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MCL coexpression mm9:1732

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Phase1 CAGE Peaks

 Short description
Mm9::chr19:55972403..55972421,+p22@Tcf7l2
Mm9::chr19:55972431..55972440,+p63@Tcf7l2
Mm9::chr19:55972441..55972456,+p18@Tcf7l2
Mm9::chr19:55985049..55985067,+p@chr19:55985049..55985067
+
Mm9::chr1:140743964..140743976,-p3@Lhx9


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0007548sex differentiation0.00119582923147353
GO:0003006reproductive developmental process0.00119582923147353
GO:0022414reproductive process0.00460555115778634
GO:0048619embryonic hindgut morphogenesis0.00597129392711993
GO:0030538embryonic genitalia morphogenesis0.00597129392711993
GO:0035112genitalia morphogenesis0.00597129392711993
GO:0005667transcription factor complex0.00651360345025033
GO:0000003reproduction0.00651360345025033
GO:0007442hindgut morphogenesis0.00651360345025033
GO:0048613embryonic ectodermal gut morphogenesis0.00651360345025033
GO:0048611embryonic ectodermal gut development0.00651360345025033
GO:0044451nucleoplasm part0.00674830909527291
GO:0048558embryonic gut morphogenesis0.00674830909527291
GO:0005654nucleoplasm0.00674830909527291
GO:0048557embryonic digestive tract morphogenesis0.00674830909527291
GO:0007439ectodermal gut development0.00674830909527291
GO:0048567ectodermal gut morphogenesis0.00674830909527291
GO:0048547gut morphogenesis0.00674830909527291
GO:0048806genitalia development0.00674830909527291
GO:0031981nuclear lumen0.00674830909527291
GO:0048566embryonic gut development0.00674830909527291
GO:0048546digestive tract morphogenesis0.00674830909527291
GO:0008013beta-catenin binding0.00674830909527291
GO:0031974membrane-enclosed lumen0.00700277597950898
GO:0043233organelle lumen0.00700277597950898
GO:0008584male gonad development0.00767422299235825
GO:0003700transcription factor activity0.00767422299235825
GO:0048565gut development0.00767422299235825
GO:0048562embryonic organ morphogenesis0.00864381628664263
GO:0046546development of primary male sexual characteristics0.00915096731892564
GO:0044428nuclear part0.00998157778245865
GO:0046661male sex differentiation0.0100699331827434
GO:0008585female gonad development0.0122628934130942
GO:0046545development of primary female sexual characteristics0.0122628934130942
GO:0046660female sex differentiation0.0122628934130942
GO:0048568embryonic organ development0.0122628934130942
GO:0048513organ development0.0154657633070033
GO:0008406gonad development0.0160071329758149
GO:0048608reproductive structure development0.0162074394662785
GO:0045137development of primary sexual characteristics0.0172906600818872
GO:0021915neural tube development0.0188968127462959
GO:0043234protein complex0.0188968127462959
GO:0048731system development0.0202777454796801
GO:0006355regulation of transcription, DNA-dependent0.0236243024285655
GO:0006351transcription, DNA-dependent0.0236243024285655
GO:0032774RNA biosynthetic process0.0236243024285655
GO:0003677DNA binding0.0237089321221221
GO:0045449regulation of transcription0.0238839324386906
GO:0048856anatomical structure development0.0238839324386906
GO:0019219regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.0238839324386906
GO:0006350transcription0.024032443516949
GO:0032991macromolecular complex0.0242324733088106
GO:0010468regulation of gene expression0.0247048942227348
GO:0031323regulation of cellular metabolic process0.0261887583221484
GO:0016055Wnt receptor signaling pathway0.0261887583221484
GO:0007275multicellular organismal development0.0265189796586637
GO:0019222regulation of metabolic process0.0267678396391529
GO:0016070RNA metabolic process0.0277133635930366
GO:0044446intracellular organelle part0.0287082445500029
GO:0044422organelle part0.0287082445500029
GO:0010467gene expression0.0377243021012196
GO:0045944positive regulation of transcription from RNA polymerase II promoter0.0377243021012196
GO:0048598embryonic morphogenesis0.0377243021012196
GO:0003676nucleic acid binding0.0377243021012196
GO:0032502developmental process0.0395612071036099
GO:0043009chordate embryonic development0.0396857185934148
GO:0009792embryonic development ending in birth or egg hatching0.0396857185934148
GO:0045893positive regulation of transcription, DNA-dependent0.0406374537402066
GO:0006139nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.0406374537402066
GO:0050794regulation of cellular process0.0460685674686323
GO:0045941positive regulation of transcription0.0469057581963048
GO:0045935positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.0472341004380639



