MCL coexpression mm9:2868

Phase1 CAGE Peaks

	Short description
Mm9::chr13:64230613..64230656,-	p1@Slc35d2
Mm9::chr14:65059705..65059760,-	p1@Msra
Mm9::chr18:24812357..24812384,+	p1@Mocos

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008113	peptide-methionine-(S)-S-oxide reductase activity	0.0088249089173742
GO:0006777	Mo-molybdopterin cofactor biosynthetic process	0.0088249089173742
GO:0043545	molybdopterin cofactor metabolic process	0.0088249089173742
GO:0019720	Mo-molybdopterin cofactor metabolic process	0.0088249089173742
GO:0032324	molybdopterin cofactor biosynthetic process	0.0088249089173742
GO:0030151	molybdenum ion binding	0.0088249089173742
GO:0016671	oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor	0.0088249089173742
GO:0042559	pteridine and derivative biosynthetic process	0.010035583815854
GO:0019438	aromatic compound biosynthetic process	0.010035583815854
GO:0042558	pteridine and derivative metabolic process	0.010035583815854
GO:0016667	oxidoreductase activity, acting on sulfur group of donors	0.0140303979737369
GO:0008483	transaminase activity	0.017355957008127
GO:0016769	transferase activity, transferring nitrogenous groups	0.0187899215836456
GO:0005351	sugar:hydrogen ion symporter activity	0.0187899215836456
GO:0051119	sugar transmembrane transporter activity	0.0187899215836456
GO:0015144	carbohydrate transmembrane transporter activity	0.0187899215836456
GO:0030170	pyridoxal phosphate binding	0.0208507923801405
GO:0008643	carbohydrate transport	0.0265186708507003
GO:0009108	coenzyme biosynthetic process	0.0335936131658487
GO:0051188	cofactor biosynthetic process	0.0368861757135079
GO:0019842	vitamin binding	0.0384041233135154
GO:0006725	aromatic compound metabolic process	0.0394341859602444
GO:0015293	symporter activity	0.0443469714640387
GO:0016829	lyase activity	0.0485198264210325
GO:0006732	coenzyme metabolic process	0.0487053843079881
GO:0048037	cofactor binding	0.0494585072045406
GO:0015291	secondary active transmembrane transporter activity	0.0498727161413483

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
trunk mesenchyme	4.20e-11	45
mesenchyme	1.40e-10	61
entire embryonic mesenchyme	1.40e-10	61
endoderm-derived structure	1.73e-10	118
endoderm	1.73e-10	118
presumptive endoderm	1.73e-10	118
digestive system	2.17e-10	116
digestive tract	2.17e-10	116
primitive gut	2.17e-10	116
subdivision of digestive tract	1.14e-09	114
exocrine gland	5.45e-09	25
exocrine system	5.45e-09	25
digestive tract diverticulum	6.84e-09	23
sac	6.84e-09	23
intestine	1.54e-08	31
liver	1.68e-08	22
epithelial sac	1.68e-08	22
digestive gland	1.68e-08	22
epithelium of foregut-midgut junction	1.68e-08	22
anatomical boundary	1.68e-08	22
hepatobiliary system	1.68e-08	22
foregut-midgut junction	1.68e-08	22
hepatic diverticulum	1.68e-08	22
liver primordium	1.68e-08	22
septum transversum	1.68e-08	22
liver bud	1.68e-08	22
gastrointestinal system	2.47e-08	47
trunk	3.57e-08	90
epithelial tube	3.75e-08	47
subdivision of trunk	2.34e-07	66
abdomen element	2.48e-07	49
abdominal segment element	2.48e-07	49
abdominal segment of trunk	2.48e-07	49
abdomen	2.48e-07	49

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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