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Coexpression cluster:C1735

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Full id: C1735_thyroid_pancreas_ductus_salivary_seminal_parotid_placenta



Phase1 CAGE Peaks

Hg19::chr15:31628024..31628049,+p@chr15:31628024..31628049
+
Hg19::chr17:26561040..26561082,-p@chr17:26561040..26561082
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Hg19::chr19:20933136..20933152,-p@chr19:20933136..20933152
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Hg19::chr19:20933174..20933181,-p@chr19:20933174..20933181
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Hg19::chr21:44375908..44375926,-p@chr21:44375908..44375926
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
endo-epithelial cell2.57e-1243
endodermal cell2.03e-1059
epithelial cell4.03e-09254
epithelial cell of alimentary canal1.56e-0821
Uber Anatomy
Ontology termp-valuen
endoderm-derived structure4.95e-21169
endoderm4.95e-21169
presumptive endoderm4.95e-21169
digestive system1.31e-17155
digestive tract1.31e-17155
primitive gut1.31e-17155
mixed endoderm/mesoderm-derived structure3.29e-16130
subdivision of digestive tract5.22e-16129
endodermal part of digestive tract5.22e-16129
adult organism6.32e-12115
orifice8.91e-1235
respiratory system2.90e-1172
foregut1.11e-0998
endo-epithelium1.83e-0882
oral opening6.73e-0821
hindgut6.75e-0819
epithelial bud2.08e-0737
mucosa2.34e-0712
respiratory tract2.66e-0753
extraembryonic membrane6.88e-0714
membranous layer6.88e-0714
Disease
Ontology termp-valuen
carcinoma6.99e-12106
squamous cell carcinoma1.28e-0914
cell type cancer5.13e-08143


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.