Coexpression cluster:C94: Difference between revisions
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Latest revision as of 10:29, 17 September 2013
Full id: C94_smallcell_adrenal_lung_nonsmall_small_somatostatinoma_teratocarcinoma
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
No results for this coexpression
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0005737 | cytoplasm | 0.00283719973544866 |
GO:0030141 | secretory granule | 0.00283719973544866 |
GO:0007189 | G-protein signaling, adenylate cyclase activating pathway | 0.00283719973544866 |
GO:0044444 | cytoplasmic part | 0.00921918044552319 |
GO:0000139 | Golgi membrane | 0.00921918044552319 |
GO:0000267 | cell fraction | 0.00921918044552319 |
GO:0005179 | hormone activity | 0.00921918044552319 |
GO:0007188 | G-protein signaling, coupled to cAMP nucleotide second messenger | 0.00921918044552319 |
GO:0044431 | Golgi apparatus part | 0.00921918044552319 |
GO:0019933 | cAMP-mediated signaling | 0.00921918044552319 |
GO:0031410 | cytoplasmic vesicle | 0.00921918044552319 |
GO:0031982 | vesicle | 0.00921918044552319 |
GO:0005625 | soluble fraction | 0.00921918044552319 |
GO:0005794 | Golgi apparatus | 0.00921918044552319 |
GO:0007190 | adenylate cyclase activation | 0.0145487135589096 |
GO:0045087 | innate immune response | 0.0145487135589096 |
GO:0007187 | G-protein signaling, coupled to cyclic nucleotide second messenger | 0.0145487135589096 |
GO:0019935 | cyclic-nucleotide-mediated signaling | 0.0145487135589096 |
GO:0051349 | positive regulation of lyase activity | 0.0145487135589096 |
GO:0045762 | positive regulation of adenylate cyclase activity | 0.0145487135589096 |
GO:0031281 | positive regulation of cyclase activity | 0.0145487135589096 |
GO:0005184 | neuropeptide hormone activity | 0.0194955752777347 |
GO:0022402 | cell cycle process | 0.0194955752777347 |
GO:0008015 | blood circulation | 0.0194955752777347 |
GO:0003013 | circulatory system process | 0.0194955752777347 |
GO:0006936 | muscle contraction | 0.0194955752777347 |
GO:0003012 | muscle system process | 0.0194955752777347 |
GO:0045761 | regulation of adenylate cyclase activity | 0.0194955752777347 |
GO:0042581 | specific granule | 0.0194955752777347 |
GO:0004441 | inositol-1,4-bisphosphate 1-phosphatase activity | 0.0194955752777347 |
GO:0048702 | embryonic neurocranium morphogenesis | 0.0194955752777347 |
GO:0004598 | peptidylamidoglycolate lyase activity | 0.0194955752777347 |
GO:0031716 | calcitonin receptor binding | 0.0194955752777347 |
GO:0004286 | proprotein convertase 2 activity | 0.0194955752777347 |
GO:0001984 | vasodilation of artery during baroreceptor response to increased systemic arterial blood pressure | 0.0194955752777347 |
GO:0042271 | susceptibility to natural killer cell mediated cytotoxicity | 0.0194955752777347 |
GO:0035150 | regulation of tube size | 0.0194955752777347 |
GO:0050880 | regulation of blood vessel size | 0.0194955752777347 |
GO:0051339 | regulation of lyase activity | 0.0194955752777347 |
GO:0031279 | regulation of cyclase activity | 0.0194955752777347 |
GO:0008016 | regulation of heart contraction | 0.0194955752777347 |
GO:0003018 | vascular process in circulatory system | 0.0195443769341191 |
GO:0006486 | protein amino acid glycosylation | 0.0195443769341191 |
GO:0043413 | biopolymer glycosylation | 0.0200595991583854 |
GO:0008375 | acetylglucosaminyltransferase activity | 0.0200900194078242 |
GO:0007154 | cell communication | 0.0200900194078242 |
