Coexpression cluster:C1026
From FANTOM5_SSTAR
Full id: C1026_Fibroblast_mesothelioma_Chondrocyte_epidermoid_Reticulocytes_clear_myxofibrosarcoma
Phase1 CAGE Peaks
Hg19::chr13:60738003..60738103,- | p1@DIAPH3 |
Hg19::chr15:66797627..66797684,+ | p1@ZWILCH |
Hg19::chr15:69706643..69706710,+ | p1@KIF23 |
Hg19::chr15:69706713..69706724,+ | p4@KIF23 |
Hg19::chr15:69706740..69706754,+ | p2@KIF23 |
Hg19::chr16:46655208..46655316,- | p1@SHCBP1 |
Hg19::chr5:137514834..137514865,+ | p2@KIF20A |
Hg19::chr7:36429461..36429486,+ | p1@ANLN |
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
p.value | FDR | nGenes | nPathway | Name |
---|---|---|---|---|
6.67157721853038e-06 | 0.00422310837932973 | 3 | 200 | DNA Replication (Reactome):REACT_383 |
2.59719623007301e-05 | 0.00822012606818106 | 3 | 315 | Cell Cycle, Mitotic (Reactome):REACT_152 |
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0007010 | cytoskeleton organization and biogenesis | 0.000253758630431385 |
GO:0006996 | organelle organization and biogenesis | 0.00299768850949541 |
GO:0003777 | microtubule motor activity | 0.00364784772441998 |
GO:0000921 | septin ring assembly | 0.00364784772441998 |
GO:0000022 | mitotic spindle elongation | 0.00364784772441998 |
GO:0032185 | septin cytoskeleton organization and biogenesis | 0.00364784772441998 |
GO:0051231 | spindle elongation | 0.00364784772441998 |
GO:0031106 | septin ring organization | 0.00364784772441998 |
GO:0005826 | contractile ring | 0.00364784772441998 |
GO:0044430 | cytoskeletal part | 0.00364784772441998 |
GO:0007018 | microtubule-based movement | 0.00364784772441998 |
GO:0005875 | microtubule associated complex | 0.00364784772441998 |
GO:0030705 | cytoskeleton-dependent intracellular transport | 0.00398926605803164 |
GO:0032153 | cell division site | 0.00404014110159463 |
GO:0032155 | cell division site part | 0.00404014110159463 |
GO:0043232 | intracellular non-membrane-bound organelle | 0.00404014110159463 |
GO:0043228 | non-membrane-bound organelle | 0.00404014110159463 |
GO:0007067 | mitosis | 0.00404014110159463 |
GO:0000087 | M phase of mitotic cell cycle | 0.00404014110159463 |
GO:0051301 | cell division | 0.00404014110159463 |
GO:0016043 | cellular component organization and biogenesis | 0.00541511559004266 |
GO:0005874 | microtubule | 0.00541511559004266 |
GO:0000279 | M phase | 0.0054585510817247 |
GO:0007017 | microtubule-based process | 0.00547302045029384 |
GO:0005856 | cytoskeleton | 0.00547302045029384 |
GO:0000278 | mitotic cell cycle | 0.00547302045029384 |
GO:0022403 | cell cycle phase | 0.00673190003874274 |
GO:0007052 | mitotic spindle organization and biogenesis | 0.00734938574349256 |
GO:0007096 | regulation of exit from mitosis | 0.00810540212515731 |
GO:0010458 | exit from mitosis | 0.00810540212515731 |
GO:0003779 | actin binding | 0.00821972114767682 |
GO:0044446 | intracellular organelle part | 0.00857158797561516 |
GO:0044422 | organelle part | 0.00857158797561516 |
GO:0042169 | SH2 domain binding | 0.00986760624313977 |
GO:0015630 | microtubule cytoskeleton | 0.00986760624313977 |
GO:0007051 | spindle organization and biogenesis | 0.00986760624313977 |
GO:0008092 | cytoskeletal protein binding | 0.0128918198713952 |
GO:0022402 | cell cycle process | 0.013414253511694 |
GO:0005871 | kinesin complex | 0.013414253511694 |
GO:0000776 | kinetochore | 0.0144770113713652 |
GO:0017048 | Rho GTPase binding | 0.0145784508666697 |
GO:0000910 | cytokinesis | 0.0151185788309958 |
GO:0044448 | cell cortex part | 0.0195287248205947 |
