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CL:0000815

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Name:regulatory T cell
Namespace:FANTOM
Definition:"A T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [GO_REF:0000031, GOC:add]
Xrefs:
links:

BTO:0004520

FMA:84070
Synonyms: "regulatory T lymphocyte" EXACT []
"regulatory T-cell" EXACT []
"regulatory T-lymphocyte" EXACT []
"suppressor T cell" BROAD []
"suppressor T lymphocyte" BROAD []
"suppressor T-cell" BROAD []
"suppressor T-lymphocyte" BROAD []
Comments:This cell type may express FoxP3 and CD25 and secretes IL-10 and TGF-beta.


Ontology association
Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.

link to ontology dataset
data


Parents

is_a:CL:0002419(mature T cell)



Children


is a:CL:0000792 (CD4-positive, CD25-positive, alpha-beta regulatory T cell),FF:11943-126A8 (CD4+CD25+ regulatory T cells, antiCD3 CD28 stimulation, 06hr, pool1 (BalbcA)),FF:11944-126A9 (CD4+CD25+ regulatory T cells, antiCD3 CD28 stimulation, 06hr, pool1 (C57BL 6J)),FF:11946-126B2 (CD4+CD25+ regulatory T cells, PMA and ionomycin stimulation, 02hr, pool1 (BalbcA))

Ontology Tree: Loaded from BioPortal


FF samples
It includes FANTOM5 samples that overlay the Cell ontology.


Human (Homo sapiens)

  • 11780-124A7 (CD4+CD25+CD45RA+ naive regulatory T cells, donor1)
  • 11782-124A9 (CD4+CD25+CD45RA- memory regulatory T cells, donor1)
  • 11814-124E5 (CD4+CD25+ regulatory T cells, pool1 (C57BL_6J))
  • 11818-124E9 (CD4+CD25+ regulatory T cells, pool2 (Balb_cAJcl))
  • 11943-126A8 (CD4+CD25+ regulatory T cells, antiCD3 CD28 stimulation, 06hr, pool1 (BalbcA))
  • 11944-126A9 (CD4+CD25+ regulatory T cells, antiCD3 CD28 stimulation, 06hr, pool1 (C57BL 6J))
  • 11945-126B1 (CD4+CD25+ regulatory T cells, PMA and ionomycin stimulation, 02hr, pool1 (C57BL 6J))
  • 11946-126B2 (CD4+CD25+ regulatory T cells, PMA and ionomycin stimulation, 02hr, pool1 (BalbcA))

Mouse (Mus musculus)

  • 11780-124A7 (CD4+CD25+CD45RA+ naive regulatory T cells, donor1)
  • 11782-124A9 (CD4+CD25+CD45RA- memory regulatory T cells, donor1)
  • 11814-124E5 (CD4+CD25+ regulatory T cells, pool1 (C57BL_6J))
  • 11818-124E9 (CD4+CD25+ regulatory T cells, pool2 (Balb_cAJcl))
  • 11943-126A8 (CD4+CD25+ regulatory T cells, antiCD3 CD28 stimulation, 06hr, pool1 (BalbcA))
  • 11944-126A9 (CD4+CD25+ regulatory T cells, antiCD3 CD28 stimulation, 06hr, pool1 (C57BL 6J))
  • 11945-126B1 (CD4+CD25+ regulatory T cells, PMA and ionomycin stimulation, 02hr, pool1 (C57BL 6J))
  • 11946-126B2 (CD4+CD25+ regulatory T cells, PMA and ionomycin stimulation, 02hr, pool1 (BalbcA))


Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000815 (regulatory T cell), sorted by p-values
Analyst: Hideya Kawaji

link to source dataset
human : data
mouse : data


P-valueFFCPShort description
4.61e-131FFCP PHASE1:Hg19::chr1:113160702..113160706,-#_7ab95dd728078da90f616e2dae394ac4p21@ST7L
4.61e-131FFCP PHASE2:Hg19::chr1:113160702..113160706,-#_7ab95dd728078da90f616e2dae394ac4p21@ST7L
5.68e-99FFCP PHASE1:Hg19::chr11:111410267..111410269,+#_f728bf5dc8a8de558b9e23cc82f780cfp@chr11:111410267..111410269, +
5.68e-99FFCP PHASE2:Hg19::chr11:111410267..111410269,+#_f728bf5dc8a8de558b9e23cc82f780cfp@chr11:111410267..111410269, +
1.55e-98FFCP PHASE1:Hg19::chr3:73015629..73015632,+#_b0723bc5add031d9fbb142c1f032198bp@chr3:73015629..73015632, +
1.55e-98FFCP PHASE2:Hg19::chr3:73015629..73015632,+#_b0723bc5add031d9fbb142c1f032198bp@chr3:73015629..73015632, +
3.07e-86FFCP PHASE1:Mm9::chr1:60944205..60944230,+#_5884893199fa68790cd27702941e5924p@chr1:60944205..60944230, +
3.07e-86FFCP PHASE1:Mm9::chr10:18908457..18908466,-#_5884893199fa68790cd27702941e5924p@chr10:18908457..18908466, -
3.07e-86FFCP PHASE2:Mm9::chr10:92842861..92842879,-#_5884893199fa68790cd27702941e5924p@chr10:92842861..92842879, -
3.07e-86FFCP PHASE1:Mm9::chr10:89010973..89010996,-#_5884893199fa68790cd27702941e5924p@chr10:89010973..89010996, -
3.07e-86FFCP PHASE2:Mm9::chr9:56267292..56267296,+#_5884893199fa68790cd27702941e5924p@chr9:56267292..56267296, +
3.07e-86FFCP PHASE1:Mm9::chr14:101876628..101876637,-#_5884893199fa68790cd27702941e5924p@chr14:101876628..101876637, -
3.07e-86FFCP PHASE1:Mm9::chrX:7154622..7154647,+#_5884893199fa68790cd27702941e5924p@chrX:7154622..7154647, +
3.07e-86FFCP PHASE1:Mm9::chr17:12884884..12884887,-#_5884893199fa68790cd27702941e5924p@chr17:12884884..12884887, -
3.07e-86FFCP PHASE2:Mm9::chr1:60967565..60967590,-#_5884893199fa68790cd27702941e5924p@chr1:60967565..60967590, -
3.07e-86FFCP PHASE1:Mm9::chr10:22023694..22023695,-#_5884893199fa68790cd27702941e5924p@chr10:22023694..22023695, -
3.07e-86FFCP PHASE1:Mm9::chr10:13765981..13765988,+#_5884893199fa68790cd27702941e5924p@chr10:13765981..13765988, +
3.07e-86FFCP PHASE2:Mm9::chr10:22022863..22022865,+#_5884893199fa68790cd27702941e5924p@chr10:22022863..22022865, +
3.07e-86FFCP PHASE1:Mm9::chr11:4397528..4397535,-#_5884893199fa68790cd27702941e5924p@chr11:4397528..4397535, -
3.07e-86FFCP PHASE1:Mm9::chr4:155396655..155396659,+#_5884893199fa68790cd27702941e5924p@chr4:155396655..155396659, +
3.07e-86FFCP PHASE1:Mm9::chr10:92842861..92842879,-#_5884893199fa68790cd27702941e5924p@chr10:92842861..92842879, -
3.07e-86FFCP PHASE1:Mm9::chrX:7172568..7172576,-#_5884893199fa68790cd27702941e5924p@chrX:7172568..7172576, -
3.07e-86FFCP PHASE2:Mm9::chr4:32512204..32512214,+#_5884893199fa68790cd27702941e5924+, p@chr4:32512204..32512214
3.07e-86FFCP PHASE1:Mm9::chr8:74526522..74526532,-#_5884893199fa68790cd27702941e5924p@chr8:74526522..74526532, -
