Coexpression cluster:C4325

Full id: C4325_Basophils_CD8_Mast_Natural_CD4_Peripheral_optic

Phase1 CAGE Peaks

Hg19::chr3:3151947..3151970,-	p5@IL5RA
Hg19::chrX:3631503..3631514,-	p7@PRKX
Hg19::chrX:3631533..3631552,-	p2@PRKX

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0019980	interleukin-5 binding	0.00459188178052133
GO:0004914	interleukin-5 receptor activity	0.00459188178052133
GO:0004691	cAMP-dependent protein kinase activity	0.00816274461151255
GO:0004690	cyclic nucleotide-dependent protein kinase activity	0.00918254698947879
GO:0004907	interleukin receptor activity	0.0203972491114866
GO:0019965	interleukin binding	0.0203972491114866
GO:0004896	hematopoietin/interferon-class (D200-domain) cytokine receptor activity	0.0301459095476488
GO:0019838	growth factor binding	0.0336262182582139
GO:0019955	cytokine binding	0.0336262182582139

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
leukocyte	6.09e-15	136
hematopoietic stem cell	2.06e-13	168
angioblastic mesenchymal cell	2.06e-13	168
hematopoietic oligopotent progenitor cell	8.96e-13	161
hematopoietic multipotent progenitor cell	8.96e-13	161
hematopoietic cell	3.91e-12	177
hematopoietic lineage restricted progenitor cell	8.25e-12	120
nongranular leukocyte	1.15e-11	115
lymphocyte	1.76e-11	53
common lymphoid progenitor	1.76e-11	53
lymphoid lineage restricted progenitor cell	5.05e-11	52
nucleate cell	1.05e-10	55
mature alpha-beta T cell	2.78e-09	18
alpha-beta T cell	2.78e-09	18
immature T cell	2.78e-09	18
mature T cell	2.78e-09	18
immature alpha-beta T cell	2.78e-09	18
histamine secreting cell	1.72e-07	5
biogenic amine secreting cell	1.72e-07	5
granulocytopoietic cell	1.72e-07	5
mast cell	1.72e-07	5
mast cell progenitor	1.72e-07	5
basophil mast progenitor cell	1.72e-07	5

Uber Anatomy

Ontology term	p-value	n
adult organism	9.68e-07	114

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.