MCL coexpression mm9:98
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0044421 | extracellular region part | 0.0203021860065777 |
| GO:0007626 | locomotory behavior | 0.0203021860065777 |
| GO:0005125 | cytokine activity | 0.0203021860065777 |
| GO:0043408 | regulation of MAPKKK cascade | 0.0255942277618279 |
| GO:0005578 | proteinaceous extracellular matrix | 0.0277167938224125 |
| GO:0005615 | extracellular space | 0.0277167938224125 |
| GO:0000165 | MAPKKK cascade | 0.0277167938224125 |
| GO:0007610 | behavior | 0.0295784110470665 |
| GO:0005102 | receptor binding | 0.0295784110470665 |
| GO:0045595 | regulation of cell differentiation | 0.0295784110470665 |
| GO:0007517 | muscle development | 0.0295784110470665 |
| GO:0033483 | gas homeostasis | 0.0295784110470665 |
| GO:0052547 | regulation of peptidase activity | 0.0295784110470665 |
| GO:0030857 | negative regulation of epithelial cell differentiation | 0.0295784110470665 |
| GO:0045908 | negative regulation of vasodilation | 0.0295784110470665 |
| GO:0033484 | nitric oxide homeostasis | 0.0295784110470665 |
| GO:0004248 | stromelysin 1 activity | 0.0295784110470665 |
| GO:0042312 | regulation of vasodilation | 0.0295784110470665 |
| GO:0004924 | oncostatin-M receptor activity | 0.0295784110470665 |
| GO:0007165 | signal transduction | 0.0402524877967486 |
| GO:0008201 | heparin binding | 0.0402524877967486 |
| GO:0005176 | ErbB-2 class receptor binding | 0.0402524877967486 |
| GO:0045019 | negative regulation of nitric oxide biosynthetic process | 0.0402524877967486 |
| GO:0043185 | vascular endothelial growth factor receptor 3 binding | 0.0402524877967486 |
| GO:0045907 | positive regulation of vasoconstriction | 0.0402524877967486 |
| GO:0048552 | regulation of metalloenzyme activity | 0.0402524877967486 |
| GO:0048554 | positive regulation of metalloenzyme activity | 0.0402524877967486 |
| GO:0007243 | protein kinase cascade | 0.0402524877967486 |
| GO:0007154 | cell communication | 0.0465489471785 |
| GO:0001937 | negative regulation of endothelial cell proliferation | 0.0499993359408931 |
| GO:0060056 | mammary gland involution | 0.0499993359408931 |
| GO:0001602 | pancreatic polypeptide receptor activity | 0.0499993359408931 |
| GO:0046426 | negative regulation of JAK-STAT cascade | 0.0499993359408931 |
| GO:0005539 | glycosaminoglycan binding | 0.0499993359408931 |
| GO:0050793 | regulation of developmental process | 0.0499993359408931 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| muscle precursor cell | 2.28e-10 | 6 |
| contractile cell | 2.28e-10 | 6 |
| muscle cell | 2.28e-10 | 6 |
| myoblast | 2.28e-10 | 6 |
| mesodermal cell | 1.07e-08 | 7 |
| Ontology term | p-value | n |
|---|---|---|
| female reproductive system | 9.78e-08 | 9 |
| aorta | 1.89e-07 | 4 |
| artery | 1.89e-07 | 4 |
| systemic artery | 1.89e-07 | 4 |
| arterial blood vessel | 1.89e-07 | 4 |
| systemic arterial system | 1.89e-07 | 4 |
| aortic system | 1.89e-07 | 4 |
| arterial system | 1.89e-07 | 4 |
| zone of skin | 3.22e-07 | 5 |
| skin epidermis | 3.22e-07 | 5 |
| skin of body | 3.22e-07 | 5 |
| integument | 3.22e-07 | 5 |
| surface | 3.22e-07 | 5 |
| outer epithelium | 3.22e-07 | 5 |
