MCL coexpression mm9:1525

Phase1 CAGE Peaks

	Short description
Mm9::chr10:68613983..68614029,+	p2@Rhobtb1
Mm9::chr10:68614034..68614054,+	p8@Rhobtb1
Mm9::chr10:68614061..68614075,+	p11@Rhobtb1
Mm9::chr4:140172977..140172999,-	p5@Arhgef10l
Mm9::chr7:19608891..19608895,-	p1@Foxa3

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0001678	cell glucose homeostasis	0.0173478783104917
GO:0009267	cellular response to starvation	0.0173478783104917
GO:0031669	cellular response to nutrient levels	0.0173478783104917
GO:0042594	response to starvation	0.0173478783104917
GO:0031668	cellular response to extracellular stimulus	0.0173478783104917
GO:0005667	transcription factor complex	0.0173478783104917
GO:0033558	protein deacetylase activity	0.0173478783104917
GO:0004407	histone deacetylase activity	0.0173478783104917
GO:0031667	response to nutrient levels	0.0173478783104917
GO:0019213	deacetylase activity	0.0173478783104917
GO:0044451	nucleoplasm part	0.0173478783104917
GO:0009991	response to extracellular stimulus	0.0173478783104917
GO:0005654	nucleoplasm	0.0173478783104917
GO:0033554	cellular response to stress	0.0173478783104917
GO:0051716	cellular response to stimulus	0.0189225423342078
GO:0000118	histone deacetylase complex	0.0189225423342078
GO:0031981	nuclear lumen	0.0189225423342078
GO:0042593	glucose homeostasis	0.0194297496760142
GO:0033500	carbohydrate homeostasis	0.0194297496760142
GO:0031974	membrane-enclosed lumen	0.0194297496760142
GO:0043233	organelle lumen	0.0194297496760142
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	0.0310715940293953
GO:0044428	nuclear part	0.0310715940293953

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
digestive tract diverticulum	1.62e-17	23
sac	1.62e-17	23
liver	1.08e-16	22
epithelial sac	1.08e-16	22
digestive gland	1.08e-16	22
epithelium of foregut-midgut junction	1.08e-16	22
anatomical boundary	1.08e-16	22
hepatobiliary system	1.08e-16	22
foregut-midgut junction	1.08e-16	22
hepatic diverticulum	1.08e-16	22
liver primordium	1.08e-16	22
septum transversum	1.08e-16	22
liver bud	1.08e-16	22
exocrine gland	1.20e-13	25
exocrine system	1.20e-13	25
trunk region element	6.75e-12	79
abdomen element	3.25e-11	49
abdominal segment element	3.25e-11	49
abdominal segment of trunk	3.25e-11	49
abdomen	3.25e-11	49
gastrointestinal system	9.44e-11	47
endoderm-derived structure	2.55e-10	118
endoderm	2.55e-10	118
presumptive endoderm	2.55e-10	118
digestive system	2.57e-10	116
digestive tract	2.57e-10	116
primitive gut	2.57e-10	116
subdivision of digestive tract	1.73e-09	114
pancreas	3.09e-09	12
trunk	1.24e-08	90
intestine	1.63e-08	31
endocrine system	1.08e-07	72
immaterial anatomical entity	9.33e-07	79

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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