GO:0007049 | cell cycle | 0.020608139162833 |
GO:0046907 | intracellular transport | 0.0231279426470676 |
GO:0043234 | protein complex | 0.0231279426470676 |
GO:0005938 | cell cortex | 0.025374928519782 |
GO:0007088 | regulation of mitosis | 0.0260052133793836 |
GO:0043623 | cellular protein complex assembly | 0.0262310674601063 |
GO:0000775 | chromosome, pericentric region | 0.0279232946214486 |
GO:0017016 | Ras GTPase binding | 0.0279232946214486 |
GO:0005819 | spindle | 0.0279232946214486 |
GO:0051649 | establishment of cellular localization | 0.0287133850572141 |
GO:0031267 | small GTPase binding | 0.0290343433953052 |
GO:0051641 | cellular localization | 0.0290343433953052 |
GO:0051020 | GTPase binding | 0.0321997196792408 |
GO:0000226 | microtubule cytoskeleton organization and biogenesis | 0.0332532401154693 |
GO:0019904 | protein domain specific binding | 0.0406149369245473 |
GO:0032991 | macromolecular complex | 0.0410585754456491 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
Ontology term | p-value | n |
---|---|---|
animal cell | 4.91e-25 | 679 |
eukaryotic cell | 4.91e-25 | 679 |
epithelial cell | 1.04e-18 | 253 |
native cell | 2.18e-14 | 722 |
embryonic cell | 6.08e-11 | 250 |
squamous epithelial cell | 2.08e-07 | 63 |
fibroblast | 2.23e-07 | 76 |
Ontology term | p-value | n |
---|---|---|
larynx | 4.53e-07 | 9 |
Ontology term | p-value | n |
---|---|---|
cancer | 7.10e-48 | 235 |
disease of cellular proliferation | 3.08e-47 | 239 |
cell type cancer | 2.52e-26 | 143 |
carcinoma | 2.87e-20 | 106 |
organ system cancer | 2.64e-19 | 137 |
hematologic cancer | 2.78e-10 | 51 |
immune system cancer | 2.78e-10 | 51 |
leukemia | 2.09e-07 | 39 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 0.393486 |
MA0004.1 | 0.455723 |
MA0006.1 | 0.300178 |
MA0007.1 | 0.437331 |
MA0009.1 | 2.12026 |
MA0014.1 | 0.727045 |
MA0017.1 | 0.896777 |
MA0019.1 | 0.602411 |
MA0024.1 | 0.813542 |
MA0025.1 | 1.05265 |
MA0027.1 | 2.5321 |
MA0028.1 | 2.32702 |
MA0029.1 | 0.832916 |
MA0030.1 | 0.821423 |
MA0031.1 | 0.756713 |
MA0038.1 | 1.3714 |
MA0040.1 | 0.838784 |
MA0041.1 | 0.474018 |
MA0042.1 | 0.442535 |
MA0043.1 | 0.919032 |
MA0046.1 | 0.90778 |
MA0048.1 | 0.316923 |
MA0050.1 | 0.443405 |
MA0051.1 | 0.553205 |
MA0052.1 | 0.842664 |
MA0055.1 | 0.283474 |
MA0056.1 | 0 |
MA0057.1 | 0.305162 |
MA0058.1 | 0.950944 |
MA0059.1 | 0.948176 |
MA0060.1 | 3.1469 |
MA0061.1 | 0.165998 |
MA0063.1 | 0 |
MA0066.1 | 1.3723 |
MA0067.1 | 1.23721 |
MA0068.1 | 0.133123 |
MA0069.1 | 0.903908 |
MA0070.1 | 0.892666 |
MA0071.1 | 0.518907 |
MA0072.1 | 0.888148 |
MA0073.1 | 0.215282 |
MA0074.1 | 0.552456 |
MA0076.1 | 2.62795 |
MA0077.1 | 0.880402 |
MA0078.1 | 0.652193 |
MA0081.1 | 0.361233 |
MA0083.1 | 0.926258 |
MA0084.1 | 1.42483 |
MA0087.1 | 0.885691 |
MA0088.1 | 0.054222 |
MA0089.1 | 0 |
MA0090.1 | 0.391903 |
MA0091.1 | 2.02209 |
MA0092.1 | 0.421159 |
MA0093.1 | 0.818737 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.571227 |
MA0101.1 | 0.30624 |
MA0103.1 | 0.291333 |
MA0105.1 | 0.279181 |
MA0106.1 | 0.59853 |
MA0107.1 | 0.236528 |
MA0108.2 | 0.753643 |
MA0109.1 | 0 |
MA0111.1 | 0.405141 |
MA0113.1 | 0.614917 |
MA0114.1 | 0.231781 |
MA0115.1 | 1.1606 |
MA0116.1 | 0.239768 |
MA0117.1 | 0.956472 |
MA0119.1 | 0.345493 |
MA0122.1 | 0.982472 |
MA0124.1 | 1.11898 |
MA0125.1 | 1.0347 |
MA0130.1 | 0 |
MA0131.1 | 0.670358 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 0.949204 |
MA0136.1 | 0.564434 |
MA0139.1 | 0.155155 |
MA0140.1 | 0.516266 |
MA0141.1 | 0.359385 |