GO:0009101 | glycoprotein biosynthetic process | 0.0200900194078242 |
GO:0003015 | heart process | 0.0200900194078242 |
GO:0060047 | heart contraction | 0.0200900194078242 |
GO:0012505 | endomembrane system | 0.0200900194078242 |
GO:0005102 | receptor binding | 0.0205864393041321 |
GO:0008146 | sulfotransferase activity | 0.0234886471417827 |
GO:0007165 | signal transduction | 0.0248165823120294 |
GO:0009100 | glycoprotein metabolic process | 0.0248165823120294 |
GO:0051649 | establishment of cellular localization | 0.0248165823120294 |
GO:0043229 | intracellular organelle | 0.0248165823120294 |
GO:0043226 | organelle | 0.0248165823120294 |
GO:0006948 | induction by virus of cell-cell fusion in host | 0.0248165823120294 |
GO:0004910 | interleukin-1, Type II, blocking receptor activity | 0.0248165823120294 |
GO:0001983 | baroreceptor response to increased systemic arterial blood pressure | 0.0248165823120294 |
GO:0019968 | interleukin-1, Type II, blocking binding | 0.0248165823120294 |
GO:0016312 | inositol bisphosphate phosphatase activity | 0.0248165823120294 |
GO:0030144 | alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity | 0.0248165823120294 |
GO:0051641 | cellular localization | 0.0248165823120294 |
GO:0048523 | negative regulation of cellular process | 0.025477497950714 |
GO:0031420 | alkali metal ion binding | 0.025477497950714 |
GO:0016782 | transferase activity, transferring sulfur-containing groups | 0.0256829987908073 |
GO:0045786 | negative regulation of progression through cell cycle | 0.0256829987908073 |
GO:0048519 | negative regulation of biological process | 0.0292832235172398 |
GO:0065002 | intracellular protein transport across a membrane | 0.0301046166136714 |
GO:0007049 | cell cycle | 0.0301046166136714 |
GO:0035313 | wound healing, spreading of epidermal cells | 0.0301046166136714 |
GO:0004504 | peptidylglycine monooxygenase activity | 0.0301046166136714 |
GO:0003829 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity | 0.0301046166136714 |
GO:0016808 | proprotein convertase activity | 0.0301046166136714 |
GO:0050961 | detection of temperature stimulus during sensory perception | 0.0301046166136714 |
GO:0050965 | detection of temperature stimulus during sensory perception of pain | 0.0301046166136714 |
GO:0045932 | negative regulation of muscle contraction | 0.0301046166136714 |
GO:0045986 | negative regulation of smooth muscle contraction | 0.0301046166136714 |
GO:0043085 | positive regulation of catalytic activity | 0.0309776874453533 |
GO:0043065 | positive regulation of apoptosis | 0.0309776874453533 |
GO:0043068 | positive regulation of programmed cell death | 0.031272145987102 |
GO:0051606 | detection of stimulus | 0.0320111792065642 |
GO:0019932 | second-messenger-mediated signaling | 0.0320111792065642 |
GO:0035239 | tube morphogenesis | 0.0320111792065642 |
GO:0002028 | regulation of sodium ion transport | 0.0320111792065642 |
GO:0043195 | terminal button | 0.0320111792065642 |
GO:0033267 | axon part | 0.0320111792065642 |
GO:0016048 | detection of temperature stimulus | 0.0320111792065642 |
GO:0050951 | sensory perception of temperature stimulus | 0.0320111792065642 |
GO:0048701 | embryonic cranial skeleton morphogenesis | 0.0320111792065642 |
GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity | 0.0320111792065642 |
GO:0007184 | SMAD protein nuclear translocation | 0.0320111792065642 |
GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity | 0.0320111792065642 |
GO:0003701 | RNA polymerase I transcription factor activity | 0.0320111792065642 |
GO:0001978 | carotid sinus baroreceptor feedback regulation of systemic arterial blood pressure | 0.0320111792065642 |
GO:0003025 | baroreceptor regulation of systemic arterial blood pressure | 0.0320111792065642 |
GO:0031403 | lithium ion binding | 0.0320111792065642 |
GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity | 0.0320111792065642 |
GO:0016021 | integral to membrane | 0.0327749287978127 |
GO:0045184 | establishment of protein localization | 0.0342165106167176 |
GO:0031224 | intrinsic to membrane | 0.0342165106167176 |
GO:0044464 | cell part | 0.0347920793349787 |
GO:0006952 | defense response | 0.035617442548693 |
GO:0008467 | heparin-glucosamine 3-O-sulfotransferase activity | 0.0369999458837642 |
GO:0048265 | response to pain | 0.0369999458837642 |
GO:0003085 | negative regulation of systemic arterial blood pressure | 0.0369999458837642 |
GO:0008104 | protein localization | 0.038105327651986 |
GO:0042995 | cell projection | 0.0401647866387421 |
GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | 0.0412863325297617 |
GO:0002027 | regulation of heart rate | 0.0412863325297617 |
GO:0001912 | positive regulation of leukocyte mediated cytotoxicity | 0.0412863325297617 |
GO:0051482 | elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) | 0.0412863325297617 |
GO:0045954 | positive regulation of natural killer cell mediated cytotoxicity | 0.0412863325297617 |
GO:0045778 | positive regulation of ossification | 0.0412863325297617 |
GO:0005856 | cytoskeleton | 0.0418085846115234 |
GO:0050794 | regulation of cellular process | 0.0424296841742674 |
GO:0007267 | cell-cell signaling | 0.042790728048361 |
GO:0033036 | macromolecule localization | 0.042790728048361 |
GO:0051049 | regulation of transport | 0.04398091260169 |
GO:0042269 | regulation of natural killer cell mediated cytotoxicity | 0.0446444351479221 |
GO:0031645 | negative regulation of neurological process | 0.0446444351479221 |
GO:0005868 | cytoplasmic dynein complex | 0.0446444351479221 |
GO:0046852 | positive regulation of bone remodeling | 0.0446444351479221 |
GO:0016023 | cytoplasmic membrane-bound vesicle | 0.046404432021233 |
GO:0035295 | tube development | 0.0471555423947684 |
GO:0031988 | membrane-bound vesicle | 0.0473811370175228 |
GO:0000074 | regulation of progression through cell cycle | 0.0473811370175228 |
GO:0048518 | positive regulation of biological process | 0.0473811370175228 |
GO:0045776 | negative regulation of blood pressure | 0.0473811370175228 |
GO:0004908 | interleukin-1 receptor activity | 0.0473811370175228 |
GO:0030279 | negative regulation of ossification | 0.0473811370175228 |
GO:0001976 | regulation of systemic arterial blood pressure by neurological process | 0.0473811370175228 |
GO:0051726 | regulation of cell cycle | 0.0473811370175228 |
GO:0005515 | protein binding | 0.0473811370175228 |
GO:0031090 | organelle membrane | 0.048147535383269 |
GO:0044425 | membrane part | 0.0491408776240159 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br><br>disease_data<br>
Ontology term | p-value | n |
---|---|---|
peptide hormone secreting cell | 4.66e-66 | 1 |
enteroendocrine cell | 4.66e-66 | 1 |
type D enteroendocrine cell | 4.66e-66 | 1 |
somatostatin secreting cell | 4.66e-66 | 1 |
pancreatic D cell | 4.66e-66 | 1 |
progenitor cell of endocrine pancreas | 4.66e-66 | 1 |
