MCL coexpression mm9:148
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0048523 | negative regulation of cellular process | 0.0188645246761372 |
| GO:0048519 | negative regulation of biological process | 0.0188645246761372 |
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 0.0350802163105439 |
| GO:0045892 | negative regulation of transcription, DNA-dependent | 0.0350802163105439 |
| GO:0050794 | regulation of cellular process | 0.0350802163105439 |
| GO:0042517 | positive regulation of tyrosine phosphorylation of Stat3 protein | 0.0350802163105439 |
| GO:0047372 | acylglycerol lipase activity | 0.0350802163105439 |
| GO:0007243 | protein kinase cascade | 0.0350802163105439 |
| GO:0042325 | regulation of phosphorylation | 0.0350802163105439 |
| GO:0051174 | regulation of phosphorus metabolic process | 0.0350802163105439 |
| GO:0019220 | regulation of phosphate metabolic process | 0.0350802163105439 |
| GO:0016481 | negative regulation of transcription | 0.0350802163105439 |
| GO:0045934 | negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.0350802163105439 |
| GO:0050793 | regulation of developmental process | 0.0350802163105439 |
| GO:0009967 | positive regulation of signal transduction | 0.0350802163105439 |
| GO:0046533 | negative regulation of photoreceptor cell differentiation | 0.0350802163105439 |
| GO:0001946 | lymphangiogenesis | 0.0350802163105439 |
| GO:0004084 | branched-chain-amino-acid transaminase activity | 0.0350802163105439 |
| GO:0009082 | branched chain family amino acid biosynthetic process | 0.0350802163105439 |
| GO:0046532 | regulation of photoreceptor cell differentiation | 0.0350802163105439 |
| GO:0050789 | regulation of biological process | 0.0350802163105439 |
| GO:0031324 | negative regulation of cellular metabolic process | 0.0416813114006787 |
| GO:0045596 | negative regulation of cell differentiation | 0.0475909014872444 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| oligodendrocyte precursor cell | 3.02e-24 | 8 |
| migratory neural crest cell | 3.18e-19 | 10 |
| neuron associated cell | 3.18e-19 | 10 |
| glial cell (sensu Vertebrata) | 3.18e-19 | 10 |
| neuron associated cell (sensu Vertebrata) | 3.18e-19 | 10 |
| glial cell | 3.18e-19 | 10 |
| glioblast | 3.18e-19 | 10 |
| glioblast (sensu Vertebrata) | 3.18e-19 | 10 |
| oligodendrocyte | 5.37e-17 | 6 |
| macroglial cell | 5.37e-17 | 6 |
| astrocyte | 5.37e-17 | 6 |
| astrocyte of the cerebral cortex | 2.55e-09 | 2 |
| astrocyte of the hippocampus | 2.55e-09 | 2 |
| central nervous system macrophage | 5.24e-09 | 2 |
| microglial cell | 5.24e-09 | 2 |
| Ontology term | p-value | n |
|---|---|---|
| aorta | 1.07e-08 | 4 |
| artery | 1.07e-08 | 4 |
| systemic artery | 1.07e-08 | 4 |
| arterial blood vessel | 1.07e-08 | 4 |
| systemic arterial system | 1.07e-08 | 4 |
| aortic system | 1.07e-08 | 4 |
| arterial system | 1.07e-08 | 4 |
| vessel | 4.78e-07 | 5 |
| epithelial tube open at both ends | 4.78e-07 | 5 |
| blood vessel | 4.78e-07 | 5 |
| vasculature | 4.78e-07 | 5 |
| vascular system | 4.78e-07 | 5 |