MA0142.1 | 0.724856 |
MA0143.1 | 0.615094 |
MA0144.1 | 0.623945 |
MA0145.1 | 0.220937 |
MA0146.1 | 0.113833 |
MA0147.1 | 0.243042 |
MA0148.1 | 0.480298 |
MA0149.1 | 0.506665 |
MA0062.2 | 5.39963 |
MA0035.2 | 0.515566 |
MA0039.2 | 0.44475 |
MA0138.2 | 0.653421 |
MA0002.2 | 0.179788 |
MA0137.2 | 0.86081 |
MA0104.2 | 0.55506 |
MA0047.2 | 0.586412 |
MA0112.2 | 0.0572179 |
MA0065.2 | 0.226158 |
MA0150.1 | 0.386144 |
MA0151.1 | 0 |
MA0152.1 | 0.52279 |
MA0153.1 | 1.01778 |
MA0154.1 | 0.274121 |
MA0155.1 | 0.43752 |
MA0156.1 | 0.865715 |
MA0157.1 | 0.697424 |
MA0158.1 | 0 |
MA0159.1 | 0.682702 |
MA0160.1 | 0.495355 |
MA0161.1 | 0 |
MA0162.1 | 0.194027 |
MA0163.1 | 0.0104024 |
MA0164.1 | 0.627336 |
MA0080.2 | 0.303167 |
MA0018.2 | 0.599912 |
MA0099.2 | 0.523145 |
MA0079.2 | 0.13841 |
MA0102.2 | 1.46209 |
MA0258.1 | 0.209744 |
MA0259.1 | 0.25092 |
MA0442.1 | 0 |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)
TF | #promoters | Enrichment | p-value | q-value |
---|---|---|---|---|
BRCA1#672 | 5 | 12.6151441520149 | 1.47177326411908e-05 | 0.000349421522917327 |
CEBPB#1051 | 5 | 4.98196726614051 | 0.00125052377879302 | 0.0084059633734546 |
CHD2#1106 | 6 | 7.75801712558764 | 1.92157406469162e-05 | 0.000434294035365349 |
E2F1#1869 | 8 | 4.90738921487932 | 2.97124777369457e-06 | 0.000101476176009446 |
E2F4#1874 | 8 | 12.6680603152844 | 1.5050509647149e-09 | 1.33434650003277e-07 |
E2F6#1876 | 7 | 4.39001126523521 | 8.25033297218753e-05 | 0.00123997197479104 |
ELF1#1997 | 7 | 3.7258357139566 | 0.000250341272551272 | 0.00269846136484491 |
ELK4#2005 | 5 | 10.1473010365425 | 4.23608403932528e-05 | 0.000758334557735847 |
ETS1#2113 | 7 | 8.51266580692704 | 8.8174082362229e-07 | 3.82267039760433e-05 |
FOS#2353 | 6 | 6.7484664816708 | 4.31702653902356e-05 | 0.000770052834686731 |
GABPB1#2553 | 6 | 5.30076287713663 | 0.00017345294309267 | 0.00211133472303676 |
HEY1#23462 | 8 | 4.04011104310571 | 1.4081650274634e-05 | 0.00033902108645286 |
IRF1#3659 | 7 | 6.68251828436841 | 4.6709523292352e-06 | 0.000145057862121022 |
IRF3#3661 | 5 | 29.363720132181 | 2.31300241196823e-07 | 1.22003868133106e-05 |
MAX#4149 | 6 | 4.83941663175534 | 0.000291750431370536 | 0.00309718675563198 |
MXI1#4601 | 7 | 8.71637517516439 | 7.48926294096089e-07 | 3.31428445886023e-05 |
NFYA#4800 | 6 | 13.8191855248729 | 6.49659712753933e-07 | 2.94614896831559e-05 |
NFYB#4801 | 6 | 12.5698449401523 | 1.13616741401493e-06 | 4.66065155350768e-05 |
PAX5#5079 | 5 | 4.16847845698614 | 0.00284750870610728 | 0.0154360511656358 |
POLR2A#5430 | 8 | 2.14745317655807 | 0.00221072578897191 | 0.0127167873250957 |
POU2F2#5452 | 4 | 4.55306202887126 | 0.00706247384683113 | 0.0294591303654124 |
RFX5#5993 | 5 | 7.52994426699694 | 0.00017791725685856 | 0.00215863155077267 |
SIN3A#25942 | 8 | 5.40888472681514 | 1.36410592556506e-06 | 5.35183541548044e-05 |
SMARCB1#6598 | 3 | 6.84476841793403 | 0.00747369013463395 | 0.0308223315420563 |
SP1#6667 | 8 | 5.6983813781409 | 8.98832477855329e-07 | 3.86309321624414e-05 |
SREBF1#6720 | 3 | 17.6271935401831 | 0.000497260515006821 | 0.00439554726422322 |
TAF1#6872 | 8 | 3.34304628574529 | 6.40776711117462e-05 | 0.00104337510028682 |
TAF7#6879 | 8 | 11.4330694049239 | 3.41987905000906e-09 | 2.81678823425785e-07 |
TBP#6908 | 8 | 3.70677068709639 | 2.80450451364125e-05 | 0.000592075291894437 |
TFAP2C#7022 | 6 | 8.10692145739517 | 1.48721435420767e-05 | 0.000352606537886709 |
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
This analysis result is provided for C0 - C305 clusters.