3.07e-86FFCP PHASE2:Mm9::chr4:102843557..102843585,+#_5884893199fa68790cd27702941e5924p@chr4:102843557..102843585, +
3.07e-86FFCP PHASE1:Mm9::chrX:7161176..7161185,-#_5884893199fa68790cd27702941e5924p@chrX:7161176..7161185, -
3.07e-86FFCP PHASE2:Mm9::chrX:7161059..7161081,-#_5884893199fa68790cd27702941e5924-, p@chrX:7161059..7161081
3.07e-86FFCP PHASE2:Mm9::chr9:14812338..14812345,-#_5884893199fa68790cd27702941e5924p@chr9:14812338..14812345, -
3.07e-86FFCP PHASE1:Mm9::chr16:89826368..89826391,+#_5884893199fa68790cd27702941e5924p@chr16:89826368..89826391, +
3.07e-86FFCP PHASE2:Mm9::chr2:32306609..32306610,+#_5884893199fa68790cd27702941e5924p@chr2:32306609..32306610, +
3.07e-86FFCP PHASE2:Mm9::chr3:142250588..142250598,+#_5884893199fa68790cd27702941e5924p@chr3:142250588..142250598, +
3.07e-86FFCP PHASE2:Mm9::chrX:7148320..7148329,+#_5884893199fa68790cd27702941e5924p@chrX:7148320..7148329, +
3.07e-86FFCP PHASE1:Mm9::chr3:142250588..142250598,+#_5884893199fa68790cd27702941e5924p@chr3:142250588..142250598, +
3.07e-86FFCP PHASE2:Mm9::chr1:60944205..60944230,+#_5884893199fa68790cd27702941e5924p@chr1:60944205..60944230, +
3.07e-86FFCP PHASE2:Mm9::chr8:129378573..129378577,+#_5884893199fa68790cd27702941e5924p@chr8:129378573..129378577, +
3.07e-86FFCP PHASE1:Mm9::chr15:59357130..59357143,-#_5884893199fa68790cd27702941e5924p@chr15:59357130..59357143, -
3.07e-86FFCP PHASE1:Mm9::chr17:35164610..35164618,-#_5884893199fa68790cd27702941e5924p5@Ng23
3.07e-86FFCP PHASE1:Mm9::chr8:84303823..84303825,+#_5884893199fa68790cd27702941e5924p@chr8:84303823..84303825, +
3.07e-86FFCP PHASE2:Mm9::chr9:13699290..13699296,+#_5884893199fa68790cd27702941e5924p@chr9:13699290..13699296, +
3.07e-86FFCP PHASE2:Mm9::chr17:26688385..26688421,+#_5884893199fa68790cd27702941e5924p@chr17:26688385..26688421, +
3.07e-86FFCP PHASE1:Mm9::chr17:12807573..12807582,+#_5884893199fa68790cd27702941e5924p@chr17:12807573..12807582, +
3.07e-86FFCP PHASE2:Mm9::chrX:7154622..7154647,+#_5884893199fa68790cd27702941e5924p@chrX:7154622..7154647, +
3.07e-86FFCP PHASE2:Mm9::chr9:14708334..14708341,-#_5884893199fa68790cd27702941e5924p11@Folr4
3.07e-86FFCP PHASE2:Mm9::chr7:80757542..80757576,-#_5884893199fa68790cd27702941e5924p@chr7:80757542..80757576, -
3.07e-86FFCP PHASE2:Mm9::chr8:74526480..74526487,-#_5884893199fa68790cd27702941e5924p@chr8:74526480..74526487, -
3.07e-86FFCP PHASE2:Mm9::chr4:151490501..151490511,+#_5884893199fa68790cd27702941e5924p5@Tnfrsf25
3.07e-86FFCP PHASE2:Mm9::chr17:35164610..35164618,-#_5884893199fa68790cd27702941e5924p5@Ng23
3.07e-86FFCP PHASE2:Mm9::chrX:7172568..7172576,-#_5884893199fa68790cd27702941e5924p@chrX:7172568..7172576, -
3.07e-86FFCP PHASE2:Mm9::chr6:49536818..49536841,+#_5884893199fa68790cd27702941e5924p@chr6:49536818..49536841, +
3.07e-86FFCP PHASE2:Mm9::chr10:18781172..18781174,+#_5884893199fa68790cd27702941e5924p@chr10:18781172..18781174, +
