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Coexpression cluster:C258

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Full id: C258_hepatoblastoma_hepatocellular_signet_colon_Intestinal_Prostate_gastric



Phase1 CAGE Peaks

Hg19::chr11:61768834..61768840,-p@chr11:61768834..61768840
-
Hg19::chr11:7625242..7625246,+p@chr11:7625242..7625246
+
Hg19::chr11:7626993..7627017,+p9@PPFIBP2
Hg19::chr12:7023055..7023065,+p30@ENO2
Hg19::chr14:69077243..69077269,-p@chr14:69077243..69077269
-
Hg19::chr15:65670360..65670378,-p2@IGDCC3
Hg19::chr17:65241888..65241898,-p@chr17:65241888..65241898
-
Hg19::chr1:156338993..156339011,+p1@RHBG
Hg19::chr1:156339014..156339028,+p2@RHBG
Hg19::chr1:164559591..164559611,+p@chr1:164559591..164559611
+
Hg19::chr1:182261598..182261603,-p@chr1:182261598..182261603
-
Hg19::chr1:205902608..205902624,-p@chr1:205902608..205902624
-
Hg19::chr1:236686717..236686738,+p7@LGALS8
Hg19::chr1:26552077..26552092,+p3@ENST00000451482
p3@uc001blq.2
Hg19::chr1:3237334..3237343,+p@chr1:3237334..3237343
+
Hg19::chr20:3869562..3869580,+p3@PANK2
Hg19::chr20:52750070..52750079,-p@chr20:52750070..52750079
-
Hg19::chr20:58615689..58615712,+p@chr20:58615689..58615712
+
Hg19::chr20:62667528..62667542,+p1@LINC00176
Hg19::chr20:62667589..62667598,+p9@LINC00176
Hg19::chr20:9313920..9313929,+p@chr20:9313920..9313929
+
Hg19::chr20:9313938..9313946,+p@chr20:9313938..9313946
+
Hg19::chr2:102172717..102172724,-p@chr2:102172717..102172724
-
Hg19::chr2:171568483..171568494,-p@chr2:171568483..171568494
-
Hg19::chr2:171568504..171568522,-p@chr2:171568504..171568522
-
Hg19::chr2:171571909..171571920,+p9@SP5
Hg19::chr2:171571931..171571959,+p3@SP5
Hg19::chr2:171572699..171572713,+p7@SP5
Hg19::chr2:171572729..171572745,+p10@SP5
Hg19::chr2:171572786..171572840,+p2@SP5
Hg19::chr2:178129619..178129633,-p16@NFE2L2
Hg19::chr2:219925416..219925419,-p2@IHH
Hg19::chr2:242750139..242750158,-p3@D55640
Hg19::chr2:242750321..242750334,+p4@NEU4
Hg19::chr3:132004251..132004258,-p10@CPNE4
Hg19::chr3:197096551..197096578,+p@chr3:197096551..197096578
+
Hg19::chr3:53878786..53878811,-p4@CHDH
Hg19::chr6:19806783..19806789,-p@chr6:19806783..19806789
-
Hg19::chr6:19839318..19839332,-p@chr6:19839318..19839332
-
Hg19::chr6:34759206..34759244,+p@chr6:34759206..34759244
+
Hg19::chr7:1017641..1017647,+p@chr7:1017641..1017647
+
Hg19::chr7:150080907..150080914,-p1@ENST00000497366
Hg19::chr7:155605098..155605105,-p6@SHH
Hg19::chr7:20826171..20826190,-p@chr7:20826171..20826190
-
Hg19::chr7:27180082..27180091,+p2@LOC100133311
Hg19::chr7:44581054..44581057,+p@chr7:44581054..44581057
+
Hg19::chr7:7222548..7222558,+p@chr7:7222548..7222558
+
Hg19::chr8:144816195..144816210,-p6@FAM83H
Hg19::chr9:132371144..132371159,+p5@METTL11A
Hg19::chr9:132371162..132371181,+p6@METTL11A
Hg19::chrX:132670045..132670060,-p@chrX:132670045..132670060
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0030908protein splicing1.43290871993427e-05
GO:0005113patched binding1.43290871993427e-05
GO:0016539intein-mediated protein splicing1.43290871993427e-05
GO:0001569patterning of blood vessels0.000590135915578549
GO:0001649osteoblast differentiation0.0023106754995096
GO:0009880embryonic pattern specification0.0023106754995096
GO:0048754branching morphogenesis of a tube0.0023106754995096
GO:0001763morphogenesis of a branching structure0.00265112393578677
GO:0045597positive regulation of cell differentiation0.00512236837715217
GO:0045596negative regulation of cell differentiation0.00671357578165101
GO:0051094positive regulation of developmental process0.00671357578165101
