MCL coexpression mm9:1879

Phase1 CAGE Peaks

	Short description
Mm9::chr10:127472693..127472711,+	p1@Naca
Mm9::chr15:101904346..101904365,+	p1@Eif4b
Mm9::chr15:43114241..43114274,-	p1@Eif3e
Mm9::chr2:104857172..104857232,-	p1@Eif3m

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0003743	translation initiation factor activity	1.64645390302682e-05
GO:0008135	translation factor activity, nucleic acid binding	2.73842277135108e-05
GO:0006412	translation	0.00090974244592492
GO:0009059	macromolecule biosynthetic process	0.0022983298963885
GO:0044249	cellular biosynthetic process	0.00336881789978311
GO:0017025	TATA-binding protein binding	0.00336881789978311
GO:0010467	gene expression	0.00336881789978311
GO:0003676	nucleic acid binding	0.00336881789978311
GO:0009058	biosynthetic process	0.00563358731139172
GO:0043170	macromolecule metabolic process	0.0398666698402492
GO:0044267	cellular protein metabolic process	0.0478404692008998
GO:0044260	cellular macromolecule metabolic process	0.0478404692008998
GO:0019538	protein metabolic process	0.0478404692008998
GO:0044238	primary metabolic process	0.0478404692008998
GO:0044237	cellular metabolic process	0.0478404692008998

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
lymphocyte	1.10e-08	13
common lymphoid progenitor	1.10e-08	13
lymphoid lineage restricted progenitor cell	2.68e-08	12
T cell	8.61e-08	11
pro-T cell	8.61e-08	11
hematopoietic cell	4.57e-07	32
hematopoietic oligopotent progenitor cell	4.57e-07	32
hematopoietic stem cell	4.57e-07	32
angioblastic mesenchymal cell	4.57e-07	32
hematopoietic multipotent progenitor cell	4.57e-07	32

Uber Anatomy

Ontology term	p-value	n
mesoderm	1.82e-09	120
mesoderm-derived structure	1.82e-09	120
presumptive mesoderm	1.82e-09	120
organism subdivision	7.81e-08	150
lateral plate mesoderm	3.44e-07	87
anterior region of body	6.26e-07	43

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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