3.07e-86FFCP PHASE2:Mm9::chr15:59354543..59354548,+#_5884893199fa68790cd27702941e5924p@chr15:59354543..59354548, +
3.07e-86FFCP PHASE1:Mm9::chr1:69729950..69729959,-#_5884893199fa68790cd27702941e5924p@chr1:69729950..69729959, -
3.07e-86FFCP PHASE1:Mm9::chr11:118084068..118084106,-#_5884893199fa68790cd27702941e5924p@chr11:118084068..118084106, -
3.07e-86FFCP PHASE1:Mm9::chrX:7148320..7148329,+#_5884893199fa68790cd27702941e5924p@chrX:7148320..7148329, +
3.07e-86FFCP PHASE2:Mm9::chr7:108729732..108729745,+#_5884893199fa68790cd27702941e5924p@chr7:108729732..108729745, +
3.07e-86FFCP PHASE1:Mm9::chr9:69148201..69148218,-#_5884893199fa68790cd27702941e5924p@chr9:69148201..69148218, -
3.07e-86FFCP PHASE2:Mm9::chrX:7170204..7170205,+#_5884893199fa68790cd27702941e5924p@chrX:7170204..7170205, +
3.07e-86FFCP PHASE1:Mm9::chr1:60970510..60970516,+#_5884893199fa68790cd27702941e5924p@chr1:60970510..60970516, +
3.07e-86FFCP PHASE2:Mm9::chrX:148215171..148215179,+#_5884893199fa68790cd27702941e5924p@chrX:148215171..148215179, +
3.07e-86FFCP PHASE1:Mm9::chr1:69728149..69728150,+#_5884893199fa68790cd27702941e5924p@chr1:69728149..69728150, +
3.07e-86FFCP PHASE2:Mm9::chr16:89826368..89826391,+#_5884893199fa68790cd27702941e5924p@chr16:89826368..89826391, +
3.07e-86FFCP PHASE2:Mm9::chr6:106741792..106741797,+#_5884893199fa68790cd27702941e5924+, p@chr6:106741792..106741797
3.07e-86FFCP PHASE1:Mm9::chr9:56267292..56267296,+#_5884893199fa68790cd27702941e5924p@chr9:56267292..56267296, +
3.07e-86FFCP PHASE2:Mm9::chr1:60970179..60970192,-#_5884893199fa68790cd27702941e5924p@chr1:60970179..60970192, -
3.07e-86FFCP PHASE2:Mm9::chr14:101876628..101876637,-#_5884893199fa68790cd27702941e5924p@chr14:101876628..101876637, -
3.07e-86FFCP PHASE1:Mm9::chr1:162743278..162743283,-#_5884893199fa68790cd27702941e5924-, p@chr1:162743278..162743283
3.07e-86FFCP PHASE1:Mm9::chr7:132631174..132631179,+#_5884893199fa68790cd27702941e5924p@chr7:132631174..132631179, +
3.07e-86FFCP PHASE2:Mm9::chrX:7147964..7147979,-#_5884893199fa68790cd27702941e5924p@chrX:7147964..7147979, -
3.07e-86FFCP PHASE2:Mm9::chr17:26709187..26709203,-#_5884893199fa68790cd27702941e5924p@chr17:26709187..26709203, -
3.07e-86FFCP PHASE2:Mm9::chr10:13765981..13765988,+#_5884893199fa68790cd27702941e5924p@chr10:13765981..13765988, +
3.07e-86FFCP PHASE1:Mm9::chr11:4397552..4397557,-#_5884893199fa68790cd27702941e5924p@chr11:4397552..4397557, -
3.07e-86FFCP PHASE2:Mm9::chr15:59357447..59357449,+#_5884893199fa68790cd27702941e5924p@chr15:59357447..59357449, +
3.07e-86FFCP PHASE1:Mm9::chr4:155400229..155400241,+#_5884893199fa68790cd27702941e5924p3@Tnfrsf18
3.07e-86FFCP PHASE1:Mm9::chr1:69815958..69815961,+#_5884893199fa68790cd27702941e5924p@chr1:69815958..69815961, +
3.07e-86FFCP PHASE1:Mm9::chr5:124484631..124484634,-#_5884893199fa68790cd27702941e5924p@chr5:124484631..124484634, -