GO:0051093negative regulation of developmental process0.00671357578165101
GO:0045581negative regulation of T cell differentiation0.00671357578165101
GO:0060020Bergmann glial cell differentiation0.00671357578165101
GO:0060019radial glial cell differentiation0.00671357578165101
GO:0007227signal transduction downstream of smoothened0.00671357578165101
GO:0008812choline dehydrogenase activity0.00671357578165101
GO:0032435negative regulation of proteasomal ubiquitin-dependent protein catabolic process0.00671357578165101
GO:0046639negative regulation of alpha-beta T cell differentiation0.00671357578165101
GO:0007228activation of hh target transcription factor0.00671357578165101
GO:0046636negative regulation of alpha-beta T cell activation0.00671357578165101
GO:0035239tube morphogenesis0.00671357578165101
GO:0001503ossification0.00675309757192503
GO:0031214biomineral formation0.00675309757192503
GO:0046849bone remodeling0.00771175918377515
GO:0016485protein processing0.00788417781018163
GO:0048771tissue remodeling0.00789246122939799
GO:0005615extracellular space0.00789246122939799
GO:0035295tube development0.00789246122939799
GO:0043587tongue morphogenesis0.00789246122939799
GO:0046637regulation of alpha-beta T cell differentiation0.00789246122939799
GO:0043586tongue development0.00789246122939799
GO:0007435salivary gland morphogenesis0.00789246122939799
GO:0022612gland morphogenesis0.00789246122939799
GO:0043237laminin-1 binding0.00789246122939799
GO:0021978telencephalon regionalization0.00789246122939799
GO:0032332positive regulation of chondrocyte differentiation0.00789246122939799
GO:0007389pattern specification process0.00844294278441691
GO:0001525angiogenesis0.00864675372337077
GO:0045944positive regulation of transcription from RNA polymerase II promoter0.00864675372337077
GO:0045595regulation of cell differentiation0.00864675372337077
GO:0030850prostate gland development0.00864675372337077
GO:0045666positive regulation of neuron differentiation0.00864675372337077
GO:0021937Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation0.00864675372337077
GO:0032434regulation of proteasomal ubiquitin-dependent protein catabolic process0.00864675372337077
GO:0043236laminin binding0.00864675372337077
GO:0021938smoothened signaling pathway in regulation of granule cell precursor cell proliferation0.00864675372337077
GO:0008519ammonium transmembrane transporter activity0.00864675372337077
GO:0007418ventral midline development0.00864675372337077
GO:0015696ammonium transport0.00864675372337077
GO:0006366transcription from RNA polymerase II promoter0.00864675372337077
GO:0048514blood vessel morphogenesis0.00864675372337077
GO:0048646anatomical structure formation0.00871448100720144
GO:0001568blood vessel development0.00871448100720144
GO:0001944vasculature development0.00871448100720144
GO:0007439ectodermal gut development0.00871448100720144
GO:0045620negative regulation of lymphocyte differentiation0.00871448100720144
GO:0021513spinal cord dorsal/ventral patterning0.00871448100720144
GO:0002052positive regulation of neuroblast proliferation0.00871448100720144
GO:0021871forebrain regionalization0.00871448100720144
GO:0050840extracellular matrix binding0.00871448100720144
GO:0007442hindgut morphogenesis0.00871448100720144
GO:0032330regulation of chondrocyte differentiation0.00871448100720144
GO:0046634regulation of alpha-beta T cell activation0.00871448100720144
GO:0048567ectodermal gut morphogenesis0.00871448100720144
GO:0007431salivary gland development0.00871448100720144
GO:0002076osteoblast development0.00871448100720144