Relative expression of the co-expression cluster over median <br>Analyst:




Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
CNS neuron (sensu Vertebrata)2.05e-1023
neuroblast (sensu Vertebrata)2.05e-1023
striatum neuron2.52e-083
granule cell5.27e-083
raphe nuclei neuron5.27e-083


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs




JASPAR motifs


Motifs-log10(p-value)
MA0003.10.211284
MA0004.10.603793
MA0006.10.419915
MA0007.10.587678
MA0009.12.41343
MA0014.10.736185
MA0017.10.449113
MA0019.10.874061
MA0024.11.01759
MA0025.11.30092
MA0027.12.72141
MA0028.10.43138
MA0029.10.995171
MA0030.11.00195
MA0031.10.965177
MA0038.10.757669
MA0040.11.07552
MA0041.10.522007
MA0042.10.507715
MA0043.11.1618
MA0046.11.09955
MA0048.10.205696
MA0050.11.55615
MA0051.10.767098
MA0052.11.08379
MA0055.10.0851423
MA0056.10
MA0057.11.68574
MA0058.10.50032
MA0059.10.513699
MA0060.10.330907
MA0061.10.955135
MA0063.10
MA0066.10.746072
MA0067.11.41352
MA0068.11.71065
MA0069.11.08414
MA0070.11.07418
MA0071.11.55428
MA0072.11.06547
MA0073.10.189951
MA0074.10.708108
MA0076.10.470037
MA0077.11.04318
MA0078.10.801834
MA0081.10.53877
MA0083.11.16099
MA0084.11.74401
MA0087.11.11687
MA0088.10.148348
MA0089.10
MA0090.10.566938
MA0091.10.617887
MA0092.10.567278
MA0093.10.440484
MA0095.10
MA0098.10
MA0100.10.695835
MA0101.10.523409
MA0103.10.460936
MA0105.10.248108
MA0106.10.809991
MA0107.10.454197
MA0108.20.897859
MA0109.10
MA0111.10.582193
MA0113.10.780358
MA0114.10.361633
MA0115.11.16466
MA0116.11.07655
MA0117.11.13165
MA0119.11.30068
MA0122.11.15196
MA0124.11.35963
MA0125.11.28445
MA0130.10
MA0131.10.869325
MA0132.10
MA0133.10
MA0135.11.19898
MA0136.10.729175
MA0139.10.295945
MA0140.10.695713
MA0141.10.482463
MA0142.10.950155
MA0143.10.797553
MA0144.10.365053
MA0145.10.157686
MA0146.12.29697
MA0147.10.378658
MA0148.10.621195
MA0149.11.31202
MA0062.20.706751
MA0035.20.700704
MA0039.20.140205
MA0138.20.861035
MA0002.20.299191
MA0137.20.479301
MA0104.20.315156
MA0047.20.75686
MA0112.20.927461
MA0065.20.158101
MA0150.10.587557
MA0151.10
MA0152.10.756973
MA0153.11.21594
MA0154.10.203217
MA0155.10.173445
MA0156.10.469089
MA0157.10.91689
MA0158.10
MA0159.10.389847
MA0160.10.624415
MA0161.10
MA0162.10.245828
MA0163.10.0644585
MA0164.10.729558
MA0080.20.455167
MA0018.20.739807
MA0099.20.854449
MA0079.20.765158
MA0102.21.79669
MA0258.11.63953
MA0259.10.366802
MA0442.10
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