3.07e-86FFCP PHASE1:Mm9::chr3:101090598..101090601,+#_5884893199fa68790cd27702941e5924p@chr3:101090598..101090601, +
3.07e-86FFCP PHASE2:Mm9::chr8:74526430..74526446,-#_5884893199fa68790cd27702941e5924p@chr8:74526430..74526446, -
3.07e-86FFCP PHASE2:Mm9::chr10:18908457..18908466,-#_5884893199fa68790cd27702941e5924p@chr10:18908457..18908466, -
3.07e-86FFCP PHASE1:Mm9::chr9:123843234..123843237,+#_5884893199fa68790cd27702941e5924p@chr9:123843234..123843237, +
3.07e-86FFCP PHASE1:Mm9::chr17:26709187..26709203,-#_5884893199fa68790cd27702941e5924p@chr17:26709187..26709203, -
3.07e-86FFCP PHASE2:Mm9::chr10:58784974..58784979,-#_5884893199fa68790cd27702941e5924p@chr10:58784974..58784979, -
3.07e-86FFCP PHASE2:Mm9::chr9:14706346..14706355,-#_5884893199fa68790cd27702941e5924p@chr9:14706346..14706355, -
3.07e-86FFCP PHASE2:Mm9::chr5:150229693..150229735,+#_5884893199fa68790cd27702941e5924p@chr5:150229693..150229735, +
3.07e-86FFCP PHASE1:Mm9::chr7:121283156..121283178,+#_5884893199fa68790cd27702941e5924p@chr7:121283156..121283178, +
3.07e-86FFCP PHASE1:Mm9::chrX:7161574..7161577,+#_5884893199fa68790cd27702941e5924p@chrX:7161574..7161577, +
3.07e-86FFCP PHASE2:Mm9::chr8:93597971..93597979,+#_5884893199fa68790cd27702941e5924p@chr8:93597971..93597979, +
3.07e-86FFCP PHASE1:Mm9::chr2:112347343..112347355,+#_5884893199fa68790cd27702941e5924p@chr2:112347343..112347355, +
3.07e-86FFCP PHASE2:Mm9::chrX:7161176..7161185,-#_5884893199fa68790cd27702941e5924p@chrX:7161176..7161185, -
3.07e-86FFCP PHASE1:Mm9::chr1:60967911..60967916,+#_5884893199fa68790cd27702941e5924p@chr1:60967911..60967916, +
3.07e-86FFCP PHASE1:Mm9::chr4:102823636..102823677,+#_5884893199fa68790cd27702941e5924p@chr4:102823636..102823677, +
3.07e-86FFCP PHASE2:Mm9::chr12:108370128..108370136,-#_5884893199fa68790cd27702941e5924p@chr12:108370128..108370136, -
3.07e-86FFCP PHASE1:Mm9::chr1:69595515..69595518,-#_5884893199fa68790cd27702941e5924p@chr1:69595515..69595518, -
3.07e-86FFCP PHASE2:Mm9::chr9:32530971..32530976,+#_5884893199fa68790cd27702941e5924p@chr9:32530971..32530976, +
3.07e-86FFCP PHASE2:Mm9::chr9:123843234..123843237,+#_5884893199fa68790cd27702941e5924p@chr9:123843234..123843237, +
3.07e-86FFCP PHASE1:Mm9::chr15:59357447..59357449,+#_5884893199fa68790cd27702941e5924p@chr15:59357447..59357449, +
3.07e-86FFCP PHASE1:Mm9::chr6:49536818..49536841,+#_5884893199fa68790cd27702941e5924+, p@chr6:49536818..49536841
3.07e-86FFCP PHASE1:Mm9::chr12:114668438..114668451,+#_5884893199fa68790cd27702941e5924p@chr12:114668438..114668451, +
3.07e-86FFCP PHASE1:Mm9::chr17:12808149..12808156,+#_5884893199fa68790cd27702941e5924p@chr17:12808149..12808156, +
3.07e-86FFCP PHASE2:Mm9::chr8:74526522..74526532,-#_5884893199fa68790cd27702941e5924p@chr8:74526522..74526532, -
3.07e-86FFCP PHASE2:Mm9::chr1:69727854..69727859,+#_5884893199fa68790cd27702941e5924+, p@chr1:69727854..69727859