12958,16873,21834,12957,12960,12961,17339,12968,12954,17116,18508!GO:0048731;system development;4.09711254815237e-05;12965,12969,12964,12959,12962,225998,12958,16873,21834,12957,12960,12961,17339,12968,12954,17116,319504,18508!GO:0007275;multicellular organismal development;0.000165782708021624;12965,12969,12964,12959,12962,225998,12958,16873,21834,12957,12960,12961,17339,12968,12954,17116,319504,18508!GO:0002088;lens development in camera-type eye;0.000199265764057703;12968,12964,17339!GO:0032502;developmental process;0.000277685306689043;12965,22178,12969,12964,232560,12959,12962,225998,12958,16873,21834,12957,12960,12961,17339,12968,12954,17116,18508,13190,319504!GO:0042803;protein homodimerization activity;0.00052656893383641;12961,12958,22178,21985,12957!GO:0006583;melanin biosynthetic process from tyrosine;0.00494743505034512;22178,13190!GO:0032501;multicellular organismal process;0.00510220334480083;12965,12969,12964,12959,12962,225998,12958,16873,107993,21834,12957,14686,30044,12960,12961,17339,12968,19661,12954,17116,238871,18508,319504,20132!GO:0042802;identical protein binding;0.00543504223972365;12961,12958,22178,21985,12957!GO:0046983;protein dimerization activity;0.00982244140145151;12961,12958,22178,21985,12957!GO:0042438;melanin biosynthetic process;0.0108520841059974;22178,13190!GO:0006582;melanin metabolic process;0.0108520841059974;22178,13190!GO:0018298;protein-chromophore linkage;0.0125761207296899;30044,20132!GO:0006570;tyrosine metabolic process;0.0169203505274675;22178,13190!GO:0042462;eye photoreceptor cell development;0.018806719076944;225998,18508!GO:0001754;eye photoreceptor cell differentiation;0.0236302765880239;225998,18508!GO:0042461;photoreceptor cell development;0.0256155598903208;225998,18508!GO:0046530;photoreceptor cell differentiation;0.037679085308237;225998,18508!GO:0007602;phototransduction;0.0393223031830384;14686,30044!GO:0009584;detection of visible light;0.0393223031830384;14686,30044!GO:0050962;detection of light stimulus during sensory perception;0.0393223031830384;14686,30044!GO:0050908;detection of light stimulus during visual perception;0.0393223031830384;14686,30044!GO:0009072;aromatic amino acid family metabolic process;0.0393223031830384;22178,13190!GO:0005921;gap junction;0.0393223031830384;17339,14611!GO:0009583;detection of light stimulus;0.0393223031830384;14686,30044!GO:0046148;pigment biosynthetic process;0.0393223031830384;22178,13190!GO:0004167;dopachrome isomerase activity;0.0393223031830384;13190!GO:0021902;commitment of a neuronal cell to a specific type of neuron in the forebrain;0.0393223031830384;18508!GO:0043437;butanoic acid metabolic process;0.0393223031830384;22178!GO:0021877;forebrain neuron fate commitment;0.0393223031830384;18508!GO:0000072;M phase specific microtubule process;0.0393223031830384;12954!GO:0043438;acetoacetic acid metabolic process;0.0393223031830384;22178!GO:0006198;cAMP catabolic process;0.0393223031830384;238871!GO:0048066;pigmentation during development;0.0437382348457268;22178,13190!GO:0042440;pigment metabolic process;0.0487134585644161;22178,13190! | ||
|ontology_enrichment_celltype= | |||
|ontology_enrichment_disease= | |||
|ontology_enrichment_uberon=UBERON:0000970!1.28e-71!9;UBERON:0000019!1.28e-71!9;UBERON:0000047!1.28e-71!9;UBERON:0010312!1.28e-71!9;UBERON:0004088!1.28e-71!9;UBERON:0002104!1.28e-71!9;UBERON:0001456!1.28e-71!9;UBERON:0003072!1.28e-71!9;UBERON:0004128!1.28e-71!9;UBERON:0003071!1.28e-71!9;UBERON:0001444!1.49e-58!11;UBERON:0000020!1.19e-53!12;UBERON:0001032!1.19e-53!12;UBERON:0004456!1.19e-53!12;UBERON:0000033!1.68e-49!13;UBERON:0005085!1.68e-49!13;UBERON:0007811!1.35e-17!36;UBERON:0003056!9.26e-16!49;UBERON:0000153!1.22e-14!43;UBERON:0002346!6.60e-12!64;UBERON:0003075!6.60e-12!64;UBERON:0007284!6.60e-12!64;UBERON:0010371!2.39e-10!73;UBERON:0010314!4.79e-08!92;UBERON:0004121!9.14e-08!95;UBERON:0000924!9.14e-08!95;UBERON:0006601!9.14e-08!95 | |||
}} | }} |
Revision as of 20:54, 11 October 2012
