MCL coexpression mm9:1534

Phase1 CAGE Peaks

	Short description
Mm9::chr10:79896129..79896163,-	p6@Tcf3
Mm9::chr17:35195986..35196075,+	p1@Ddah2
Mm9::chr17:35196090..35196101,+	p4@Ddah2
Mm9::chr17:35196103..35196114,+	p3@Ddah2
Mm9::chr17:35196118..35196133,+	p2@Ddah2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0016403	dimethylargininase activity	0.0140581485744978
GO:0007263	nitric oxide mediated signal transduction	0.0140581485744978
GO:0006527	arginine catabolic process	0.0140581485744978
GO:0009065	glutamine family amino acid catabolic process	0.0140581485744978
GO:0006525	arginine metabolic process	0.0140581485744978
GO:0000051	urea cycle intermediate metabolic process	0.0140581485744978
GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	0.0144590175354349
GO:0046209	nitric oxide metabolic process	0.0159295124047435
GO:0006809	nitric oxide biosynthetic process	0.0159295124047435
GO:0009064	glutamine family amino acid metabolic process	0.0252907999632458
GO:0009063	amino acid catabolic process	0.0352383780418792
GO:0009310	amine catabolic process	0.0360999982242433
GO:0044270	nitrogen compound catabolic process	0.0360999982242433
GO:0046982	protein heterodimerization activity	0.0360999982242433
GO:0044271	nitrogen compound biosynthetic process	0.0426594836289343
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	0.0473422454075528
GO:0042803	protein homodimerization activity	0.0499882081296951

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br><br><br>

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Cell Type

Ontology term	p-value	n
ectodermal cell	1.71e-10	44
neurectodermal cell	1.71e-10	44
neural cell	5.80e-10	43
non-terminally differentiated cell	5.88e-09	49
neuron	1.25e-07	33
neuronal stem cell	1.25e-07	33
neuroblast	1.25e-07	33
electrically signaling cell	1.25e-07	33

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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