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CL:0000792

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Name:CD4-positive, CD25-positive, alpha-beta regulatory T cell
Namespace:FANTOM
Definition:"A CD4-positive, CD25-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [GOC:add, GOC:tfm, ISBN:0781735149, PMID:19464985]
Xrefs:
links:
FMA:84070
Synonyms: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte" EXACT []
"CD4-positive, CD25-positive, alpha-beta regulatory T-cell" EXACT []
"CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte" EXACT []
"suppressor T cell" BROAD []
"suppressor T lymphocyte" BROAD []
"suppressor T-cell" BROAD []
"suppressor T-lymphocyte" BROAD []


Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:CL:0000624(CD4-positive, alpha-beta T cell),CL:0000815(regulatory T cell)



Children


is a:CL:0002677 (naive regulatory T cell),CL:0002678 (memory regulatory T cell)
derives from:FF:0011454 (CD4-positiveCD25-positive regulatory T cells (C57BL_6J) sample),FF:0011455 (CD4-positiveCD25-positive regulatory T cells (Balb_cAJcl) sample)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)


FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.

Human (Homo sapiens)

  • 11780-124A7 (CD4+CD25+CD45RA+ naive regulatory T cells, donor1)
  • 11782-124A9 (CD4+CD25+CD45RA- memory regulatory T cells, donor1)
  • 11814-124E5 (CD4+CD25+ regulatory T cells, pool1 (C57BL_6J))
  • 11818-124E9 (CD4+CD25+ regulatory T cells, pool2 (Balb_cAJcl))
  • 11945-126B1 (CD4+CD25+ regulatory T cells, PMA and ionomycin stimulation, 02hr, pool1 (C57BL 6J))

Mouse (Mus musculus)

  • 11780-124A7 (CD4+CD25+CD45RA+ naive regulatory T cells, donor1)
  • 11782-124A9 (CD4+CD25+CD45RA- memory regulatory T cells, donor1)
  • 11814-124E5 (CD4+CD25+ regulatory T cells, pool1 (C57BL_6J))
  • 11818-124E9 (CD4+CD25+ regulatory T cells, pool2 (Balb_cAJcl))
  • 11945-126B1 (CD4+CD25+ regulatory T cells, PMA and ionomycin stimulation, 02hr, pool1 (C57BL 6J))


Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000792 (CD4-positive, CD25-positive, alpha-beta regulatory T cell), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
4.61e-131FFCP PHASE1:Hg19::chr1:113160702..113160706,-#_7eb629238f20182fa932493119f8e655p21@ST7L
4.61e-131FFCP PHASE2:Hg19::chr1:113160702..113160706,-#_7eb629238f20182fa932493119f8e655p21@ST7L
5.68e-99FFCP PHASE2:Hg19::chr11:111410267..111410269,+#_4b57093f8beed8fd80c81e4dee882aeap@chr11:111410267..111410269, +
5.68e-99FFCP PHASE1:Hg19::chr11:111410267..111410269,+#_4b57093f8beed8fd80c81e4dee882aeap@chr11:111410267..111410269, +
1.55e-98FFCP PHASE1:Hg19::chr3:73015629..73015632,+#_eb9aa43f6eeb17bec4109741d89cab77p@chr3:73015629..73015632, +
1.55e-98FFCP PHASE2:Hg19::chr3:73015629..73015632,+#_eb9aa43f6eeb17bec4109741d89cab77p@chr3:73015629..73015632, +
3.07e-86FFCP PHASE1:Mm9::chr10:18908457..18908466,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr10:18908457..18908466, -
3.07e-86FFCP PHASE1:Mm9::chr9:14662914..14662922,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr9:14662914..14662922, +
3.07e-86FFCP PHASE1:Mm9::chr17:26688385..26688421,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr17:26688385..26688421, +
3.07e-86FFCP PHASE2:Mm9::chr12:111613723..111613727,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr12:111613723..111613727, +
3.07e-86FFCP PHASE2:Mm9::chr1:60967956..60967966,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr1:60967956..60967966, +
3.07e-86FFCP PHASE2:Mm9::chr17:12884847..12884852,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr17:12884847..12884852, -
3.07e-86FFCP PHASE1:Mm9::chr9:69148201..69148218,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr9:69148201..69148218, -
3.07e-86FFCP PHASE2:Mm9::chr4:151490501..151490511,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp5@Tnfrsf25
3.07e-86FFCP PHASE2:Mm9::chr17:26709187..26709203,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr17:26709187..26709203, -
3.07e-86FFCP PHASE1:Mm9::chr12:111613723..111613727,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr12:111613723..111613727, +
3.07e-86FFCP PHASE1:Mm9::chr7:108729732..108729745,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr7:108729732..108729745, +
3.07e-86FFCP PHASE1:Mm9::chr4:155400229..155400241,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp3@Tnfrsf18
3.07e-86FFCP PHASE2:Mm9::chr7:106142059..106142061,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr7:106142059..106142061, -
3.07e-86FFCP PHASE1:Mm9::chr17:26709187..26709203,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr17:26709187..26709203, -
3.07e-86FFCP PHASE1:Mm9::chr6:48670473..48670480,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr6:48670473..48670480, +
3.07e-86FFCP PHASE2:Mm9::chr8:74526522..74526532,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr8:74526522..74526532, -
3.07e-86FFCP PHASE2:Mm9::chr2:78812885..78812894,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr2:78812885..78812894, +
3.07e-86FFCP PHASE1:Mm9::chr14:101876628..101876637,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr14:101876628..101876637, -
3.07e-86FFCP PHASE2:Mm9::chrX:7170204..7170205,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chrX:7170204..7170205, +
3.07e-86FFCP PHASE1:Mm9::chr1:69729950..69729959,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr1:69729950..69729959, -
3.07e-86FFCP PHASE2:Mm9::chr6:49536818..49536841,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr6:49536818..49536841, +
3.07e-86FFCP PHASE1:Mm9::chr13:43627067..43627074,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr13:43627067..43627074, +
3.07e-86FFCP PHASE1:Mm9::chr8:129378573..129378577,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr8:129378573..129378577, +
3.07e-86FFCP PHASE2:Mm9::chr6:106741792..106741797,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr6:106741792..106741797, +
3.07e-86FFCP PHASE1:Mm9::chr2:78812885..78812894,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr2:78812885..78812894, +
3.07e-86FFCP PHASE1:Mm9::chr17:12807573..12807582,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr17:12807573..12807582, +
3.07e-86FFCP PHASE2:Mm9::chr1:60770897..60770901,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr1:60770897..60770901, +
3.07e-86FFCP PHASE1:Mm9::chr9:14707496..14707511,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr9:14707496..14707511, -
3.07e-86FFCP PHASE2:Mm9::chr1:69729718..69729723,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr1:69729718..69729723, -
3.07e-86FFCP PHASE1:Mm9::chr1:69727659..69727696,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr1:69727659..69727696, -
3.07e-86FFCP PHASE2:Mm9::chr4:102843557..102843585,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr4:102843557..102843585, +
3.07e-86FFCP PHASE1:Mm9::chr17:87518592..87518603,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr17:87518592..87518603, +
3.07e-86FFCP PHASE1:Mm9::chr15:59356135..59356143,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr15:59356135..59356143, -
3.07e-86FFCP PHASE1:Mm9::chr9:13699290..13699296,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr9:13699290..13699296, +
3.07e-86FFCP PHASE2:Mm9::chr1:69727659..69727696,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr1:69727659..69727696, -
3.07e-86FFCP PHASE2:Mm9::chr9:13699290..13699296,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr9:13699290..13699296, +
3.07e-86FFCP PHASE2:Mm9::chr1:60967565..60967590,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr1:60967565..60967590, -
3.07e-86FFCP PHASE2:Mm9::chr15:59356135..59356143,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr15:59356135..59356143, -
3.07e-86FFCP PHASE2:Mm9::chr16:36770181..36770184,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr16:36770181..36770184, -
3.07e-86FFCP PHASE2:Mm9::chr17:26688385..26688421,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr17:26688385..26688421, +
3.07e-86FFCP PHASE1:Mm9::chr10:13765981..13765988,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr10:13765981..13765988, +
3.07e-86FFCP PHASE1:Mm9::chr16:89837454..89837462,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr16:89837454..89837462, -
3.07e-86FFCP PHASE2:Mm9::chrX:7148320..7148329,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chrX:7148320..7148329, +
3.07e-86FFCP PHASE1:Mm9::chr2:112347343..112347355,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr2:112347343..112347355, +
