MCL coexpression mm9:953

Phase1 CAGE Peaks

	Short description
Mm9::chr14:119337147..119337214,+	p1@Dnajc3
Mm9::chr14:73002752..73002810,-	p2@Fndc3a
Mm9::chr1:36300977..36301021,-	p2@Uggt1
Mm9::chr4:48292416..48292485,-	p1@Erp44
Mm9::chr6:47746242..47746246,-	p@chr6:47746242..47746246 -
Mm9::chr9:106794239..106794251,-	p2@Manf
Mm9::chr9:44187619..44187707,+	p1@Hyou1
Mm9::chr9:44200284..44200288,+	p@chr9:44200284..44200288 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0006986	response to unfolded protein	0.000760466938137463
GO:0051789	response to protein stimulus	0.000760466938137463
GO:0005783	endoplasmic reticulum	0.00578683079327287
GO:0006950	response to stress	0.00578683079327287
GO:0009607	response to biotic stimulus	0.0119287071954611
GO:0044444	cytoplasmic part	0.0119287071954611
GO:0005788	endoplasmic reticulum lumen	0.022777665929277
GO:0042221	response to chemical stimulus	0.0354537894644572
GO:0004860	protein kinase inhibitor activity	0.0382727595647032
GO:0005615	extracellular space	0.0382727595647032
GO:0019210	kinase inhibitor activity	0.0382727595647032
GO:0001669	acrosome	0.0382727595647032
GO:0044421	extracellular region part	0.0382727595647032
GO:0005737	cytoplasm	0.0423176696192316
GO:0006469	negative regulation of protein kinase activity	0.0423176696192316
GO:0033673	negative regulation of kinase activity	0.0423176696192316
GO:0051348	negative regulation of transferase activity	0.0423176696192316
GO:0045454	cell redox homeostasis	0.0423176696192316
GO:0007286	spermatid development	0.0423176696192316
GO:0048515	spermatid differentiation	0.0423176696192316
GO:0043086	negative regulation of catalytic activity	0.0423176696192316
GO:0031072	heat shock protein binding	0.0423176696192316
GO:0009566	fertilization	0.0423176696192316
GO:0012506	vesicle membrane	0.0462945999488851
GO:0043231	intracellular membrane-bound organelle	0.0462945999488851
GO:0043227	membrane-bound organelle	0.0462945999488851
GO:0019887	protein kinase regulator activity	0.0462945999488851

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
epithelial cell	2.27e-07	25

Uber Anatomy

Ontology term	p-value	n
trunk	1.22e-14	90
trunk region element	8.06e-13	79
endoderm-derived structure	9.35e-12	118
endoderm	9.35e-12	118
presumptive endoderm	9.35e-12	118
digestive system	7.99e-11	116
digestive tract	7.99e-11	116
primitive gut	7.99e-11	116
trunk mesenchyme	1.06e-10	45
immaterial anatomical entity	1.17e-10	79
exocrine gland	2.49e-10	25
exocrine system	2.49e-10	25
subdivision of digestive tract	4.05e-10	114
gastrointestinal system	2.45e-09	47
intestine	4.41e-09	31
digestive tract diverticulum	4.89e-09	23
sac	4.89e-09	23
liver	9.48e-09	22
epithelial sac	9.48e-09	22
digestive gland	9.48e-09	22
epithelium of foregut-midgut junction	9.48e-09	22
anatomical boundary	9.48e-09	22
hepatobiliary system	9.48e-09	22
foregut-midgut junction	9.48e-09	22
hepatic diverticulum	9.48e-09	22
liver primordium	9.48e-09	22
septum transversum	9.48e-09	22
liver bud	9.48e-09	22
mesenchyme	2.32e-08	61
entire embryonic mesenchyme	2.32e-08	61
pancreas	4.15e-08	12
subdivision of trunk	1.62e-07	66
abdomen element	6.19e-07	49
abdominal segment element	6.19e-07	49
abdominal segment of trunk	6.19e-07	49
abdomen	6.19e-07	49

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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