GO:0048547gut morphogenesis0.00923709333081289
GO:0048546digestive tract morphogenesis0.00923709333081289
GO:0021930granule cell precursor proliferation0.00923709333081289
GO:0021940positive regulation of granule cell precursor proliferation0.00923709333081289
GO:0004308exo-alpha-sialidase activity0.00923709333081289
GO:0004594pantothenate kinase activity0.00923709333081289
GO:0048678response to axon injury0.00923709333081289
GO:0021534cell proliferation in hindbrain0.00923709333081289
GO:0016997alpha-sialidase activity0.00923709333081289
GO:0021511spinal cord patterning0.00923709333081289
GO:0021924cell proliferation in the external granule layer0.00923709333081289
GO:0021936regulation of granule cell precursor proliferation0.00923709333081289
GO:0042177negative regulation of protein catabolic process0.0109443447133047
GO:0001501skeletal development0.0111212779342219
GO:0015937coenzyme A biosynthetic process0.0120391285321079
GO:0030856regulation of epithelial cell differentiation0.0120391285321079
GO:0031069hair follicle morphogenesis0.0120391285321079
GO:0045893positive regulation of transcription, DNA-dependent0.0120391285321079
GO:0008284positive regulation of cell proliferation0.012548959196457
GO:0009790embryonic development0.012548959196457
GO:0050793regulation of developmental process0.012548959196457
GO:0035272exocrine system development0.012548959196457
GO:0014003oligodendrocyte development0.012548959196457
GO:0042130negative regulation of T cell proliferation0.012548959196457
GO:0030901midbrain development0.012548959196457
GO:0042733embryonic digit morphogenesis0.012548959196457
GO:0044421extracellular region part0.0129107769170461
GO:0009895negative regulation of catabolic process0.0133953229826029
GO:0002062chondrocyte differentiation0.0133953229826029
GO:0030539male genitalia development0.0133953229826029
GO:0015695organic cation transport0.0133953229826029
GO:0015101organic cation transmembrane transporter activity0.0138894019342398
GO:0001755neural crest cell migration0.0138894019342398
GO:0000015phosphopyruvate hydratase complex0.0138894019342398
GO:0001658ureteric bud branching0.0138894019342398
GO:0045580regulation of T cell differentiation0.0138894019342398
GO:0021510spinal cord development0.0138894019342398
GO:0004634phosphopyruvate hydratase activity0.0138894019342398
GO:0045941positive regulation of transcription0.0140700865705134
GO:0005737cytoplasm0.0140700865705134
GO:0048565gut development0.0140700865705134
GO:0050868negative regulation of T cell activation0.0140700865705134
GO:0015936coenzyme A metabolic process0.0140700865705134
GO:0050672negative regulation of lymphocyte proliferation0.0140700865705134
GO:0008209androgen metabolic process0.0140700865705134
GO:0048709oligodendrocyte differentiation0.0140700865705134
GO:0032945negative regulation of mononuclear cell proliferation0.0140700865705134
GO:0045935positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.0147871953746878
GO:0048806genitalia development0.0150823246680163
GO:0044424intracellular part0.0156492155543383
GO:0009888tissue development0.0159249293429539
GO:0021782glial cell development0.0159249293429539
GO:0014032neural crest cell development0.0165897615557974
GO:0007224smoothened signaling pathway0.0165897615557974
GO:0048663neuron fate commitment0.0165897615557974
GO:0014033neural crest cell differentiation0.0165897615557974
GO:0001708cell fate specification0.0176288057379137
GO:0019866organelle inner membrane0.01772162535577
GO:0051146striated muscle cell differentiation0.0179335409506194
