MCL coexpression mm9:262
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0007389 | pattern specification process | 0.000473097416261886 |
| GO:0003700 | transcription factor activity | 0.00128291389413705 |
| GO:0005667 | transcription factor complex | 0.00128291389413705 |
| GO:0043565 | sequence-specific DNA binding | 0.00128291389413705 |
| GO:0009887 | organ morphogenesis | 0.00147536142509066 |
| GO:0044451 | nucleoplasm part | 0.00147536142509066 |
| GO:0001501 | skeletal development | 0.00147536142509066 |
| GO:0009653 | anatomical structure morphogenesis | 0.00147536142509066 |
| GO:0005654 | nucleoplasm | 0.00147536142509066 |
| GO:0031981 | nuclear lumen | 0.00259470647301078 |
| GO:0048513 | organ development | 0.00266446791328663 |
| GO:0031974 | membrane-enclosed lumen | 0.00317368745954419 |
| GO:0043233 | organelle lumen | 0.00317368745954419 |
| GO:0030326 | embryonic limb morphogenesis | 0.00415540629745191 |
| GO:0035113 | embryonic appendage morphogenesis | 0.00415540629745191 |
| GO:0048731 | system development | 0.00489650441409066 |
| GO:0035107 | appendage morphogenesis | 0.00489650441409066 |
| GO:0035108 | limb morphogenesis | 0.00489650441409066 |
| GO:0060173 | limb development | 0.00489650441409066 |
| GO:0048736 | appendage development | 0.00489650441409066 |
| GO:0044428 | nuclear part | 0.00551324171480623 |
| GO:0006355 | regulation of transcription, DNA-dependent | 0.00551324171480623 |
| GO:0006351 | transcription, DNA-dependent | 0.00551324171480623 |
| GO:0032774 | RNA biosynthetic process | 0.00551324171480623 |
| GO:0003677 | DNA binding | 0.00560995379016853 |
| GO:0045449 | regulation of transcription | 0.00578422189955604 |
| GO:0048856 | anatomical structure development | 0.00587999880279197 |
| GO:0019219 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.00587999880279197 |
| GO:0006350 | transcription | 0.00602887185361421 |
| GO:0010468 | regulation of gene expression | 0.0067870812496044 |
| GO:0031323 | regulation of cellular metabolic process | 0.00790017989892396 |
| GO:0007275 | multicellular organismal development | 0.00849566317085947 |
| GO:0019222 | regulation of metabolic process | 0.00876372901634206 |
| GO:0016070 | RNA metabolic process | 0.00958001881999868 |
| GO:0046332 | SMAD binding | 0.0139741292509268 |
| GO:0045843 | negative regulation of striated muscle development | 0.0139741292509268 |
| GO:0005518 | collagen binding | 0.0139741292509268 |
| GO:0048598 | embryonic morphogenesis | 0.0162956286286687 |
| GO:0043234 | protein complex | 0.0180532963462087 |
| GO:0010467 | gene expression | 0.0183035077001981 |
| GO:0003676 | nucleic acid binding | 0.0198566542060702 |
| GO:0035115 | embryonic forelimb morphogenesis | 0.0208469733473235 |
| GO:0032502 | developmental process | 0.0208469733473235 |
| GO:0016202 | regulation of striated muscle development | 0.0208469733473235 |
| GO:0010092 | specification of organ identity | 0.0208469733473235 |
| GO:0001759 | induction of an organ | 0.0208469733473235 |
| GO:0031128 | induction | 0.0215104325091062 |
| GO:0045168 | cell-cell signaling during cell fate commitment | 0.0215104325091062 |
| GO:0030246 | carbohydrate binding | 0.0216351742869658 |
| GO:0035136 | forelimb morphogenesis | 0.022120169814977 |
| GO:0006139 | nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.0222185820997572 |
| GO:0005540 | hyaluronic acid binding | 0.0226823841787019 |
| GO:0050794 | regulation of cellular process | 0.0290204774403076 |
| GO:0032991 | macromolecular complex | 0.0299126914371503 |
| GO:0035137 | hindlimb morphogenesis | 0.0307801926670324 |
| GO:0050789 | regulation of biological process | 0.043652504504262 |