| integumental system | 3.22e-07 | 5 |
| enveloping layer of ectoderm | 3.22e-07 | 5 |
| musculature of body | 3.81e-07 | 10 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 9.64327e-17 |
| MA0004.1 | 0.0254247 |
| MA0006.1 | 0.00211979 |
| MA0007.1 | 0.0975926 |
| MA0009.1 | 1.02382 |
| MA0014.1 | 2.35999e-09 |
| MA0017.1 | 0.0499095 |
| MA0019.1 | 0.280753 |
| MA0024.1 | 0.302908 |
| MA0025.1 | 0.129643 |
| MA0027.1 | 1.31025 |
| MA0028.1 | 0.00779706 |
| MA0029.1 | 0.0268465 |
| MA0030.1 | 0.281518 |
| MA0031.1 | 0.0215611 |
| MA0038.1 | 0.605461 |
| MA0040.1 | 0.388721 |
| MA0041.1 | 1.00815 |
| MA0042.1 | 0.548065 |
| MA0043.1 | 0.250375 |
| MA0046.1 | 4.01626 |
| MA0048.1 | 0.135653 |
| MA0050.1 | 0.0155356 |
| MA0051.1 | 0.0599561 |
| MA0052.1 | 1.54543 |
| MA0055.1 | 0.0141954 |
| MA0056.1 | 0 |
| MA0057.1 | 0.953295 |
| MA0058.1 | 0.0296957 |
| MA0059.1 | 0.016105 |
| MA0060.1 | 0.000391441 |
| MA0061.1 | 0.017054 |
| MA0063.1 | 0 |
| MA0066.1 | 0.116531 |
| MA0067.1 | 0.189645 |
| MA0068.1 | 0.89243 |
| MA0069.1 | 0.402357 |
| MA0070.1 | 0.686697 |
| MA0071.1 | 0.172938 |
| MA0072.1 | 0.163743 |
| MA0073.1 | 7.24895e-07 |
| MA0074.1 | 0.0333388 |
| MA0076.1 | 0.00696808 |
| MA0077.1 | 0.613392 |
| MA0078.1 | 0.518582 |
| MA0081.1 | 0.0999699 |
| MA0083.1 | 0.249569 |
| MA0084.1 | 0.418593 |
| MA0087.1 | 1.69079 |
| MA0088.1 | 0.191849 |
| MA0089.1 | 0 |
| MA0090.1 | 0.657686 |
| MA0091.1 | 0.353412 |
| MA0092.1 | 2.60802 |
| MA0093.1 | 0.00955208 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.00114591 |
| MA0101.1 | 0.0190031 |
| MA0103.1 | 0.00572658 |
| MA0105.1 | 0.00673714 |
| MA0106.1 | 0.188467 |
| MA0107.1 | 0.326166 |
| MA0108.2 | 0.159844 |
| MA0109.1 | 0 |
| MA0111.1 | 0.0453055 |
| MA0113.1 | 0.00363774 |
| MA0114.1 | 0.000353907 |
| MA0115.1 | 0.0725533 |
| MA0116.1 | 0.145018 |
| MA0117.1 | 0.221259 |
| MA0119.1 | 0.334143 |
| MA0122.1 | 0.0681555 |
| MA0124.1 | 1.49478 |
| MA0125.1 | 0.386144 |
| MA0130.1 | 0 |
| MA0131.1 | 0.0480303 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 0.603223 |
| MA0136.1 | 0.197339 |
| MA0139.1 | 0.169357 |
| MA0140.1 | 0.833565 |
| MA0141.1 | 0.00301594 |
| MA0142.1 | 0.68005 |
| MA0143.1 | 1.02857 |
| MA0144.1 | 1.10137 |
| MA0145.1 | 3.71892e-06 |
| MA0146.1 | 1.70753e-08 |
| MA0147.1 | 0.0118068 |
| MA0148.1 | 0.234877 |
| MA0149.1 | 4.18069e-05 |
| MA0062.2 | 2.15227e-06 |
| MA0035.2 | 0.624133 |
| MA0039.2 | 3.12606e-08 |
| MA0138.2 | 0.0449283 |
| MA0002.2 | 0.518832 |
| MA0137.2 | 0.304261 |
| MA0104.2 | 0.00897519 |
| MA0047.2 | 0.0167434 |
| MA0112.2 | 0.00301248 |
| MA0065.2 | 0.000413019 |
| MA0150.1 | 0.0974595 |
| MA0151.1 | 0 |
| MA0152.1 | 0.848645 |
| MA0153.1 | 2.78952 |
| MA0154.1 | 0.0651347 |
| MA0155.1 | 0.260598 |
| MA0156.1 | 0.036503 |
| MA0157.1 | 0.179331 |
| MA0158.1 | 0 |
| MA0159.1 | 0.0904406 |
| MA0160.1 | 0.143341 |
| MA0161.1 | 0 |
| MA0162.1 | 2.19794e-12 |
| MA0163.1 | 8.10288e-07 |
| MA0164.1 | 0.515007 |
| MA0080.2 | 0.0961355 |
| MA0018.2 | 0.0138149 |
| MA0099.2 | 2.56621 |
| MA0079.2 | 1.06766e-12 |
| MA0102.2 | 0.460621 |
| MA0258.1 | 0.0384822 |
| MA0259.1 | 0.000423747 |
| MA0442.1 | 0 |
