MCL coexpression mm9:1714

Phase1 CAGE Peaks

	Short description
Mm9::chr18:36823760..36823778,+	p2@Eif4ebp3
Mm9::chr18:36823786..36823811,+	p1@Eif4ebp3
Mm9::chr18:36824975..36825001,+	p@chr18:36824975..36825001 +
Mm9::chr2:4816920..4816926,+	p@chr2:4816920..4816926 +
Mm9::chr6:22293710..22293720,-	p10@Fam3c

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008190	eukaryotic initiation factor 4E binding	0.00365236764732738
GO:0031369	translation initiation factor binding	0.00365236764732738
GO:0045947	negative regulation of translational initiation	0.00365236764732738
GO:0006446	regulation of translational initiation	0.00949615588305119
GO:0017148	negative regulation of translation	0.00949615588305119
GO:0031327	negative regulation of cellular biosynthetic process	0.00949615588305119
GO:0009890	negative regulation of biosynthetic process	0.0100179226898122
GO:0006413	translational initiation	0.0120528132361804
GO:0051248	negative regulation of protein metabolic process	0.015339944118775
GO:0022618	protein-RNA complex assembly	0.015339944118775
GO:0006417	regulation of translation	0.0253839551489253
GO:0031326	regulation of cellular biosynthetic process	0.0253839551489253
GO:0009889	regulation of biosynthetic process	0.0261284762462651
GO:0022613	ribonucleoprotein complex biogenesis and assembly	0.0295841779433518
GO:0051246	regulation of protein metabolic process	0.0336017823554119
GO:0031324	negative regulation of cellular metabolic process	0.0399934257382348
GO:0065003	macromolecular complex assembly	0.0401760441206012
GO:0009892	negative regulation of metabolic process	0.0401760441206012
GO:0022607	cellular component assembly	0.0427903704365829
GO:0006412	translation	0.0466772585328439

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
metabolising cell	1.31e-09	5
endopolyploid cell	1.31e-09	5
parenchymal cell	1.31e-09	5
polyploid cell	1.31e-09	5
hepatocyte	1.31e-09	5

Uber Anatomy

Ontology term	p-value	n
liver	2.22e-13	22
epithelial sac	2.22e-13	22
digestive gland	2.22e-13	22
epithelium of foregut-midgut junction	2.22e-13	22
anatomical boundary	2.22e-13	22
hepatobiliary system	2.22e-13	22
foregut-midgut junction	2.22e-13	22
hepatic diverticulum	2.22e-13	22
liver primordium	2.22e-13	22
septum transversum	2.22e-13	22
liver bud	2.22e-13	22
digestive tract diverticulum	1.26e-12	23
sac	1.26e-12	23
exocrine gland	2.64e-11	25
exocrine system	2.64e-11	25

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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