| GO:0044446 | intracellular organelle part | 0.0481157019908402 |
| GO:0044422 | organelle part | 0.0481157019908402 |
| GO:0009790 | embryonic development | 0.0488680045372098 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| forelimb | 2.69e-17 | 7 |
| pectoral appendage | 2.69e-17 | 7 |
| pectoral appendage bud | 2.69e-17 | 7 |
| forelimb bud | 2.69e-17 | 7 |
| forelimb/pectoral fin field | 2.69e-17 | 7 |
| pectoral complex | 5.66e-15 | 8 |
| appendage | 1.49e-09 | 12 |
| paired limb/fin | 1.49e-09 | 12 |
| limb | 1.49e-09 | 12 |
| paired limb/fin bud | 1.49e-09 | 12 |
| limb bud | 1.49e-09 | 12 |
| limb/fin field | 1.49e-09 | 12 |
| limb field | 1.49e-09 | 12 |
| appendage girdle complex | 1.01e-08 | 13 |
| surface structure | 3.05e-07 | 22 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 0.630339 |
| MA0004.1 | 0.555731 |
| MA0006.1 | 0.228715 |
| MA0007.1 | 1.34507 |
| MA0009.1 | 0.93858 |
| MA0014.1 | 0.181411 |
| MA0017.1 | 0.11299 |
| MA0019.1 | 0.221321 |
| MA0024.1 | 0.322453 |
| MA0025.1 | 0.553002 |
| MA0027.1 | 1.91746 |
| MA0028.1 | 0.099689 |
| MA0029.1 | 0.305809 |
| MA0030.1 | 0.836147 |
| MA0031.1 | 0.284004 |
| MA0038.1 | 0.150331 |
| MA0040.1 | 0.366712 |
| MA0041.1 | 0.397031 |
| MA0042.1 | 0.0421363 |
| MA0043.1 | 0.435645 |
| MA0046.1 | 0.385571 |
| MA0048.1 | 0.227772 |
| MA0050.1 | 0.311127 |
| MA0051.1 | 0.155655 |
| MA0052.1 | 0.373177 |
| MA0055.1 | 0.263203 |
| MA0056.1 | 0 |
| MA0057.1 | 3.31814 |
| MA0058.1 | 0.64262 |
| MA0059.1 | 0.679523 |
| MA0060.1 | 1.27911 |
| MA0061.1 | 0.310047 |
| MA0063.1 | 0 |
| MA0066.1 | 0.869432 |
| MA0067.1 | 0.652366 |
| MA0068.1 | 5.90148 |
| MA0069.1 | 0.373449 |
| MA0070.1 | 0.365675 |
| MA0071.1 | 0.0930503 |
| MA0072.1 | 0.358914 |
| MA0073.1 | 24.212 |
| MA0074.1 | 0.123701 |
| MA0076.1 | 0.0318933 |
| MA0077.1 | 0.341791 |
| MA0078.1 | 0.175945 |
| MA0081.1 | 0.192641 |
| MA0083.1 | 0.434982 |
| MA0084.1 | 0.958921 |
| MA0087.1 | 0.399335 |
| MA0088.1 | 0.168242 |
| MA0089.1 | 0 |
| MA0090.1 | 0.0615811 |
| MA0091.1 | 0.584863 |
| MA0092.1 | 0.833305 |
| MA0093.1 | 0.781254 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.374893 |
| MA0101.1 | 0.0468921 |
| MA0103.1 | 0.122326 |
| MA0105.1 | 0.542683 |
| MA0106.1 | 1.02229 |
| MA0107.1 | 0.0280799 |
| MA0108.2 | 1.24164 |
| MA0109.1 | 0 |
| MA0111.1 | 0.512045 |
| MA0113.1 | 0.163276 |
| MA0114.1 | 0.150918 |
| MA0115.1 | 0.437985 |
| MA0116.1 | 0.435156 |
| MA0117.1 | 0.411186 |
| MA0119.1 | 0.400754 |
| MA0122.1 | 0.427622 |
| MA0124.1 | 0.604388 |
| MA0125.1 | 0.538769 |
| MA0130.1 | 0 |
| MA0131.1 | 0.218222 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 1.17732 |
| MA0136.1 | 0.134737 |
| MA0139.1 | 0.027105 |
| MA0140.1 | 0.374733 |
| MA0141.1 | 0.140263 |
| MA0142.1 | 0.27329 |
| MA0143.1 | 0.173388 |
| MA0144.1 | 0.155067 |
| MA0145.1 | 0.831393 |
| MA0146.1 | 1.35282 |
| MA0147.1 | 0.341028 |
| MA0148.1 | 0.0829136 |
| MA0149.1 | 0.183385 |
| MA0062.2 | 0.00237099 |
| MA0035.2 | 0.119926 |
| MA0039.2 | 2.74685 |
| MA0138.2 | 0.212837 |
| MA0002.2 | 0.336369 |
| MA0137.2 | 0.322137 |
| MA0104.2 | 0.379989 |
| MA0047.2 | 0.149878 |
| MA0112.2 | 1.61978 |
| MA0065.2 | 0.310259 |
| MA0150.1 | 0.0692983 |
| MA0151.1 | 0 |
| MA0152.1 | 1.43731 |
| MA0153.1 | 0.480495 |
| MA0154.1 | 0.0222139 |
| MA0155.1 | 2.5538 |
| MA0156.1 | 0.031657 |
| MA0157.1 | 0.250083 |
| MA0158.1 | 0 |
| MA0159.1 | 0.909317 |
| MA0160.1 | 0.0842824 |
| MA0161.1 | 0 |
| MA0162.1 | 1.86634 |
| MA0163.1 | 1.23775 |
| MA0164.1 | 0.831004 |
| MA0080.2 | 0.117725 |
| MA0018.2 | 0.140467 |
| MA0099.2 | 0.208596 |
| MA0079.2 | 17.9282 |
| MA0102.2 | 1.0092 |
| MA0258.1 | 2.21524 |
| MA0259.1 | 0.0586005 |
| MA0442.1 | 0 |
