MCL coexpression mm9:486

Phase1 CAGE Peaks

	Short description
Mm9::chr11:109005654..109005691,-	p1@E030025P04Rik
Mm9::chr19:24200299..24200336,-	p@chr19:24200299..24200336 -
Mm9::chr19:60220585..60220600,+	p1@ENSMUST00000065383
Mm9::chr3:79594253..79594277,-	p@chr3:79594253..79594277 -
Mm9::chr4:88526110..88526132,-	p1@Ifne
Mm9::chr6:144996156..144996180,-	p4@Bcat1
Mm9::chr6:82855186..82855200,-	p@chr6:82855186..82855200 -
Mm9::chr8:108053276..108053315,-	p@chr8:108053276..108053315 -
Mm9::chr9:53916368..53916376,-	p4@Tnfaip8l3
Mm9::chr9:8899828..8899855,+	p3@Pgr
Mm9::chr9:8900409..8900425,+	p2@Pgr
Mm9::chr9:8900459..8900489,+	p1@Pgr
Mm9::chr9:8900490..8900502,+	p4@Pgr
Mm9::chr9:8900563..8900574,+	p5@Pgr
Mm9::chr9:8901535..8901549,+	p@chr9:8901535..8901549 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0009082	branched chain family amino acid biosynthetic process	0.0289243744861156
GO:0050847	progesterone receptor signaling pathway	0.0289243744861156
GO:0004084	branched-chain-amino-acid transaminase activity	0.0289243744861156
GO:0002070	epithelial cell maturation	0.043176633121409
GO:0009083	branched chain family amino acid catabolic process	0.043176633121409
GO:0002064	epithelial cell development	0.043176633121409
GO:0009081	branched chain family amino acid metabolic process	0.043176633121409
GO:0001542	ovulation from ovarian follicle	0.043176633121409
GO:0030728	ovulation	0.043176633121409
GO:0030518	steroid hormone receptor signaling pathway	0.043176633121409
GO:0030522	intracellular receptor-mediated signaling pathway	0.043176633121409
GO:0030879	mammary gland development	0.043176633121409
GO:0050678	regulation of epithelial cell proliferation	0.043176633121409
GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism	0.043176633121409
GO:0008483	transaminase activity	0.043176633121409
GO:0022601	menstrual cycle phase	0.043176633121409
GO:0022602	menstrual cycle process	0.043176633121409
GO:0015985	energy coupled proton transport, down electrochemical gradient	0.043176633121409
GO:0050673	epithelial cell proliferation	0.043176633121409
GO:0015986	ATP synthesis coupled proton transport	0.043176633121409
GO:0008652	amino acid biosynthetic process	0.043176633121409
GO:0016769	transferase activity, transferring nitrogenous groups	0.043176633121409
GO:0008585	female gonad development	0.043176633121409
GO:0007292	female gamete generation	0.043176633121409
GO:0006754	ATP biosynthetic process	0.043176633121409
GO:0006753	nucleoside phosphate metabolic process	0.043176633121409
GO:0046933	hydrogen ion transporting ATP synthase activity, rotational mechanism	0.043176633121409
GO:0046545	development of primary female sexual characteristics	0.043176633121409
GO:0030855	epithelial cell differentiation	0.043176633121409
GO:0046660	female sex differentiation	0.043176633121409
GO:0016469	proton-transporting two-sector ATPase complex	0.043176633121409
GO:0046961	hydrogen ion transporting ATPase activity, rotational mechanism	0.043176633121409
GO:0042698	menstrual cycle	0.043176633121409
GO:0046034	ATP metabolic process	0.043176633121409
GO:0009145	purine nucleoside triphosphate biosynthetic process	0.043176633121409
GO:0009206	purine ribonucleoside triphosphate biosynthetic process	0.043176633121409
GO:0009201	ribonucleoside triphosphate biosynthetic process	0.043176633121409
GO:0009063	amino acid catabolic process	0.043176633121409
GO:0005496	steroid binding	0.043176633121409
GO:0003707	steroid hormone receptor activity	0.043176633121409