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0005212 | structural constituent of eye lens | 4.11466020467449e-27 |
GO:0007423 | sensory organ development | 1.62980638952321e-15 |
GO:0001654 | eye development | 3.95907961543224e-09 |
GO:0007601 | visual perception | 1.45215011567418e-07 |
GO:0050953 | sensory perception of light stimulus | 1.45215011567418e-07 |
GO:0048856 | anatomical structure development | 1.49085116853024e-06 |
GO:0043010 | camera-type eye development | 7.23467980032763e-06 |
GO:0048513 | organ development | 1.2006488370482e-05 |
GO:0048731 | system development | 4.09711254815237e-05 |
GO:0007275 | multicellular organismal development | 0.000165782708021624 |
GO:0002088 | lens development in camera-type eye | 0.000199265764057703 |
GO:0032502 | developmental process | 0.000277685306689043 |
GO:0042803 | protein homodimerization activity | 0.00052656893383641 |
GO:0006583 | melanin biosynthetic process from tyrosine | 0.00494743505034512 |
GO:0032501 | multicellular organismal process | 0.00510220334480083 |
GO:0042802 | identical protein binding | 0.00543504223972365 |
GO:0046983 | protein dimerization activity | 0.00982244140145151 |
GO:0042438 | melanin biosynthetic process | 0.0108520841059974 |
GO:0006582 | melanin metabolic process | 0.0108520841059974 |
GO:0018298 | protein-chromophore linkage | 0.0125761207296899 |
GO:0006570 | tyrosine metabolic process | 0.0169203505274675 |
GO:0042462 | eye photoreceptor cell development | 0.018806719076944 |
GO:0001754 | eye photoreceptor cell differentiation | 0.0236302765880239 |
GO:0042461 | photoreceptor cell development | 0.0256155598903208 |
GO:0046530 | photoreceptor cell differentiation | 0.037679085308237 |
GO:0007602 | phototransduction | 0.0393223031830384 |
GO:0009584 | detection of visible light | 0.0393223031830384 |
GO:0050962 | detection of light stimulus during sensory perception | 0.0393223031830384 |
GO:0050908 | detection of light stimulus during visual perception | 0.0393223031830384 |
GO:0009072 | aromatic amino acid family metabolic process | 0.0393223031830384 |
GO:0005921 | gap junction | 0.0393223031830384 |
GO:0009583 | detection of light stimulus | 0.0393223031830384 |
GO:0046148 | pigment biosynthetic process | 0.0393223031830384 |
GO:0004167 | dopachrome isomerase activity | 0.0393223031830384 |
GO:0021902 | commitment of a neuronal cell to a specific type of neuron in the forebrain | 0.0393223031830384 |
GO:0043437 | butanoic acid metabolic process | 0.0393223031830384 |
GO:0021877 | forebrain neuron fate commitment | 0.0393223031830384 |
GO:0000072 | M phase specific microtubule process | 0.0393223031830384 |
GO:0043438 | acetoacetic acid metabolic process | 0.0393223031830384 |
GO:0006198 | cAMP catabolic process | 0.0393223031830384 |
GO:0048066 | pigmentation during development | 0.0437382348457268 |
GO:0042440 | pigment metabolic process | 0.0487134585644161 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
Ontology term | p-value | n |
---|---|---|
eye | 1.28e-71 | 9 |
camera-type eye | 1.28e-71 | 9 |
simple eye | 1.28e-71 | 9 |
immature eye | 1.28e-71 | 9 |
ocular region | 1.28e-71 | 9 |
visual system | 1.28e-71 | 9 |
face | 1.28e-71 | 9 |
optic cup | 1.28e-71 | 9 |
optic vesicle | 1.28e-71 | 9 |
eye primordium | 1.28e-71 | 9 |
subdivision of head | 1.49e-58 | 11 |
sense organ | 1.19e-53 | 12 |
sensory system | 1.19e-53 | 12 |
entire sense organ system | 1.19e-53 | 12 |
head | 1.68e-49 | 13 |
ectodermal placode | 1.68e-49 | 13 |
craniocervical region | 1.35e-17 | 36 |
pre-chordal neural plate | 9.26e-16 | 49 |
anterior region of body | 1.22e-14 | 43 |
neurectoderm | 6.60e-12 | 64 |
neural plate | 6.60e-12 | 64 |
presumptive neural plate | 6.60e-12 | 64 |
ecto-epithelium | 2.39e-10 | 73 |
structure with developmental contribution from neural crest | 4.79e-08 | 92 |
ectoderm-derived structure | 9.14e-08 | 95 |
ectoderm | 9.14e-08 | 95 |
presumptive ectoderm | 9.14e-08 | 95 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
{{{tfbs_overrepresentation_jaspar}}} |