MCL coexpression mm9:3345

Phase1 CAGE Peaks

	Short description
Mm9::chr2:32502137..32502153,+	p2@Eng
Mm9::chr2:32513120..32513133,+	p@chr2:32513120..32513133 +
Mm9::chr5:148537902..148537933,-	p2@Flt1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0001525	angiogenesis	0.00220559422418758
GO:0048514	blood vessel morphogenesis	0.00220559422418758
GO:0048646	anatomical structure formation	0.00220559422418758
GO:0001568	blood vessel development	0.00220559422418758
GO:0001944	vasculature development	0.00220559422418758
GO:0007167	enzyme linked receptor protein signaling pathway	0.00306796781243553
GO:0009887	organ morphogenesis	0.00923341233469388
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	0.0105892547704009
GO:0005021	vascular endothelial growth factor receptor activity	0.0105892547704009
GO:0048010	vascular endothelial growth factor receptor signaling pathway	0.0133409986228701
GO:0001569	patterning of blood vessels	0.0190543912102855
GO:0009653	anatomical structure morphogenesis	0.0267401967997023
GO:0009880	embryonic pattern specification	0.0292999848394325
GO:0007179	transforming growth factor beta receptor signaling pathway	0.0304491083090175
GO:0048513	organ development	0.0304491083090175
GO:0048754	branching morphogenesis of a tube	0.0333077109297246
GO:0004714	transmembrane receptor protein tyrosine kinase activity	0.0333077109297246
GO:0001763	morphogenesis of a branching structure	0.0333077109297246
GO:0019199	transmembrane receptor protein kinase activity	0.0347977274493042
GO:0048731	system development	0.0347977274493042
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	0.0357844064905917
GO:0048856	anatomical structure development	0.043008826230973
GO:0005615	extracellular space	0.0440411494199876
GO:0044421	extracellular region part	0.0474130161089944
GO:0007275	multicellular organismal development	0.0474130161089944

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
trunk region element	1.67e-11	79
splanchnic layer of lateral plate mesoderm	3.68e-11	33
primary circulatory organ	8.63e-11	18
heart	8.63e-11	18
primitive heart tube	8.63e-11	18
primary heart field	8.63e-11	18
anterior lateral plate mesoderm	8.63e-11	18
heart tube	8.63e-11	18
heart primordium	8.63e-11	18
cardiac mesoderm	8.63e-11	18
cardiogenic plate	8.63e-11	18
heart rudiment	8.63e-11	18
trunk	1.84e-10	90
cardiovascular system	6.92e-10	23
circulatory system	6.92e-10	23
subdivision of trunk	4.92e-09	66
epithelial tube	8.07e-09	47
compound organ	6.42e-08	43

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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