GO:0001839neural plate morphogenesis0.0179335409506194
GO:0045619regulation of lymphocyte differentiation0.0179335409506194
GO:0046632alpha-beta T cell differentiation0.0179335409506194
GO:0001841neural tube formation0.0179335409506194
GO:0030162regulation of proteolysis0.0180781453938118
GO:0001840neural plate development0.0180781453938118
GO:0007405neuroblast proliferation0.0180781453938118
GO:0008907integrase activity0.0180781453938118
GO:0042176regulation of protein catabolic process0.0180781453938118
GO:0015485cholesterol binding0.0180781453938118
GO:0001838embryonic epithelial tube formation0.0180781453938118
GO:0050679positive regulation of epithelial cell proliferation0.0181778094461828
GO:0022404molting cycle process0.0181778094461828
GO:0001942hair follicle development0.0181778094461828
GO:0022405hair cycle process0.0181778094461828
GO:0042633hair cycle0.0181778094461828
GO:0042303molting cycle0.0181778094461828
GO:0001570vasculogenesis0.0181778094461828
GO:0009887organ morphogenesis0.0181778094461828
GO:0031325positive regulation of cellular metabolic process0.0182057151642484
GO:0001657ureteric bud development0.0182057151642484
GO:0021915neural tube development0.0182057151642484
GO:0042475odontogenesis of dentine-containing teeth0.0182057151642484
GO:0046631alpha-beta T cell activation0.0182057151642484
GO:0030336negative regulation of cell migration0.0182057151642484
GO:0051250negative regulation of lymphocyte activation0.0182057151642484
GO:0048568embryonic organ development0.0190358556751456
GO:0009893positive regulation of metabolic process0.0198696412915676
GO:0016331morphogenesis of embryonic epithelium0.0206631744665421
GO:0051271negative regulation of cell motility0.0211891200991955
GO:0030902hindbrain development0.0211891200991955
GO:0043161proteasomal ubiquitin-dependent protein catabolic process0.0211891200991955
GO:0040013negative regulation of locomotion0.0215612788377167
GO:0014031mesenchymal cell development0.0215612788377167
GO:0048762mesenchymal cell differentiation0.0215612788377167
GO:0001656metanephros development0.0215612788377167
GO:0006357regulation of transcription from RNA polymerase II promoter0.021851444770121
GO:0042476odontogenesis0.0220480644954898
GO:0009894regulation of catabolic process0.0220480644954898
GO:0046546development of primary male sexual characteristics0.0226520442942366
GO:0045664regulation of neuron differentiation0.0226520442942366
GO:0006066alcohol metabolic process0.0232414760306504
GO:0032934sterol binding0.0232414760306504
GO:0009953dorsal/ventral pattern formation0.0239569694659131
GO:0010001glial cell differentiation0.0246638449621801
GO:0042127regulation of cell proliferation0.0250707327498834
GO:0051091positive regulation of transcription factor activity0.0250707327498834
GO:0050678regulation of epithelial cell proliferation0.0250707327498834
GO:0044464cell part0.0256034667782936
GO:0015074DNA integration0.0256082661952266
GO:0044444cytoplasmic part0.0260858782406668
GO:0046661male sex differentiation0.0261334806487915
GO:0030326embryonic limb morphogenesis0.0264995669898537
GO:0035113embryonic appendage morphogenesis0.0264995669898537
GO:0050673epithelial cell proliferation0.0264995669898537
GO:0043010camera-type eye development0.0270002244300642
GO:0042129regulation of T cell proliferation0.0270002244300642
GO:0001822kidney development0.0278478952098251
GO:0042063gliogenesis0.0278478952098251
GO:0051216cartilage development0.0278478952098251
GO:0030855epithelial cell differentiation0.0278478952098251
GO:0044265cellular macromolecule catabolic process0.0278478952098251