3.07e-86FFCP PHASE2:Mm9::chr8:84303823..84303825,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr8:84303823..84303825, +
3.07e-86FFCP PHASE1:Mm9::chr11:4397552..4397557,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr11:4397552..4397557, -
3.07e-86FFCP PHASE2:Mm9::chrX:7172178..7172190,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chrX:7172178..7172190, -
3.07e-86FFCP PHASE1:Mm9::chr16:36770181..36770184,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr16:36770181..36770184, -
3.07e-86FFCP PHASE1:Mm9::chr9:56267292..56267296,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr9:56267292..56267296, +
3.07e-86FFCP PHASE1:Mm9::chr1:69815958..69815961,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr1:69815958..69815961, +
3.07e-86FFCP PHASE2:Mm9::chr16:89826368..89826391,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr16:89826368..89826391, +
3.07e-86FFCP PHASE2:Mm9::chr1:155570551..155570558,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr1:155570551..155570558, -
3.07e-86FFCP PHASE2:Mm9::chr11:4397552..4397557,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr11:4397552..4397557, -
3.07e-86FFCP PHASE2:Mm9::chr10:18908457..18908466,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr10:18908457..18908466, -
3.07e-86FFCP PHASE1:Mm9::chr7:80757542..80757576,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr7:80757542..80757576, -
3.07e-86FFCP PHASE1:Mm9::chr1:69729718..69729723,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr1:69729718..69729723, -
3.07e-86FFCP PHASE1:Mm9::chr8:84303823..84303825,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr8:84303823..84303825, +
3.07e-86FFCP PHASE2:Mm9::chr4:151490543..151490552,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp6@Tnfrsf25
3.07e-86FFCP PHASE1:Mm9::chr10:58784974..58784979,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr10:58784974..58784979, -
3.07e-86FFCP PHASE2:Mm9::chr1:69595515..69595518,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr1:69595515..69595518, -
3.07e-86FFCP PHASE1:Mm9::chr1:60967911..60967916,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr1:60967911..60967916, +
3.07e-86FFCP PHASE1:Mm9::chrX:7148320..7148329,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chrX:7148320..7148329, +
3.07e-86FFCP PHASE1:Mm9::chr2:139885951..139885958,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr2:139885951..139885958, -
3.07e-86FFCP PHASE2:Mm9::chr9:14708334..14708341,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp11@Folr4
3.07e-86FFCP PHASE1:Mm9::chr12:108370128..108370136,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr12:108370128..108370136, -
3.07e-86FFCP PHASE1:Mm9::chr16:89826368..89826391,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr16:89826368..89826391, +
3.07e-86FFCP PHASE1:Mm9::chr10:89010973..89010996,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr10:89010973..89010996, -
3.07e-86FFCP PHASE1:Mm9::chr17:12808149..12808156,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr17:12808149..12808156, +
3.07e-86FFCP PHASE1:Mm9::chr10:22023694..22023695,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr10:22023694..22023695, -
3.07e-86FFCP PHASE2:Mm9::chr1:69815958..69815961,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr1:69815958..69815961, +
3.07e-86FFCP PHASE2:Mm9::chr4:32512204..32512214,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr4:32512204..32512214, +
3.07e-86FFCP PHASE2:Mm9::chr9:14706346..14706355,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr9:14706346..14706355, -
3.07e-86FFCP PHASE1:Mm9::chrX:7172568..7172576,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chrX:7172568..7172576, -
3.07e-86FFCP PHASE1:Mm9::chr7:105641398..105641405,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr7:105641398..105641405, -
3.07e-86FFCP PHASE2:Mm9::chr13:105413537..105413540,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr13:105413537..105413540, +
3.07e-86FFCP PHASE1:Mm9::chr9:32530971..32530976,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr9:32530971..32530976, +
3.07e-86FFCP PHASE2:Mm9::chr9:123843234..123843237,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr9:123843234..123843237, +
3.07e-86FFCP PHASE1:Mm9::chr1:69727854..69727859,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr1:69727854..69727859, +
3.07e-86FFCP PHASE1:Mm9::chrX:7161059..7161081,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chrX:7161059..7161081, -
3.07e-86FFCP PHASE1:Mm9::chr8:74526430..74526446,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr8:74526430..74526446, -
3.07e-86FFCP PHASE1:Mm9::chr4:32512204..32512214,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr4:32512204..32512214, +
3.07e-86FFCP PHASE1:Mm9::chr10:18781172..18781174,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr10:18781172..18781174, +
3.07e-86FFCP PHASE1:Mm9::chr5:124484631..124484634,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr5:124484631..124484634, -
3.07e-86FFCP PHASE1:Mm9::chrX:148215171..148215179,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chrX:148215171..148215179, +
3.07e-86FFCP PHASE2:Mm9::chr8:129378573..129378577,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr8:129378573..129378577, +
3.07e-86FFCP PHASE2:Mm9::chr6:48670473..48670480,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr6:48670473..48670480, +
3.07e-86FFCP PHASE2:Mm9::chr12:108370128..108370136,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr12:108370128..108370136, -
3.07e-86FFCP PHASE2:Mm9::chr1:60944205..60944230,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr1:60944205..60944230, +
3.07e-86FFCP PHASE1:Mm9::chr7:106142059..106142061,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr7:106142059..106142061, -
3.07e-86FFCP PHASE2:Mm9::chr8:74526430..74526446,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr8:74526430..74526446, -
3.07e-86FFCP PHASE2:Mm9::chr10:22022863..22022865,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr10:22022863..22022865, +
3.07e-86FFCP PHASE1:Mm9::chr12:17040514..17040521,+#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chr12:17040514..17040521, +
3.07e-86FFCP PHASE2:Mm9::chrX:7161059..7161081,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp@chrX:7161059..7161081, -
3.07e-86FFCP PHASE1:Mm9::chr9:14708334..14708341,-#_9c02a21c1f6f8f1d9c8d1adc11a8b2ddp11@Folr4

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