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Coexpression cluster:C1243

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Full id: C1243_submaxillary_salivary_smallcell_esophagus_cervical_tonsil_tongue



Phase1 CAGE Peaks

Hg19::chr19:51527943..51527947,-p@chr19:51527943..51527947
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Hg19::chr19:51530766..51530777,-p6@KLK11
Hg19::chr19:51530794..51530801,-p7@KLK11
Hg19::chr19:51530812..51530834,-p5@KLK11
Hg19::chr19:51530837..51530842,-p10@KLK11
Hg19::chr19:51530894..51530910,-p2@KLK11
Hg19::chr19:51530916..51530937,-p3@KLK11


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
orifice6.42e-1735
oral opening9.48e-1621
respiratory system7.36e-1572
endoderm-derived structure1.16e-14169
endoderm1.16e-14169
presumptive endoderm1.16e-14169
mouth5.22e-1228
stomodeum5.22e-1228
digestive system1.65e-10155
digestive tract1.65e-10155
primitive gut1.65e-10155
saliva-secreting gland5.86e-106
gland of oral region5.86e-106
gland of foregut5.86e-106
oral gland5.86e-106
oral cavity5.86e-106
adult organism1.71e-09115
surface structure2.23e-0995
subdivision of digestive tract3.21e-09129
endodermal part of digestive tract3.21e-09129
gland of gut5.87e-0910
subdivision of head1.98e-0848
respiratory tract6.13e-0853
neck8.08e-0810
mixed endoderm/mesoderm-derived structure1.39e-07130
mixed ectoderm/mesoderm/endoderm-derived structure2.46e-0718
foregut7.16e-0798
mouth mucosa7.44e-075
Disease
Ontology termp-valuen
squamous cell carcinoma7.29e-0714


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.