GO:0060173limb development0.0278478952098251
GO:0035107appendage morphogenesis0.0278478952098251
GO:0035108limb morphogenesis0.0278478952098251
GO:0048589developmental growth0.0278478952098251
GO:0048736appendage development0.0278478952098251
GO:0042098T cell proliferation0.0291932955248312
GO:0001655urogenital system development0.0297839142040696
GO:0030217T cell differentiation0.0303682890953978
GO:0032944regulation of mononuclear cell proliferation0.0306354950844985
GO:0050670regulation of lymphocyte proliferation0.0306354950844985
GO:0030324lung development0.0306354950844985
GO:0030323respiratory tube development0.0312034992921382
GO:0005622intracellular0.0312278993165916
GO:0048469cell maturation0.0323220049963033
GO:0030900forebrain development0.032393950708822
GO:0045121lipid raft0.032393950708822
GO:0042692muscle cell differentiation0.032393950708822
GO:0048732gland development0.032393950708822
GO:0001654eye development0.0329334309438586
GO:0031967organelle envelope0.0357199774192478
GO:0031975envelope0.0357199774192478
GO:0009057macromolecule catabolic process0.0357199774192478
GO:0051090regulation of transcription factor activity0.0357199774192478
GO:0032943mononuclear cell proliferation0.0358912475091553
GO:0046651lymphocyte proliferation0.0358912475091553
GO:0021700developmental maturation0.0358912475091553
GO:0007267cell-cell signaling0.0365271080616658
GO:0048730epidermis morphogenesis0.0367199227902124
GO:0009952anterior/posterior pattern formation0.0367199227902124
GO:0006355regulation of transcription, DNA-dependent0.0368192780603154
GO:0007411axon guidance0.0370406749543051
GO:0050863regulation of T cell activation0.0388304880886745
GO:0045137development of primary sexual characteristics0.0390393505072002
GO:0030334regulation of cell migration0.0390393505072002
GO:0006351transcription, DNA-dependent0.0390393505072002
GO:0032774RNA biosynthetic process0.0390575131274154
GO:0002009morphogenesis of an epithelium0.0405178409584665
GO:0030098lymphocyte differentiation0.0409728326599113
GO:0051270regulation of cell motility0.0439469432088522
GO:0045165cell fate commitment0.045009205564013
GO:0048729tissue morphogenesis0.0452313172019513
GO:0040012regulation of locomotion0.0452313172019513
GO:0008283cell proliferation0.0452313172019513
GO:0040011locomotion0.0454658312192687
GO:0045449regulation of transcription0.0458650075863592
GO:0051249regulation of lymphocyte activation0.046909049259456
GO:0044237cellular metabolic process0.046986142197881
GO:0019219regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.0477818211711771
GO:0050865regulation of cell activation0.0487242778783049
GO:0007548sex differentiation0.0491188347581561



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
subdivision of digestive tract6.77e-13129
endodermal part of digestive tract6.77e-13129
digestive system5.40e-12155
digestive tract5.40e-12155
primitive gut5.40e-12155
endoderm-derived structure1.28e-11169
endoderm1.28e-11169
presumptive endoderm1.28e-11169
gastrointestinal system5.41e-1135
organ1.50e-09511
mixed endoderm/mesoderm-derived structure2.22e-09130
intestine3.72e-0927
embryo4.56e-08612
endo-epithelium8.15e-0882
multi-cellular organism9.68e-08659
foregut2.46e-0798
adult organism7.10e-07115
Disease
Ontology termp-valuen
carcinoma9.49e-20106
cell type cancer1.40e-17143
cancer2.85e-13235
disease of cellular proliferation3.87e-12239
adenocarcinoma4.07e-0825


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


"{{{coexpression_dpi_cluster_scores_median}}}" is not a number.