MCL coexpression mm9:1135

Phase1 CAGE Peaks

	Short description
Mm9::chr14:55050434..55050510,+	p1@Mmp14
Mm9::chr14:55050533..55050544,+	p2@Mmp14
Mm9::chr16:37777131..37777151,+	p1@Fstl1
Mm9::chr16:37777154..37777165,+	p3@Fstl1
Mm9::chr16:37777178..37777192,+	p2@Fstl1
Mm9::chr16:37834557..37834607,+	p@chr16:37834557..37834607 +
Mm9::chr16:37834640..37834657,+	p@chr16:37834640..37834657 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0031638	zymogen activation	0.0130524352190759
GO:0030574	collagen catabolic process	0.0130524352190759
GO:0044256	protein digestion	0.0130524352190759
GO:0044254	multicellular organismal protein catabolic process	0.0130524352190759
GO:0044266	multicellular organismal macromolecule catabolic process	0.0130524352190759
GO:0044259	multicellular organismal macromolecule metabolic process	0.0130524352190759
GO:0044243	multicellular organismal catabolic process	0.0130524352190759
GO:0044268	multicellular organismal protein metabolic process	0.0130524352190759
GO:0005509	calcium ion binding	0.0130524352190759
GO:0032963	collagen metabolic process	0.0130524352190759
GO:0044236	multicellular organismal metabolic process	0.0130524352190759
GO:0007586	digestion	0.0251744122614664
GO:0048754	branching morphogenesis of a tube	0.0276721088505452
GO:0008201	heparin binding	0.0276721088505452
GO:0001763	morphogenesis of a branching structure	0.0276721088505452
GO:0030324	lung development	0.0276721088505452
GO:0030323	respiratory tube development	0.0276721088505452
GO:0016485	protein processing	0.0276721088505452
GO:0005539	glycosaminoglycan binding	0.0293868873408014
GO:0030247	polysaccharide binding	0.0305312052801401
GO:0001871	pattern binding	0.0305312052801401
GO:0004222	metalloendopeptidase activity	0.0349291874710246
GO:0005615	extracellular space	0.0349291874710246
GO:0044421	extracellular region part	0.037605042039508
GO:0035239	tube morphogenesis	0.044577337318088

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
cardiovascular system	1.83e-08	23
circulatory system	1.83e-08	23
splanchnic layer of lateral plate mesoderm	1.93e-07	33
primary circulatory organ	2.84e-07	18
heart	2.84e-07	18
primitive heart tube	2.84e-07	18
primary heart field	2.84e-07	18
anterior lateral plate mesoderm	2.84e-07	18
heart tube	2.84e-07	18
heart primordium	2.84e-07	18
cardiac mesoderm	2.84e-07	18
cardiogenic plate	2.84e-07	18
heart rudiment	2.84e-07	18
multi-cellular organism	3.91e-07	333

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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