MCL coexpression mm9:179
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0005739 | mitochondrion | 0.039404521968793 |
| GO:0018112 | proline racemase activity | 0.039404521968793 |
| GO:0050113 | inositol oxygenase activity | 0.039404521968793 |
| GO:0004856 | xylulokinase activity | 0.039404521968793 |
| GO:0006790 | sulfur metabolic process | 0.039404521968793 |
| GO:0030534 | adult behavior | 0.039404521968793 |
| GO:0000105 | histidine biosynthetic process | 0.039404521968793 |
| GO:0004486 | methylenetetrahydrofolate dehydrogenase activity | 0.039404521968793 |
| GO:0009076 | histidine family amino acid biosynthetic process | 0.039404521968793 |
| GO:0001960 | negative regulation of cytokine and chemokine mediated signaling pathway | 0.039404521968793 |
| GO:0045079 | negative regulation of chemokine biosynthetic process | 0.039404521968793 |
| GO:0004477 | methenyltetrahydrofolate cyclohydrolase activity | 0.039404521968793 |
| GO:0005118 | sevenless binding | 0.039404521968793 |
| GO:0004795 | threonine synthase activity | 0.039404521968793 |
| GO:0004329 | formate-tetrahydrofolate ligase activity | 0.039404521968793 |
| GO:0004488 | methylenetetrahydrofolate dehydrogenase (NADP+) activity | 0.039404521968793 |
| GO:0016155 | formyltetrahydrofolate dehydrogenase activity | 0.039404521968793 |
| GO:0047961 | glycine N-acyltransferase activity | 0.039404521968793 |
| GO:0051934 | catecholamine uptake during transmission of nerve impulse | 0.039404521968793 |
| GO:0051583 | dopamine uptake | 0.039404521968793 |
| GO:0060081 | membrane hyperpolarization | 0.039404521968793 |
| GO:0016838 | carbon-oxygen lyase activity, acting on phosphates | 0.039404521968793 |
| GO:0001959 | regulation of cytokine and chemokine mediated signaling pathway | 0.039404521968793 |
| GO:0006855 | multidrug transport | 0.039404521968793 |
| GO:0016855 | racemase and epimerase activity, acting on amino acids and derivatives | 0.039404521968793 |
| GO:0060080 | regulation of inhibitory postsynaptic membrane potential | 0.039404521968793 |
| GO:0051937 | catecholamine transport | 0.039404521968793 |
| GO:0042732 | D-xylose metabolic process | 0.039404521968793 |
| GO:0001505 | regulation of neurotransmitter levels | 0.0478113021337323 |
| GO:0019238 | cyclohydrolase activity | 0.0490112222716904 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| metabolising cell | 6.09e-07 | 5 |
| endopolyploid cell | 6.09e-07 | 5 |
| parenchymal cell | 6.09e-07 | 5 |
| polyploid cell | 6.09e-07 | 5 |
| hepatocyte | 6.09e-07 | 5 |
| Ontology term | p-value | n |
|---|---|---|
| liver | 1.01e-31 | 22 |
| epithelial sac | 1.01e-31 | 22 |
| digestive gland | 1.01e-31 | 22 |
| epithelium of foregut-midgut junction | 1.01e-31 | 22 |
| anatomical boundary | 1.01e-31 | 22 |
| hepatobiliary system | 1.01e-31 | 22 |
| foregut-midgut junction | 1.01e-31 | 22 |
| hepatic diverticulum | 1.01e-31 | 22 |
| liver primordium | 1.01e-31 | 22 |
| septum transversum | 1.01e-31 | 22 |
| liver bud | 1.01e-31 | 22 |
| digestive tract diverticulum | 4.30e-30 | 23 |
| sac | 4.30e-30 | 23 |
| exocrine gland | 3.16e-27 | 25 |
| exocrine system | 3.16e-27 | 25 |
| abdomen element | 2.53e-25 | 49 |
| abdominal segment element | 2.53e-25 | 49 |
| abdominal segment of trunk | 2.53e-25 | 49 |
| abdomen | 2.53e-25 | 49 |
| mesenchyme | 8.11e-19 | 61 |
| entire embryonic mesenchyme | 8.11e-19 | 61 |
| subdivision of trunk | 8.22e-17 | 66 |
| trunk region element | 8.35e-13 | 79 |
| trunk mesenchyme | 1.18e-12 | 45 |
| epithelial tube | 6.87e-12 | 47 |
| trunk | 2.43e-10 | 90 |
| gut epithelium | 2.13e-09 | 55 |
| endocrine gland | 3.43e-08 | 60 |
| kidney | 5.48e-08 | 14 |
| kidney mesenchyme | 5.48e-08 | 14 |
| upper urinary tract | 5.48e-08 | 14 |
| kidney rudiment | 5.48e-08 | 14 |
| kidney field | 5.48e-08 | 14 |
| gland | 3.52e-07 | 65 |
| unilaminar epithelium | 5.35e-07 | 66 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
{{{tfbs_overrepresentation_jaspar}}} |
