Coexpression cluster:C4842

Full id: C4842_Small_amniotic_salivary_oral_Gingival_Amniotic_chorionic

Phase1 CAGE Peaks

Hg19::chrX:107641254..107641280,-	p@chrX:107641254..107641280 -
Hg19::chrX:107641284..107641300,-	p@chrX:107641284..107641300 -
Hg19::chrX:107641318..107641327,-	p@chrX:107641318..107641327 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
epithelial cell	2.38e-24	253
squamous epithelial cell	3.10e-19	63
endo-epithelial cell	2.58e-14	42
embryonic cell	2.72e-11	250
respiratory epithelial cell	1.94e-09	13
endodermal cell	2.05e-09	58
epithelial cell of alimentary canal	1.74e-08	20
endothelial cell of artery	1.96e-08	9
lining cell	5.89e-08	58
barrier cell	5.89e-08	58
animal cell	1.83e-07	679
eukaryotic cell	1.83e-07	679
blood vessel endothelial cell	3.66e-07	18
embryonic blood vessel endothelial progenitor cell	3.66e-07	18

Uber Anatomy

Ontology term	p-value	n
mouth mucosa	2.65e-11	13
mouth	4.59e-11	29
stomodeum	4.59e-11	29
extraembryonic membrane	2.52e-10	14
membranous layer	2.52e-10	14
oral opening	1.51e-08	22
endothelial tube	1.96e-08	9
arterial system endothelium	1.96e-08	9
endothelium of artery	1.96e-08	9
head	1.99e-08	56
orifice	3.76e-08	36
respiratory system	6.55e-08	74
mucosa	6.62e-08	20
endoderm-derived structure	7.60e-08	160
endoderm	7.60e-08	160
presumptive endoderm	7.60e-08	160
organ component layer	1.10e-07	66
chorion	1.34e-07	7
subdivision of head	2.14e-07	49
blood vessel endothelium	3.66e-07	18
endothelium	3.66e-07	18
cardiovascular system endothelium	3.66e-07	18
surface structure	3.87e-07	99
anterior region of body	4.73e-07	62
craniocervical region	4.73e-07	62
gingiva	5.38e-07	8

Disease

Ontology term	p-value	n
squamous cell carcinoma	6.64e-08	14

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
BATF#10538	3	24.3578017923036	6.91705216281876e-05	0.00110257938161268
BCL11A#53335	3	28.3694551036071	4.37778126761649e-05	0.000779957519291365
CEBPB#1051	3	7.97114762582482	0.00197418705528856	0.0115904278974243
EBF1#1879	3	8.906466846569	0.0014152328356098	0.0091981767451772
EP300#2033	3	6.7739417262232	0.00321688050010379	0.016866699259518
FOS#2353	3	8.9979553088944	0.00137249927241713	0.00902773973497749
GATA2#2624	3	12.744931733554	0.000482952770428379	0.00439441578591824
JUN#3725	3	12.5128291923363	0.000510331399272625	0.00446685392294952
JUND#3727	3	6.99466394187103	0.00292184504273499	0.0157833130453191
MEF2A#4205	3	18.7432309096441	0.000151824390562247	0.00195564720349414
MEF2C#4208	3	41.3113544926241	1.41744912101957e-05	0.000340941890258321
NR3C1#2908	3	14.973023331173	0.000297833119467548	0.00310681114303549
STAT3#6774	3	10.5194649971542	0.000858918453041531	0.00646333196319652

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.