GO:0019829	cation-transporting ATPase activity	0.043176633121409
GO:0004879	ligand-dependent nuclear receptor activity	0.043176633121409
GO:0009142	nucleoside triphosphate biosynthetic process	0.043176633121409
GO:0009205	purine ribonucleoside triphosphate metabolic process	0.043176633121409
GO:0009199	ribonucleoside triphosphate metabolic process	0.043176633121409
GO:0006119	oxidative phosphorylation	0.043176633121409
GO:0008406	gonad development	0.043176633121409
GO:0009144	purine nucleoside triphosphate metabolic process	0.043176633121409
GO:0015992	proton transport	0.043176633121409
GO:0048608	reproductive structure development	0.043176633121409
GO:0006752	group transfer coenzyme metabolic process	0.043176633121409
GO:0044249	cellular biosynthetic process	0.043176633121409
GO:0009141	nucleoside triphosphate metabolic process	0.043176633121409
GO:0044270	nitrogen compound catabolic process	0.043176633121409
GO:0009310	amine catabolic process	0.043176633121409
GO:0009152	purine ribonucleotide biosynthetic process	0.043176633121409
GO:0006818	hydrogen transport	0.043176633121409
GO:0045137	development of primary sexual characteristics	0.043176633121409
GO:0009309	amine biosynthetic process	0.043176633121409
GO:0015662	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	0.043176633121409
GO:0009260	ribonucleotide biosynthetic process	0.043176633121409
GO:0009150	purine ribonucleotide metabolic process	0.044532669425093
GO:0006164	purine nucleotide biosynthetic process	0.044532669425093
GO:0009259	ribonucleotide metabolic process	0.0449529148313214
GO:0005923	tight junction	0.0449529148313214
GO:0048609	reproductive process in a multicellular organism	0.0449529148313214
GO:0032504	multicellular organism reproduction	0.0449529148313214
GO:0007548	sex differentiation	0.0449529148313214
GO:0048469	cell maturation	0.0449529148313214
GO:0006163	purine nucleotide metabolic process	0.0449529148313214
GO:0048732	gland development	0.0449529148313214
GO:0044271	nitrogen compound biosynthetic process	0.0455191505253952
GO:0042625	ATPase activity, coupled to transmembrane movement of ions	0.0478295860260173
GO:0009108	coenzyme biosynthetic process	0.0483403062850561
GO:0003006	reproductive developmental process	0.0494075198078521
GO:0043296	apical junction complex	0.0496125512930327
GO:0016327	apicolateral plasma membrane	0.0496125512930327
GO:0015078	hydrogen ion transmembrane transporter activity	0.0496125512930327
GO:0021700	developmental maturation	0.0496125512930327

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
female reproductive system	1.40e-47	9
female reproductive organ	2.45e-42	8
female organism	9.32e-39	11
internal female genitalia	1.74e-27	5
reproductive structure	2.09e-23	26
reproductive system	2.09e-23	26
embryonic uterus	2.84e-22	4
uterus	2.84e-22	4
internal genitalia	1.83e-21	9
reproductive organ	6.40e-21	24
extraembryonic membrane	1.94e-16	3
extraembryonic structure	1.94e-16	3
membranous layer	1.94e-16	3
female gonad	2.19e-16	3
placenta	1.03e-11	2
chorion	1.03e-11	2
allantois	1.03e-11	2
renal system	1.69e-09	19
somatic layer of lateral plate mesoderm	8.73e-08	3
external genitalia	1.61e-07	17
indifferent external genitalia	1.61e-07	17
indifferent gonad	1.61e-07	17
gonad	4.31e-07	18
gonad primordium	4.31e-07	18
urinary system structure	4.73e-07	18
uterus or analog	6.50e-07	1
vagina	7.38e-07	1
oviduct	8.36e-07	1

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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