| blood vasculature | 4.78e-07 | 5 |
| vascular cord | 4.78e-07 | 5 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 0.12546 |
| MA0004.1 | 0.199126 |
| MA0006.1 | 0.030871 |
| MA0007.1 | 0.516185 |
| MA0009.1 | 0.126401 |
| MA0014.1 | 0.0150891 |
| MA0017.1 | 5.13719 |
| MA0019.1 | 0.0520677 |
| MA0024.1 | 0.34325 |
| MA0025.1 | 0.266379 |
| MA0027.1 | 1.54541 |
| MA0028.1 | 0.152858 |
| MA0029.1 | 0.653803 |
| MA0030.1 | 0.0986115 |
| MA0031.1 | 0.0835307 |
| MA0038.1 | 0.0241079 |
| MA0040.1 | 0.414229 |
| MA0041.1 | 0.19915 |
| MA0042.1 | 0.303297 |
| MA0043.1 | 0.179063 |
| MA0046.1 | 0.144981 |
| MA0048.1 | 0.144507 |
| MA0050.1 | 0.0453796 |
| MA0051.1 | 0.0258811 |
| MA0052.1 | 0.136894 |
| MA0055.1 | 0.408348 |
| MA0056.1 | 0 |
| MA0057.1 | 0.160396 |
| MA0058.1 | 0.286363 |
| MA0059.1 | 0.317358 |
| MA0060.1 | 3.06926e-05 |
| MA0061.1 | 0.442797 |
| MA0063.1 | 0 |
| MA0066.1 | 1.07295 |
| MA0067.1 | 0.346597 |
| MA0068.1 | 0.333032 |
| MA0069.1 | 0.840203 |
| MA0070.1 | 0.132073 |
| MA0071.1 | 1.33831 |
| MA0072.1 | 0.127776 |
| MA0073.1 | 1.24941 |
| MA0074.1 | 4.35568 |
| MA0076.1 | 0.0591105 |
| MA0077.1 | 0.117104 |
| MA0078.1 | 1.30246 |
| MA0081.1 | 0.379658 |
| MA0083.1 | 0.178598 |
| MA0084.1 | 0.616887 |
| MA0087.1 | 0.468122 |
| MA0088.1 | 0.46871 |
| MA0089.1 | 0 |
| MA0090.1 | 1.25071 |
| MA0091.1 | 0.388577 |
| MA0092.1 | 0.151222 |
| MA0093.1 | 0.0901194 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 1.22733 |
| MA0101.1 | 0.103305 |
| MA0103.1 | 0.49405 |
| MA0105.1 | 0.411113 |
| MA0106.1 | 0.327026 |
| MA0107.1 | 0.313235 |
| MA0108.2 | 0.0594652 |
| MA0109.1 | 0 |
| MA0111.1 | 0.0764388 |
| MA0113.1 | 0.837078 |
| MA0114.1 | 1.78587 |
| MA0115.1 | 0.53344 |
| MA0116.1 | 0.701759 |
| MA0117.1 | 0.487992 |
| MA0119.1 | 0.202507 |
| MA0122.1 | 0.515783 |
| MA0124.1 | 0.307255 |
| MA0125.1 | 0.255313 |
| MA0130.1 | 0 |
| MA0131.1 | 0.0506646 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 0.200965 |
| MA0136.1 | 0.216715 |
| MA0139.1 | 0.202122 |
| MA0140.1 | 0.350568 |
| MA0141.1 | 0.392534 |
| MA0142.1 | 0.267911 |
| MA0143.1 | 0.308628 |
| MA0144.1 | 2.14043 |
| MA0145.1 | 1.74097 |
| MA0146.1 | 0.0256176 |
| MA0147.1 | 0.237408 |
| MA0148.1 | 0.0365899 |
| MA0149.1 | 0.0456724 |
| MA0062.2 | 0.102742 |
| MA0035.2 | 0.183273 |
| MA0039.2 | 0.114661 |
| MA0138.2 | 0.181809 |
| MA0002.2 | 0.428112 |
| MA0137.2 | 0.563183 |
| MA0104.2 | 0.105202 |
| MA0047.2 | 0.0239597 |
| MA0112.2 | 0.981031 |
| MA0065.2 | 1.97468 |
| MA0150.1 | 0.321875 |
| MA0151.1 | 0 |
| MA0152.1 | 0.102811 |
| MA0153.1 | 0.211316 |
| MA0154.1 | 0.198539 |
| MA0155.1 | 1.04375 |
| MA0156.1 | 0.220347 |
| MA0157.1 | 0.065799 |
| MA0158.1 | 0 |
| MA0159.1 | 0.963372 |
| MA0160.1 | 0.907906 |
| MA0161.1 | 0 |
| MA0162.1 | 0.00145342 |
| MA0163.1 | 0.0983946 |
| MA0164.1 | 0.0193046 |
| MA0080.2 | 0.315811 |
| MA0018.2 | 0.0921331 |
| MA0099.2 | 0.702314 |
| MA0079.2 | 0.00341934 |
| MA0102.2 | 0.663408 |
| MA0258.1 | 0.515743 |
| MA0259.1 | 0.208179 |
| MA0442.1 | 0 |
