MCL coexpression mm9:947

Phase1 CAGE Peaks

	Short description
Mm9::chr13:54691582..54691628,+	p1@Higd2a
Mm9::chr17:31657078..31657114,+	p2@Ndufv3
Mm9::chr17:31657115..31657156,+	p1@Ndufv3
Mm9::chr18:36904172..36904207,-	p1@Ndufa2
Mm9::chr6:83059065..83059108,+	p1@Mrpl53
Mm9::chr8:72425531..72425556,-	p@chr8:72425531..72425556 -
Mm9::chr8:86090623..86090714,+	p1@Ndufb7
Mm9::chrX:20194388..20194415,-	p1@Ndufb11

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0003954	NADH dehydrogenase activity	9.92756832831844e-09
GO:0008137	NADH dehydrogenase (ubiquinone) activity	9.92756832831844e-09
GO:0050136	NADH dehydrogenase (quinone) activity	9.92756832831844e-09
GO:0016655	oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor	9.92756832831844e-09
GO:0016651	oxidoreductase activity, acting on NADH or NADPH	2.69754622110827e-08
GO:0009055	electron carrier activity	4.22632194422487e-07
GO:0005739	mitochondrion	1.53363318564445e-05
GO:0005743	mitochondrial inner membrane	0.000246676531560567
GO:0016491	oxidoreductase activity	0.000246676531560567
GO:0019866	organelle inner membrane	0.000246676531560567
GO:0031966	mitochondrial membrane	0.000253537101248045
GO:0005740	mitochondrial envelope	0.000292830429940016
GO:0044429	mitochondrial part	0.000441221674244483
GO:0031975	envelope	0.000635323993806063
GO:0031967	organelle envelope	0.000635323993806063
GO:0031090	organelle membrane	0.00158077024502968
GO:0044444	cytoplasmic part	0.00231874999342916
GO:0045271	respiratory chain complex I	0.00666739374011737
GO:0030964	NADH dehydrogenase complex (quinone)	0.00666739374011737
GO:0005747	mitochondrial respiratory chain complex I	0.00666739374011737
GO:0005746	mitochondrial respiratory chain	0.0250280328214345
GO:0005737	cytoplasm	0.0250280328214345
GO:0044455	mitochondrial membrane part	0.0362587023427898
GO:0043231	intracellular membrane-bound organelle	0.0454890527855033
GO:0043227	membrane-bound organelle	0.0454890527855033

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
embryonic cell	2.39e-07	70

Uber Anatomy

Ontology term	p-value	n
primary circulatory organ	3.79e-09	18
heart	3.79e-09	18
primitive heart tube	3.79e-09	18
primary heart field	3.79e-09	18
anterior lateral plate mesoderm	3.79e-09	18
heart tube	3.79e-09	18
heart primordium	3.79e-09	18
cardiac mesoderm	3.79e-09	18
cardiogenic plate	3.79e-09	18
heart rudiment	3.79e-09	18
cardiovascular system	1.51e-07	23
circulatory system	1.51e-07	23
epithelial tube	3.02e-07	47
compound organ	6.26e-07	43

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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