MCL coexpression mm9:2211

Phase1 CAGE Peaks

	Short description
Mm9::chr17:37330834..37330842,+	p2@Ubd
Mm9::chr6:85770930..85770956,-	p1@Gm11128
Mm9::chr6:85770959..85770971,-	p1@Cml3 p1@Cml5
Mm9::chr6:85770975..85770984,-	p2@Cml3 p2@Cml5

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0007162	negative regulation of cell adhesion	0.0494120910174751
GO:0001702	gastrulation with mouth forming second	0.0494120910174751
GO:0030155	regulation of cell adhesion	0.0494120910174751
GO:0008080	N-acetyltransferase activity	0.0494120910174751
GO:0016410	N-acyltransferase activity	0.0494120910174751
GO:0016407	acetyltransferase activity	0.0494120910174751
GO:0007369	gastrulation	0.0494120910174751

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
epithelial cell	9.20e-15	25
brush border epithelial cell	2.19e-13	6
gut absorptive cell	2.19e-13	6
absorptive cell	2.19e-13	6
enterocyte	2.19e-13	6
columnar/cuboidal epithelial cell	2.34e-11	7
intestinal epithelial cell	2.50e-11	9
epithelial cell of alimentary canal	2.50e-11	9
endodermal cell	2.96e-11	20
transporting cell	4.28e-08	3
M cell of gut	4.28e-08	3
metabolising cell	2.75e-07	5
endopolyploid cell	2.75e-07	5
parenchymal cell	2.75e-07	5
polyploid cell	2.75e-07	5
hepatocyte	2.75e-07	5

Uber Anatomy

Ontology term	p-value	n
intestine	4.36e-32	31
mucosa	2.33e-23	15
gastrointestinal system	3.52e-19	47
intestinal mucosa	4.49e-19	13
anatomical wall	4.49e-19	13
wall of intestine	4.49e-19	13
gastrointestinal system mucosa	4.49e-19	13
organ component layer	2.12e-13	24
digestive system	4.54e-12	116
digestive tract	4.54e-12	116
primitive gut	4.54e-12	116
endoderm-derived structure	9.75e-12	118
endoderm	9.75e-12	118
presumptive endoderm	9.75e-12	118
epithelium of mucosa	2.50e-11	9
gastrointestinal system epithelium	2.50e-11	9
intestinal epithelium	2.50e-11	9
subdivision of digestive tract	3.52e-10	114
small intestine	3.13e-09	4
simple columnar epithelium	4.61e-09	11
ileal mucosa	2.30e-07	3
ileum	2.30e-07	3
mucosa of small intestine	2.30e-07	3
wall of small intestine	2.30e-07	3

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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