MCL coexpression mm9:1500

Phase1 CAGE Peaks

	Short description
Mm9::chr10:128026678..128026698,-	p1@Erbb3
Mm9::chr10:128026706..128026729,-	p3@Erbb3
Mm9::chr10:128026735..128026750,-	p2@Erbb3
Mm9::chr3:60806700..60806705,+	p2@P2ry1
Mm9::chr3:60806708..60806733,+	p1@P2ry1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0021545	cranial nerve development	0.0191702026015879
GO:0016328	lateral plasma membrane	0.0191702026015879
GO:0014037	Schwann cell differentiation	0.0191702026015879
GO:0016494	C-X-C chemokine receptor activity	0.0191702026015879
GO:0019958	C-X-C chemokine binding	0.0191702026015879
GO:0021675	nerve development	0.0191702026015879
GO:0043524	negative regulation of neuron apoptosis	0.0242636265920812
GO:0007422	peripheral nervous system development	0.0242636265920812
GO:0001637	G-protein chemoattractant receptor activity	0.0242636265920812
GO:0004950	chemokine receptor activity	0.0242636265920812
GO:0019956	chemokine binding	0.0242636265920812
GO:0043523	regulation of neuron apoptosis	0.0242636265920812
GO:0001608	nucleotide receptor activity, G-protein coupled	0.0242636265920812
GO:0045028	purinergic nucleotide receptor activity, G-protein coupled	0.0242636265920812
GO:0016502	nucleotide receptor activity	0.0242636265920812
GO:0001614	purinergic nucleotide receptor activity	0.0242636265920812
GO:0051402	neuron apoptosis	0.0242636265920812
GO:0010001	glial cell differentiation	0.0242636265920812
GO:0042063	gliogenesis	0.0247992843785981
GO:0016324	apical plasma membrane	0.0281500833507036
GO:0044459	plasma membrane part	0.0320131465064437
GO:0004714	transmembrane receptor protein tyrosine kinase activity	0.0323688831531588
GO:0019955	cytokine binding	0.0334538483107821
GO:0019199	transmembrane receptor protein kinase activity	0.0349252253364959
GO:0045177	apical part of cell	0.0353614959694466
GO:0005886	plasma membrane	0.0417949587817344
GO:0001653	peptide receptor activity	0.0417949587817344
GO:0008528	peptide receptor activity, G-protein coupled	0.0417949587817344
GO:0004888	transmembrane receptor activity	0.0442357757106788
GO:0042277	peptide binding	0.0496786384722613

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
epithelial cell	4.90e-07	25

Uber Anatomy

Ontology term	p-value	n
intestine	2.45e-16	31
gastrointestinal system	1.54e-13	47
digestive system	1.78e-10	116
digestive tract	1.78e-10	116
primitive gut	1.78e-10	116
endoderm-derived structure	2.03e-10	118
endoderm	2.03e-10	118
presumptive endoderm	2.03e-10	118
mucosa	7.18e-10	15
subdivision of digestive tract	1.32e-09	114
intestinal mucosa	1.11e-08	13
anatomical wall	1.11e-08	13
wall of intestine	1.11e-08	13
gastrointestinal system mucosa	1.11e-08	13
peripheral nervous system	2.86e-07	11
simple columnar epithelium	7.15e-07	11

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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