glandular epithelial cell | 1.21e-08 | 9 |
endocrine cell | 1.21e-08 | 9 |
Ontology term | p-value | n |
---|---|---|
somatostatinoma | 4.66e-66 | 1 |
lung small cell carcinoma | 8.69e-18 | 4 |
neuroendocrine tumor | 2.74e-12 | 6 |
bronchus cancer | 8.99e-11 | 7 |
bronchogenic carcinoma | 8.99e-11 | 7 |
lung carcinoma | 1.12e-08 | 9 |
neuroectodermal tumor | 6.56e-08 | 10 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 3.78364e-12 |
MA0004.1 | 0.559702 |
MA0006.1 | 0.0580193 |
MA0007.1 | 0.102577 |
MA0009.1 | 1.78813 |
MA0014.1 | 1.78329e-06 |
MA0017.1 | 0.342658 |
MA0019.1 | 1.23179 |
MA0024.1 | 0.107867 |
MA0025.1 | 0.394897 |
MA0027.1 | 1.1536 |
MA0028.1 | 0.00793547 |
MA0029.1 | 0.257037 |
MA0030.1 | 2.50866 |
MA0031.1 | 2.00437 |
MA0038.1 | 0.0184211 |
MA0040.1 | 0.128944 |
MA0041.1 | 0.364024 |
MA0042.1 | 0.365892 |
MA0043.1 | 0.0184883 |
MA0046.1 | 0.197984 |
MA0048.1 | 0.460736 |
MA0050.1 | 0.0345077 |
MA0051.1 | 0.706746 |
MA0052.1 | 0.272178 |
MA0055.1 | 3.72153 |
MA0056.1 | 0 |
MA0057.1 | 0.00856762 |
MA0058.1 | 0.468473 |
MA0059.1 | 0.736045 |
MA0060.1 | 0.139175 |
MA0061.1 | 0.086592 |
MA0063.1 | 0 |
MA0066.1 | 0.730072 |
MA0067.1 | 0.362202 |
MA0068.1 | 0.229239 |
MA0069.1 | 0.19367 |
MA0070.1 | 0.0148776 |
MA0071.1 | 2.30965 |
MA0072.1 | 2.05901 |
MA0073.1 | 0.000477995 |
MA0074.1 | 0.152853 |
MA0076.1 | 0.0648658 |
MA0077.1 | 0.562791 |
MA0078.1 | 0.538809 |
MA0081.1 | 0.259167 |
MA0083.1 | 0.0870687 |
MA0084.1 | 1.14826 |
MA0087.1 | 1.21119 |
MA0088.1 | 0.240856 |
MA0089.1 | 0 |
MA0090.1 | 0.0257873 |
MA0091.1 | 0.73947 |
MA0092.1 | 1.4878 |
MA0093.1 | 0.851641 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.0225669 |
MA0101.1 | 0.0123577 |
MA0103.1 | 9.11696 |
MA0105.1 | 0.0083636 |
MA0106.1 | 0.367331 |
MA0107.1 | 0.026509 |
MA0108.2 | 1.98133 |
MA0109.1 | 0 |
MA0111.1 | 0.910788 |
MA0113.1 | 0.273798 |
MA0114.1 | 0.084483 |
MA0115.1 | 0.0809316 |
MA0116.1 | 0.198038 |
MA0117.1 | 0.104966 |
MA0119.1 | 0.058282 |
MA0122.1 | 0.291109 |
MA0124.1 | 1.31087 |
MA0125.1 | 1.44956 |
MA0130.1 | 0 |
MA0131.1 | 0.00113568 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 0.100479 |
MA0136.1 | 1.23571 |
MA0139.1 | 0.10825 |
MA0140.1 | 0.908084 |
MA0141.1 | 0.452249 |
MA0142.1 | 0.580585 |
MA0143.1 | 0.803288 |
MA0144.1 | 3.10044 |
MA0145.1 | 0.734457 |
MA0146.1 | 4.16644e-06 |
MA0147.1 | 0.112872 |
MA0148.1 | 3.18546 |
MA0149.1 | 0.00224719 |
MA0062.2 | 0.0350445 |
MA0035.2 | 0.263234 |
MA0039.2 | 0.00378608 |
MA0138.2 | 0.0619275 |
MA0002.2 | 0.180278 |
MA0137.2 | 1.22879 |
MA0104.2 | 0.136427 |
MA0047.2 | 0.881478 |
MA0112.2 | 0.143379 |
MA0065.2 | 0.148731 |
MA0150.1 | 0.182402 |
MA0151.1 | 0 |
MA0152.1 | 0.183225 |
MA0153.1 | 0.341438 |
MA0154.1 | 0.0972809 |
MA0155.1 | 0.0837171 |
MA0156.1 | 2.4178 |
MA0157.1 | 1.25074 |
MA0158.1 | 0 |
MA0159.1 | 2.76806 |
MA0160.1 | 1.21236 |
MA0161.1 | 0 |
MA0162.1 | 5.33483e-08 |
MA0163.1 | 4.08873e-06 |
MA0164.1 | 0.455341 |
MA0080.2 | 1.38272 |
MA0018.2 | 0.371332 |
MA0099.2 | 0.95231 |
MA0079.2 | 4.24304e-15 |
MA0102.2 | 0.236057 |
MA0258.1 | 1.94283 |
MA0259.1 | 0.186857 |
MA0442.1 | 0 |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)
TF | #promoters | Enrichment | p-value | q-value |
---|---|---|---|---|
FOXA1#3169 | 29 | 1.62303622592009 | 0.00657924540417041 | 0.0281126671616952 |
SUZ12#23512 | 10 | 2.53110004601328 | 0.00685254677668615 | 0.0290416399306223 |
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data