MCL coexpression mm9:1250

Phase1 CAGE Peaks

	Short description
Mm9::chr10:75398601..75398617,+	p2@Chchd10
Mm9::chr11:21471777..21471783,-	p3@Mdh1
Mm9::chr11:21471789..21471800,-	p2@Mdh1
Mm9::chr11:21471801..21471830,-	p1@Mdh1
Mm9::chr2:136716867..136716922,-	p1@Mkks
Mm9::chr4:49610103..49610140,-	p4@2810432L12Rik

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0030060	L-malate dehydrogenase activity	0.0190549152086506
GO:0006108	malate metabolic process	0.0190549152086506
GO:0035058	sensory cilium biogenesis	0.0190549152086506
GO:0009296	flagellum biogenesis	0.0190549152086506
GO:0050910	detection of mechanical stimulus during sensory perception of sound	0.0190549152086506
GO:0043064	flagellum organization and biogenesis	0.0190549152086506
GO:0016615	malate dehydrogenase activity	0.0190549152086506
GO:0035176	social behavior	0.0190549152086506
GO:0043648	dicarboxylic acid metabolic process	0.0190549152086506
GO:0045494	photoreceptor cell maintenance	0.0190549152086506
GO:0050974	detection of mechanical stimulus during sensory perception	0.0190549152086506
GO:0050982	detection of mechanical stimulus	0.0204115057637613
GO:0042384	cilium biogenesis	0.0204115057637613
GO:0006100	tricarboxylic acid cycle intermediate metabolic process	0.0204115057637613
GO:0009612	response to mechanical stimulus	0.0215884707863897
GO:0051705	behavioral interaction between organisms	0.0260537194172215
GO:0006099	tricarboxylic acid cycle	0.0260537194172215
GO:0046356	acetyl-CoA catabolic process	0.0260537194172215
GO:0009060	aerobic respiration	0.0260537194172215
GO:0009109	coenzyme catabolic process	0.0271929747010297
GO:0045333	cellular respiration	0.0271929747010297
GO:0051187	cofactor catabolic process	0.027684356969329
GO:0006084	acetyl-CoA metabolic process	0.0281326476356857
GO:0007286	spermatid development	0.0313072361893202
GO:0009582	detection of abiotic stimulus	0.0313072361893202
GO:0048515	spermatid differentiation	0.0313072361893202
GO:0006096	glycolysis	0.0313072361893202
GO:0030031	cell projection biogenesis	0.0313072361893202
GO:0009581	detection of external stimulus	0.0313072361893202
GO:0006007	glucose catabolic process	0.0313072361893202
GO:0046365	monosaccharide catabolic process	0.0313072361893202
GO:0019320	hexose catabolic process	0.0313072361893202
GO:0050906	detection of stimulus during sensory perception	0.0313072361893202
GO:0046164	alcohol catabolic process	0.0313072361893202
GO:0044275	cellular carbohydrate catabolic process	0.0348288268246058
GO:0015980	energy derivation by oxidation of organic compounds	0.0348288268246058
GO:0051606	detection of stimulus	0.0354220185997714
GO:0016052	carbohydrate catabolic process	0.0359834968058255
GO:0007605	sensory perception of sound	0.0447508290867581
GO:0006006	glucose metabolic process	0.0448690181277649
GO:0050954	sensory perception of mechanical stimulus	0.0448690181277649
GO:0007601	visual perception	0.0478074123073098
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.0478074123073098
GO:0050953	sensory perception of light stimulus	0.0478074123073098

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
multi-tissue structure	1.98e-08	230
intestine	2.63e-08	31
epithelial tube	5.84e-07	47
primary circulatory organ	5.91e-07	18
heart	5.91e-07	18
primitive heart tube	5.91e-07	18
primary heart field	5.91e-07	18
anterior lateral plate mesoderm	5.91e-07	18
heart tube	5.91e-07	18
heart primordium	5.91e-07	18
cardiac mesoderm	5.91e-07	18
cardiogenic plate	5.91e-07	18
heart rudiment	5.91e-07	18
mucosa	7.23e-07	15
compound organ	8.30e-07	43

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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