MCL coexpression mm9:1817

Phase1 CAGE Peaks

	Short description
Mm9::chr5:92566966..92567000,+	p1@Uso1
Mm9::chr9:44575875..44575921,-	p1@Arcn1
Mm9::chr9:86465382..86465454,-	p1@Pgm3
Mm9::chr9:98464123..98464156,+	p1@Copb2
Mm9::chrX:136219519..136219621,+	p1@Tbc1d8b

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008565	protein transporter activity	0.000219104891027456
GO:0006886	intracellular protein transport	0.00111354618758562
GO:0016192	vesicle-mediated transport	0.00111354618758562
GO:0030117	membrane coat	0.00111354618758562
GO:0048475	coated membrane	0.00111354618758562
GO:0005794	Golgi apparatus	0.0019364197904871
GO:0046907	intracellular transport	0.0019364197904871
GO:0015031	protein transport	0.0019364197904871
GO:0045184	establishment of protein localization	0.0019364197904871
GO:0004610	phosphoacetylglucosamine mutase activity	0.0019364197904871
GO:0019255	glucose 1-phosphate metabolic process	0.0019364197904871
GO:0008104	protein localization	0.0019364197904871
GO:0051649	establishment of cellular localization	0.0019364197904871
GO:0051641	cellular localization	0.0019364197904871
GO:0033036	macromolecule localization	0.0019364197904871
GO:0006461	protein complex assembly	0.00202299057196888
GO:0006042	glucosamine biosynthetic process	0.00269868565779547
GO:0006045	N-acetylglucosamine biosynthetic process	0.00269868565779547
GO:0006048	UDP-N-acetylglucosamine biosynthetic process	0.00269868565779547
GO:0022892	substrate-specific transporter activity	0.00274667040158796
GO:0046349	amino sugar biosynthetic process	0.00366220096683051
GO:0004614	phosphoglucomutase activity	0.00445796520704365
GO:0006047	UDP-N-acetylglucosamine metabolic process	0.00445796520704365
GO:0019028	viral capsid	0.00533983193064862
GO:0065003	macromolecular complex assembly	0.00814726273194818
GO:0016868	intramolecular transferase activity, phosphotransferases	0.00823588975050593
GO:0030126	COPI vesicle coat	0.00823588975050593
GO:0030663	COPI coated vesicle membrane	0.00823588975050593
GO:0009225	nucleotide-sugar metabolic process	0.00883471110649204
GO:0022607	cellular component assembly	0.00909045551765844
GO:0030137	COPI-coated vesicle	0.00909045551765844
GO:0044423	virion part	0.0112053550578375
GO:0006041	glucosamine metabolic process	0.0135549638033076
GO:0006044	N-acetylglucosamine metabolic process	0.0135549638033076
GO:0006040	amino sugar metabolic process	0.0161628604484584
GO:0030119	AP-type membrane coat adaptor complex	0.0161628604484584
GO:0030120	vesicle coat	0.0161628604484584
GO:0030131	clathrin adaptor complex	0.0161628604484584
GO:0030662	coated vesicle membrane	0.0170579924476089
GO:0005798	Golgi-associated vesicle	0.0179079475735374
GO:0016866	intramolecular transferase activity	0.0180936511887276
GO:0006810	transport	0.019141762380073
GO:0016043	cellular component organization and biogenesis	0.0193196814823016
GO:0051234	establishment of localization	0.0193196814823016
GO:0030118	clathrin coat	0.0193196814823016
GO:0048471	perinuclear region of cytoplasm	0.0194539622026284
GO:0030659	cytoplasmic vesicle membrane	0.0206669543727467
GO:0051179	localization	0.0255386519276412
GO:0044433	cytoplasmic vesicle part	0.0255386519276412
GO:0012506	vesicle membrane	0.028586831706178
GO:0044444	cytoplasmic part	0.0377021893542771
GO:0016051	carbohydrate biosynthetic process	0.038703507010042
GO:0030135	coated vesicle	0.0417911382075104
GO:0006006	glucose metabolic process	0.0456942515727502

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
intestine	4.60e-11	31
endoderm-derived structure	3.04e-09	118
endoderm	3.04e-09	118
presumptive endoderm	3.04e-09	118
gastrointestinal system	4.55e-09	47
digestive system	1.22e-08	116
digestive tract	1.22e-08	116
primitive gut	1.22e-08	116
subdivision of digestive tract	7.12e-08	114
immaterial anatomical entity	1.66e-07	79

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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