MCL coexpression mm9:1812

Phase1 CAGE Peaks

	Short description
Mm9::chr5:125758107..125758123,-	p@chr5:125758107..125758123 -
Mm9::chr5:125758205..125758235,-	p@chr5:125758205..125758235 -
Mm9::chr5:125770095..125770131,-	p@chr5:125770095..125770131 -
Mm9::chr7:151027144..151027159,+	p4@Dhcr7
Mm9::chr7:151033782..151033809,+	p@chr7:151033782..151033809 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008203	cholesterol metabolic process	0.000634016565012102
GO:0016125	sterol metabolic process	0.000634016565012102
GO:0008202	steroid metabolic process	0.001654991596933
GO:0047598	7-dehydrocholesterol reductase activity	0.00232838437517121
GO:0006066	alcohol metabolic process	0.00327912857149358
GO:0043534	blood vessel endothelial cell migration	0.00465638604416634
GO:0006707	cholesterol catabolic process	0.00465638604416634
GO:0016127	sterol catabolic process	0.00465638604416634
GO:0008283	cell proliferation	0.00532100087915992
GO:0006706	steroid catabolic process	0.00532100087915992
GO:0043542	endothelial cell migration	0.00532100087915992
GO:0044255	cellular lipid metabolic process	0.00532100087915992
GO:0001935	endothelial cell proliferation	0.00532100087915992
GO:0016599	caveolar membrane	0.00532100087915992
GO:0005901	caveola	0.00539204299110468
GO:0006629	lipid metabolic process	0.00539204299110468
GO:0000299	integral to membrane of membrane fraction	0.00657228069792494
GO:0030301	cholesterol transport	0.00698247418228115
GO:0015918	sterol transport	0.00698247418228115
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	0.00698247418228115
GO:0006695	cholesterol biosynthetic process	0.00975142626251612
GO:0044242	cellular lipid catabolic process	0.011734148517821
GO:0016126	sterol biosynthetic process	0.011734148517821
GO:0009791	post-embryonic development	0.0120200993621696
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	0.0156291691335456
GO:0035264	multicellular organism growth	0.0215828059196272
GO:0030324	lung development	0.0215828059196272
GO:0030323	respiratory tube development	0.0215828059196272
GO:0006694	steroid biosynthetic process	0.0221185166423629
GO:0006869	lipid transport	0.0229274507513982
GO:0016042	lipid catabolic process	0.0278701945656588

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
abdomen element	5.00e-12	49
abdominal segment element	5.00e-12	49
abdominal segment of trunk	5.00e-12	49
abdomen	5.00e-12	49
immaterial anatomical entity	1.69e-11	79
exocrine gland	2.44e-10	25
exocrine system	2.44e-10	25
trunk region element	2.90e-10	79
liver	6.83e-10	22
epithelial sac	6.83e-10	22
digestive gland	6.83e-10	22
epithelium of foregut-midgut junction	6.83e-10	22
anatomical boundary	6.83e-10	22
hepatobiliary system	6.83e-10	22
foregut-midgut junction	6.83e-10	22
hepatic diverticulum	6.83e-10	22
liver primordium	6.83e-10	22
septum transversum	6.83e-10	22
liver bud	6.83e-10	22
trunk mesenchyme	7.24e-10	45
endocrine system	1.89e-09	72
digestive tract diverticulum	2.25e-09	23
sac	2.25e-09	23
trunk	2.72e-08	90
subdivision of trunk	5.06e-08	66
body cavity precursor	7.47e-08	38
anatomical cavity	1.39e-07	39
gland	1.40e-07	65
body cavity	1.42e-07	37
body cavity or lining	1.42e-07	37
mesenchyme	2.17e-07	61
entire embryonic mesenchyme	2.17e-07	61
endocrine gland	2.26e-07	60
organism subdivision	4.14e-07	150

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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